Medical Directors Fibromyalgia Resource Center
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What are fibromyalgia tender points?
MayoClinic.com Full Feed
2/28/2014 7:00:00 PM
Can you be diagnosed with fibromyalgia if you don't have tender points? (Source: MayoClinic.com Full Feed)

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Teenagers With Fibromyalgia Unlikely to 'Outgrow' the PainTeenagers With Fibromyalgia Unlikely to 'Outgrow' the Pain
Medscape Today Headlines
2/28/2014 12:47:35 PM
Half of adolescents with juvenile-onset fibromyalgia met diagnostic criteria for adult fibromyalgia within 6 years. Medscape Medical News (Source: Medscape Today Headlines)
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Long-Term Outcomes of Adolescents With Juvenile-Onset Fibromyalgia in Early Adulthood
PEDIATRICS
2/27/2014 7:00:00 PM
Juvenile-onset fibromyalgia (JFM) is a poorly understood chronic pain condition, typically identified in adolescence and accompanied by physical and social impairment and mood difficulties. There are no long-term studies on the prognosis of adolescents with JFM into adulthood. This prospective study demonstrated that pain and other symptoms persisted into adulthood for >80% of JFM patients, with associated impairments in physical functioning and mood. At follow-up, one-half of the sample met full criteria for adult fibromyalgia. (Read the full article) (Source: PEDIATRICS)

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TENS therapy: An option for fibromyalgia treatment?
MayoClinic.com - Ask a Specialist
2/26/2014 7:00:00 PM
TENS therapy may be effective for fibromyalgia pain. (Source: MayoClinic.com - Ask a Specialist)
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Effects of Cranial Electrical Stimulation on Activity in Regions of the Basal Ganglia in Individuals with Fibromyalgia
The Journal of Alternative and Complementary Medicine
2/26/2014 12:48:13 PM
The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0. (Source: The Journal of Alternative and Complementary Medicine)
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Most Teens With Fibromyalgia Suffer Pain, Fatigue as Adults
WebMD Health
2/26/2014 9:15:34 AM
Four of five continued to experience symptoms, while half had full-blown disorder, study finds (Source: WebMD Health)
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Most Teens with Fibromyalgia Suffer Pain, Fatigue as Adults
MedlinePlus Health News
2/26/2014 9:00:00 AM
Four of five continued to experience symptoms, while half had full-blown disorder, study findsSource: HealthDay Related MedlinePlus Pages: Fibromyalgia, Pain, Teen Health (Source: MedlinePlus Health News)
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Most Teens With Fibromyalgia Suffer Pain, Fatigue as Adults
MedicineNet Chronic Pain General
2/26/2014 2:00:00 AM
Title: Most Teens With Fibromyalgia Suffer Pain, Fatigue as AdultsCategory: Health NewsCreated: 2/26/2014 9:35:00 AMLast Editorial Review: 2/26/2014 12:00:00 AM (Source: MedicineNet Chronic Pain General)

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Suffer from fibromyalgia? You might be sensory defensive
NaturalNews.com
2/25/2014 1:00:00 AM
(Source: NaturalNews.com)
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Pain and sleep
Sound Medicine
2/22/2014 7:00:00 PM
Widespread pain affecting various parts of the body--a condition known as fibromyalgia--plagues around 13 percent of people older than 50. And did you know that one of the main risk factors may be restless sleep?.... (Source: Sound Medicine)
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Impact of interdisciplinary treatment on physical and psychosocial parameters in patients with fibromyalgia: results of a randomised trial
International Journal of Clinical Practice
2/21/2014 9:32:43 AM
ConclusionAn interdisciplinary intervention may be appropriate for patients referred to a hospital pain management unit. (Source: International Journal of Clinical Practice)
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Massage Therapy for Health Purposes: What You Need To Know
NCCAM Featured Content
2/20/2014 5:09:53 PM
This fact sheet discusses the safety and effectiveness of massage therapy for health conditions such as pain, cancer, fibromyalgia, HIV/AIDS, depression, and more. (Source: NCCAM Featured Content)
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Mean platelet volume in patients with fibromyalgia.
Zeitschrift fur Rheumatologie
2/19/2014 7:00:00 PM
Authors: Haliloğlu S, Carlioglu A, Sahiner E, Karaaslan Y, Kosar A Abstract Fibromyalgia is a syndrome characterised by chronic widespread pain at multiple tender points, as well as joint stiffness and systemic symptoms. The aetiology and pathogenesis of fibromyalgia still remain unclear, although many contributory factors have been suggested. The presence of some common features between fibromyalgia and cardiovascular risk factors (e.g. depression and sleep disturbance) led to question of whether there is there a relationship between fibromyalgia and cardiovascular disease and/or atherosclerosis. Mean platelet volume, which is a determinant of platelet activation, is a newly emerging independent risk factor for cardiovascular disease.The present study was designed to evaluate lev...
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Music as a sleep aid in fibromyalgia.
Pain Research and Management
2/18/2014 7:00:00 PM
Authors: Picard LM, Bartel LR, Gordon AS, Cepo D, Wu Q, Pink LR PMID: 24555178 [PubMed - as supplied by publisher] (Source: Pain Research and Management)
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Is a new perspective for definition and diagnostic criteria of fibromyalgia in early stage cancer patients necessary?
Medical Hypotheses
2/17/2014 7:00:00 PM
In conclusion, there is it may more prevalence of fibromyalgia in patients with cancer. For the diagnosis of fibromyalgia, be new diagnostic criteria for early-stage cancer patients. (Source: Medical Hypotheses)
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Response to ‘Remarkable prevalence of celiac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study’
BioMed Central
2/16/2014 7:00:00 PM
No description available (Source: BioMed Central)
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Response to ‘Remarkable prevalence of celiac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study’ – authors’ reply
Epidemiologic Perspectives and Innovations
2/16/2014 7:00:00 PM
No description available (Source: Epidemiologic Perspectives and Innovations)
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Response to `Remarkable prevalence of celiac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study¿
Arthritis Research and Therapy
2/16/2014 7:00:00 PM
No description available (Source: Arthritis Research and Therapy)
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Response to `Remarkable prevalence of celiac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study¿ ¿ authors¿ reply
Arthritis Research and Therapy
2/16/2014 7:00:00 PM
No description available (Source: Arthritis Research and Therapy)

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Could restless sleep cause widespread pain in older people?
ScienceDaily Headlines
2/13/2014 8:37:11 AM
Researchers in the U.K. report that non-restorative sleep is the strongest, independent predictor of widespread pain onset among adults over the age of 50. According to the study anxiety, memory impairment, and poor physical health among older adults may also increase the risk of developing widespread pain. Muscle, bone and nerve (musculoskeletal) pain is more prevalent as people age, with up to 80% of people 65 years of age and older experiencing daily pain. Widespread pain that affects multiple areas of the body —- the hallmark feature of fibromyalgia —- affects 15% of women and 10% of men over age 50 according to previous studies. (Source: ScienceDaily Headlines)

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Judge: Lack Of 'Objective Findings' Is Not Sufficient Basis For Denial
LexisNexis® Mealey's™ Disability Insurance Legal News
2/12/2014 2:20:19 PM
SAN FRANCISCO - An ERISA-governed disability insurer that denied benefits to a claimant with fibromyalgia and chronic fatigue syndrome was not reasonably supported by the record, a California federal judge ruled Jan. 22. The judge said a lack of "objective findings" is not a sufficient basis for a benefit denial (Debra J. Eisner v. The Prudential Insurance Company of America, No. 12-cv-01238, N.D. Calif.; 2014 U.S. Dist. LEXIS 8554). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
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Trigeminal nerve stimulation (TNS) for fibromyalgia: A case study.
Epilepsy and Behaviour
2/10/2014 7:00:00 PM
Authors: Shiozawa P, da Silva ME, Cordeiro Q PMID: 24530850 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
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Fibromyalgia Program Review | Discover A New Treatment For...
PRWeb: Medical Pharmaceuticals
2/10/2014 8:40:07 AM
Fibromyalgia Program designed by Christian G is the latest program that covers natural and safe methods for treating fibromyalgia syndrome. A full review on the site Vinamy.com indicates if...(PRWeb February 10, 2014)Read the full story at http://www.prweb.com/releases/fibromyalgia-program/review/prweb11568268.htm (Source: PRWeb: Medical Pharmaceuticals)
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What is the proper control group for a fibromyalgia study?
Arthritis and Rheumatism
2/9/2014 7:00:00 PM
(Source: Arthritis and Rheumatism)

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Social security work disability and its predictors in patients with fibromyalgia
Arthritis Care and Research
2/9/2014 7:00:00 PM
Conclusions. The prevalence of SSD is high in fibromyalgia, but not higher than in RA and OA patients who satisfy fibromyalgia criteria. The best predictors of work disability are functional status variables. © 2014 American College of Rheumatology. (Source: Arthritis Care and Research)
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Reply to the Letter to the Editor by Dr. Lampman (“What is a proper control group in fibromyalgia study?”)
Arthritis and Rheumatism
2/9/2014 7:00:00 PM
(Source: Arthritis and Rheumatism)
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Diagnostic Classification Based on Functional Connectivity in Chronic Pain: Model Optimization in Fibromyalgia and Rheumatoid Arthritis
Academic Radiology
2/7/2014 8:56:48 PM
Conclusions: Observed accuracies are not sufficient to reliably differentiate between FMS and RA for diagnostic purposes. However, some indirect evidence in support of the feasibility of this approach is provided. This exploratory analysis constitutes a fundamental model optimization effort to be based on in further investigations. (Source: Academic Radiology)
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Effects of physical exercise on serum levels of serotonin and its metabolite in fibromyalgia: a randomized pilot study
Revista Brasileira de Reumatologia
2/2/2014 10:45:45 PM
Avaliar os efeitos do treinamento aeróbico e do alongamento sobre os níveis séricos de serotonina (5-HT) e seu principal metabólito ácido 5-hidroxiindolacético (5-HIAA). Foram randomizadas 22 mulheres com fibromialgia (FM) em uma de duas modalidades de exercício (exercício aeróbico de caminhada ou exercício de alongamento) a serem realizadas três vezes por semana, por 20 semanas. Os níveis séricos de 5-HT e 5-HIAA foram avaliados antes e após o programa de exercícios por cromatografia líquida de alta eficiência (CLAE) com detecção colorimétrica. A análise de grupo (pré-pós) mostrou que os níveis séricos de 5-HT e 5-HIAA mudaram significativamente no grupo aeróbico durante o período de 20 semanas de terapia (5-HT: p = 0,03; 5-HIAA: p = 0,003). No grupo alongamento...
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Pain, quality of life, self perception of health and depression in patients with fibromyalgia, submited to hydrocinesiotherapy
Revista Brasileira de Reumatologia
2/2/2014 10:45:45 PM
CONCLUSIONS: The study suggests that hydrocinesiotherapy was effective as an alternative therapy for fibromyalgia, however further studies are recommended to test the associations between the variables and intervention programs and using the water activities, and the modifiability of the parameters of physical and mental health when these individuals undergo programs of short, medium and long duration. (Source: Revista Brasileira de Reumatologia)
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Correlation between demographic and clinical variables and fibromyalgia severity
Revista Brasileira de Reumatologia
2/2/2014 10:45:45 PM
INTRODUÇÃO: A fibromialgia (FM) é uma condição reumatológica que se caracteriza por um quadro de dor crônica generalizada, hiperalgesia e alodinia. Podem estar presentes sintomas como fadiga, distúrbios do sono, rigidez matinal, cefaleia e parestesias. Também está associada a outras comorbidades, como depressão, ansiedade, síndrome do intestino irritável, síndrome miofascial e síndrome uretral inespecífica. Poucos trabalhos têm abordado a evolução da FM, em especial em relação a médio e longo prazo. Por que alguns pacientes se saem melhor do que outros, apesar de serem submetidos ao mesmo tratamento? OBJETIVO: Determinar se há correlação entre variáveis demográficas e clínicas, e a gravidade da FM. MATERIAL E MÉTODOS: Sessenta mulheres que preencheram os crité...
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Criteria for the diagnosis of fibromyalgia: Validation of the modified 2010 preliminary ACR criteria and the development of alternative criteria
Arthritis Care and Research
1/31/2014 7:00:00 PM
Conclusion. The 2011ModCr had robust operating characteristics. Alternative criteria (2013 AltCr), based on symptom items from the SIQR and pain locations from the PLI, had comparable operating characteristics with somewhat better specificity and ease‐of‐use. © 2014 American College of Rheumatology. (Source: Arthritis Care and Research)
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Validity and reliability of the Spanish version of the 10-item CD-RISC in patients with fibromyalgia
Health and Quality of Life Outcomes
1/31/2014 7:00:00 PM
Conclusions: Our study confirms that the Spanish version of the 10-item CD-RISC shows, in patients with fibromyalgia, acceptable psychometric properties, with a high level of reliability and validity. (Source: Health and Quality of Life Outcomes)

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Evaluation of the Interdisciplinary PSYMEPHY Treatment on Patients with Fibromyalgia: A Randomized Control Trial
Pain Medicine
1/31/2014 7:00:00 PM
ConclusionsThis study highlights the beneficial effects of an interdisciplinary treatment for FM patients in a hospital pain management unit. A 6‐week interdisciplinary intervention showed significant improvement in key domains of fibromyalgia, as quality of life, pain, fatigue, rested, and anxiety at 12 months. (Source: Pain Medicine)
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Endogenous Pain Modulation in Response to Exercise in Patients with Rheumatoid Arthritis, Patients with Chronic Fatigue Syndrome and Comorbid Fibromyalgia, and Healthy Controls: A Double‐Blind Randomized Controlled Trial
Pain Practice
1/31/2014 7:00:00 PM
ConclusionThis study evaluates pain scores, TS, and CPM in response to submaximal exercise in 2 different chronic pain populations and healthy controls. In patients with RA, exercise had positive effects on TS, suggesting normal EIA. In patients with CFS/FM, these positive effects were only observed after paracetamol and results were inconsistent. (Source: Pain Practice)
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Resistance, Aerobic Training May Reduce Pain in FibromyalgiaResistance, Aerobic Training May Reduce Pain in Fibromyalgia
Medscape Nurses Headlines
1/31/2014 5:59:22 PM
Patients with fibromyalgia gained function, strength, and reduced pain and tenderness with resistance training. Aerobic training also reduced pain. Medscape Medical News (Source: Medscape Nurses Headlines)
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The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Toxicon
1/30/2014 7:00:00 PM
This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM). Repeated administration of reserpine (0.25 mg/kg sc) once daily for three consecutive days significantly decreased thermal hyperalgesia, mechanical allodynia, and dopamine and serotonin content in the brain on the 4th day. Phα1β and pregabalin treatment completely reverted the mechanical allodynia and thermal hyperalgesia induced by reserpine treatment on the 4th day, but diclofenac was ineffective. Reserpine treatment significantly increased the immobility time in the forced swim test, which is indicative of depression in the animals. Phα1β, but not pregabalin, reduced the immobility time (56%), suggesting that Phα1β may control persistent pathological pain in FM. ...

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Living with the unexplained: Coping, distress, and depression among women with chronic fatigue syndrome (CFS) and/or fibromyalgia comparedto an autoimmune disorder.
Anxiety, Stress, and Coping
1/29/2014 7:00:00 PM
Authors: McInnis OA, Matheson K, Anisman H Abstract Chronic fatigue syndrome (CFS) and fibromyalgia are disabling conditions without objective diagnostic tests, clear-cut treatments, or established etiologies. Those with the disorders are viewed suspiciously, and claims of malingering are common, thus promoting further distress. It was hypothesized in the current study that levels of unsupportive social interactions and the coping styles used among those with CFS/fibromyalgia would be associated with perceived distress and depressive symptoms. Women with CFS/fibromyalgia (n=39), in fact, reported higher depression scores, greater perceived distress and more frequent unsupportive relationships than healthy women (n=55), whereas those with a chronic, but medically accepted illness co...
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Twice Daily Versus Once Nightly Dosing of Pregabalin for Fibromyalgia: A Double‐Blind Randomized Clinical Trial of Efficacy and Safety
Arthritis Care and Research
1/28/2014
ConclusionWhile a nightly dosing schedule of pregabalin has been used by clinicians hoping to improve treatment, this study showed no significant difference (either beneficial or detrimental) between either treatment option. While there was a decrease in total patient‐reported adverse events in the once nightly arm, the lack of specificity in relation to a particular adverse event suggested no real difference in adverse events. (Source: Arthritis Care and Research)
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Suicidal ideation in patients with fibromyalgia: A cross-sectional study - Calandre EP, Navajas-Rojas MA, Ballesteros J, Garcia-Carrillo J, Garcia-Leiva JM, Rico-Villademoros F.
SafetyLit: All (Unduplicated)
1/23/2014 12:35:18 PM
Chronic pain, sleep disturbances, and depression, which are relevant symptoms of fibromyalgia syndrome, have been demonstrated to be associated with an increased likelihood of suicidal behaviors. Mortality from suicide has been shown to be greater among pa... (Source: SafetyLit: All (Unduplicated))
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Reducing Fibromyalgia Pain with Vitamin D Supplements
Disabled World
1/23/2014 9:11:39 AM
Patients with fibromyalgia syndrome (FMS) typically have widespread chronic pain and fatigue. For those with low vitamin D levels, vitamin D supplements can reduce pain and may be a cost-effective alternative or adjunct to other treatment, say researchers in the current issue of PAIN(R). (Source: Disabled World)

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Vitamin D supplemenation helps fibromyalgia patients manage pain
NaturalNews.com
1/22/2014 1:00:00 AM
Fibromyalgia is a state of inflammation and fatigue that causes muscle pains and sensitivity. It's a condition that tears down one's quality of life, bringing anxiety and depression. It's a condition that more people are experiencing; estimates show that 1 in 25 now... (Source: NaturalNews.com)
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Fibromyalgia and Cytokines.
Immunology Letters
1/22/2014
Authors: Rodriguez-Pintó I, Agmon-Levin N, Howard A, Shoenfeld Y Abstract Fibromyalgia is a common chronic pain syndrome characterized by widespread pains and characteristic somatic symptoms. Current evidence suggests that cytokines and especially chemokines may have a role in the pathogenesis of this syndrome. Cytokines are small soluble factors that work as immune system messengers. They can be classified as pro-inflammatory and anti-inflammatory cytokines. Chemokines are a special kind of pro-inflammatory cytokines that guide the movement of circulating mononuclear cells to the injured side. Some pro-inflammatory cytokine levels (i.e. IL-1RA, IL-6, and IL-8) and, recently, some chemokines levels have been found to be increased in patients with fibromyalgia. Thus, herein we revi...
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Effects of vitamin D on patients with fibromyalgia syndrome: A randomized placebo-controlled trial
Pain
1/21/2014 11:00:32 AM
Summary: In patients with fibromyalgia syndrome, we investigated the effects of adequately optimized serum calcifediol levels on their perception of pain, health-related quality of life, and comorbidities.Abstract: The role of calcifediol in the perception of chronic pain is a widely discussed subject. Low serum levels of calcifediol are especially common in patients with severe pain and fibromyalgia syndrome (FMS). We lack evidence of the role of vitamin D supplementation in these patients. To our knowledge, no randomized controlled trial has been published on the subject. Thirty women with FMS according to the 1990 and 2010 American College of Rheumatology criteria, with serum calcifediol levels (Source: Pain)

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Attentional Bias Toward Negative Information in Patients with Fibromyalgia Syndrome
Pain Medicine
1/21/2014
ConclusionsThe study provides evidence of emotionally driven selective attention in FMS. Attentional bias to negative information may play an important role in the vicious circle between negative affective state and pain augmentation. In the management of FMS pain, strategies aiming at conscious direction of attention may be helpful, e.g., imagery techniques or mindfulness training. (Source: Pain Medicine)
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Vitamin D supplements reduce pain in fibromyalgia sufferers (Medical Xpress, 17 January 2014)
Society for Endocrinology
1/17/2014 7:00:00 AM
An Austrian study in Pain investigated whether Vitamin D supplementation would reduce the degree of chronic pain experienced by fibromyalgia sufferers with low levels of calcifediol. Full link (Source: Society for Endocrinology)
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Vitamin D Supplements May Help Ease Fibromyalgia Pain: Study
MedicineNet Chronic Pain General
1/17/2014 2:00:00 AM
Title: Vitamin D Supplements May Help Ease Fibromyalgia Pain: StudyCategory: Health NewsCreated: 1/17/2014 9:35:00 AMLast Editorial Review: 1/17/2014 12:00:00 AM (Source: MedicineNet Chronic Pain General)
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Suicidal Ideation in Patients with Fibromyalgia: A Cross‐Sectional Study
Pain Practice
1/17/2014
This study aimed to assess the prevalence of suicidal ideation among a sample of patients with fibromyalgia and to evaluate its relationship with the clinical symptomatology of fibromyalgia. Baseline data from fibromyalgia patients willing to participate in different clinical studies were collected. Outcome measures included the Fibromyalgia Impact Questionnaire, the Beck Depression Inventory, the Pittsburgh Sleep Quality Index, the Brief Pain Inventory, and the SF‐12 Health Survey. The scores for these scales were compared between patients with and without suicidal ideation. The presence of suicidal ideation was assessed using the answer provided to item 9 of the Beck Depression Inventory. The results were adjusted by age, sex, total comorbidity, and time since diagnosis with multiple l...
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Review of pharmacological therapies in fibromyalgia syndrome
BioMed Central
1/17/2014
This review addresses the current status of drug therapy for the management of fibromyalgia syndrome (FMS) and is based on interdisciplinary FMS management guidelines, meta-analyses of drug trial data, and observational studies. In the absence of a single gold-standard medication, patients are treated with a variety of drugs from different categories, often with limited evidence. Drug therapy is not mandatory for the management of FMS. Pregabalin, duloxetine, milnacipran, and amitriptyline are the current first-line prescribed agents but have had a mostly modest effect. With only a minority of patients expected to experience substantial benefit, most will discontinue therapy because of either a lack of efficacy or tolerability problems. Many drug treatments have undergone limited study and...
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Vitamin D supplements reduce pain in fibromyalgia sufferers
EurekAlert! - Biology
1/17/2014
(Elsevier Health Sciences) Patients with fibromyalgia syndrome typically have widespread chronic pain and fatigue. For those with low vitamin D levels, vitamin D supplements can reduce pain and may be a cost-effective alternative or adjunct to other treatment, say researchers in the current issue of PAIN®. (Source: EurekAlert! - Biology)
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Characteristics, Treatment, and Health Care Expenditures of Medicare Supplemental‐Insured Patients with Painful Diabetic Peripheral Neuropathy, Post‐Herpetic Neuralgia, or Fibromyalgia
Pain Medicine
1/16/2014
ConclusionsThe numerous comorbidities, polypharmacy, and magnitude of expenditures in this sample of Medicare supplemental‐insured patients with pDPN, PHN, or fibromyalgia underscore the complexity and importance of appropriate management of these chronic pain patients. (Source: Pain Medicine)

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The impact of thyroid autoimmunity on arterial stiffness in postmenopausal patients with fibromyalgia
APLAR Journal of Rheumatology
1/11/2014
ConclusionAge, functional status and presence of TPO Ab were significantly associated with increased arterial stiffness in postmenopausal FM patients. Given the combined thyroid autoimmunity in FM patients, a re‐evaluation of the effects on the vasculature may be necessary. (Source: APLAR Journal of Rheumatology)
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Fibromyalgia and Complementary Health Approaches
NCCAM Featured Content
1/8/2014 4:13:07 PM
This fact sheet provides basic information on fibromyalgia and “what the science says” about the effectiveness of CAM practices that many people with fibromyalgia use. (Source: NCCAM Featured Content)

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Potential Drug–Drug and Drug–Condition Interactions among Fibromyalgia Patients Initiating Pregabalin or Duloxetine: Prevalence and Health Care Expenditure Impact
Pain Medicine
1/8/2014
ConclusionsAmong fibromyalgia patients initiating pregabalin or duloxetine, potential duloxetine DDI could be highly prevalent. Among duloxetine initiators, potential duloxetine DDI/DCI were significantly associated with increased health care expenditures. (Source: Pain Medicine)
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An Epidemiological Internet Survey of Fibromyalgia and Chronic Pain in Japan
Arthritis Care and Research
1/8/2014
Conclusion. Because FM usually presents with more severe and more widely distributed pain, as well as more non‐painful symptoms than CP, our results suggest that FM is a different clinical phenotype of CP. © 2013 American College of Rheumatology. (Source: Arthritis Care and Research)

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Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia.
Cochrane Database of Systematic Reviews
1/3/2014
CONCLUSIONS: There is adequate amounts of moderate quality evidence from eight studies performed by the manufacturers of duloxetine that doses of 60 mg and 120 mg daily are efficacious for treating pain in diabetic peripheral neuropathy but lower daily doses are not. Further trials are not required. In fibromyalgia, there is lower quality evidence that duloxetine is effective at similar doses to those used in diabetic peripheral neuropathy and with a similar magnitude of effect. The effect in fibromyalgia may be achieved through a greater improvement in mental symptoms than in somatic physical pain. There is low to moderate quality evidence that pain relief is also achieved in pain associated with depressive symptoms, but the NNTB of 8 in fibromyalgia and depression is not an indication of...
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Fibromyalgia research criteria.
J Rheumatol
1/1/2014
Authors: Wolfe F PMID: 24382930 [PubMed - in process] (Source: J Rheumatol)

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Chronic Fatigue Syndrome, Fibromyalgia, and Myalgic Encephalomyelitis: A Clinical Perspective.
Alternative Therapies in Health and Medicine
1/1/2014
Authors: Teitelbaum J Abstract No Abstract Available. PMID: 24445355 [PubMed - as supplied by publisher] (Source: Alternative Therapies in Health and Medicine)
http://www.medworm.com/rss/comments.php?id=10557126
Pregabalin in neuropathic pain: evidences and possible mechanisms.
Current Neuropharmacology
12/31/2013 7:00:00 PM
Authors: Verma V, Singh N, Singh Jaggi A Abstract Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the symptoms of various types of neuropathic pain and presents itself as a first line therapeutic agent with remarkable safety and efficacy. Preclinical studies in various animal models of neuropathic pain have shown its effectiveness in treating the symptoms like allodynia and hyperalgesia. Clinical studies in different age groups and in different types of neuropathic pain (peripheral diabetic neuropathy, fibromyalgia, post-herpetic neuralgia, cancer chemotherapy-induced neuropathic pain) have projected it as the most effective agent either as monothera...
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Small nerve fiber involvement in patients referred for fibromyalgia
Muscle and Nerve
12/28/2013
Conclusion A subset of FM subjects have SFN which may contribute to their sensory and autonomic symptoms. Skin biopsy should be considered in the diagnostic workup of FM. © 2013 Wiley Periodicals, Inc. (Source: Muscle and Nerve)
http://www.medworm.com/rss/comments.php?id=7894569
Chronic Widespread Pain, Including FibromyalgiaChronic Widespread Pain, Including Fibromyalgia
Medscape Today Headlines
12/27/2013 3:29:55 AM
This article describes the development of a pathway for the management of fibromyalgia and chronic pain. British Journal of Anaesthesia (Source: Medscape Today Headlines)
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Fibromyalgia: is it possible to measure the association of subjective and objective pain?
Arthritis Care and Research
12/24/2013
(Source: Arthritis Care and Research)

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Piecing Together the Puzzle of Fibromyalgia
Alternative and Complementary Therapies
12/23/2013 2:26:21 PM
Alternative and Complementary Therapies Dec 2013, Vol. 19, No. 6: 296-300. (Source: Alternative and Complementary Therapies)
http://www.medworm.com/rss/comments.php?id=7883296
Fibromyalgia Pain Management Update
ChiroACCESS: Tools for Better Patient Care
12/15/2013 7:00:00 PM
Nearly 600 scientific papers related to fibromyalgia have been published in 2013, yet fibromyalgia remains a complex issue with a weak understanding of its etiology, diagnosis, effective palliative management or cure. (Source: ChiroACCESS: Tools for Better Patient Care)
http://www.medworm.com/rss/comments.php?id=7859456
Central Pain Sensitization, COMT Val158Met Polymorphism, and Emotional Factors in Fibromyalgia
The Journal of Pain
12/15/2013 7:00:00 PM
Abstract: Neurobiological evidence points to altered central nervous system processing of nociceptive stimuli in fibromyalgia. Enzymes like catechol-O-methyl-transferase (COMT) are involved in the elimination of catecholamines playing a possible role in central sensitization and pain. We used quantitative sensory testing to evidence central sensitization in fibromyalgia patients and test whether COMTVal158Met polymorphism, associated with a reduction in enzyme activity, plays a role in sensitized patients. Pain evaluation and quantitative sensory testing were performed including the spinal nociceptive flexion reflex, a physiologic correlate for the evaluation of central nociceptive pathways. Quality of life and distress questionnaires were used. A total of 137 fibromyalgia patients were as...
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Are Your Fibromyalgia Symptoms Due to Lyme Disease?
Psychology Today Depression Center
12/15/2013 2:25:43 PM
Lyme disease is the number one vector borne spreading epidemic worldwide, and mimics common diseases such as Fibromyalgia (FM), Chronic Fatigue Syndrome (myalgic encephalomyelitis), autoimmune diseases like rheumatoid arthritis and MS, as well as psychiatric conditions such as depression and anxiety.read more (Source: Psychology Today Depression Center)
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Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine.
Dermatol Online J
12/13/2013 12:25:30 PM
Authors: Scheinfeld N Abstract Hidradenitis Supprurativa is a painful dermatological condition. Although the pain of HS has unique aspects, the pain of HS pain shares common elements with essential pain, fibromyalgia, and pure neuropathic pain syndromes. Futhermore, depression plays an important role in the pain of HS. This paper reviews the potential for use of nonsteroidal anti-inflammatory drug (NSAIDS), acetaminophen, celecoxib, gabpentin, pregabalin, and the serotonin and norepinephrine reuptake inhibitors (SNRIs), duloxetine and venlafaxine, for treating HS related pain. No studies exist for pain control in HS. Initially, the pain of HS is treated medically e.g. oral rifampin and clindamycin or adalimumab to decrease inflammation, but an analysis of pain medications to treat ...
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Changes in the Clinical Manifestation of Fibromyalgia in an Individual with Dementia
Journal of the American Geriatrics Society
12/12/2013
(Source: Journal of the American Geriatrics Society)
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EpiFibro - a nationwide databank for fibromyalgia syndrome: the initial analysis of 500 women
Revista Brasileira de Reumatologia
12/10/2013 10:15:51 AM
CONCLUSION: Depression and anxiety were seen as the main triggers of FM symptoms, but a significant proportion of the subjects perceived work strain as the initial trigger.We also observed a delay of a few years in seeking medical help and examination by a rheumatologist. (Source: Revista Brasileira de Reumatologia)
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8th Circuit: Record Supports Insurer's Decision To Deny Benefits
LexisNexis® Mealey's™ Disability Insurance Legal News
12/10/2013 6:00:11 AM
ST. LOUIS - A disability plan administrator that terminated benefits to a claimant with fibromyalgia did not abuse its discretion, the Eighth Circuit U.S. Court of Appeals ruled Nov. 29 (Lisa Gerhardt v. Liberty Life Assurance Company of Boston, et al., No. 12-3159, 8th Cir.; 2013 U.S. App. LEXIS 23912). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)

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Recovery of upper limb muscle function in chronic fatigue syndrome with and without fibromyalgia
European Journal of Clinical Investigation
12/9/2013
ConclusionsThis study reveals, for the first time, delayed recovery of upper limb muscle function in CFS+FM, but not in CFS‐only patients. The results underline that CFS is a heterogeneous disorder suggesting that reducing the heterogeneity of the disorder in future research is important to make progress towards a better understanding and uncovering of mechanisms regarding the nature of divers impairments in these patients. (Source: European Journal of Clinical Investigation)
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Chronic widespread pain, including fibromyalgia: a pathway for care developed by the British Pain Society
British Journal of Anaesthesia
12/6/2013
Chronic widespread pain (CWP), including fibromyalgia, is a highly prevalent condition with a range of disabling symptoms, both physical and psychological. The British Pain Society (BPS) is supporting the treatment of this group of patients through a care pathway and this article describes the rationale and discussion points relevant to the CWP and fibromyalgia pathway. There are several aims in producing this pathway: to reduce variation in the standards of care, to reduce delays at all stages of care, and in particular, to enable clinicians to help patients accept a diagnosis of CWP. This diagnosis should be based on the presence and distribution of symptoms in the absence of another defined pathological process: the features in the history or clinical examination are generally more impo...

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Animal models of fibromyalgia
Arthritis Research and Therapy
12/5/2013
We describe the methods for induction of the model, pathophysiological mechanisms for each model, and treatment profiles. (Source: Arthritis Research and Therapy)
http://www.medworm.com/rss/comments.php?id=7819979
Characteristics of Chronic Pain Patients Who Take Opioids and Persistently Report High Pain Intensity.
Pain Physician
12/4/2013
CONCLUSIONS: Our findings suggest that patients with persistently high pain scores despite opioid therapy are more likely than those with lower levels of pain to present with characteristics associated with having centralized pain. This study cannot determine whether these characteristics were present before (fibromyalgia-like patient) or after the initiation of opioids (opioid-induced hyperalgesia). Regardless, patients with a centralized pain phenotype are thought to be less responsive to opioids and may merit alternative approaches. PMID: 24310048 [PubMed - as supplied by publisher] (Source: Pain Physician)
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Lamotrigine for chronic neuropathic pain and fibromyalgia in adults.
Cochrane Database of Systematic Reviews
12/3/2013
CONCLUSIONS: Large, high-quality, long-duration studies reporting clinically useful levels of pain relief for individual participants provided no convincing evidence that lamotrigine is effective in treating neuropathic pain and fibromyalgia at doses of about 200 to 400 mg daily. Given the availability of more effective treatments including antiepileptics and antidepressant medicines, lamotrigine does not have a significant place in therapy based on the available evidence. The adverse effect profile of lamotrigine is also of concern. PMID: 24297457 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
http://www.medworm.com/rss/comments.php?id=7816098
Evaluation of the fibromyalgia diagnostic screen in clinical practice
Journal of Evaluation in Clinical Practice
12/1/2013
ConclusionsThe Fibromyalgia Diagnostic Screen is a useful new clinical tool to aid in the evaluation of FM in clinical practice. (Source: Journal of Evaluation in Clinical Practice)
http://www.medworm.com/rss/comments.php?id=7802701
Psychological Resilience, Affective Mechanisms and Symptom Burden in a Tertiary‐care Sample of Patients with Fibromyalgia
Stress and Health
12/1/2013
This study examined the relationship between affect, resilience and fibromyalgia symptom burden in a clinical sample of patients with fibromyalgia. We hypothesized that (a) positive and negative affect would be associated with fibromyalgia symptom burden; (b) resilience would be associated with positive and negative affect; (c) resilience would be associated with fibromyalgia symptom burden; and (d) the connection between resilience and fibromyalgia symptom burden would be mediated by both positive and negative affect. A sample of 858 patients with fibromyalgia completed questionnaires. Mediation modelling revealed statistically significant direct effects of resilience on fibromyalgia symptom burden (β = −0.10, P < 0.001) and statistically significant indirect effects of resi...
http://www.medworm.com/rss/comments.php?id=7890267
Chronic Pain Perspectives: Diagnosing fibromyalgia and myofascial pain syndrome: A guide.
The Journal of Family Practice
12/1/2013
Authors: Gerwin RD Abstract The instruments and physical exam techniques described here will help you to diagnose these 2 common soft-tissue pain conditions. PMID: 24340342 [PubMed - in process] (Source: The Journal of Family Practice)

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Evaluation of health‐related physical fitness parameters and association analysis with depression, anxiety, and quality of life in patients with fibromyalgia
APLAR Journal of Rheumatology
11/30/2013
ConclusionOur results suggested that muscle strength, HRQoL, depression and anxiety symptomatology were impaired in fibromyalgia patients compared to healthy controls. Low muscle strength is related to reduced HRQoL and increased depression and anxiety symptomatology in patients with fibromyalgia. Also we suggest that performing daily exercises, including aerobic and strength training, as part of one's lifestyle may have beneficial effects in fibromyalgia patients. (Source: APLAR Journal of Rheumatology)
http://www.medworm.com/rss/comments.php?id=7805038
Beyond pain in fibromyalgia: insights into the symptom of fatigue
Arthritis Research and Therapy
11/29/2013
Fatigue is a disabling, multifaceted symptom that is highly prevalent and stubbornly persistent. Although fatigue is a frequent complaint among patients with fibromyalgia, it has not received the same attention as pain. Reasons for this include lack of standardized nomenclature to communicate about fatigue, lack of evidence-based guidelines for fatigue assessment, and a deficiency in effective treatment strategies. Fatigue does not occur in isolation; rather, it is present concurrently in varying severity with other fibromyalgia symptoms such as chronic widespread pain, unrefreshing sleep, anxiety, depression, cognitive difficulties, and so on. Survey-based and preliminary mechanistic studies indicate that multiple symptoms feed into fatigue and it may be associated with a variety of physi...
http://www.medworm.com/rss/comments.php?id=7805031
Can alcohol consumption be an alternative treatment for fibromyalgia?
Arthritis Research and Therapy
11/29/2013
Treatment of chronic pain conditions such as fibromyalgia is challenging due to limitations of drug therapies. An initial exploration into the relationships between self-reported alcohol consumption, symptom severity, and quality of life for individuals with fibromyalgia sheds new light on plausible hypotheses and potential mechanisms of action for future research. Evidence suggests that alcohol consumption may improve social and psychological factors because of activity in the ascending and descending pain pathways in modulating gamma-aminobutyric acid neurotransmission. Further methodologically rigorous studies in this field to improve well-being of individuals with fibromyalgia are warranted. (Source: Arthritis Research and Therapy)
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Care of patients with fibromyalgia: assessment and management.
Nursing Standard
11/27/2013
Authors: Ryan S Abstract Fibromyalgia is a common condition characterised by widespread musculoskeletal pain, muscle stiffness, unrefreshed sleep and fatigue. The condition is associated with several physical and psychological manifestations, including irritable bowel syndrome and anxiety. The efficacy of drug therapy is limited, therefore the nurse has an important role in providing advice and guidance on symptom management to optimise functioning for patients. PMID: 24279570 [PubMed - in process] (Source: Nursing Standard)
http://www.medworm.com/rss/comments.php?id=7800147
Overlapping Structural and Functional Brain Changes in Patients With Long‐Term Exposure to Fibromyalgia Pain
Arthritis and Rheumatism
11/27/2013
ConclusionThe combined integration of structural and functional measures allowed for a unique characterization of the impact of FM pain on the brain. These data may lead to the identification of early structural and functional brain alterations in response to pain, which could be used to develop markers for predicting the development of FM and other pain disorders. (Source: Arthritis and Rheumatism)
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Prevalence of the Fibromyalgia Phenotype in Patients With Spine Pain Presenting to a Tertiary Care Pain Clinic and the Potential Treatment Implications
Arthritis and Rheumatism
11/27/2013
ConclusionUsing the FM criteria and severity scales, we demonstrated profound phenotypic differences in a population of patients with spine pain. Although centralized pain cannot be confirmed with a self‐report instrument alone, the pathophysiology of FM may help explain a portion of the variability of responses to spine interventions. (Source: Arthritis and Rheumatism)
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Remarkable prevalence of celiac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study
Arthritis Research and Therapy
11/27/2013
IntroductionIrritable bowel syndrome (IBS) and fibromyalgia syndrome (FMS) are two common central sensitization disorders frequently associated in the same patient, and some of these patients with IBS plus FMS (IBS/FMS) could actually be undiagnosed of celiac disease (CD). The present study was an active case finding for CD in two IBS cohorts, one constituted by IBS/FMS subjects and the other by people with isolated IBS. Methods: A total of 104 patients (89.4% females), fulfilling the 1990-ACR criteria for FMS and the Roma III criteria for IBS classification, and 125 unrelated, age and sex matched IBS no-FMS patients underwent the following studies: hematological, coagulation and biochemistry test, serological and genetic markers for CD (i.e., tissue-Transglutaminase-2, tTG-2, and major hi...

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Circadian variations of 5‐hydroxytryptamine in female with fibromyalgia syndrome: A case control study
Sleep and Biological Rhythms
11/27/2013
Abstract The aim of the present study was to evaluate circadian variation in serum serotonin (5‐hydroxytryptamine; 5‐HT) levels and correlate it with Tender Points Count (TPC) and Fibromyalgia Impact Questionnaire Revised (FIQR) in female fibromyalgia syndrome (FMS) patients. Serum levels of 5‐HT were measured at 6‐h intervals in 50 women with FMS satisfying American College of Rheumatology (ACR) 1990 criteria (Age 36.6 ± 9.8) as well as 50 healthy control women (Age 32.8 ± 10.5). The FIQR and TPC were used to assess FMS severity. Significantly low serum 5‐HT levels were found in patients with FMS throughout the day compared to controls. However, only weak and non‐significant circadian variations were found in circulating levels of serum 5‐HT in patients with lowest level i...

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Interdisciplinary Treatment of Patients with Fibromyalgia: Improvement of Their Health‐Related Quality of Life
Pain Practice
11/27/2013
ConclusionsThis interdisciplinary intervention has shown effectiveness in improving the HRQoL of this sample of patients with FM. The number of physical illnesses was identified as a predictor of that improvement. (Source: Pain Practice)
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Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises
ClinicalTrials.gov
11/26/2013 12:00:00 PM
Condition:   FibromyalgiaInterventions:   Other: strengthening exercise;   Other: flexibility exerciseSponsor:   Federal University of Espirito SantoCompleted - verified December 2013 (Source: ClinicalTrials.gov)

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Written Pain Neuroscience Education in Fibromyalgia: A Multicenter Randomized Controlled Trial
Pain Practice
11/20/2013
This study aimed at examining whether written education about pain neuroscience improves illness perceptions, catastrophizing, and health status in patients with fibromyalgia. A double‐blind, multicenter randomized controlled clinical trial with 6‐month follow‐up was conducted. Patients with FM (n = 114) that consented to participate were randomly allocated to receive either written pain neuroscience education or written relaxation training. Written pain neuroscience education comprised of a booklet with pain neuroscience education plus a telephone call to clarify any difficulties; the relaxation group received a booklet with relaxation education and a telephone call. The revised illness perception questionnaire, Pain Catastrophizing Scale, and fibromyalgia impact questionnaire wer...
http://www.medworm.com/rss/comments.php?id=7788933
Nutcracker esophagus: demographic, clinical features, and esophageal tests in 115 patients
Diseases of the Esophagus
11/20/2013
In this study, NE patients were more commonly middle‐aged females experiencing a considerable amount of time between symptom onset and diagnosis. Many were initially evaluated by internists for dysphagia or chest pain and had a history of GERD. Medication prescribed prior to diagnoses frequently involved acid suppression, but narcotic and psychotropic prescriptions were also commonly used. Central sensitization syndromes (fibromyalgia and IBS), psychiatric comorbidity, and reflux commonly coexisted. Our study suggests that future investigations should address the role and interaction of GERD and psychiatric disorders in NE. (Source: Diseases of the Esophagus)
http://www.medworm.com/rss/comments.php?id=7778616
Recognition of facially expressed emotions in patients with fibromyalgia syndrome.
Behavioral Medicine
11/19/2013 1:01:32 PM
Authors: Weiß S, Winkelmann A, Duschek S Abstract The study investigated the ability to identify facially expressed emotions in fibromyalgia syndrome (FMS) and its association with clinical parameters. Thirty-five FMS patients and 35 healthy controls accomplished a face recognition task. Additionally, pain severity, alexithymia, depression, anxiety, psychiatric co-morbidity and medication use were assessed. The patients displayed reduced task performance in terms of more misclassifications of emotional expressions than controls. Pain severity, alexithymia, depression and anxiety were inversely related to recognition performance, with pain severity accounting for the largest portion of test score variance. Psychiatric co-morbidity and medication had no impact on performance. The st...
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Prevalence of Fibromyalgia in Vasovagal SyncopePrevalence of Fibromyalgia in Vasovagal Syncope
Medscape Rheumatology Headlines
11/19/2013 12:00:00 PM
How frequent is fibromyalgia in women with vasovagal syncope? Journal of Clinical Rheumatology (Source: Medscape Rheumatology Headlines)
http://www.medworm.com/rss/comments.php?id=7783144
An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: Role of IL-8 and noradrenaline.
Brain, Behavior, and Immunity
11/17/2013
Authors: Bote ME, García JJ, Hinchado MD, Ortega E Abstract Fibromyalgia (FM) syndrome is associated with elevated systemic inflammatory and stress biomarkers, and an elevated innate cellular response mediated by monocytes and neutrophils. Exercise is accepted as a good non-pharmacological therapy for FM. We have previously found that regular aquatic exercise decreases the release of inflammatory cytokines by monocytes from FM patients. However, its effects on the functional capacity of neutrophils have not been studied. The aim of the present exploratory study was to evaluate, in 10 women diagnosed with FM, the effect of an aquatic exercise program (8 months, 2 sessions/week, 60 min/session) on their neutrophils' function (phagocytic process), and on IL-8 and NA as potential infl...
http://www.medworm.com/rss/comments.php?id=7787024
Evaluation and treatment of musculoskeletal chest pain.
Primary Care
11/16/2013 7:25:05 PM
This article summarizes the evaluation and treatment of musculoskeletal causes of chest pain. Conditions such as costochondritis, rib pain caused by stress fractures, slipping rib syndrome, chest wall muscle injuries, fibromyalgia, and herpes zoster are discussed, with emphasis on evaluation and treatment of these and other disorders. Many of these conditions can be diagnosed by the primary care clinician in the office by history and physical examination. Treatment is also discussed, including description of manual therapy and exercises as needed for some of the conditions. PMID: 24209723 [PubMed - in process] (Source: Primary Care)
http://www.medworm.com/rss/comments.php?id=7765149
Hyperexcitable C nociceptors in fibromyalgia
Annals of Neurology
11/16/2013
ABSTRACT Objective: To test the hypothesis that peripheral C nociceptor function may be abnormal in fibromyalgia and that C nociceptor dysfunction may contribute to the symptoms reported by these patients. Methods: Microneurography was used to record from C nociceptors of 30 female patients meeting criteria for fibromyalgia and compared with recordings from 17 female patients with small fiber neuropathy and 9 female controls. Results: We obtained stable recordings from 186 C nociceptors in the fibromyalgia group, 114 from small fiber neuropathy patients, and 66 from controls. The mechano‐sensitive nociceptors in the fibromyalgia patients behaved normally, but the silent nociceptors in 76.6% of fibromyalgia patients exhibited abnormalities. Spontaneous activity was detected in 31% of sile...
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Assessment of enthesopathy in patients with fibromyalgia by using new sonographic enthesitis index
Revista Brasileira de Reumatologia
11/14/2013 8:16:13 PM
CONCLUSIONS: Misdiagnoses of FM are harmful to patients and the community, and the presence of enthesopathy among FM patients increases. Its detection with the MASEI score may help to discriminate FM patients presenting with ill-defined symptoms and signs, in order to prevent mistreatment. (Source: Revista Brasileira de Reumatologia)
http://www.medworm.com/rss/comments.php?id=7758911
Evaluation and Treatment of Musculoskeletal Chest Pain
Primary Care: Clinics in Office Practice
11/14/2013 2:15:44 PM
This article summarizes the evaluation and treatment of musculoskeletal causes of chest pain. Conditions such as costochondritis, rib pain caused by stress fractures, slipping rib syndrome, chest wall muscle injuries, fibromyalgia, and herpes zoster are discussed, with emphasis on evaluation and treatment of these and other disorders. Many of these conditions can be diagnosed by the primary care clinician in the office by history and physical examination. Treatment is also discussed, including description of manual therapy and exercises as needed for some of the conditions. (Source: Primary Care: Clinics in Office Practice)

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The Spanish version of the Fibromyalgia Rapid Screening Tool: translation, validity and reliability
Rheumatology
11/14/2013
Conclusion. The Spanish version of the FiRST may be used as a screening tool for fibromyalgia even in those patients whose cognitive style is characterized by catastrophizing about pain and high levels of functional disability, anxiety and depression. The clinical consequences of the moderate specificity shown by this Spanish version of the FiRST are discussed. (Source: Rheumatology)
http://www.medworm.com/rss/comments.php?id=7771403
A systematic review and meta-analysis of mindfulness-based stress reduction for the fibromyalgia syndrome
Journal of Psychosomatic Research
11/12/2013
Conclusions: This systematic review found that MBSR might be a useful approach for FMS patients. According to the quality of evidence only a weak recommendation for MBSR can be made at this point. Further high quality RCTs are required for a conclusive judgment of its effects. (Source: Journal of Psychosomatic Research)
http://www.medworm.com/rss/comments.php?id=7803810
When the brain expects pain: common neural responses to pain anticipation are related to clinical pain and distress in fibromyalgia and osteoarthritis
European Journal of Neuroscience
11/12/2013
Abstract Supraspinal processes in humans can have a top‐down enhancing effect on nociceptive processing in the brain and spinal cord. Studies have begun to suggest that such influences occur in conditions such as fibromyalgia (FM), but it is not clear whether this is unique to FM pain or common to other forms of chronic pain, such as that associated with osteoarthritis (OA). We assessed top‐down processes by measuring anticipation‐evoked potentials and their estimated sources, just prior (< 500 ms) to laser heat pain stimulation, in 16 patients with FM, 16 patients with OA and 15 healthy participants, by using whole‐brain statistical parametric mapping. Clinical pain and psychological coping factors (pain catastrophizing, anxiety, and depression) were well matched between the ...
http://www.medworm.com/rss/comments.php?id=7765744
Internet-Delivered Acceptance and Values-Based Exposure Treatment for Fibromyalgia: A Pilot Study.
Cognitive Behaviour Therapy
11/12/2013
Conclusions: An Internet-delivered psychological treatment based on acceptance and exposure principles seems to be an efficacious, acceptable, and cost-effective treatment for FM. Randomized controlled trials are needed to confirm these results. PMID: 24215278 [PubMed - as supplied by publisher] (Source: Cognitive Behaviour Therapy)
http://www.medworm.com/rss/comments.php?id=7765008
Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews.
Cochrane Database of Systematic Reviews
11/11/2013
CONCLUSIONS: Clinical trial evidence supported the use of only gabapentin and pregabalin in some neuropathic pain conditions (painful diabetic neuropathy, postherpetic neuralgia, and central neuropathic pain) and fibromyalgia. Only a minority of people achieved acceptably good pain relief with either drug, but it is known that quality of life and function improved markedly with the outcome of at least 50% pain intensity reduction. For other antiepileptic drugs there was no evidence, insufficient evidence, or evidence of a lack of effect; this included carbamazepine. Evidence from clinical practice and experience is that some patients can achieve good results with antiepileptics other than gabapentin or pregabalin.There is no firm evidence to answer the important pragmatic questions about w...
http://www.medworm.com/rss/comments.php?id=7764099
Long-term tolerability and maintenance of therapeutic response to sodium oxybate in an open-label extension study in patients with fibromyalgia
Arthritis Research and Therapy
11/11/2013
Conclusions: The long-term safety profile of SXB in FM patients was similar to that in the previously reported controlled clinical trials. Improvement in pain and other FM clinical domains was maintained during long-term use.Trial registration: ClinicalTrials.gov NCT00423605. (Source: Arthritis Research and Therapy)
http://www.medworm.com/rss/comments.php?id=7758905
Lack of evidence for retroviral infections formerly related to chronic fatigue in Spanish Fibromyalgia patients
Virology Journal
11/11/2013
Conclusions: Previous associations between MLV-related or HTLV-2 retrovirus infection with chronic fatigue must be discarded. Thus, studies showing positive amplification of HTLV-2 sequences from chronic fatigue participants should be revised for possible undetected technical problems.To avoid false positives of viral infection, not only extreme precautions should be taken when nested-PCR reactions are prepared and exhaustive foreign DNA contamination controls performed, but also consistent amplification of diverse regions of the virus in independent preparations from the same individual must be demanded.The fact that our cohort of patients did not present evidence of any of the two types of retroviral infection formerly associated to chronic fatigue does not rule out the possibility that ...

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Clinical impact of a gluten-free diet on health-related quality of life in seven fibromyalgia syndrome patients with associated celiac disease
BMC Gastroenterology
11/9/2013
Conclusion: Results of this pilot study show that the adherence to a GFD by CD-related IBS/FMS patients can simultaneously improve CD and IBS/FMS symptoms, and indicate the merit of further research on a larger cohort. (Source: BMC Gastroenterology)
http://www.medworm.com/rss/comments.php?id=7754798
Ehlers–Danlos syndrome, hypermobility type: A characterization of the patients' lived experience
American Journal of Medical Genetics Part A
11/6/2013
This article presents a large‐scale study that reports the lived experience of EDS‐HT patients, the broad range of symptoms that individuals with EDS‐HT experience, and the impact these symptoms have on daily functioning. A 237‐item online survey, including validated questions regarding pain and depression, was developed. Four hundred sixty‐six (466) adults (90% female, 52% college or higher degree) with a self‐reported diagnosis of EDS‐HT made in a clinic or hospital were included. The most frequently reported symptoms were joint pain (99%), hypermobility (99%), and limb pain (91%). They also reported a high frequency of other conditions including chronic fatigue (82%), anxiety (73%), depression (69%), and fibromyalgia (42%). Forty‐six percent of respondents reported const...
http://www.medworm.com/rss/comments.php?id=7748924
Fibromyalgia Brain Misreads Pleasure/Pain SignalsFibromyalgia Brain Misreads Pleasure/Pain Signals
Medscape Today Headlines
11/5/2013 8:27:18 PM
Fibromyalgia patients have disordered CNS signaling for anticipated reward and anticipated punishment. Medscape Medical News (Source: Medscape Today Headlines)
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Pregabalin Works in Fibromyalgia Patients on AntidepressantsPregabalin Works in Fibromyalgia Patients on Antidepressants
Medscape Today Headlines
11/5/2013 2:59:19 PM
Antidepressants can be safely continued in patients with fibromyalgia who are being treated with pregabalin, report researchers. Medscape Medical News (Source: Medscape Today Headlines)
http://www.medworm.com/rss/comments.php?id=7734509
Pain and Relief Signals Muted in Fibromyalgia (CME/CE)
MedPage Today Rheumatology
11/5/2013 1:22:23 PM
(MedPage Today) -- Patients with fibromyalgia showed less activation in brain responses to pain-related "punishment and reward" anticipatory signaling on functional MRI than healthy controls, a small study showed. (Source: MedPage Today Rheumatology)
http://www.medworm.com/rss/comments.php?id=7735795
Brain Scans Show Fibromyalgia Patients Process Pain Differently
WebMD Health
11/5/2013 9:16:58 AM
Activity in certain regions suggests why they're less able to prepare for pain or respond to pain relief (Source: WebMD Health)

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Pleasure and pain brain signals disrupted in fibromyalgia patients
Health News from Medical News Today
11/5/2013 5:00:00 AM
New research indicates that a disruption of brain signals for reward and punishment contributes to increased pain sensitivity, known as hyperalgesia, in fibromyalgia patients. Results published in Arthritis & Rheumatism, a journal of the American College of Rheumatology, suggest that this altered brain processing might contribute to widespread pain and lack of response to opioid therapy in patients with fibromyalgia... (Source: Health News from Medical News Today)
http://www.medworm.com/rss/comments.php?id=7733140
Brain Scans Show Fibromyalgia Patients Process Pain Differently
MedicineNet Chronic Pain General
11/5/2013 2:00:00 AM
Title: Brain Scans Show Fibromyalgia Patients Process Pain DifferentlyCategory: Health NewsCreated: 11/5/2013 9:35:00 AMLast Editorial Review: 11/5/2013 12:00:00 AM (Source: MedicineNet Chronic Pain General)
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Pleasure and pain brain signals disrupted in fibromyalgia patients
EurekAlert! - Social and Behavioral Science
11/5/2013
(Wiley) New research indicates that a disruption of brain signals for reward and punishment contributes to increased pain sensitivity, known as hyperalgesia, in fibromyalgia patients. Results published in Arthritis & Rheumatism, a journal of the American College of Rheumatology, suggest that this altered brain processing might contribute to widespread pain and lack of response to opioid therapy in patients with fibromyalgia. (Source: EurekAlert! - Social and Behavioral Science)
http://www.medworm.com/rss/comments.php?id=7732619
Pleasure and pain circuitry disrupted in brains of fibromyalgia patients
OnMedica Latest News
11/5/2013
Might explain poor response to pain relief and heightened pain sensitivity Related items from OnMedicaNICE offers guidance on opioidsModerate exercise may reduce risk of chronic painExperts issue pain syndrome guidelinesThe pain of fibromyalgia (Source: OnMedica Latest News)

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Erratum to “Is brief psychodynamic psychotherapy in primary fibromyalgia syndrome with concurrent depression an effective treatment? A randomized controlled trial” General Hospital Psychiatry 35 (2013) 160–167
General Hospital Psychiatry
11/4/2013
In the above article, in Section “3.2. Clinical Outcomes,” the sentence: “Within-group effect sizes for these measures ranged between 0.08 (HADS anxiety, active control group) and 0.63 (SOMS, ASTPP)” needs to be corrected as follows: “Within-group effect sizes for these measures ranged between 0.08 (HADS anxiety, active control group) and 0.52 (PID, ASTPP).” (Source: General Hospital Psychiatry)
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Antidepressants, Lyrica OK Combo in Fibromyalgia
MedPage Today Psychiatry
11/1/2013 11:50:17 AM
SAN DIEGO (MedPage Today) -- Patients with fibromyalgia who were taking antidepressants found that their pain was successfully managed with pregabalin (Lyrica), a researcher said here. (Source: MedPage Today Psychiatry)
http://www.medworm.com/rss/comments.php?id=7728122
Disrupted brain circuitry for pain‐related reward/punishment in fibromyalgia
Arthritis and Rheumatism
10/31/2013 11:00:00 PM
CONCLUSION: FM patients exhibit disrupted brain responses to reward/punishment. The VTA is a source for reward‐linked dopaminergic/GABAergic neurotransmission in the brain and our observations are compatible with reports of altered dopaminergic/GABAergic neurotransmission in FM. Reduced reward/punishment signaling in FM may relate to the augmented central processing of pain and reduced efficacy of opioid treatments in these patients. © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)
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Fibromyalgia Might Be Harder on Younger Patients, Study Finds
MedicineNet Chronic Pain General
10/30/2013 2:00:00 AM
Title: Fibromyalgia Might Be Harder on Younger Patients, Study FindsCategory: Health NewsCreated: 10/30/2013 12:35:00 AMLast Editorial Review: 10/30/2013 12:00:00 AM (Source: MedicineNet Chronic Pain General)
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Young People Report Worse Fibromyalgia Than Older Patients
Mayo Clinic Rochester News
10/29/2013 8:02:36 AM
It may seem counterintuitive, but young and middle-aged fibromyalgia patients report worse symptoms and poorer quality of life than older patients, a Mayo Clinic study shows. (Source: Mayo Clinic Rochester News)
http://www.medworm.com/rss/comments.php?id=7715843
A Blood Test for Fibromyalgia?
MedicineNet Chronic Pain General
10/29/2013 2:00:00 AM
Title: A Blood Test for Fibromyalgia?Category: Health NewsCreated: 10/29/2013 11:00:00 AMLast Editorial Review: 10/29/2013 12:00:00 AM (Source: MedicineNet Chronic Pain General)
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Lyrica May Ease Pain for Depressed Fibromyalgia Patients
MedicineNet Chronic Pain General
10/29/2013 2:00:00 AM
Title: Lyrica May Ease Pain for Depressed Fibromyalgia PatientsCategory: Health NewsCreated: 10/28/2013 2:36:00 PMLast Editorial Review: 10/29/2013 12:00:00 AM (Source: MedicineNet Chronic Pain General)
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Worse fibromyalgia symptoms reported by young people
Health News from Medical News Today
10/29/2013 2:00:00 AM
It may seem counterintuitive, but young and middle-aged fibromyalgia patients report worse symptoms and poorer quality of life than older patients, a Mayo Clinic study shows. Fibromyalgia most often strikes women. It is characterized by widespread musculoskeletal pain with fatigue, sleep, memory and mood issues. The research, one of several Mayo studies presented at the American College of Rheumatology annual meeting, suggests the disorder plays out differently among different age groups... (Source: Health News from Medical News Today)
http://www.medworm.com/rss/comments.php?id=7714693
Lyrica May Ease Pain for Depressed Fibromyalgia Patients
WebMD Health
10/28/2013 3:15:21 PM
Study finds drug safe, effective in combination with antidepressants (Source: WebMD Health)
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A 57-Year-Old Woman With Sjögren SyndromeA 57-Year-Old Woman With Sjögren Syndrome
Medscape Today Headlines
10/28/2013 10:37:44 AM
A 57-year-old woman With Sjögren syndrome, fibromyalgia, and rheumatoid arthritis presented with worsening vision. What should be done to improve her vision and eye comfort? Medscape Optometry (Source: Medscape Today Headlines)
http://www.medworm.com/rss/comments.php?id=7713014
Fibromyalgia Might Be Harder on Younger Patients, Study Finds
MedicineNet Chronic Pain General
10/28/2013 2:00:00 AM
Title: Fibromyalgia Might Be Harder on Younger Patients, Study FindsCategory: Health NewsCreated: 10/26/2013 5:35:00 PMLast Editorial Review: 10/28/2013 12:00:00 AM (Source: MedicineNet Chronic Pain General)
http://www.medworm.com/rss/comments.php?id=7717665
Clinical Characteristics and Medication Uses Among Fibromyalgia Patients Newly Prescribed Amitriptyline, Duloxetine, Gabapentin, or Pregabalin
Arthritis Care and Research
10/27/2013 11:00:00 PM
ConclusionPatients who started 1 of the 4 common drugs for fibromyalgia similarly had multiple comorbidities and other fibromyalgia‐related medication use, but continued the treatment only for a short time. The dose of the 4 drugs was not increased in most patients during the followup period. (Source: Arthritis Care and Research)

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Utility of the PedsQL Rheumatology Module as an Outcome Measure in Juvenile Fibromyalgia
Arthritis Care and Research
10/27/2013 11:00:00 PM
ConclusionThe PedsQL rheumatology module generally appears to have good utility for use in juvenile FM patients, but there are some caveats to the interpretation of specific scales in this population. (Source: Arthritis Care and Research)
http://www.medworm.com/rss/comments.php?id=7735833
Young fibromyalgia patients report worse symptoms than older patients, Mayo Clinic study shows
EurekAlert! - Medicine and Health
10/27/2013 11:00:00 PM
(Mayo Clinic) It may seem counterintuitive, but young and middle-aged fibromyalgia patients report worse symptoms and poorer quality of life than older patients, a Mayo Clinic study shows. Fibromyalgia most often strikes women. It is characterized by widespread musculoskeletal pain with fatigue, sleep, memory and mood issues. (Source: EurekAlert! - Medicine and Health)
http://www.medworm.com/rss/comments.php?id=7713039
Fibromyalgia Might Be Harder on Younger Patients, Study Finds
MedlinePlus Health News
10/26/2013 4:00:00 PM
Research compared symptom severity, quality of life in various age groups Source: HealthDay Related MedlinePlus Page: Fibromyalgia (Source: MedlinePlus Health News)

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Serum Leptin in Egyptian patients with fibromyalgia syndrome: relation to disease severity
APLAR Journal of Rheumatology
10/25/2013 11:00:00 PM
ConclusionWe found a significant decrease in serum leptin in FMS patients compared to controls and this decrease correlated with disease severity. (Source: APLAR Journal of Rheumatology)
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Young people report worse fibromyalgia than older patients, Mayo Clinic study shows
EurekAlert! - Medicine and Health
10/25/2013 11:00:00 PM
(Mayo Clinic) It may seem counterintuitive, but young and middle-aged fibromyalgia patients report worse symptoms and poorer quality of life than older patients, a Mayo Clinic study shows. (Source: EurekAlert! - Medicine and Health)
http://www.medworm.com/rss/comments.php?id=7705726
37. A clinical and neurophysiological study of pain in patients with Ehlers Danlos syndrome
Clinical Neurophysiology
10/21/2013 5:15:42 AM
Although pain is a frequent complaint in patients with Ehlers Danlos syndrome, its underlying mechanism is still debated, thus limiting the effectiveness of treatment. Although some recent reports suggested that most patients with Ehlers Danlos syndrome suffered from neuropathic pain, no studies have assessed pain associated to this rare condition with the recently proposed diagnostic criteria for neuropathic pain. In this prospective study we aimed at assessing prevalence, clinical features and underlying mechanism of pain in 20 patients with Ehlers Danlos syndrome. All patients underwent a detailed clinical and neurological examination, including the DN4 questionnaires for diagnosing neuropathic pain and the fibromyalgia rapid screening tool. We also recorded the standard nerve conductio...
http://www.medworm.com/rss/comments.php?id=7692634
Personality profiles and coping styles in migraine patients with fibromyalgia comorbidity
Comprehensive Psychiatry
10/20/2013 11:00:00 PM
In this study we aimed to compare personality profiles and coping styles across 23 migraine without aura patients sharing FM comorbidity (MWA-FM), 28 migraine without aura patients without FM symptoms (MWA) and 51 age- and sex-matched controls, by means of Big Five Questionnaire (BFQ) and Coping Orientation to Problem Experienced (COPE), and to correlate main results with clinical features. The “Energy” personality factor was significantly reduced in patients presenting with FM symptoms, compared to both migraine without aura patients and controls. A low score in “Dynamism” sub-item with a high score in denial coping style was able to distinguish MWA from MW-FM groups with an accuracy of 82.35% (Wilks lambda=0.98; chi-square=8.99, DF=1, p=0.005). In particular, lower “Dynamism”...

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Quetiapine fumarate extended‐release for the treatment of major depression with comorbid fibromyalgia syndrome: A double‐blind, randomized, placebo‐controlled study
Arthritis and Rheumatism
10/20/2013 11:00:00 PM
Conclusion: This is the first study to demonstrate that measures of depression, pain and quality of life are significantly improved with quetiapine XR versus placebo in dually diagnosed patients with MDD and fibromyalgia. © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)
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Pfizer unveils top-line results from two Phase IIIb studies of pregabalin drug
Drug Development Technology
10/20/2013 6:00:00 PM
Pfizer has reported top-line results from two Phase IIIb, placebo-controlled trials with Lyrica (pregabalin) capsules CV in patients with fibromyalgia (FM) and painful diabetic peripheral neuropathy (DPN) respectively. (Source: Drug Development Technology)
http://www.medworm.com/rss/comments.php?id=7696211
Worldwide database of brain images for chronic pain conditions designed to accelerate research, treatments
Health News from Medical News Today
10/19/2013 2:00:00 AM
What do migraine, irritable bowel syndrome, fibromyalgia and rheumatoid arthritis have in common? All involve chronic pain. A new database featuring hundreds of brain scans and other key clinical information will help researchers tease out similarities and differences between these and many other chronic-pain conditions, helping to accelerate research and treatment development... (Source: Health News from Medical News Today)
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[Review] Combination pharmacotherapy for management of chronic pain: from bench to bedside
Lancet Neurology
10/18/2013 2:21:18 AM
Chronic pain, a frequently neglected problem, is treated with different classes of drugs. Current agents are limited by incomplete efficacy and dose-limiting side-effects. Knowledge of pain processing implicates multiple concurrent mechanisms of nociceptive transmission and modulation. Thus, synergistic interactions of drug combinations might provide superior analgesia and fewer side-effects than monotherapy by targeting of multiple mechanisms. Several trials in neuropathic pain, fibromyalgia, arthritis, and other disorders have assessed various two-drug combinations containing antidepressants, anticonvulsants, non-steroidal anti-inflammatories, opioids, and other agents. (Source: Lancet Neurology)
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Judge: Benefit Termination Decision Was Arbitrary, Capricious
LexisNexis® Mealey's™ Disability Insurance Legal News
10/18/2013 1:15:22 AM
DETROIT - An ERISA-governed disability insurer that terminated benefits to a claimant with fibromyalgia acted arbitrarily and capriciously, a Michigan federal judge ruled Sept. 30 (Marcie Scofield v. Liberty Life Assurance Company of Boston, et al., No. 1:12-CV-200, W.D. Mich.; 2013 U.S. Dist. LEXIS 139996). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
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Metabolic cost and mechanics of walking in women with fibromyalgia syndrome
BMC Research Notes
10/17/2013 11:00:00 PM
Conclusions: The altered gait patterns and greater perceptions of effort and pain did not significantly increase the metabolic costs of walking in women with FS and hence, increased sensations of fatigue in FS women may not be related to alteration in metabolic cost of ambulation. (Source: BMC Research Notes)
http://www.medworm.com/rss/comments.php?id=7685923
UCLA to house worldwide database of brain images for chronic-pain conditions
UCLA Newsroom: Health Sciences
10/16/2013 2:35:00 PM
What do migraine, irritable bowel syndrome, fibromyalgia and rheumatoid arthritis have in common? All involve chronic pain.   A new database featuring hundreds of brain scans and other key clinical information will help researchers tease out similarities and differences between these and many other chronic-pain conditions, helping to accelerate research and treatment development.   The Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress at UCLA will serves as the main hub for this new Pain and Interoception Imaging Network (PAIN), the first-ever standardized database for brain imaging associated with chronic pain. So far, 14 institutions in North America and Europe are participating.   Building upon their experiences creating a similar but smaller ne...

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Creatine Supplements to Improve Strength in FibromyalgiaCreatine Supplements to Improve Strength in Fibromyalgia
Medscape Today Headlines
10/16/2013 1:21:12 PM
A study determines whether a dietary supplement can improve muscle strength in fibromyalgia. Medscape Rheumatology (Source: Medscape Today Headlines)
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Anticonvulsants for fibromyalgia.
Cochrane Database of Systematic Reviews
10/15/2013 11:00:00 PM
CONCLUSIONS: The anticonvulsant, pregabalin, demonstrated a small benefit over placebo in reducing pain and sleep problems. Pregabalin use was shown not to substantially reduce fatigue compared with placebo. Study dropout rates due to adverse events were higher with pregabalin use compared with placebo. Dizziness was a particularly frequent adverse event seen with pregabalin use. At the time of writing this review, pregabalin is the only anticonvulsant drug approved for treating FM in the US and in 25 other non-European countries. However, pregabalin has not been approved for treating FM in Europe. The amount and quality of evidence were insufficient to draw definite conclusions on the efficacy and safety of gabapentin, lacosamide and levetiracetam in FM. PMID: 24129853 [PubMed - as su...
http://www.medworm.com/rss/comments.php?id=7689340
Isokinetic muscle performance of the hip and ankle muscles in women with fibromyalgia
APLAR Journal of Rheumatology
10/15/2013 11:00:00 PM
ConclusionsIn the light of our results, we may conclude that muscle strength and muscle fatigue seem to decrease in FMS patients' both proximal and distal lower extremity muscles. (Source: APLAR Journal of Rheumatology)
http://www.medworm.com/rss/comments.php?id=7697930
Is fibromyalgia diagnosed with new criteria considerably different from fibromyalgia diagnosed with old criteria?
Arthritis Care and Research
10/13/2013 11:00:00 PM
(Source: Arthritis Care and Research)
http://www.medworm.com/rss/comments.php?id=7697964
What is fibromyalgia, how is it diagnosed and what does it really mean?
Arthritis Care and Research
10/13/2013 11:00:00 PM
(Source: Arthritis Care and Research)
http://www.medworm.com/rss/comments.php?id=7697959
[Original Articles] The Impact of Emotion-Related Autonomic Nervous System Responsiveness on Pain Sensitivity in Female Patients With Fibromyalgia
Psychosomatic Medicine
10/13/2013 11:00:00 PM
Conclusions These data suggest that the ANS is not hyporesponsive to elicited emotions in fibromyalgia; however, patients with a larger pain response showed an ANS response pattern reflecting heightened β-adrenergic and reduced α-adrenergic reactivity. Future research should test whether a specific ANS response pattern to emotions is a consequence of increased pain or whether it amplifies pain. (Source: Psychosomatic Medicine)

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A multilevel structural equation modeling analysis of vulnerabilities and resilience resources influencing affective adaptation to chronic pain
Pain
10/13/2013 11:00:00 PM
We examined the social, cognitive, and affective context of daily pain adaptation in individuals with fibromyalgia and osteoarthritis. By using a sample of 260 women with fibromyalgia or osteoarthritis, we examined the contributions of pain catastrophizing, negative interpersonal events, and positive interpersonal events to daily negative and positive affect across 30days of daily diary data. Individual differences and daily fluctuations in predictor variables were estimated simultaneously by utilizing multilevel structural equation modeling techniques. The relationships between pain and negative and positive affect were mediated by stable and day-to-day levels of pain catastrophizing as well as day-to-day positive interpersonal events, but not negative interpersonal events. There were sig...
http://www.medworm.com/rss/comments.php?id=9856279
Understanding Somatic Symptom Disorder: The Role of Translational Neuroscience
Biological Psychiatry
10/11/2013 11:55:17 AM
Depression, anxiety, and somatoform disorders are among the most prevalent psychiatric disorders; they have overlapping symptoms, and they frequently co-occur. In many respects, however, somatoform disorders, such as somatization disorder, have received the least attention from researchers. First, relatively few randomized controlled trials have been undertaken on these disorders, although some presumably related conditions, such as fibromyalgia, now have Food and Drug Administration approved drug treatments. Second, there are comparatively few studies of the neurobiology of these conditions, although there have been significant advances in the clinical neuroscience of pain. Third, there are few animal models of somatoform disorders, although, again, there have been important advances in t...

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Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: Four case reports and literature review
Nutrition
10/9/2013 5:16:47 AM
Abstract: Recently, Coenzyme Q10 (CoQ10) deficiency has been implicated in the pathophysiology of fibromyalgia (FM). It is our objective to present the findings of the FM evaluation before and after oral CoQ10 treatment using the American College of Rheumatology (ACR) Diagnostic Criteria of 1990 and 2010, and Symptom Checklist-Revised (Scl-90-R). Four patients with FM were examined using the trigger points, the Fibromyalgia Impact Questionnaire, visual analog scale (pain, fatigue, and sleep), Widespread Pain Index, symptom severity scale, and Scl-90-R. Previously, CoQ10 contents from patients were analyzed by high-performance liquid chromatography. All patients showed CoQ10 deficiency. All patients meet the ACR 1990 and 2010 criteria. After treatment, all patients showed an important impro...
http://www.medworm.com/rss/comments.php?id=7660629
Occipital Nerve Stimulation in Fibromyalgia: A Double‐Blind Placebo‐Controlled Pilot Study With a Six‐Month Follow‐Up
Neuromodulation
10/6/2013 11:00:00 PM
ConclusionsOur data strongly suggest that ONS is beneficial in the treatment of fibromyalgia. The beneficial effects are stable at six months after permanent implantation. Subsensory threshold stimulation is feasible in designing a placebo‐controlled trial. (Source: Neuromodulation)
http://www.medworm.com/rss/comments.php?id=7660162
Advocates pressure Oregon to cover fibromyalgia treatments
bizjournals.com Health Care:Pharmaceuticals headlines
10/4/2013 4:10:08 PM
Oregon is the only state whose Medicaid program doesn’t cover treatment for fibromyalgia, which causes chronic muscle pain. But patients, doctors and advocates are working to change that — and soon. Next Thursday, they will ask Oregon health policymakers to consider adding fibromyalgia onto the Prioritized List of 498 conditions covered by Oregon Medicaid reimbursement. They will testify before a subcommittee of the Health Evidence Review Commission. One reason the condition is currently listed… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
http://www.medworm.com/rss/comments.php?id=7650285
A practical approach to prescribing antidepressants
Cleveland Clinic Journal of Medicine
9/30/2013 11:00:00 PM
This article provides insight into the art of prescribing antidepressants in primary care, with recommendations for prescribing for patients with chronic pain, sexual dysfunction, anxiety, chronic fatigue syndrome, fibromyalgia, severe insomnia, old age, diabetes, and heart problems. (Source: Cleveland Clinic Journal of Medicine)
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Fibromylagia.
Australian Family Physician
9/30/2013 11:00:00 PM
Authors: Guymer E, Littlejohn G Abstract Fibromyalgia is a common and potentially disabling condition affecting 2-5% of the population in developed countries, predominantly young to middle-aged women. Fibromyalgia has a varied and fluctuating clinical spectrum. Cardinal features include widespread musculoskeletal pain and tenderness, poor quality, unrefreshing sleep and significant levels of fatigue. Other key features include cognitive disturbances, particularly problems with concentration and memory, and high distress levels. Fibromyalgia can be considered part of a group of clinical syndromes, including chronic fatigue syndrome, multiple chemical sensitivities and irritable bowel syndrome, whose clinical features reflect similar pathophysiological processes - termed by some as '...
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Prevalence of juvenile fibromyalgia syndrome in an urban population of Turkish adolescents: impact on depressive symptoms, quality of life and school performance.
Chinese Medical Journal
9/30/2013 11:00:00 PM
CONCLUSION: The prevalence of JFMS is high in school age children. Since JFMS is a common problem of childhood, early diagnosis and identification of the disorder and more comprehensive and successful treatment approaches with appropriate psychological assistance may prevent more complex and severe problems in adulthood. PMID: 24112168 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
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How To Cure Fibromyalgia | "How To Reverse Fibromyalgia Now"...
PRWeb: Medical Pharmaceuticals
9/30/2013 11:15:18 AM
How To Reverse Fibromyalgia Now created by Matt Traverso is a comprehensive program that teaches people how to cure fibromyalgia naturally and effectively. A full overview of How To Reverse...(PRWeb September 30, 2013)Read the full story at http://www.prweb.com/releases/how-to/cure-fibromyalgia/prweb11175374.htm (Source: PRWeb: Medical Pharmaceuticals)
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Home Remedies For Fibromyalgia | How “Treating And Beating...
PRWeb: Medical Pharmaceuticals
9/30/2013 11:15:18 AM
Treating And Beating Fibromyalgia developed by Dr. Rodger Murphree is a comprehensive e-guide covering home remedies for fibromyalgia that help people get rid of fibromyalgia quickly and naturally. A...(PRWeb September 29, 2013)Read the full story at http://www.prweb.com/releases/home-remedies/for-fibromyalgia/prweb11174362.htm (Source: PRWeb: Medical Pharmaceuticals)
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Natural Fibromyalgia Treatment | How “Natural Cure To Fibromyalgia”...
PRWeb: Medical Pharmaceuticals
9/30/2013 11:15:18 AM
Natural Cure To Fibromyalgia created by Jane Thompson is a natural fibromyalgia treatment that helps people treat their problem naturally and effectively. A full overview of Natural Cure To...(PRWeb September 29, 2013)Read the full story at http://www.prweb.com/releases/natural-fibromyalgia/treatment/prweb11174320.htm (Source: PRWeb: Medical Pharmaceuticals)
http://www.medworm.com/rss/comments.php?id=7637849
Characteristics of patients with internal diseases who use relaxation techniques as a coping strategy.
Complementary Therapies in Medicine
9/25/2013 8:15:04 AM
CONCLUSION: In a German sample of patients with internal diseases, relaxation techniques were used as a coping strategy by about 43%. Users were more likely to be middle-aged, female, well-educated, diagnosed with fibromyalgia, not smoking, not full-time employed, and not to have a good health status or high life satisfaction. A high internal health locus of control predicted relaxation techniques use. Considering health locus of control might improve adherence to relaxation techniques in internal medicine patients. PMID: 24050583 [PubMed - in process] (Source: Complementary Therapies in Medicine)
http://www.medworm.com/rss/comments.php?id=7624507
Dimensionality, Reliability, and Validity of the Revised Fibromyalgia Impact Questionnaire in Two Spanish Samples
Arthritis Care and Research
9/23/2013 11:00:00 PM
ConclusionOur results indicate that the Spanish version of the FIQR has a complex factor structure, has excellent reliability, and shows good construct validity. (Source: Arthritis Care and Research)
http://www.medworm.com/rss/comments.php?id=7628378
Vulnerability to traumatic stress in fibromyalgia patients: 19 month follow-up after the great east Japan disaster
Arthritis Research and Therapy
9/22/2013 11:00:00 PM
Conclusions: Although response to acute stress induced by the great earthquake was likely to be settled within seven months after the disaster, depression-related symptoms have been increasing for more than one year after the disaster, despite exclusion of patients with major depression at baseline. This long-lasting worsening of depression-related symptoms may have been in response to chronic stress induced by the fear of radiation due to the nuclear power disaster. These findings suggest that patients with fibromyalgia are vulnerable to chronic stress rather than acute stress. (Source: Arthritis Research and Therapy)
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Alterations in excitatory and inhibitory brainstem interneuronal circuits in fibromyalgia: Evidence of brainstem dysfunction
Clinical Neurophysiology
9/22/2013 7:00:00 PM
Conclusions: Blink reflex is normal, whereas blink reflex excitability recovery is enhanced and blink reflex prepulse inhibition is reduced in patients with FMS, suggesting functional changes at the brainstem level in FMS.Significance: Reduced blink reflex prepulse inhibition concurs with altered sensory gating in patients with FMS. (Source: Clinical Neurophysiology)

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Physical activity level and physical performance in the 6-minute walk test in women with fibromyalgia
Revista Brasileira de Reumatologia
9/21/2013 6:15:39 PM
CONCLUSIONS: Women with FM had physical activity levels similar to women without FM but exhibited worse physical performance. This functional impairment may be related to lifestyle adopted because there was a relationship between physical activity level and physical performance in those patients. (Source: Revista Brasileira de Reumatologia)
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Importance of cutaneous silent period in fibromyalgia and its relationship with disease characteristics, psychological disorders and quality of life of patients
Revista Brasileira de Reumatologia
9/21/2013 6:15:39 PM
CONCLUSIONS: CSP latencies in both upper and lower extremities in patients with FM are longer than in healthy volunteers. Moreover, prolongation of CSP latency in the lower extremity is associated with disease severity and physical functional disability. (Source: Revista Brasileira de Reumatologia)
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Stress and Orality(Hartmann et al.)
Springer Medicine titles
9/20/2013 10:40:51 AM
New Data About Teeth Clenching & Outcomes, Migraine, Fibromyalgia, Fatigue“The reading of STRESS and ORALITY written by F. HARTMANN and G. CUCCHI led me to believe that we should consider the problem of certain migraines, neck pain, fibromyalgia, and chronic fatigue from a radically different angle than the historically traditional approach.”  Pr Roger Guillemin (Nobel Laureate in Medicine)Are oral disorders only an issue for dentists? The answer is no.If your ... (Source: Springer Medicine titles)

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NLRP3 Inflammasome Is Activated in Fibromyalgia: The Effect of Coenzyme Q10
Antioxidants and Redox Signaling
9/19/2013 8:31:17 AM
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)

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Concerns with fibromyalgia guidelines.
cmaj
9/16/2013 11:00:00 PM
Authors: Fitzcharles MA, Ste-Marie PA PMID: 24043755 [PubMed - in process] (Source: cmaj)
http://www.medworm.com/rss/comments.php?id=7617435
Significant Aspirations: Recurrent Pneumonia
The American Journal of Medicine
9/16/2013 11:00:00 PM
The source of recurrent pneumonia was difficult to pinpoint in a 65-year-old white woman without typical risk factors. She presented to her primary physician with a productive cough, dyspnea, fever, and fatigue of 1-week duration. A former smoker, she had quit 25 years earlier. Her medical history was significant for hypothyroidism, gastroesophageal reflux, osteoporosis, fibromyalgia, and depression. Prior surgeries included gastric bypass surgery for obesity, cholecystectomy, hysterectomy, and breast reduction. She denied a history of seizure as well as alcohol, sedative or illicit drug use. (Source: The American Journal of Medicine)
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Spine Treatments Little Help in Fibromyalgia (CME/CE)
MedPage Today Psychiatry
9/16/2013 11:43:16 AM
(MedPage Today) -- Individuals reporting back pain whose symptom pattern was typical of fibromyalgia derived little benefit from minimally invasive spine therapies such as epidural steroid injections, researchers found. (Source: MedPage Today Psychiatry)
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Voice disorder in patients with Fibromyalgia
Auris, Nasus, Larynx
9/16/2013 5:16:22 AM
Abstract: Objective: To investigate several perceptual, acoustic and aerodynamic voice evaluation parameters in Fibromyalgia patients.Methods: A total number of 30 Fibromyalgia patients had voice evaluations by means of laryngostroboscopy, acoustic analysis (jitter, shimmer, and harmonic to noise ratio), aerodynamic measurements (maximum phonation time, s/z ratio), and perceptual analysis (GRBAS and Voice Handicap Index-10 scales). Data obtained from the patients was compared to control subjects.Results: Mean intensity was found to be significantly higher in control subjects (73.70±4.73dB) than Fibromyalgia patients (64.50±6.92dB), (p (Source: Auris, Nasus, Larynx)
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Personality does not distinguish people with fibromyalgia but identifies subgroups of patients
General Hospital Psychiatry
9/15/2013 11:00:00 PM
Conclusions: Identifying personality-based subgroups of FM might allow implementing specific preventive strategies. FM treatment might be optimized by increasing medication compliance, improving therapeutic alliance and testing different therapeutic options and treatment sequencing for each personality subgroup. (Source: General Hospital Psychiatry)
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Ultrasound Assessment of the Entheses in Primary Sjögren Syndrome
Ultrasound in Medicine and Biology
9/15/2013 11:00:00 PM
The objective of this study was to determine whether tendon pain in pSS is related to involvement of the tendons and entheses. We performed a physical examination of 288 entheseal insertion sites in 16 patients with active pSS and 162 entheseal insertion sites in 9 healthy controls without symptoms or medications. Then ultrasound was used to assess entheseal and tendon sites of these patients (n = 208) and controls (n = 117). Ultrasound was performed in B mode first to detect structural damages, and in power Doppler mode to detect blood flow abnormalities. By physical examination, 9 (56%) of the 16 pSS patients had pain to palpation of fibromyalgia tender points, two of whom had more than 11 tender points. The number of positive points ranged from 2 to 18, with a mean of 8 ± 6.0. None o...
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Women with fibromyalgia's experience with three motion-controlled video game consoles and indicators of symptom severity and performance of activities of daily living.
Disability and Rehabilitation. Assistive Technology.
9/11/2013 11:00:00 PM
Conclusion: This study demonstrated MCVG as an effective healthcare intervention for the women with FMS who completed the program, with regards to temporary pain relief and enjoyable low impact exercise. Implications for Rehabilitation Exercise is recommended in the management of fibromyalgia syndrome (FMS). People with FMS often find it counterintuitive to exercise because of pain exacerbation, which may influence adherence to an exercise program. Motion-controlled video games may offer temporary pain relief and fun low impact exercise for women with FMS. PMID: 24028282 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation. Assistive Technology.)
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Prevalence of the fibromyalgia phenotype in spine pain patients presenting to a tertiary care pain clinic and the potential treatment implications
Arthritis and Rheumatism
9/9/2013 11:00:00 PM
Conclusion: Using the survey criteria for fibromyalgia, we demonstrated profound phenotypic differences in a spine pain population. Although centralized pain cannot be confirmed with a survey alone, the pathophysiology of fibromyalgia may help explain a portion of the variability of responses to spine interventions. © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)

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Cognitive behavioural therapies for fibromyalgia.
Cochrane Database of Systematic Reviews
9/9/2013 11:00:00 PM
CONCLUSIONS: CBTs provided a small incremental benefit over control interventions in reducing pain, negative mood and disability at the end of treatment and at long-term follow-up. The dropout rates due to any reason did not differ between CBTs and controls. PMID: 24018611 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
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Reports of Chronic Pain in Childhood and Adolescence Among Patients at a Tertiary Care Pain Clinic
The Journal of Pain
9/8/2013 11:00:00 PM
Abstract: Although chronic pain in childhood can last into adulthood, few studies have evaluated the characteristics of adults with chronic pain who report childhood chronic pain. Thus, 1,045 new patients (mean age, 49.5 ± 15.4) at an academic tertiary care pain clinic were prospectively evaluated using validated self-report questionnaires. Patients also responded to questions about childhood pain. We found that almost 17% (n = 176) of adult chronic pain patients reported a history of chronic pain in childhood or adolescence, with close to 80% indicating that the pain in childhood continues today. Adults reporting childhood chronic pain were predominantly female (68%), commonly reported widespread pain (85%), and had almost 3 times the odds of meeting survey criteria for fibromyalgia (odd...
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What is the evidence for specific factors in the psychotherapeutic treatment of fibromyalgia? Comment on “Is brief psychodynamic psychotherapy in primary fibromyalgia syndrome with concurrent depression an effective treatment? A randomized controlled trial”
General Hospital Psychiatry
9/2/2013 11:00:00 PM
This study is a welcome addition to the growing evidence base demonstrating the efficacy of PDT in fibromyalgia and related conditions . (Source: General Hospital Psychiatry)
http://www.medworm.com/rss/comments.php?id=7738210
Juvenile Fibromyalgia Syndrome and Improved Recognition by Pediatric Primary Care Providers
Journal of Pediatric Health Care
8/31/2013 11:00:00 PM
Juvenile fibromyalgia syndrome (JFS) is a medically unexplained illness that can affect the child or adolescent with persistent diffuse pain and difficulty with sleep. These symptoms can lead to anxiety or depression, absence from school or work and adversely affect a child's quality of life and family relationships. Prompt recognition of JFS helps to decrease problems for these patients, but pediatric primary care provider's lack of familiarity with JFS can cause a delay in diagnosis. A DNP project was developed to determine if a screening tool would help improve recognition of JFS in the primary pediatric setting and decrease referral time to the pediatric rheumatologist for treatment. (Source: Journal of Pediatric Health Care)
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Work-related Physical Trauma and Fibromyalgia.
J Rheumatol
8/31/2013 11:00:00 PM
Authors: Harth M PMID: 23996999 [PubMed - in process] (Source: J Rheumatol)
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Creatine No Help for Fibromyalgia (CME/CE)
MedPage Today Primary Care
8/30/2013 1:00:00 PM
(MedPage Today) -- Creatine supplementation improved several measures of muscle function in patients with fibromyalgia in a small randomized trial, but most symptoms didn't improve. (Source: MedPage Today Primary Care)
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Topiramate for neuropathic pain and fibromyalgia in adults.
Cochrane Database of Systematic Reviews
8/29/2013 11:00:00 PM
CONCLUSIONS: Topiramate is without evidence of efficacy in diabetic neuropathic pain, the only neuropathic condition in which it has been adequately tested. The data we have includes the likelihood of major bias due to LOCF imputation, where adverse event withdrawals are much higher with active treatment than placebo control. Despite the strong potential for bias, no difference in efficacy between topiramate and placebo was apparent. PMID: 23996081 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
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Juvenile Fibromyalgia Syndrome and Improved Recognition by Pediatric Primary Care Providers
Journal of Pediatric Health Care
8/27/2013 7:00:00 PM
Conclusion: Pediatric provider education and development of a screening tool assists with the recognition of JFS. (Source: Journal of Pediatric Health Care)
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Stress and Orality(Hartmann et al.)
Springer Medicine titles
8/27/2013 3:45:31 AM
New Data About Teeth Clenching & Outcomes, Migraine, Fibromyalgia, FatigueAre oral disorders only an issue for dentists? The answer is no.If your patients complain of pain and/or discomfort, if some are diagnosed as suffering from migraines, fibromyalgia or chronic fatigue, and if classical therapies have remained ineffective, this book could help in your daily practice. When it comes to the complex pathology called Temporo-Mandibular Disorders (TMD) most ... (Source: Springer Medicine titles)
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Overlapping structural and functional brain changes in patients with long‐term exposure to fibromyalgia
Arthritis and Rheumatism
8/26/2013 11:00:00 PM
Conclusion: The combined integration of structural and functional measures allowed for a unique characterization of the impact of FM pain on the brain. Our data may lead to the identification of early structural and functional brain alterations in response to pain, which could be used to develop markers to predict the development of FM and other pain disorders. © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)

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Reply: Small fibre neuropathy, fibromyalgia and dorsal root ganglia sodium channels
Brain
8/26/2013 11:00:00 PM
(Source: Brain)
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Small fibre neuropathy, fibromyalgia and dorsal root ganglia sodium channels
Brain
8/26/2013 11:00:00 PM
(Source: Brain)
http://www.medworm.com/rss/comments.php?id=7539808
Creatine Supplementation in Fibromyalgia: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Arthritis Care and Research
8/25/2013 11:00:00 PM
ConclusionCreatine supplementation increased intramuscular phosphorylcreatine content and improved lower‐ and upper‐body muscle function, with minor changes in other fibromyalgia features. These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients. (Source: Arthritis Care and Research)
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Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial.
Psychological Medicine
8/22/2013 11:00:00 PM
CONCLUSIONS: CBT and GET were more effective in reducing the frequency of both muscle and joint pain than APT and SMC. When compared to SMC, GET also reduced the frequency of co-morbid fibromyalgia; the size of this effect on pain was small. PMID: 23967878 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
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In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation
Journal of Affective Disorders
8/22/2013 9:50:36 AM
This study has been carried out to examine the autoimmune responses to 5-HT in ME/CFS in relation to inflammation and bacterial translocation.Methods: We examined 5-HT antibodies in 117 patients with ME/CFS (diagnosed according to the centers for disease control and prevention criteria, CDC) as compared with 43 patients suffering from chronic fatigue (CF) but not fulfilling the CDC criteria and 35 normal controls. Plasma interleukin-1 (IL-1), tumor necrosis factor (TNF)α, neopterin and the IgA responses to Gram-negative bacteria were measured. Severity of physio-somatic symptoms was measured using the fibromyalgia and chronic fatigue syndrome rating scale (FF scale).Results: The incidence of positive autoimmune activity against 5-HT was significantly higher (p (Source: Journal of Affectiv...
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An Endogenous Pain Control System is Altered in Subjects with Interstitial Cystitis
The Journal of Urology
8/21/2013 11:00:00 PM
Conclusions: An endogenous pain inhibitory system normally observed with conditioned pain modulation was altered in subjects with interstitial cystitis/bladder pain syndrome. This finding identifies interstitial cystitis/bladder pain syndrome as similar to several other chronic pain disorders such as fibromyalgia and irritable bowel syndrome, and suggests that a deficit in endogenous pain inhibitory systems may contribute to such chronic pain disorders. (Source: The Journal of Urology)

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[2013 vulvodynia update.]
Gynecologie, Obstetrique et Fertilite
8/20/2013 11:00:00 PM
Authors: de Belilovsky C Abstract Provoked vestibulodynia represents the most frequent cause of dyspareunia before menopause. Vulvodynia's pain and burning sensations are related to neuropathic pain and associated to various degrees of vulvar mucosal hypersensitivity (mostly in the vestibular area), pelvic floor muscles dysfunction, a disorder of general perception of pain and/or various complex regional pain syndromes such as fibromyalgia, glossodynia, painful bladder syndrome (interstitial cystitis)… Vaginal infections such as candidiasis and vaginosis are important trigger and risk factors. Women suffering from vulvodynia are often described as vulnerable, pessimistic, developing feelings of guilt towards their partner. They tend to be hyper vigilant to their pain and develop ...
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General or specific factors in the treatment of primary fibromyalgia syndrome? Comment to Luyten P. and Abbass A. “What is the evidence for specific factors in the psychotherapeutic treatment of fibromyalgia?”
General Hospital Psychiatry
8/20/2013 11:00:00 PM
Dr. Luyten and Dr Abbass in their comment on our paper “Is brief psychodynamic psychotherapy in primary fibromyalgia syndrome with concurrent depression an effective treatment ?” raise some important issues concerning the main results of the study and the potential limitations of the conclusions, to which we will respond in the subsequent paragraphs: (Source: General Hospital Psychiatry)
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Interpersonal communication research in the context of pain
Pain
8/18/2013 11:00:00 PM
Researchers and clinicians have become increasingly interested in how patients and their loved ones communicate about illness and pain. Extending this line of inquiry to fibromyalgia, Lyons and colleagues have investigated the degree to which patients and their spouses provide similar reports about various aspects of the patients’ illness. While couples, on average, did not differ in their reports of patients’ pain and impairment, each partner’s perceptions of illness-related communication correlated with the extent to which couples were incongruent in their reports of patient functioning. We believe that this paper makes a substantial contribution to the literature and would like to comment on 3 issues: analytic approach, communication measurement, and congruence research. (Source: ...
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Continuing efficacy of milnacipran following long-term treatment in fibromyalgia: a randomized trial
Arthritis Research and Therapy
8/15/2013 11:00:00 PM
IntroductionPrevious studies of long-term treatment response in fibromyalgia and other chronic pain states have generally been limited to approximately a year, leaving questions about the longer-term durability of response. The purpose of this study was to demonstrate continuing efficacy of milnacipran by characterizing changes in pain and other fibromyalgia symptoms after discontinuing long-term treatment. The mean length of milnacipran treatment at time of randomized withdrawal was 36.1 months from initial exposure to milnacipran (range, 17.9 to 54.4 months). Methods: After completing a long-term, open-label, lead-in study of milnacipran (which followed varying periods of exposure in previous studies), adult patients with fibromyalgia entered the 4-week open-label period of the current s...

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Contributions of a group-based exercise program for coping with fibromyalgia: a qualitative study giving voice to female patients.
Women and Health
8/14/2013 12:57:08 PM
This study was conducted with 25 women who had fibromyalgia and were participating in a nine-month, group-based exercise program. The aim was to provide an in-depth description and analysis of the perceived physical and psychosocial benefits of participation. Qualitative data were collected through observation, interviews, and focus groups. The exercise program not only alleviated the physical symptoms of fibromyalgia, but social interactions within the group helped to counteract the isolation, frustration, and depression often associated with this chronic condition. The data from this study may contribute to a deeper understanding of the benefits of exercise for women with fibromyalgia and might be useful for the improvement of future exercise programs for this population. PMID: 2393...
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The words patients use to describe chronic pain: Implications for measuring pain quality
Pain
8/11/2013 11:00:00 PM
Summary: Patients with chronic pain describe their pain using words that reflect a relatively small subset of pain quality domains. Knowledge regarding the domains used provides important information that can inform the evaluation and development of pain measures.Abstract: Patients with low back pain (LBP; N=102), fibromyalgia (FM; N=100), and headache (HA; N=100) were asked to describe their pain in their own words, and the words and phrases they used were then classified into 7 global domains (eg, Pain Quality, Pain Magnitude) and as many specific subdomains as needed to capture all of the ideas expressed (eg, under Pain Quality, subdomains such as sharp, achy, and throbbing). Fifteen pain quality subdomains were identified as most common. Nine of these demonstrated significant between-g...

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Sono-myography and Sono-myoelastography of the Tender Points of Women with Fibromyalgia
Ultrasound in Medicine and Biology
8/11/2013 11:00:00 PM
The objective of this study was to use the same techniques to investigate the morphology, stiffness and blood flow of tender points in women with fibromyalgia and to compare the results with those for samples from healthy patients. Algometry tests indicated significant differences between groups (p  (Source: Ultrasound in Medicine and Biology)
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Fibromyalgia or pseudo fibromyalgia? – We have to get it right
APLAR Journal of Rheumatology
8/10/2013 11:00:00 PM
(Source: APLAR Journal of Rheumatology)
http://www.medworm.com/rss/comments.php?id=7504500
Voice disorder in patients with Fibromyalgia
Auris, Nasus, Larynx
8/10/2013 7:31:36 AM
Abstract: Objective: To investigate several perceptual, acoustic and aerodynamic voice evaluation parameters in Fibromyalgia patients.Methods: A total number of 30 Fibromyalgia patients had voice evaluations by means of laryngostroboscopy, acoustic analysis (jitter, shimmer, and harmonic to noise ratio), aerodynamic measurements (maximum phonation time, s/z ratio), and perceptual analysis (GRBAS and Voice Handicap Index-10 scales). Data obtained from the patients was compared to control subjects.Results: Mean intensity was found to be significantly higher in control subjects (73.70±4.73dB) than Fibromyalgia patients (64.50±6.92dB), (p (Source: Auris, Nasus, Larynx)
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Tender points
Patient Education and Counseling
8/4/2013 11:00:00 PM
I met Paloma in 2009, about 6 months after starting as a primary care physician at the city hospital in Denver, Colorado. Her presentation was confusing to me at first. She noted pain and numbness in her hands, headaches, occasional dizziness, even falls. She was in her early 50s and seemingly healthy, having recently supervised over 30 employees in a restaurant job. Her physical exam, hand X-rays, routine blood tests, and special tests for autoimmune diseases all were unremarkable. We tried migraine medications for her headaches, but it helped only slightly. After several visits, it occurred to me that she probably had fibromyalgia, a condition involving diffuse pain and tender points in the muscles, and increased pain perception, but with no objective physical abnormalities. Most patient...
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Stenberg Shatters Fibromyalgia Control Record
PRWeb: Medical Pharmaceuticals
8/3/2013 5:17:34 AM
Fibromyalgia shattered the Fibromyalgia control record: 77% symptom improvement in weeks with no significant side effects.(PRWeb August 01, 2013)Read the full story at http://www.prweb.com/releases/2013/8/prweb10985679.htm (Source: PRWeb: Medical Pharmaceuticals)

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Study finds evidence of nerve damage in around half of fibromyalgia patients
Health News from Medical News Today
8/1/2013 2:00:00 AM
About half of a small group of patients with fibromyalgia - a common syndrome that causes chronic pain and other symptoms - was found to have damage to nerve fibers in their skin and other evidence of a disease called small-fiber polyneuropathy (SFPN). Unlike fibromyalgia, which has had no known causes and few effective treatments, SFPN has a clear pathology and is known to be caused by specific medical conditions, some of which can be treated and sometimes cured. The study from Massachusetts General Hospital (MGH) researchers will appear in the journal Pain and has been released online... (Source: Health News from Medical News Today)
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Pharmacological treatment of multi-organ bodily distress syndrome: A double-blind, placebo-controlled trial of the effects of imipramine (stress-3)
Journal of Psychosomatic Research
7/31/2013 11:00:00 PM
Background: Bodily Distress Syndrome (BDS) is characterised by multiple persistent bodily symptoms not attributable to well-defined disease. BDS is related to centrally mediated pain conditions and has been shown to encompass functional somatic syndromes such as fibromyalgia, irritable bowel syndrome and chronic fatigue syndrome. The most severe form of BDS, multi-organ BDS, is characterised by symptoms from several organ systems. (Source: Journal of Psychosomatic Research)
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Validation of a Spanish version of the Revised Fibromyalgia Impact Questionnaire (FIQR)
Health and Quality of Life Outcomes
7/31/2013 11:00:00 PM
Conclusions: The Spanish version of the FIQR has a good internal consistency and our findings support its validity for assessing fibromyalgia patients. It might be a valid instrument to apply in clinical and investigational grounds. (Source: Health and Quality of Life Outcomes)

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Recent Findings Related to Fibromyalgia
Psychology Today Depression Center
7/31/2013 10:06:57 AM
Fibromyalgia is a complex disorder with distressing physical and behavioral symptoms. Recent research demonstrates abnormalities in a specific type of nerve fiber. This work helps clarify the nature of this painful disorder.read more (Source: Psychology Today Depression Center)
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EpicGenetics, Inc., Developer Of The First Blood Test For Fibromyalgia, Releases Fibromyalgia App
Medical Design Online News
7/30/2013 1:11:19 AM
The revolutionary medical diagnostic company, EpicGenetics, Inc. -- developers of the first blood test for Fibromyalgia -- announces the release of the new My FM/a® app this month (Source: Medical Design Online News)
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Study finds evidence of nerve damage in around half of fibromyalgia patients
EurekAlert! - Medicine and Health
7/29/2013 11:00:00 PM
(Massachusetts General Hospital) About half of a small group of patients with fibromyalgia -- a common syndrome that causes chronic pain and other symptoms -- was found to have damage to nerve fibers in their skin and other evidence of a disease called small-fiber polyneuropathy (SFPN). Unlike fibromyalgia, SFPN has a clear pathology and is known to be caused by specific medical conditions, some of which can be treated and sometimes cured. (Source: EurekAlert! - Medicine and Health)
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New Version of Fibromyalgia Drug OK'd for Depression
MedPage Today Psychiatry
7/29/2013 11:43:01 AM
(MedPage Today) -- The FDA has approved levomilnacipran (Fetzima), a single-enantiomer version of the fibromyalgia drug milnacipran (Savella), for treating major depression, its developers said. (Source: MedPage Today Psychiatry)

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Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia
Pain
7/28/2013 11:00:00 PM
Summary: Pain and fatigue during movement, but not at rest, are reduced by a onetime 30-m treatment with active transcutaneous electrical nerve stimulation (TENS) in individuals with fibromyalgia.Abstract: Because transcutaneous electrical nerve stimulation (TENS) works by reducing central excitability and activating central inhibition pathways, we tested the hypothesis that TENS would reduce pain and fatigue and improve function and hyperalgesia in people with fibromyalgia who have enhanced central excitability and reduced inhibition. The current study used a double-blinded randomized, placebo-controlled cross-over design to test the effects of a single treatment of TENS with people with fibromyalgia. Three treatments were assessed in random order: active TENS, placebo TENS and no TENS. T...
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Correspondence to Tesarz et al. Alterations in endogenous pain modulation in endurance athletes: An experimental study using quantitative sensory testing and the cold-pressor task. PAIN® 154, 1022–29, 2013
Pain
7/28/2013 11:00:00 PM
With great interest we read the paper published by Tesarz et al. in PAIN. The authors found a reduced analgesic response to a heterotopic noxious stimulus in a so-called conditioned pain modulation (CPM) paradigm in endurance athletes compared to untrained control subjects. This is astonishing because physical activity has been suggested to be an appropriate treatment of many chronic pain disorders such as headache or fibromyalgia . On the other hand, weakly supporting an analgesic effect of endurance training, Tesarz et al. found nonsignificant trends for increased QST pain thresholds, lower unconditioned heat pain perception, and marginally increased cold pain tolerance in the athletes. Although the authors included the cold pressor (CP) ratings as covariates in their CPM analysis, they ...
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FDA Approves Fetzima for the Treatment of Depression
About.com Depression
7/28/2013 11:00:00 PM
On July 26, 2013 the FDA announced its approval of a new antidepressant medication called Fetzima (levomilnacipran extended-release capsules) for the treatment of Major Depressive Disorder (MDD) in adults. It is not yet, however, approved for the treatment of fibromyalgia pain....Read Full Post (Source: About.com Depression)
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Reply to the Letter to the Editor
Pain
7/25/2013 11:00:00 PM
We welcome Üçeyler and Sommer’s letter highlighting our similar articles about fibromyalgia syndrome (FMS) . Along with our prior article linking juvenile-onset FMS to small-fiber polyneuropathy (SFPN), and similar preliminary data from others , there is now strong evidence of peripheral-nerve involvement in FMS . In contrast, the bruited attribution of FMS to “central sensitization” never found factual basis given that FMS-associated brain imaging alterations initially thought causal were later understood to be nonspecific . (Source: Pain)
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Effect of Moderate to Vigorous Physical Activity on Long‐Term Clinical Outcomes and Pain Severity in Fibromyalgia
Arthritis Care and Research
7/25/2013 11:00:00 PM
ConclusionIncreased participation in MVPA for at least 12 weeks improved physical function and overall well‐being in patients with FM. Although sustained physical activity was not associated with greater clinical benefit compared with unsustained physical activity, these findings also suggest that performing greater volumes of physical activity is not associated with worsening pain in FM. Future research is needed to determine the relationship between sustained MVPA participation and subsequent improvement in patient outcomes. (Source: Arthritis Care and Research)
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Potential for a faster, simpler diagnosis for fibromyalgia using a finger-stick blood sample
Health News from Medical News Today
7/25/2013 5:00:00 AM
Researchers have developed a reliable way to use a finger-stick blood sample to detect fibromyalgia syndrome, a complicated pain disorder that often is difficult to diagnose. If it were someday made available to primary care physicians, the test could knock up to five years off of the wait for a diagnosis, researchers predict. In a pilot study, the scientists used a high-powered and specialized microscope to detect the presence of small molecules in blood-spot samples from patients known to have fibromyalgia... (Source: Health News from Medical News Today)
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Muscle Blood Flow and Oxygenation in FibromyalgiaMuscle Blood Flow and Oxygenation in Fibromyalgia
Medscape Today Headlines
7/24/2013 8:05:21 AM
How does muscle oxygenation differ in women with fibromyalgia? Arthritis Research & Therapy (Source: Medscape Today Headlines)
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New Fast and Easy Test for Fibromyalgia May be Close
Disabled World
7/23/2013 3:14:21 PM
If it were someday made available to primary care physicians, the test could knock up to five years off of the wait for a diagnosis, researchers predict. (Source: Disabled World)
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Faster, simpler diagnosis for fibromyalgia may be on the horizon
EurekAlert! - Medicine and Health
7/22/2013 11:00:00 PM
(Ohio State University) Researchers have developed a reliable way to use a finger-stick blood sample to detect fibromyalgia syndrome, a complicated pain disorder that often is difficult to diagnose. (Source: EurekAlert! - Medicine and Health)

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Including a Range of Outcome Targets Offers a Broader View of Fibromyalgia Treatment Outcome: Results from a Retrospective Review of Multidisciplinary Treatment
Musculoskeletal Care
7/22/2013 11:00:00 PM
ConclusionDespite modest albeit statistically significant improvements in standard measures of pain severity and the FIQ, more substantial pain improvement was noted when utilizing alternative measures of pain and functional improvement. Alternative symptom assessment measures might be important outcome measures to include in drug and non‐drug studies to better understand fibromyalgia treatment effectiveness. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Musculoskeletal Care)

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Couple perceptions of fibromyalgia symptoms: The role of communication
Pain
7/21/2013 11:00:00 PM
The objectives of the current study were to describe fibromyalgia patient–spouse incongruence regarding patient pain, fatigue, and physical function; and to examine the associations of individual and interpersonal factors with patient–spouse incongruence. Two hundred four fibromyalgia patients and their coresiding partners rated the patient’s symptoms and function. Multilevel modeling revealed that spouses, on average, rated patient fatigue significantly lower than patients. Couple incongruence was not significantly different from zero, on average, for pain severity, interference, or physical function. However, there was significant variability across couples in how they rated the severity of symptoms and function, and how much incongruence existed within couples. Controlling for ind...
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Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin or pregabalin
Arthritis Care and Research
7/15/2013 11:00:00 PM
Conclusion: Patients who started one of the four common drugs for fibromyalgia similarly had multiple comorbidities and other fibromyalgia‐related drug use, but continued the treatment only for a short time. The dose of the four drugs was not increased in most patients during the follow‐up. © 2013 American College of Rheumatology. (Source: Arthritis Care and Research)
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‘Migraines are associated with functional somatic syndromes’
Journal of Psychosomatic Research
7/9/2013 11:00:00 PM
We thank our colleague, Ms. Bulow-Olsen, for her comments on our article. Implicit in her letter is that there is no widely accepted and useful definition of functional somatic syndromes (FSSs), and we agree with this assessment. The article by Henningsen et al. was cited not for migraine but as a comprehensive and accessible paper describing the FSSs. The syndromes we studied were simply those in which onset during the incidence year could be determined; we noted in the Methods section that “for ease of discussion, these seven syndromes will be termed FSSs” . In the article, we repeated the calculations using only the three syndromes most widely accepted as FSSs, i.e., fibromyalgia (FM), chronic fatigue syndrome (CFS), and irritable bowel syndrome (IBS) (migraine was not included), an...

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Reduced N-acetylaspartate in the hippocampus in patients with fibromyalgia: A meta-analysis
Psychiatry Research: Neuroimaging
7/7/2013 11:00:00 PM
Abstract: Fibromyalgia (FM) is a stress-associated syndrome with chronic, widespread pain. Patients with FM also present disturbances of cognition and memory. As the hippocampus is vulnerable to stress exposure and involved in cognition, memory and pain perception, we hypothesize that the abnormal function of the hippocampus is implicated in the pathophysiology of FM. N-acetylaspartate (NAA), a metabolite that can be measured using proton magnetic resonance spectroscopy (1H MRS), is recognized as a marker of neuronal structure and function. We performed a systematic review and meta-analysis of 1H MRS studies investigating NAA levels in patients with FM. A comprehensive literature search through MEDLINE, Embase and Web of Science yielded nine studies; among these nine, four studies met our ...
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Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: A systematic review
Seminars in Arthritis and Rheumatism
7/7/2013 11:00:00 PM
Conclusion: FM patients show more HRV aberrances and indices of increased sympathetic activity. Increased sympathetic activity is only present in CFS patients at night. Since direct comparisons are lacking and some confounders have to be taken into account, further research is warranted. The role of pain and causality can be subject of further research, as well as therapy studies directed to reduced HRV. (Source: Seminars in Arthritis and Rheumatism)
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Effects of Shiatsu in the Management of Fibromyalgia Symptoms: A Controlled Pilot Study
Journal of Manipulative and Physiological Therapeutics
7/7/2013 11:00:00 PM
Conclusion: This pilot study showed the potential of Shiatsu in the improvement of pain intensity, pressure pain threshold, sleep quality, and symptoms impact on health of patients with fibromyalgia. The proposed Shiatsu treatment protocol was feasible and well accepted by the patients. (Source: Journal of Manipulative and Physiological Therapeutics)
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Serum levels of high mobility group box 1 protein and its association with quality of life and psychological and functional status in patients with fibromyalgia
APLAR Journal of Rheumatology
7/1/2013 11:00:00 PM
ConclusionHMGB1 protein might be a good laboratory‐sourced candidate for the assessment of functional status and disease severity in patients with FM. (Source: APLAR Journal of Rheumatology)

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Shaped magnetic field pulses by multi-coil repetitive transcranial magnetic stimulation (rTMS) differentially modulate anterior cingulate cortex responses and pain in volunteers and fibromyalgia patients
Molecular Pain
7/1/2013 11:00:00 PM
Conclusion: Multi-coil rTMS may be a safe and effective treatment option for acute as well as for chronic pain, such as that accompanying fibromyalgia. Further studies are necessary to optimize configurations and settings as well as to elucidate the mechanisms that lead to the long-lasting pain control produced by these treatments. (Source: Molecular Pain)
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Canadian Pain Society and Canadian Rheumatology Association Recommendations for Rational Care of Persons with Fibromyalgia. A Summary Report.
J Rheumatol
6/30/2013 11:00:00 PM
CONCLUSION: These guidelines should provide the health community with reassurance for the global care of patients with FM with the aim of improving patient outcome by reducing symptoms and maintaining function. PMID: 23818709 [PubMed - as supplied by publisher] (Source: J Rheumatol)
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The effectiveness of aquatic physical therapy in the treatment of fibromyalgia: a systematic review with meta-analysis.
Clinical Rehabilitation
6/30/2013 11:00:00 PM
Conclusion:Three meta-analyses showed statistically significant results in favour of the aquatic physical therapy (Fibromyalgia Impact Questionnaire, stiffness and the 6-minute walk test) during a period of longer than 20 weeks. Due to the low methodological rigor, the results were insufficient to demonstrate statistical and clinical differences in most of the outcomes. PMID: 23818412 [PubMed - as supplied by publisher] (Source: Clinical Rehabilitation)
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A Questionnaire Using the Modified 2010 American College of Rheumatology Criteria for Fibromyalgia: Specificity and Sensitivity in Clinical Practice.
J Rheumatol
6/30/2013 11:00:00 PM
CONCLUSION: The Modified ACR 2010 criteria questionnaire can be used in primary care as a tool to assist physicians in the diagnosis of FM with high specificity and sensitivity. Calculating the total score on a Modified ACR 2010 criteria questionnaire, and setting the value of ≥ 13 as the cutoff for a diagnosis of FM appears to be the most effective approach. The Modified ACR 2010 criteria may reduce the need for rheumatology referral simply for the diagnosis of FM. PMID: 23818707 [PubMed - as supplied by publisher] (Source: J Rheumatol)
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Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia
Pain
6/27/2013 11:00:00 PM
We read with interest the article by Oaklander and colleagues on small-fiber pathology in patients with fibromyalgia syndrome (FMS) . The authors describe the results of small-fiber assessments in patients with FMS and report on small-fiber impairment as shown by reduced intraepidermal nerve fiber density and altered autonomic function. We are pleased to see that they reproduce findings that we recently published describing small-fiber pathology in patients with FMS . However, we believe that it is important to interpret these findings with caution. (Source: Pain)
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Migraine is not a functional somatic syndrome
Journal of Psychosomatic Research
6/24/2013 11:00:00 PM
The paper J. W. Warren, P. Langenberg og D. J. Clauw, 2013. The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs. J Psychosom Res.74, 12-7 lists fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, migraine and chronic pelvic pain as functional somatic syndromes. Migraine is only sometimes included, according to the authors. (Source: Journal of Psychosomatic Research)
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Clinical researches on the efficacy of spa therapy in fibromyalgia. A systematic review.
Annali dell'Istituto Superiore di Sanita
6/23/2013 8:00:02 AM
Conclusion. Study data confirms that spa therapy could improve the symptoms of fibromyalgia including pain, depression and minor symptoms. PMID: 23771266 [PubMed - in process] (Source: Annali dell'Istituto Superiore di Sanita)
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Effect of fibromyalgia on bone mineral density in patients with fibromylagia and rheumatoid arthritis
Journal of Postgraduate Medicine
6/20/2013 11:00:00 PM
Conclusions: In spite of functional disability, FM does not cause a decrease in BMD. The presence of FM in RA patients does not result in a change in BMD. (Source: Journal of Postgraduate Medicine)

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[Fibromyalgia syndrome as a psychosomatic disorder - Diagnosis and therapy according to current evidence-based guidelines.]
Zeitschrift fur Psychosomatische Medizin und Psychotherapie
6/20/2013 8:35:08 PM
Conclusions: The coordinated recommendations of both guidelines can synthesize general medical, somatic, and psychosocial perspectives, and can promote graduated care of patients diagnosed with FMS. PMID: 23775553 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Psychosomatische Medizin und Psychotherapie)
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Are Peripheral Pain Generators Important in Fibromyalgia and Chronic Widespread Pain?
Pain Medicine
6/19/2013 11:00:00 PM
(Source: Pain Medicine)
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Rational Biological Source Of Pain Found In The Skin Of Patients With Fibromyalgia
Health News from Medical News Today
6/19/2013 4:00:00 AM
Fibromyalgia, a painful condition affecting approximately 10 million people in the U.S., is not imaginary after all, as some doctors have believed. A discovery, published this month in PAIN MEDICINE (the journal of the American Academy of Pain Medicine), clearly now demonstrates that fibromyalgia may have a rational biological basis located in the skin. Fibromyalgia is a severely debilitating affliction characterized by widespread deep tissue pain, tenderness in the hands and feet, fatigue, sleep disorders, and cognitive decline... (Source: Health News from Medical News Today)
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Fibromyalgia is not all in your head, new research confirms
EurekAlert! - Social and Behavioral Science
6/16/2013 11:00:00 PM
(Integrated Tissue Dynamics (INTIDYN)) Integrated Tissue Dynamics has discovered the first physically-detectable pathology associated with fibromyalgia, an enigmatic disease often viewed as more mental than physical. The research, published in Pain Medicine, revealed that female fibromyalgia patients have an excessive sensory nerve supply to small valves (shunts) among blood vessels deep in the palmar skin. This discovery provides a first logical rationale for fibromyalgia symptoms of extreme tenderness in the hands as well as widespread muscular aching and fatigue. (Source: EurekAlert! - Social and Behavioral Science)
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A Mindful Future for Fibromyalgia?: a Comment on Davis and Zautra.
Annals of Behavioral Medicine
6/14/2013 11:00:00 PM
Authors: Jones KD Abstract PMID: 23771864 [PubMed - as supplied by publisher] (Source: Annals of Behavioral Medicine)

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No clear link between weather and fibromyalgia
Reuters: Health
6/14/2013 4:33:32 PM
NEW YORK (Reuters Health) - Despite common complaints that the weather can aggravate fibromyalgia symptoms, a new study finds little consistency in the type of weather conditions linked to worsening of the mysterious pain syndrome. (Source: Reuters: Health)
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No Clear Link Between Weather and FibromyalgiaNo Clear Link Between Weather and Fibromyalgia
Medscape Medical News Headlines
6/14/2013 11:00:00 AM
Despite common complaints that the weather can aggravate fibromyalgia, a new study finds little consistency in the type of weather conditions linked to worsening of symptoms. Reuters Health Information (Source: Medscape Medical News Headlines)

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A patient and physician survey of Fibromyalgia across Latin America and Europe
BMC Musculoskeletal Disorders
6/13/2013 11:00:00 PM
Background: Patients and physicians from three Latin American (LA) and six European countries were surveyed in order to describe differences in journey to diagnosis, impact, and management of fibromyalgia (FM). Methods: 900 patients (300 LA; 600 Europe) and 1824 physicians (604 LA; 1220 Europe) were surveyed between October-December 2010 (LA) and February-April 2008 (Europe). Patients and physicians (GP or specialists) completed separate questionnaires, on symptoms, impact, and FM management. Interviews were conducted in local languages. Appropriate rating scales were used throughout. Data were analyzed using cross-tabulations and descriptive statistics. Significance was determined at P < 0.05 (indicated by *). Results: In LA versus Europe, patients reported having FM symptoms for longer (...
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Rheumatic manifestations in inflammatory bowel disease.
Autoimmunity Reviews
6/13/2013 11:00:00 PM
Authors: Atzeni F, Defendenti C, Ditto MC, Batticciotto A, Ventura D, Antivalle M, Ardizzone S, Sarzi-Puttini P Abstract Musculoskeletal symptoms (articular, periarticular and muscular involvement, osteoporosis and related fractures, and fibromyalgia) are the most common frequent extra-intestinal manifestations of inflammatory bowel disease (IBD) and affect 6-46% of patients. IBD-related arthropathy is one of a group of inflammatory arthritides known as seronegative spondyloarthropathies (SpA), which also includes idiopathic ankylosing spondylitis (AS), reactive arthritis, psoriatic arthritis, and undifferentiated SpA. The articular involvement in IBD significantly affects the patients' quality of the life. Although magnetic resonance imaging (MRI) is still the gold standard for as...
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Longitudinal Observation of Treatment Patterns and Outcomes for Patients with Fibromyalgia: 12‐Month Findings from the REFLECTIONS Study
Pain Medicine
6/10/2013 11:00:00 PM
ConclusionsIn this real‐world setting, patients with fibromyalgia reported modest improvements, high resource, and medication use, and were satisfied with the care they received. Cohort differences were difficult to discern because of the high rates of drug discontinuation and concomitant medication use over the 12‐month study period. (Source: Pain Medicine)

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Really?: The Claim: Fibromyalgia Is Affected by Weather
NYT
6/10/2013 11:02:31 AM
Most studies have not found much evidence of a link between fibromyalgia symptoms and weather patterns.     (Source: NYT)
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Well: Really? The Claim: Fibromyalgia Is Affected by Weather
NYT Health
6/10/2013 11:02:31 AM
Most studies have not found much evidence of a link between fibromyalgia symptoms and weather patterns.     (Source: NYT Health)
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Nerve Stimulation Might Ease Fibromyalgia Pain
WebMD Health
6/10/2013 10:32:22 AM
Small early study saw improvement in patients' quality of life (Source: WebMD Health)
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Deficient modulation of pain by a positive emotional context in fibromyalgia patients
Pain
6/9/2013 11:00:00 PM
This study aimed to investigate the modulating effects of emotional context on pain perception in 16 patients with fibromyalgia syndrome (FMS) and 16 healthy control (HC) subjects. An infrared laser was used to apply individually adapted painful stimuli to the dorsum of the left hand. The emotional background of the painful stimuli was modulated by concurrent presentations of negative, neutral, and positive picture stimuli selected from the International Affective Picture System. As control conditions, painful stimuli and the pictures were also presented by themselves. During each of the 5 laser-picture trials, subjects received 10 painful stimuli and were asked to rate the average intensity and unpleasantness of the experienced pain. Functional magnetic resonance images were obtained, usi...
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Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia
Pain
6/6/2013 11:00:00 PM
Summary: Comparing symptoms, examinations, skin biopsies, and autonomic functions in fibromyalgia as opposed to control subjects suggests that approximately half of fibromyalgia patients have previously unrecognized small-fiber polyneuropathy.Abstract: Fibromyalgia is a common, disabling syndrome that includes chronic widespread pain plus diverse additional symptoms. No specific objective abnormalities have been identified, which precludes definitive testing, disease-modifying treatments, and identification of causes. In contrast, small-fiber polyneuropathy (SFPN), despite causing similar symptoms, is definitionally a disease caused by the dysfunction and degeneration of peripheral small-fiber neurons. SFPN has established causes, some diagnosable and definitively treatable, eg, diabetes. ...
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[Female Patients with Fibromyalgia Syndrome in Somatic and Psychosomatic Rehabilitation Center - an Exploratory Study on Access Routes and Differences in Patient Characteristics.]
Die Rehabilitation
6/6/2013 11:00:00 PM
Authors: Ullrich A, Glattacker M, Sibold M, Egle UT, Ehlebracht-König I, Geigges W, Köllner V, Kruse M, Jäckel WH Abstract Fibromyalgia syndrome (FMS) is characterized by e. g. chronic, multilocular pain, and mental health problems. In Germany, patients with FMS are treated in somatic and psychosomatic rehabilitation centers - specialized for rheumatic diseases (somatic) or psychosomatic diseases. The aim of this study is to identify the status quo of FMS patients' access routes to the rehabilitation system, and to identify their predictors for being assigned to one or the other indication group.Our cohort consists of 197 FMS pa-tients from 3 psychosomatic (M=49.9 years) and 223 FMS patients (M=50.2 years) from 3 somatic rehabilitation centers. At the beginning of rehabilitation...
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Weather ‘does not’ affect fibromyalgia pain or fatigue
Nursing Times Breaking News
6/5/2013 7:33:00 PM
Weather conditions including temperature, sunshine, and precipitation have no overall impact on fibromyalgia symptoms in female patients, according to Dutch researchers. (Source: Nursing Times Breaking News)
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Small fibre pathology in patients with fibromyalgia syndrome
Brain
6/4/2013 11:00:00 PM
We examined small fibre function by quantitative sensory testing and pain-related evoked potentials, and quantified intraepidermal nerve fibre density and regenerating intraepidermal nerve fibres in skin punch biopsies of the lower leg and upper thigh. The results were compared with data from 10 patients with monopolar depression without pain and with healthy control subjects matched for age and gender. Neurological and standard neurophysiological examination was normal in all patients, excluding large fibre polyneuropathy. Patients with fibromyalgia syndrome had increased scores in neuropathic pain questionnaires compared with patients with depression and with control subjects (P < 0.001 each). Compared with control subjects, patients with fibromyalgia syndrome but not patients with de...
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Weather Doesn't Trigger Fibromyalgia Symptoms, Study Finds
WebMD Health
6/4/2013 11:05:45 AM
But some patients still may be more sensitive than others (Source: WebMD Health)
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Weather Conditions Do Not Affect Fibromyalgia Pain Or Fatigue
Health News from Medical News Today
6/4/2013 11:00:00 AM
Individual Patients May Experience Some Weather Sensitivity Dutch researchers report that weather conditions including temperature, sunshine, and precipitation have no impact on fibromyalgia symptoms in female patients. Results published in published in Arthritis Care & Research, a journal of the American College of Rheumatology (ACR), suggest that individual patients may be sensitive to some changes in the weather. Medical evidence shows that fibromyalgia affects 2% of the world population with a greater prevalence among women. In the U.S... (Source: Health News from Medical News Today)
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Weather Doesn't Trigger Fibromyalgia Symptoms, Study Finds
MedlinePlus Health News
6/4/2013 8:00:00 AM
But some patients still may be more sensitive than othersSource: HealthDay Related MedlinePlus Page: Fibromyalgia (Source: MedlinePlus Health News)
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Weather Doesn't Trigger Fibromyalgia Symptoms, Study Finds
MedicineNet Chronic Pain General
6/4/2013 2:00:00 AM
Title: Weather Doesn't Trigger Fibromyalgia Symptoms, Study FindsCategory: Health NewsCreated: 6/4/2013 10:35:00 AMLast Editorial Review: 6/4/2013 12:00:00 AM (Source: MedicineNet Chronic Pain General)

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Weather conditions do not affect fibromyalgia pain or fatigue
EurekAlert! - Medicine and Health
6/3/2013 11:00:00 PM
(Wiley) Dutch researchers report that weather conditions including temperature, sunshine, and precipitation have no impact on fibromyalgia symptoms in female patients. Results published in published in Arthritis Care & Research, a journal of the American College of Rheumatology, suggest that individual patients may be sensitive to some changes in the weather. (Source: EurekAlert! - Medicine and Health)
http://www.medworm.com/rss/comments.php?id=7315188
Efficacy and Safety of Mirtazapine in Fibromyalgia Syndrome Patients: A Randomized Placebo-Controlled Pilot Study (July/August).
The Annals of Pharmacotherapy
6/3/2013 11:00:00 PM
CONCLUSIONS:Patients with FMS taking mirtazapine exhibited within-group significant improvement in most of the measured outcomes. Between-group analysis was predictably compromised by the small sample size. Mirtazapine was well tolerated. Further study with a larger sample size is likely to be useful. PMID: 23737510 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
http://www.medworm.com/rss/comments.php?id=7325666
The influence of weather on daily symptoms of pain and fatigue in female patients with fibromyalgia: A multilevel regression analysis
Arthritis Care and Research
6/3/2013 11:00:00 PM
Conclusion.There is more evidence against than in support of a uniform influence of weather on daily pain and fatigue in female patients with fibromyalgia. While individuals appear to be differentially sensitive to certain weather conditions, there is no indication that specific patient characteristics play a role in weather sensitivity. © 2013 by the American College of Rheumatology (Source: Arthritis Care and Research)
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Exercise may help those with fibromyalgia
Health News - UPI.com
6/3/2013 6:47:29 PM
WINSTON-SALEM, N.C., June 3 (UPI) -- U.S. researchers say exercise may help those with fibromyalgia, who have pain in muscles, joints and tendons. (Source: Health News - UPI.com)
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Assessing the traumatic load in the narratives of women suffering fibromyalgia: When the researchers' perspective meets the women's perceptions
Journal of Psychosomatic Research
5/31/2013 11:00:00 PM
Objective: In patients with fibromyalgia (FM), pain is often associated to emotional distress. While investigating patients' attributions of symptom onset, we assessed the researchers' appraisal of the traumatic load in the patients' narratives. (Source: Journal of Psychosomatic Research)
http://www.medworm.com/rss/comments.php?id=7323615
A Medicolegal Analysis of Worker Appeals for Fibromyalgia as a Compensable Condition Following Workplace Soft-tissue Injury. Fitzcharles MA, Ste-Marie PA, Shir Y. J Rheumatol 2013;40(3):323–8. Epub 2013 Jan 15
The Spine Journal
5/31/2013 11:00:00 PM
We examined the appeals by workers directed to an appeals tribunal for causation of FM following soft-tissue injury sustained in the workplace. (Source: The Spine Journal)

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Overactive bladder and fibromyalgia: The true story
Neurourology and Urodynamics
5/31/2013 11:00:00 PM
(Source: Neurourology and Urodynamics)
http://www.medworm.com/rss/comments.php?id=7359832
Could Mitochondrial Dysfunction Be a Differentiating Marker Between Chronic Fatigue Syndrome and Fibromyalgia?
Antioxidants and Redox Signaling
5/29/2013 8:52:56 AM
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
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FRANKINCENSE AND MYRRH FIBROMYALGIA (Aconitum Napellus, Bryonia Alba, Geranium Maculatum, Hypericum) Oil [Wise Consumer Products]
DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
5/29/2013
Updated Date: May 29, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
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Increased power spectral density in resting-state pain-related brain networks in fibromyalgia
Pain
5/27/2013 11:00:00 PM
Summary: Higher power spectral density in patients with fibromyalgia may implicate the enhanced resting-state baseline neural activity in several brain regions associated with pain processing.Abstract: Fibromyalgia (FM), characterized by chronic widespread pain, is known to be associated with heightened responses to painful stimuli and atypical resting-state functional connectivity among pain-related regions of the brain. Previous studies of FM using resting-state functional magnetic resonance imaging (rs-fMRI) have focused on intrinsic functional connectivity, which maps the spatial distribution of temporal correlations among spontaneous low-frequency fluctuation in functional MRI (fMRI) resting-state data. In the current study, using rs-fMRI data in the frequency domain, we investigated ...
http://www.medworm.com/rss/comments.php?id=7517003
Sleep disorders in functional dyspepsia and future therapy.
Journal of Nippon Medical School
5/26/2013 12:30:02 PM
Authors: Futagami S, Shimpuku M, Yamawaki H, Izumi N, Kodaka Y, Nagoya H, Wakabayashi T, Shindo T, Kawagoe T, Sakamoto C Abstract Sleep disorder is a common medical problem. Sleep disorder has been associated with several diseases, including pulmonary disease, gastroesophageal reflux disease (GERD) and fibromyalgia. Interest in sleep phenomenology and gastrointestinal functioning has recently increased, because sleep disorder causes significant morbidity, as evidenced by the increased need for general medical and mental health treatment for emotional problems. A number of studies have found an association between sleep disorders and functional gastrointestinal (GI) disorders. Although arousal from sleep serves several protective roles, such as increase in the speed of esophageal cl...
http://www.medworm.com/rss/comments.php?id=7291509
[Cognitive dysfunction in fibromyalgia.]
Revista de Neurologia
5/25/2013 10:45:02 AM
CONCLUSIONS. Studies that have examined cognitive function in people diagnosed with fibromyalgia have been few and mostly with small samples. Deficits have been identified mainly in working memory and complex attentional functions, where the distraction factor has an important significance. Impairment has also been identified in long-term memory and executive functions. There is consensus among the studies in which the degree of pain is directly related to the level of cognitive dysfunction, while no full consensus to explain the influence of depression and anxiety on cognitive functioning in these patients. PMID: 23703060 [PubMed - as supplied by publisher] (Source: Revista de Neurologia)
http://www.medworm.com/rss/comments.php?id=7282755
Fibromyalgia syndrome – Novel therapeutic targets
Maturitas
5/20/2013 11:00:00 PM
Abstract: Fibromyalgia is a syndrome characterized by the presence of chronic widespread pain, representing sensitization of the central nervous system. The pthophysiology of fibromyalgia is a complex and remains in evolution, encompassing diverse issues such as disturbed patterns of sleep, alter processing and decreased conditioned pain modulation at the spinal level, as well as increased connectivity between various pain – processing areas of the brain. This evolution is continuously uncovering potential novel therapeutic targets.Treatment of fibromyalgia is a multi – faceted endeavor, inevitably combining pharmacological as well as non – pharmacological approaches. 2δ ligands and selective nor-epinephrine – serotonin reuptake inhibitors are the current mainstays of pharmacologi...
http://www.medworm.com/rss/comments.php?id=7416546
Excessive Peptidergic Sensory Innervation of Cutaneous Arteriole–Venule Shunts (AVS) in the Palmar Glabrous Skin of Fibromyalgia Patients: Implications for Widespread Deep Tissue Pain and Fatigue
Pain Medicine
5/19/2013 11:00:00 PM
ConclusionsThe excessive sensory innervation to the glabrous skin AVS is a likely source of severe pain and tenderness in the hands of FM patients. Importantly, glabrous AVS regulate blood flow to the skin in humans for thermoregulation and to other tissues such as skeletal muscle during periods of increased metabolic demand. Therefore, blood flow dysregulation as a result of excessive innervation to AVS would likely contribute to the widespread deep pain and fatigue of FM. SNRI compounds may provide partial therapeutic benefit by enhancing the impact of sympathetically mediated inhibitory modulation of the excess sensory innervation. (Source: Pain Medicine)

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http://www.medworm.com/rss/comments.php?id=7264905
Gene expression profiles of fatigued fibromyalgia patients with different categories of pain and catastrophizing: A preliminary report
Nursing Outlook
5/19/2013 11:00:00 PM
Conclusion: Findings provide preliminary evidence that specific physiological pathways may possibly delineate pain and catastrophizing mechanisms. Further investigation via the use of a larger and more homogenous sample is warranted. (Source: Nursing Outlook)
http://www.medworm.com/rss/comments.php?id=7415734
[Mental disorders in patients with fibromyalgia syndrome : Screening in centres of different medical specialties.]
Schmerz
5/18/2013 11:00:00 PM
CONCLUSION: Potential mental disorders were frequent in FMS patients regardless of the medical specialty. All FMS patients of all types of clinical settings should be screened for mental disorders. PMID: 23685994 [PubMed - as supplied by publisher] (Source: Schmerz)
http://www.medworm.com/rss/comments.php?id=7271802
The utility of the PedsQL™ Rheumatology Module as an outcome measure in juvenile fibromyalgia
Arthritis Care and Research
5/16/2013 11:00:00 PM
ConclusionThe PedsQL™ Rheumatology Module generally appears to have good utility for use in JFM patients but some caveats to interpretation of the specific scales in this population are discussed. © 2013 American College of Rheumatology. (Source: Arthritis Care and Research)
http://www.medworm.com/rss/comments.php?id=7280610
An Online Mindfulness Intervention Targeting Socioemotional Regulation in Fibromyalgia: Results of a Randomized Controlled Trial.
Annals of Behavioral Medicine
5/13/2013 11:00:00 PM
CONCLUSIONS: FM patients experience increases in self-efficacy for coping with pain and positive engagement in relationships, marginal increases in positive affect, and decreases in relationship stress from an automated online intervention that targets socioemotional regulation skills. Findings highlight the potential utility of widely accessible, low-cost intervention methods for fibromyalgia (Clinicaltrials.gov number NCT01748786). PMID: 23670111 [PubMed - as supplied by publisher] (Source: Annals of Behavioral Medicine)
http://www.medworm.com/rss/comments.php?id=7289779
Exercise May Ease Pain of Fibromyalgia, Study Suggests
MedicineNet Chronic Pain General
5/13/2013 2:00:00 AM
Title: Exercise May Ease Pain of Fibromyalgia, Study SuggestsCategory: Health NewsCreated: 5/10/2013 2:35:00 PMLast Editorial Review: 5/13/2013 12:00:00 AM (Source: MedicineNet Chronic Pain General)
http://www.medworm.com/rss/comments.php?id=7238039
Do participation and personalization matter? A model-driven evaluation of an Internet-based patient education intervention for fibromyalgia patients
Patient Education and Counseling
5/12/2013 11:00:00 PM
Conclusion: This study empirically confirmed that the adoption of a participatory approach to the design of eHealth interventions and the use of personalized contents enhance the overall effectiveness of systems.Practice implications: More time and effort should be invested in involving patients in the preliminary phases of the development of Internet-based patient education interventions and in the definition of models that can guide the systems’ evaluation beyond technology-related variables such as usability, accessibility or adoption. (Source: Patient Education and Counseling)

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Fibromyalgia Guidelines Trigger Changes for FPsFibromyalgia Guidelines Trigger Changes for FPs
Medscape Today Headlines
5/11/2013 9:44:35 PM
Fibromyalgia diagnosis does not need extensive testing, treatment includes drug and nondrug therapies, and FM symptoms are easily faked, sometimes for financial gain, Canadian guidelines say. Medscape Medical News (Source: Medscape Today Headlines)

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Exercise May Ease Pain of Fibromyalgia, Study Suggests
MedlinePlus Health News
5/10/2013 1:00:00 PM
Moderate physical activity doesn't exacerbate symptoms, researchers find Source: HealthDay Related MedlinePlus Pages: Exercise and Physical Fitness, Fibromyalgia (Source: MedlinePlus Health News)
http://www.medworm.com/rss/comments.php?id=7237086
Comparative efficacy of pharmacological and non-pharmacological interventions in fibromyalgia syndrome: network meta-analysis
Annals of the Rheumatic Diseases
5/9/2013 11:00:00 PM
Conclusions Benefits of pharmacological treatments in FMS are of questionable clinical relevance and evidence for benefits of non-pharmacological interventions is limited. A combination of pregabalin or SNRIs as pharmacological interventions and multicomponent therapy, aerobic exercise and CBT as non-pharmacological interventions seems most promising for the management of FMS. (Source: Annals of the Rheumatic Diseases)
http://www.medworm.com/rss/comments.php?id=7233180
Incidence and predictors of secondary fibromyalgia in an early arthritis cohort
Annals of the Rheumatic Diseases
5/9/2013 11:00:00 PM
Conclusions The incidence of FM was from 3.58 to 6.77 cases per 100 person-years, and was highest during the first 12 months after diagnosis of inflammatory arthritis. Although inflammation was not associated with the clinical diagnosis of FM, pain severity and poor mental health were associated with the clinical diagnosis of FM. Seropositivity was inversely associated with the clinical diagnosis of FM. (Source: Annals of the Rheumatic Diseases)
http://www.medworm.com/rss/comments.php?id=7233179
Muscle fatigue in fibromyalgia is in the brain, not in the muscles: a case-control study of perceived versus objective muscle fatigue
Annals of the Rheumatic Diseases
5/9/2013 11:00:00 PM
Conclusions Women with FM had shorter exhaustion times and showed fewer objective signs of muscle fatigue during an exhausting isometric shoulder abduction compared with younger HC. This indicates that perceived muscle fatigue may be of central origin and supports the notion of central nervous dysfunction as basic pathological changes in FM. (Source: Annals of the Rheumatic Diseases)
http://www.medworm.com/rss/comments.php?id=7233181
Fibromyalgia Treatment: New Canadian Guidelines
Health News from Medical News Today
5/9/2013 3:00:00 AM
Physicians from the McGill University Health Centre (MUHC) and the University of Calgary have published a review article in the CMAJ (Canadian Medical Association Journal) to help family doctors diagnose and treat fibromyalgia. The article represents the first time researchers have published Canadian guidelines to help manage the condition. Fibromyalgia is a chronic condition that affects the central nervous system causing pain throughout the body. It is often accompanied by fatigue, depression and sleep problems... (Source: Health News from Medical News Today)
http://www.medworm.com/rss/comments.php?id=7227593
In People With Fibromyalgia, Pain Is Not Worsened By Regular, Moderate Exercise
Health News from Medical News Today
5/7/2013 2:00:00 AM
For many people who have fibromyalgia, even the thought of exercising is painful. Yet a new study from Wake Forest Baptist Medical Center shows that exercise does not worsen the pain associated with the disorder and may even lessen it over time. The findings are published in the current online issue of the journal Arthritis Care & Research. According to Dennis Ang, M.D... (Source: Health News from Medical News Today)
http://www.medworm.com/rss/comments.php?id=7224619
Managing Fibromyalgia: A Guide For Physicians
Health News from Medical News Today
5/6/2013 11:00:00 AM
Fibromyalgia, now recognized as a true health syndrome with origins in the central nervous system, has seen many recent evolutions regarding its diagnosis and management which should instil new approaches , states a review article published in CMAJ (Canadian Medical Association Journal). "The cause of fibromyalgia is unknown, but there is some evidence for a genetic predisposition, abnormalities in the stress response system or hypothalamic-pituitary axis, and possible triggering events," writes Dr... (Source: Health News from Medical News Today)
http://www.medworm.com/rss/comments.php?id=7223360
New Canadian guidelines for treating fibromyalgia
EurekAlert! - Medicine and Health
5/5/2013 11:00:00 PM
(McGill University Health Centre) Physicians from the McGill University Health Centre and the University of Calgary have published a review article in the CMAJ to help family doctors diagnose and treat fibromyalgia. The article represents the first time researchers have published Canadian guidelines to help manage the condition. (Source: EurekAlert! - Medicine and Health)

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Supplement builds strength in fibromyalgia trial
Reuters: Health
5/3/2013 3:52:57 PM
NEW YORK (Reuters Health) - Creatine, a supplement favored by bodybuilders, modestly boosted muscle strength in patients with fibromyalgia, Brazilian researchers report. (Source: Reuters: Health)
http://www.medworm.com/rss/comments.php?id=7218058
Supplement Builds Strength in Fibromyalgia Trial
MedlinePlus Health News
5/3/2013 2:52:54 PM
Creatine, a supplement favored by bodybuilders, modestly boosted muscle strength in patients with fibromyalgia, Brazilian researchers report.Source: Reuters Health Related MedlinePlus Pages: Dietary Supplements, Fibromyalgia (Source: MedlinePlus Health News)
http://www.medworm.com/rss/comments.php?id=7221113
Fibromyalgia: Can acupuncture relieve symptoms?
MayoClinic.com Full Feed
5/3/2013
Fibromyalgia symptoms may be reduced by acupuncture treatments. (Source: MayoClinic.com Full Feed)
http://www.medworm.com/rss/comments.php?id=7218013
Orofacial pain and sensory characteristics of chronic patients compared with controls
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
5/2/2013 11:00:00 PM
Objectives: To investigate orofacial and sensorial characteristics of patients with orofacial pain and healthy controls.Study design: Case–control. Seventy-five patients (61 women) who had chronic orofacial pain for more than 6 months (i.e., idiopathic trigeminal neuralgia, burning mouth syndrome, persistent idiopathic facial pain, nonidiopathic neuropathic pain, fibromyalgia or temporomandibular disorders were compared with 41 healthy subjects (19 women). They were evaluated with a quantitative sensory testing protocol involving a combination of gustative, olfactory, thermal, mechanical and pain stimuli. Mean pain duration in this population was 6.27 ± 6.06 years. Orofacial characteristics (masticatory and articular abnormalities), oral health and sensitivity to muscular palpation w...

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Yoga with Fibromyalgia: Carol Royal's Story
U.S. News - Health
5/2/2013 8:35:00 AM
How one grandmother became a true believer in yoga for pain management (Source: U.S. News - Health)

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Regular, moderate exercise does not worsen pain in people with fibromyalgia
EurekAlert! - Medicine and Health
5/1/2013 11:00:00 PM
(Wake Forest Baptist Medical Center) For many people who have fibromyalgia, even the thought of exercising is painful. Yet a new study from Wake Forest Baptist Medical Center shows that exercise does not worsen the pain associated with the disorder and may even lessen it over time. (Source: EurekAlert! - Medicine and Health)
http://www.medworm.com/rss/comments.php?id=7213926
FIBROMYALGIA (Aconitum Napellus, Bryonia Alba, Geranium Maculatum, Hypericum) Oil [Wise Consumer Products]
DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
4/29/2013
Updated Date: Apr 29, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
http://www.medworm.com/rss/comments.php?id=7209126
Altered Psychophysiological Responses to the View of Others' Pain and Anger Faces in Fibromyalgia Patients
The Journal of Pain
4/28/2013 11:00:00 PM
Abstract: Facial expression provides information for an accurate estimation of others' pain. Nevertheless, little is known about psychophysiological responses to pain faces in chronic pain. Event-related potentials and brain oscillations, corrugator activity, and heart rate were recorded in 20 fibromyalgia patients and 20 pain-free controls when viewing pain, anger, happy, and neutral faces. Pain and anger faces elicited greater unpleasantness and arousal than happy and neutral faces, and pain faces evoked greater corrugator response than the rest of faces in all participants. Fibromyalgia patients displayed greater cardiac deceleration to all facial expressions than pain-free controls, and enhanced N100 amplitudes to pain and anger faces in comparison with neutral faces. Pain-free control...
http://www.medworm.com/rss/comments.php?id=7389118
Dimensionality, reliability and validity of the Revised Fibromyalgia Impact Questionnaire (FIQR) in two Spanish samples
Arthritis Care and Research
4/21/2013 11:00:00 PM
Conclusion.Our results indicate that the Spanish version of the FIQR has a complex factor structure, excellent reliability and shows good construct validity. © 2013 by the American College of Rheumatology (Source: Arthritis Care and Research)
http://www.medworm.com/rss/comments.php?id=7192646
Construction of a US Fibromyalgia Registry Using the Fibromyalgia Research Survey Criteria
Clinical and Translational Science
4/18/2013 11:00:00 PM
Abstract Utilizing billing records, we identified patients seen at Mayo Clinic with a diagnosis or history of fibromyalgia who were then contacted for enrollment in a fibromyalgia research registry. Fibromyalgia was confirmed through medical record review. Eligible patients were mailed an invitation that included a demographic questionnaire and the Fibromyalgia Research Survey. The Fibromyalgia Research Survey yields a widespread pain score (scale range 0–19) and a symptom severity score (scale range 0–12). A total of 4,034 patients returned the completed survey; 92.8% were female, their mean age was 57.4 (±13.4), and 83.7% were from the Midwest region of the United States. The mean widespread pain score for all participants was 11.3 (±4.5) and the mean symptom severity score was 8.2...
http://www.medworm.com/rss/comments.php?id=7185912
Single-arm, Open-label, Phase II Trial of HD-tDCS in Fibromyalgia Patients
ClinicalTrials.gov
4/18/2013 11:00:00 AM
Conditions:   Fibromyalgia;   Chronic PainIntervention:   Device: High Definition transcranial Direct Current StimulationSponsors:   Spaulding Rehabilitation Hospital;   Spaulding Rehabilitation Hospital;   ElMindA LtdNot yet recruiting - verified April 2013 (Source: ClinicalTrials.gov)
http://www.medworm.com/rss/comments.php?id=7212511
Validation of a Spanish version of the psychological inflexibility in pain scale (PIPS) and an evaluation of its relation with acceptance of pain and mindfulness in sample of persons with fibromyalgia
BioMed Central
4/17/2013 11:00:00 PM
Conclusions: The Spanish PIPS scale appears to be a valid and reliable instrument for the evaluation of psychological inflexibility among a sample of fibromyalgia patients. These results ensure the use of this scale in research as well as in clinical practice. Psychological inflexibility measures processes different from other related components such as acceptance and mindfulness. (Source: BioMed Central)
http://www.medworm.com/rss/comments.php?id=7179105
Effects of Hydrotherapy on Physical Function and Quality of Life of Women With Fibromyalgia
ClinicalTrials.gov
4/17/2013 11:00:00 AM
Condition:   FibromyalgiaIntervention:   Other: HydrotherapySponsors:   Universidade Federal de Sao Carlos;   Mariana Arias AvilaActive, not recruiting - verified April 2013 (Source: ClinicalTrials.gov)
http://www.medworm.com/rss/comments.php?id=7202721
A Bloodspot-based Diagnostic Test for Fibromyalgia Syndrome and Related Disorders
RSC - Analyst latest articles
4/15/2013 3:10:34 AM
Analyst, 2013, Accepted ManuscriptDOI: 10.1039/C3AN36615D, PaperKevin V Hackshaw, LE Rodriguez-Saona, Marcal Plans Pujolras, Lauren Nicole Bell, Tony BuffingtonThe aim of this study was to investigate the ability of a rapid biomarker-based method for diagnosis of fibromyalgia syndrome (FM) using mid-infrared microspectroscopy (IRMS) to differentiate patients with FM...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
http://www.medworm.com/rss/comments.php?id=7172330
Preop Ketamine May Lower Pain in Fibromyalgia
MedPage Today Meeting Coverage
4/13/2013 1:43:08 PM
FORT LAUDERDALE (MedPage Today) -- In fibromyalgia patients undergoing knee or hip replacement surgery, low-dose, intraoperative ketamine appeared to reduce the need for post-surgical opioid therapy, researchers said here. (Source: MedPage Today Meeting Coverage)
http://www.medworm.com/rss/comments.php?id=7155205
[Are members of fibromyalgia syndrome self-help groups "different"? : Demographic and clinical characteristics of members and non-members of fibromyalgia syndrome self-help groups.]
Zeitschrift fur Rheumatologie
4/12/2013 11:00:00 PM
CONCLUSIONS: Membership in FMS self-help groups was associated with less psychological distress and a more frequent use of active self-management strategies. PMID: 23579856 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
http://www.medworm.com/rss/comments.php?id=7290771
Parental Involvement of Mothers With Chronic Illness and Children's Academic Achievement
Journal of Family Issues
4/11/2013 11:00:00 PM
This study examined how maternal chronic illnesses may affect children’s academic achievement through parental involvement. A total of 189 mothers diagnosed with chronic illnesses, such as multiple sclerosis, diabetes, cancer, HIV/AIDS, chronic pain, asthma, myelodysplasic syndrome, and fibromyalgia, and with a child in middle school or high school (age 10-18 years) completed questionnaires assessing the demands of illness on family functioning, parental involvement, and the child’s academic functioning. The results suggested that the majority of children of mothers with chronic illness were able to function adequately in terms of academic achievement. However, children’s academic functioning might be at risk when family functioning was more disrupted as the result of mat...
http://www.medworm.com/rss/comments.php?id=7161094
Relationship between Sleep and Pain in Adolescents with Juvenile Primary Fibromyalgia Syndrome
Sleep
4/11/2013 9:10:04 PM
Conclusions:Although perceived sleep quality improved in adolescents with JPFS after treatment, objective measures did not. Our findings do not suggest exercise therapy for pain improves sleep by reducing ADS, nor do they support causal relationships between ADS and chronic pain or subjective sleep quality.Citation:Olsen MN; Sherry DD; Boyne K; McCue R; Gallagher PR; Brooks LJ. Relationship between sleep and pain in adolescents with juvenile primary fibromyalgia syndrome. SLEEP 2013;36(4):509-516. (Source: Sleep)

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Brief, Self‐Report Fibromyalgia Screener Evaluated in a Sample of Chronic Pain Patients
Pain Medicine
4/10/2013 11:00:00 PM
ConclusionA self‐administered, brief fibromyalgia screening questionnaire can effectively identify chronic pain patients who will likely have clinical fibromyalgia. (Source: Pain Medicine)
http://www.medworm.com/rss/comments.php?id=7147111
Augmented Central Pain Processing in Vulvodynia
The Journal of Pain
4/10/2013 11:00:00 PM
Abstract: Vulvodynia (VVD) is a chronic pain disorder wherein women display sensitivity to evoked stimuli at the vulva and/or spontaneous vulvar pain. Our previous work suggests generalized hyperalgesia in this population; however, little is known about central neurobiological factors that may influence pain in VVD. Here we investigated local (vulvar) and remote (thumb) pressure-evoked pain processing in 24 VVD patients compared to 13 age-matched, pain-free healthy controls (HCs). As a positive control we also examined thumb pressure pain in 24 fibromyalgia patients. The VVD and fibromyalgia patients displayed overlapping insular brain activations that were greater than HCs in response to thumb stimulation (P < .005 corrected). Compared to HCs, VVD participants displayed greater levels of ...
http://www.medworm.com/rss/comments.php?id=7306469
Can Coenzyme Q10 Improve Clinical and Molecular Parameters in Fibromyalgia?
Antioxidants and Redox Signaling
4/6/2013 1:07:00 PM
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
http://www.medworm.com/rss/comments.php?id=7163024
Posttraumatic stress disorder in fibromyalgia syndrome: Prevalence, temporal relationship between posttraumatic stress and fibromyalgia symptoms, and impact on clinical outcome
Pain
4/3/2013 11:00:00 PM
Summary: The prevalence of posttraumatic stress disorder in 395 fibromyalgia syndrome patients of different clinical settings was 45.3%, and was 3.0% in age- and sex-matched population controls.Abstract: A link between fibromyalgia syndrome (FMS) and posttraumatic stress disorder (PTSD) has been suggested because both conditions share some similar symptoms. The temporal relationships between traumatic experiences and the onset of PTSD and FMS symptoms have not been studied until now. All consecutive FMS patients in 8 study centres of different specialties were assessed from February 1 to July 31, 2012. Data on duration of chronic widespread pain (CWP) were based on patients’ self-reports. Potential traumatic experiences and year of most burdensome traumatic experience were assessed by th...
http://www.medworm.com/rss/comments.php?id=7389527
Targeting cortical representations in the treatment of chronic pain: a review. Moseley GL, Flor H. Neurorehabil Neural Repair 2012;26(6):646–52. Epub 2012 Feb 13.
The Spine Journal
3/31/2013 11:00:00 PM
Recent neuroscientific evidence has confirmed the important role of cognitive and behavioral factors in the development and treatment of chronic pain. Neuropathic and musculoskeletal pain are associated with substantial reorganization of the primary somatosensory and motor cortices as well as regions such as the anterior cingulate cortex and insula. What is more, in patients with chronic low back pain and fibromyalgia, the amount of reorganizational change increases with chronicity; in phantom limb pain and other neuropathic pain syndromes, cortical reorganization correlates with the magnitude of pain. These findings have implications for both our understanding of chronic pain and its prevention and treatment. For example, central alterations may be viewed as pain memories that modulate th...
http://www.medworm.com/rss/comments.php?id=7159927
Creatine supplementation in fibromyalgia: A double‐blind, randomized, placebo‐controlled trial
Arthritis Care and Research
3/31/2013 11:00:00 PM
Conclusion:Creatine supplementation increased intramuscular phosphorylcreatine content and improved lower‐ and upper‐body muscle function, with minor changes in other fibromyalgia features. These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients. © 2013 by the American College of Rheumatology (Source: Arthritis Care and Research)
http://www.medworm.com/rss/comments.php?id=7165043
Juvenile fibromyalgia: Guidance for its management
Pediatrics International
3/31/2013 11:00:00 PM
Abstract Juvenile fibromyalgia (JFM) is a disease that patients complain acute and chronic severe pain for which an overt primary cause for the pain cannot be found or surmised. Although patients with JFM mainly complaint systemic pain or allodynia in the medical interview and physical examination, the concept of the disease is the total sum of painful illness, chronic fatigue, hypothermia and many other autonomic symptoms and signs. Many issues are interacting including individual traits (personality, temperament, sensitivity, memory of pain, age: early adolescence), individual states (self‐esteem, anxiety, developmental level), and external stressors (parent especially mother, school environment). In order to diagnose the patient as having JFM, the disease history, physical examination...
http://www.medworm.com/rss/comments.php?id=7338946
Upping vigorous exercise may improve fibromyalgia
Reuters: Health
3/28/2013 11:49:50 AM
NEW YORK (Reuters Health) - For those who are able, exercising once or twice more weekly may alleviate some symptoms of a chronic pain condition without making joints feel worse, according to a new study. (Source: Reuters: Health)
http://www.medworm.com/rss/comments.php?id=7131404
Upping Vigorous Exercise May Improve Fibromyalgia
MedlinePlus Health News
3/28/2013 10:49:47 AM
For those who are able, exercising once or twice more weekly may alleviate some symptoms of a chronic pain condition without making joints feel worse, according to a new study.Source: Reuters Health Related MedlinePlus Pages: Exercise and Physical Fitness, Fibromyalgia (Source: MedlinePlus Health News)
http://www.medworm.com/rss/comments.php?id=7131450
The Fibromyalgia Family Study: A Genome‐Wide Linkage Scan Study
Arthritis and Rheumatism
3/27/2013 11:00:00 PM
ConclusionThe estimated sibling recurrence risk ratio (λs) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome‐wide suggestive linkage of fibromyalgia to the chromosome 17p11.2–q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia. (Source: Arthritis and Rheumatism)

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http://www.medworm.com/rss/comments.php?id=7165028
Changes in Pain Coping, Catastrophizing, and Coping Efficacy After Cognitive-Behavioral Therapy in Children and Adolescents With Juvenile Fibromyalgia
The Journal of Pain
3/27/2013 11:00:00 PM
Abstract: A recent randomized multisite clinical trial found that cognitive-behavioral therapy (CBT) was significantly more effective than fibromyalgia education (FE) in reducing functional disability in adolescents with juvenile fibromyalgia (JFM). The primary objective of this study was to examine the psychological processes of CBT effectiveness by evaluating changes in pain coping, catastrophizing, and coping efficacy and to test these changes as mediators of continued improvements in functional disability and depressive symptoms at 6-month follow-up. One hundred adolescents (11–18 years old) with JFM completed the clinical trial. Coping, catastrophizing, and coping efficacy (Pain Coping Questionnaire) and the outcomes of functional disability (Functional Disability Inventory) and dep...
http://www.medworm.com/rss/comments.php?id=7218729
Metabolic rate, cardiac response, and aerobic capacity in fibromyalgia: a case-control study.
Scandinavian Journal of Rheumatology
3/25/2013 11:00:00 PM
Conclusions: The current study indicates that patients with FM have similar metabolic and cardiovascular responses to submaximal exercise as HCs. However, these patients have reduced ability to reach VO2max and a possible deficit in the metabolic system when exercising above the AT. PMID: 23527918 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
http://www.medworm.com/rss/comments.php?id=7290937
Symptoms of subordinated importance in fibromyalgia when differentiating working from non-working women.
Work
3/25/2013 11:00:00 PM
CONCLUSION: To change prevailing attitudes and values towards persons with a work disability, a process of active intervention involving staff is needed. Educating employers as to how a disability may influence a work situation, and the importance of social support, can be improved. PMID: 23531567 [PubMed - as supplied by publisher] (Source: Work)
http://www.medworm.com/rss/comments.php?id=7293012
Emotional modulation of pain and spinal nociception in fibromyalgia
Pain
3/20/2013 11:00:00 PM
Summary: Fibromyalgia is associated with disrupted emotional processing and emotional modulation of pain, but intact descending emotional modulation of spinal nociception.Abstract: Fibromyalgia (FM) is characterized by widespread pain, as well as affective disturbance (eg, depression). Given that emotional processes are known to modulate pain, a disruption of emotion and emotional modulation of pain and nociception may contribute to FM. The present study used a well-validated affective picture-viewing paradigm to study emotional processing and emotional modulation of pain and spinal nociception. Participants were 18 individuals with FM, 18 individuals with rheumatoid arthritis (RA), and 19 healthy pain-free controls (HC). Mutilation, neutral, and erotic pictures were presented in 4 blocks;...

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Fibromyalgia: Moderate Drinking May Ease SymptomsFibromyalgia: Moderate Drinking May Ease Symptoms
Medscape Today Headlines
3/15/2013 7:02:00 PM
Patients with fibromyalgia who consume 1 to 7 drinks per week reported less pain, better functioning, and better quality of life than nondrinkers. Medscape Medical News (Source: Medscape Today Headlines)
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Alcohol, Fibromyalgia, And Quality Of Life
Health News from Medical News Today
3/15/2013 2:00:00 AM
Low and moderate drinkers of alcohol reported lower severity of symptoms of fibromyalgia than teetotallers, finds a study in BioMed Central's open access journal Arthritis Research & Therapy. Too much alcohol reversed this effect. The chronic pain of fibromyalgia is thought to affect one in 20 people worldwide but there is no known cause or cure. It often goes hand in hand with fatigue and sleep problems, headaches, depression and irritable bowel and bladder problems. Treatment is based around pain management and lifestyle changes... (Source: Health News from Medical News Today)

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Alcohol, fibromyalgia, and quality of life
EurekAlert! - Social and Behavioral Science
3/13/2013 11:00:00 PM
(BioMed Central) Low and moderate drinkers of alcohol reported lower severity of symptoms of fibromyalgia than teetotallers, finds a study in BioMed Central's open access journal Arthritis Research & Therapy. Too much alcohol reversed this effect. (Source: EurekAlert! - Social and Behavioral Science)
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Direct Medical Costs and Medication Compliance among Fibromyalgia Patients: Duloxetine Initiators vs. Pregabalin Initiators
Pain Practice
3/13/2013 11:00:00 PM
ConclusionsIn a real‐world setting, patients with fibromyalgia who initiated duloxetine in 2008 had better medication compliance and consumed less inpatient, outpatient, and total medical costs than those who initiated pregabalin. (Source: Pain Practice)
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The Central Sensitization Inventory (CSI): Establishing Clinically Significant Values for Identifying Central Sensitivity Syndromes in an Outpatient Chronic Pain Sample
The Journal of Pain
3/12/2013 11:00:00 PM
Abstract: Central sensitization (CS) is a proposed physiological phenomenon in which central nervous system neurons become hyperexcitable, resulting in hypersensitivity to both noxious and non-noxious stimuli. The term central sensitivity syndrome (CSS) describes a group of medically indistinct (or nonspecific) disorders, such as fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome, for which CS may be a common etiology. In a previous study, the Central Sensitization Inventory (CSI) was introduced as a screening instrument for clinicians to help identify patients with a CSS. It was found to have high reliability and validity (test-retest reliability = .82; Cronbach's alpha = .88). The present study investigated a cohort of 121 patients who were referred to a multidiscip...
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Effectiveness of high-frequency transcutaneous electrical nerve stimulation at tender points as adjuvant therapy for patients with fibromyalgia.
European Journal of Physical and Rehabilitation Medicine
3/12/2013 11:00:00 PM
Conclusion: It has suggested that high-frequency TENS as an adjuvant therapy is effective in relieving pain, anxiety, fatigue, stiffness, and in improving ability to work of patients with fibromyalgia. Clinical rehabilitation impact: High-frequency TENS may be used as a short-term complementary treatment of fibromyalgia. PMID: 23486303 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)
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Psychiatric Comorbidities
Psychiatric Times
3/4/2013 7:00:00 AM
This slide show series provides a quick look at the salient features associated with some of the most frequent psychiatric comorbidities including fibromyalgia, movement disorders, and migraine. (Source: Psychiatric Times)
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Effect of Experimental Stress in 2 Different Pain Conditions Affecting the Facial Muscles
The Journal of Pain
3/4/2013
Abstract: Chronic facial muscle pain is a common feature in both fibromyalgia (FM) and myofascial (MF) pain conditions. In this controlled study, a possible difference in the mode of deregulation of the physiological response to a stressing stimulus was explored by applying an acute mental stress to FM and MF patients and to controls. The effects of the stress test were observed on pain, sympathetic variables, and both tonic and reflex electromyographic activities of masseteric and temporal muscles. The statistical analyses were performed through a generalized linear model including mixed effects. Painful reaction to the stressor was stronger (P  (Source: The Journal of Pain)

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Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome.
Cochrane Database of Systematic Reviews
3/1/2013 8:50:03 PM
CONCLUSIONS: The SNRIs duloxetine and milnacipran provided a small incremental benefit over placebo in reducing pain. The superiority of duloxetine and milnacipran over placebo in reducing fatigue and limitations of QOL was not substantial. Duloxetine and milnacipran were not superior to placebo in reducing sleep problems. The dropout rates due to adverse events were higher for duloxetine and milnacipran than for placebo. The most frequently reported symptoms leading to stopping medication were nausea, dry mouth, constipation, headache, somnolence/dizziness and insomnia. Rare complications of both drugs may include suicidality, liver damage, abnormal bleeding, elevated blood pressure and urinary hesitation. PMID: 23440848 [PubMed - in process] (Source: Cochrane Database of Systematic R...
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Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial.
Revista Brasileira de Psiquiatria
3/1/2013
Authors: Braz AS, Morais LC, Paula AP, Diniz MF, Almeida RN Abstract The purpose of the study was to evaluate the efficacy of an extract of Panax ginseng in patients with fibromyalgia. A randomized, double-blind, controlled clinical trial was carried out over 12 weeks to compare the effects of P. ginseng (100 mg/d) with amitriptyline (25 mg/d) and placebo in 38 patients with fibromyalgia: 13 in Group I (amitriptyline), 13 in Group II (placebo), and 12 in Group III (P. ginseng). Ratings on the Visual Analogue Scale (VAS) revealed a reduction in pain in the P. ginseng group (p < .0001), an improvement in fatigue (p < .0001) and an improvement in sleep (p < .001), with respect to baseline characteristics, but there were no differences between the three groups. With respect to...
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Cursing the darkness: Reactions to fibromyalgia.
Pain Research and Management
3/1/2013
Authors: Harth M PMID: 23662286 [PubMed - in process] (Source: Pain Research and Management)
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Geographic variation of chronic opioid use in fibromyalgia.
Clinical Therapeutics
3/1/2013
CONCLUSIONS: Geographic variation in chronic opioid use among patients with FM exists at rates similar to those seen in other studies examining opioid use. This large level of geographic variation suggests that the prescribing decision is not based solely on physician-patient interaction but also on contextual and structural factors at the state level. The level of physician and condition prevalence suggest that information dissemination and peer-to-peer interaction may play a key role in adopting evidence-based medicine for the treatment of patients suffering from FM and related conditions. Level of diagnosis prevalence as a predictor of evidence-based practice has not been reported in the literature and is an important contribution to research on geographic variation. PMID: 23485077 ...

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Small Benefit of SNRIs for Fibromyalgia PainSmall Benefit of SNRIs for Fibromyalgia Pain
Medscape Today Headlines
2/28/2013 4:22:35 PM
New meta-analysis shows selective serotonin and noradrenaline reuptake inhibitors may ease pain in some patients, but they don't significantly improve sleep or quality of life and may have adverse effects. Medscape Medical News (Source: Medscape Today Headlines)
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Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin?
Arthritis Research and Therapy
2/27/2013
Conclusions: Exercise reduced fatigue in all FM patients, this effect was achieved earlier in lean patients. Baseline levels of resistin in both serum and CSF associated negatively with fatigue. Resistin was increased after the exercise period which correlated with decreased fatigue. Changes in IGF-1 indicate similar long-term effects in obese patients. This study shows reduced fatigue after moderate exercise in FM and indicates the involvement of IGF-1 and resistin in these beneficial effects.Trial registration: ClinicalTrials.gov NCT00643006. (Source: Arthritis Research and Therapy)
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Physical activity monitoring in adolescents with juvenile fibromyalgia: Findings from a clinical trial of cognitive–behavioral therapy
Arthritis Care and Research
2/26/2013
ConclusionActigraphy monitoring provides a unique source of information about patient outcomes. CBT intervention was not associated with increased physical activity in adolescents with JFM, indicating that combining CBT with interventions to increase physical activity may enhance treatment effects. (Source: Arthritis Care and Research)
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Efficacy of a multidisciplinary fibromyalgia treatment adapted for women with low educational levels: A randomized controlled trial
Arthritis Care and Research
2/26/2013
ConclusionMultidisciplinary treatment adapted for individuals with low educational levels is effective in reducing key symptoms of FM. Some improvements were maintained 1 year after completing the multidisciplinary treatment. (Source: Arthritis Care and Research)
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Important Evidence Supporting Fibromyalgia As A Spectrum Disorder
Health News from Medical News Today
2/20/2013 3:00:00 AM
Researchers have determined that fibromyalgia prevalence is 2.1% of the general population in Germany. Results appearing in Arthritis Care & Research, a journal published by Wiley on behalf of the American College of Rheumatology (ACR), suggest that fibromyalgia is a spectrum disorder rather than a categorical illness. Additionally, a number of fibromyalgia cases in the general population satisfy proposed criteria for physical symptom disorder - the presence of one or more physical symptoms that impair function, which cannot be explained by another clinical or psychiatric illness... (Source: Health News from Medical News Today)

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Heart rate variability in fibromyalgia patients and healthy controls during non-REM and REM sleep: a case-control study.
Scandinavian Journal of Rheumatology
2/20/2013
Conclusions: RMSSD, indicative of parasympathetic predominance, is attenuated in FM patients compared to HCs during N2 sleep and REM sleep. This difference was not present for the HF component. HRV during sleep in FM patients is moderately and positively associated with sleep quality and moderately and negatively associated with neck/shoulder pain. PMID: 23425526 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
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Fibromyalgia Not One-Size-Fits-All Disorder (CME/CE)
MedPage Today Primary Care
2/19/2013 3:57:03 PM
(MedPage Today) -- Fibromyalgia should be considered a condition that exists across a continuum in a population, and is not a categorical disorder as it has often been considered, researchers concluded from a survey analysis in Germany. (Source: MedPage Today Primary Care)
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Fibromyalgia prevalence at 2.1 percent of general German population
EurekAlert! - Medicine and Health
2/19/2013
(Wiley) Researchers have determined that fibromyalgia prevalence is 2.1 percent of the general population in Germany. Results appearing in Arthritis Care & Research, a journal published by Wiley on behalf of the American College of Rheumatology, suggest that fibromyalgia is a spectrum disorder rather than a categorical illness. (Source: EurekAlert! - Medicine and Health)
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Painful effects of auditory startle, forehead cooling and psychological stress in patients with fibromyalgia or rheumatoid arthritis
Journal of Psychosomatic Research
2/19/2013
Conclusions: These findings suggest that processes linked with individual differences in distress aggravate pain in rheumatoid arthritis, whereas some other mechanism (e.g., failure of stress-related pain modulation processes or an aberrant interaction between nociceptive afferent and sympathetic efferent fibers) triggers stress-induced pain in fibromyalgia. (Source: Journal of Psychosomatic Research)

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Focal Modulation of the Primary Motor Cortex in Fibromyalgia Using 4×1-Ring High-Definition Transcranial Direct Current Stimulation (HD-tDCS): Immediate and Delayed Analgesic Effects of Cathodal and Anodal Stimulation
The Journal of Pain
2/18/2013
Abstract: Fibromyalgia is a prevalent chronic pain syndrome characterized by altered pain and sensory processing in the central nervous system, which is often refractory to multiple therapeutic approaches. Given previous evidence supporting analgesic properties of noninvasive brain stimulation techniques in this condition, this study examined the effects of a novel, more focal method of transcranial direct current stimulation (tDCS), using the 4×1-ring configuration of high-definition (HD)-tDCS, on overall perceived pain in fibromyalgia patients. In this patient- and assessor-blind, sham-controlled, crossover trial, 18 patients were randomized to undergo single 20-minute sessions of anodal, cathodal, and sham HD-tDCS at 2.0 mA in a counterbalanced fashion. The center electrode was positio...
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Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome
NeLM - Disease Focused Reviews
2/18/2013
Source: Cochrane Area: Evidence > Disease Focused Reviews Background Fibromyalgia syndrome (FMS) is a clinically well-defined chronic condition of unknown etiology characterized by chronic widespread pain that often co-exists with sleep disturbances, cognitive dysfunction and fatigue. Patients often report high disability levels and poor quality of life (QOL). Drug therapy focuses on reducing key symptoms and improving quality of life.   Objectives To assess the benefits and harms of serotonin and noradrenaline reuptake inhibitors (SNRIs) compared with placebo for treating FMS symptoms in adults.   Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), (The Cochrane Library 2012, Issue 9), MEDLINE (1966 to September 2012), EM...
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Effects of milnacipran on cognitive flexibility following chronic stress in rats.
European Journal of Pharmacology
2/16/2013
In this study, we tested the effects of chronic milnacipran treatment on cognitive set-shifting after CUS. Male Sprague-Dawley rats were treated chronically by minipump with milnacipran (30mg/kg/day), the positive control drug, desipramine (5mg/kg/day), or vehicle, and exposed to CUS or unstressed control conditions. For CUS, a different acute stressor was presented daily for 14 days. On Day 17, rats were tested on the AST. Consistent with previous results, CUS impaired cognitive set-shifting. Further, chronic treatment with either milnacipran or desipramine preserved cognitive flexibility after CUS, suggesting that milnacipran may have efficacy in the management of cognitive dysfunction as a component of stress-related illnesses, including fibromyalgia and depression. PMID: 23422875 [...
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Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.
Redox Report : communications in free radical research
2/15/2013 1:10:01 AM
Authors: Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T, Iizuka Y, Kikuchi M, Imagawa T, Natsumeda Y, Yokota S, Yamamoto Y Abstract Fibromyalgia (FM) is characterized by generalized pain and chronic fatigue of unknown etiology. To evaluate the role of oxidative stress in this disorder, we measured plasma levels of ubiquinone-10, ubiquinol-10, free cholesterol (FC), cholesterol esters (CE), and free fatty acids (FFA) in patients with juvenile FM (n = 10) and in healthy control subjects (n = 67). Levels of FC and CE were significantly increased in juvenile FM as compared with controls, suggesting the presence of hypercholesterolemia in this disease. However, plasma level of ubiquinol-10 was significantly decreased and the ratio of ubiquinone-10 to total coenzyme Q10 (%CoQ1...
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Neuropathic pain and use of PainDETECT in patients with fibromyalgia: a cohort study
BMC Neurology
2/14/2013
Conclusion: This study highlights the importance of thorough clinical examination. The Neuropathic pain screening tool PainDETECT is not as useful in patients with fibromyalgia as in patients with uncompromised central pain control. (Source: BMC Neurology)
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Reduction of Intraepidermal Nerve Fiber Density (IENFD) in the Skin Biopsies of Patients with Fibromyalgia: A Controlled Study (P01.141)
Neurology
2/14/2013
CONCLUSIONS: Patients with FM demonstrate a SFN, based on the significant reduction of IENFD. Although FM remains a complex disorder causing diffuse pains, SFN appears to be a contributing factor. The cause of reduced IENFD is unclear but immune, chemokine/cytokine disturbances or cytotoxic factors are currently explored. The observations, if confirmed with a larger series, suggest that non-psychogenic factors may play a causative role for the pain syndrome in some FM patients.Disclosure: Dr. Kosmidis has nothing to disclose. Dr. Koutsogeorgopoulou has nothing to disclose. Dr. Mamali has nothing to disclose. Dr. Alexopoulos has nothing to disclose. Dr. Vlachoyiannopoulos has nothing to disclose. Dr. Voulgarelis has nothing to disclose. Dr. Tzioufas has nothing to disclose. Dr. Dalakas has ...
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Benefit Denial Was Reasonably Supported, 2nd Circuit Rules
LexisNexis® Mealey's™ Disability Insurance Legal News
2/11/2013 6:16:03 PM
NEW YORK - An ERISA-governed insurer's benefit denial to a claimant with fibromyalgia was not arbitrary and capricious, the Second Circuit U.S. Court of Appeals ruled Jan. 24 (Virginia Ianniello v. Hartford Life and Accident Insurance Co., et al., No. 12-718, 2nd Cir.; 2013 U.S. App. LEXIS 1573). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
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Moderate‐vigorous physical activity improves long‐term clinical outcomes without worsening pain in fibromyalgia
Arthritis Care and Research
2/11/2013
Conclusion:Increased participation in MVPA for at least 12 weeks improves physical function and overall well‐being in patients with FM. Although sustained physical activity was not associated with greater clinical benefit compared to unsustained physical activity, these findings also suggest that performing greater volumes of physical activity is not associated with worsening pain in FM. Future research is needed to determine the relationship between sustained MVPA participation and subsequent improvement in patient outcomes. (Source: Arthritis Care and Research)
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Drugs to Treat Fibromyalgia Just as Likely to Harm as Help
Health Behavior News Service
2/6/2013 3:45:03 AM
01/31/2013, Among fibromyalgia patients taking either of two commonly prescribed drugs to reduce pain, 22 percent report substantial improvement while 21 percent had to quit the regimen due to unpleasant side effects, according to a new review in The Cochrane Library. (Source: Health Behavior News Service)

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Development of a multidimensional measure of fibromyalgia symptomatology: The comprehensive rating scale for fibromyalgia symptomatology
Journal of Psychosomatic Research
2/5/2013
Conclusion: The CRSFS is a valid and reliable 4-factor scale that evaluates the most frequent clinical symptoms of patients with FM. (Source: Journal of Psychosomatic Research)

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Chicago Chiropractor Provides Personal Pain Management Programs
Medical News (via PRIMEZONE)
2/3/2013 11:45:36 PM
CHICAGO, Feb. 3, 2013 (GLOBE NEWSWIRE) -- Dr. Mark Cohen, DC of the Chicago Pain Center has developed an integrated, whole body approach to helping his patients deal with pain. Whether patients come to the center looking for relief from pain associated with a personal injury accident or a work-related accident, are dealing with the debilitating effects of a chronic condition such as fibromyalgia or arthritis, or want to improve wellness, Chicago Pain Center will put together a unique (Source: Medical News (via PRIMEZONE))
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Psychoneuroimmunological Relationships in Women With Fibromyalgia
Biological Research For Nursing
2/3/2013
Discussion: Relationships among perceived stress and symptoms supported the PNI framework. Study findings are similar to previous studies showing that cytokines in persons with FMS do not show a consistent pattern. The elevated CRP levels suggest higher levels of generalized inflammation in the sample and provide evidence for continued development of biobehavioral interventions to address both symptoms and their biological markers over time. (Source: Biological Research For Nursing)
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Prevalence and Risk of Migraine Headaches in Adult Fragile X Premutation Carriers.
Clinical Genetics
2/1/2013
Authors: Au J, Scott Akins R, Berkowitz-Sutherland L, Tang HT, Chen Y, Boyd A, Tassone F, Nguyen DV, Hagerman R Abstract FMR1 premutation carriers are common in the general population (1/130-260 females and 1/250 - 810 males) and can be affected by fragile X-associated tremor ataxia syndrome (FXTAS), fragile X-associated primary ovarian insufficiency (FXPOI), anxiety, depression, hypertension, sleep apnea, fibromyalgia, and hypothyroidism. Here we report the results of a pilot study to assess the prevalence and risk of migraine in FMR1 premutation carriers. 315 carriers (203 females; 112 males) and 154 controls (83 females; 71 males) were seen sequentially as part of a family study. A standardized medical history, physical examination and confirmation of diagnosis of migraine heada...
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Fibromyalgia prevalence, somatic symptom reporting, and the dimensionality of polysymptomatic distress: Results from a survey of the general population
Arthritis Care and Research
2/1/2013
Conclusions:The modified 2010 diagnostic criteria do not result in high levels of fibromyalgia. PSD and fibromyalgia are strongly related to somatic symptom severity. There is evidence in support of fibromyalgia as a dimensional or continuum disorder. This has important ramifications for neurobiologic and epidemiology research, and for clinical diagnosis, treatment, and ascertainment of disability. © 2013 by the American College of Rheumatology (Source: Arthritis Care and Research)
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National survey of knowledge, attitude and practice of fibromyalgia among rheumatologists in China
APLAR Journal of Rheumatology
2/1/2013
ConclusionThe awareness and perception of FM are still low among Chinese rheumatologists. CME on FM is needed for improving the quality of health care in China. (Source: APLAR Journal of Rheumatology)
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Drugs to Treat Fibromyalgia Just as Likely to Harm as Help
Health Behavior News Service
1/31/2013 12:25:01 AM
01/31/2013, The Cochrane Library, Among fibromyalgia patients taking either of two commonly prescribed drugs to reduce pain, 22 percent report substantial improvement while 21 percent had to quit the regimen due to unpleasant side effects, according to a new review in The Cochrane Library. (Source: Health Behavior News Service)
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Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women
Arthritis and Rheumatism
1/28/2013
ConclusionPeripheral mechanisms, i.e., altered muscle fiber size distribution and decreased capillary density, may contribute to postexertional fatigue in FM. Understanding of these defects in fibromyalgic muscle may provide valuable insight with regard to treatment. (Source: Arthritis and Rheumatism)

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Low‐dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double‐blind, placebo‐controlled, counterbalanced, crossover trial assessing daily pain levels
Arthritis and Rheumatism
1/28/2013
ConclusionThe preliminary evidence continues to show that low‐dose naltrexone has a specific and clinically beneficial impact on fibromyalgia pain. The medication is widely available, inexpensive, safe, and well‐tolerated. Parallel‐group randomized controlled trials are needed to fully determine the efficacy of the medication. (Source: Arthritis and Rheumatism)
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[Whole body hyperthermia in pain therapy : A controlled trial on patients with fibromyalgia.]
Schmerz
1/27/2013
CONCLUSION: There is evidence that mild water-filtered near infrared whole body hyperthermia is a reasonable complement to multimodal rehabilitation in the treatment of fibromyalgia. PMID: 23354314 [PubMed - as supplied by publisher] (Source: Schmerz)
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Bilateral deficits in fine motor control ability and manual dexterity in women with fibromyalgia syndrome.
Experimental Brain Research
1/26/2013
Authors: Pérez-de-Heredia-Torres M, Martínez-Piédrola RM, Cigarán-Méndez M, Ortega-Santiago R, Fernández-de-Las-Peñas C Abstract The aim of the current study was to investigate fine motor control ability and manual dexterity women with fibromyalgia syndrome (FMS) without symptoms in the upper extremity compared to healthy women. Subtests of the Purdue Pegboard Test (one-hand, bilateral and assembly) and of the Jebsen-Taylor hand-function test (writing, turning cards, picking up small, light and large heavy objects, simulated feeding and stacking checkers) were evaluated bilaterally in 20 women with FMS (aged 35-55 years) without symptoms in the upper limb and 20 age- and hand dominance-matched healthy women. Differences between sides and groups were analysed with several an...
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Behavioral approach system activity and self‐reported somatic symptoms in fibromyalgia: an exploratory study
APLAR Journal of Rheumatology
1/24/2013
Abstract The first objective was to investigate the behavioural activity in the systems of Gray's theory; these are the Behavioural Inhibition System (BIS) and Behavioural Approach System (BAS), in fibromyalgia (FM) patients. The second aim was to assess in FM patients whether there is an association between BIS or BAS with self‐reported somatic symptoms. Twenty FM patients and 20 healthy controls completed questionnaire measures of BIS and BAS activity (Sensitivity to Punishment and Sensitivity to Reward Questionnaire), self‐reported somatic symptoms (Somatic Symptoms Scale Revised), positive and negative affect (Positive and Negative Affect Schedule) and health status (EuroQoL Visual Analogue Scale). The results showed that FM patients had lower Sensitivity to Reward (SR) scores than...
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'A giant mess' - making sense of complexity in the accounts of people with fibromyalgia.
British Journal of Health Psychology
1/24/2013
CONCLUSIONS: Three key issues were discussed. First, there was not one overall symptom (e.g., pain) driving the unpleasantness of fibromyalgia; second, participants spent excessive time and energy trying to manage forces outside their control; third, because there is no definitive 'fibromyalgia experience', each diagnosis is unique, and our participants often appeared to be struggling to understand the course of their illness. Issues of stigma and legitimacy need to be considered carefully by health professionals in the context of the complex and uncertain experience of patients. STATEMENT OF CONTRIBUTION: What is already known on this subject? Diagnosis of fibromyalgia is based on exclusion of clinical problems combined with symptom report. Diagnosis is therefore uncertain, controversial ...

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Primary attributions in women suffering fibromyalgia emphasize the perception of a disruptive onset for a long-lasting pain problem
Journal of Psychosomatic Research
1/24/2013
Conclusion: Attributions often referred to the psychological dimension of the events surrounding FM onset, even though some of them also had a clear somatic dimension. Many narratives mentioned successive disruptive events and suggested an increasing loss of control. Addressing these illness representations may contribute to tailor the treatment and to help patients gain self-coherency by providing means to understand pain onset but also to guide future behaviours, particularly in terms of adjustment and help-seeking. (Source: Journal of Psychosomatic Research)
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Amitriptyline for neuropathic pain and fibromyalgia in adults
Prescriber
1/23/2013
(Source: Prescriber)
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Factors promoting sustainable work in women with fibromyalgia.
Disability and Rehabilitation
1/22/2013
Conclusions: Promoting factors for work were identified, involving individual and environmental factors. These working women with FM had developed advanced well-functioning strategies to enhance their work ability. The development of such strategies should be supported by health-care professionals as well as employers to promote sustainable work in women with FM. Implications for Rehabilitation Work disability is a common consequence of fibromyalgia (FM). Working women with FM appear to have developed advanced well-functioning individual strategies to enhance their work ability. The development of individual strategies should be supported by health-care professionals as well as employers to promote sustainable work and health in women with FM. PMID: 23336119 [PubMed - as suppl...
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Effect of fibromyalgia syndrome on the health-related quality of life and economic burden in Korea
Rheumatology
1/21/2013
Conclusion. Patients with FMS experience a decline in their HRQOL and constitute a significant economic burden on health-service utilization. The improvement in health-related costs and HRQOL after a diagnosis of FMS demonstrates a need for early diagnosis and treatment of FMS to reduce costs and enhance HRQOL. (Source: Rheumatology)
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Identifying and Treating Common Psychiatric Conditions Comorbid With
Psychiatric Times
1/18/2013 7:00:00 AM
This article reviews the diagnostic criteria for both myalgic encephalomyelitis and fibromyalgia and describes how to differentiate them from depressive and anxiety disorders, the psychiatric conditions with which they are most often confused. (Source: Psychiatric Times)
http://www.medworm.com/rss/comments.php?id=6962176
Identifying and Treating Common Psychiatric Conditions Comorbid with Myalgic Encephalomyelitis and/or Fibromyalgia
Psychiatric Times
1/18/2013 7:00:00 AM
This article reviews the diagnostic criteria for both myalgic encephalomyelitis and fibromyalgia and describes how to differentiate them from depressive and anxiety disorders, the psychiatric conditions with which they are most often confused. (Source: Psychiatric Times)

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Telephone-based cognitive-behavioural therapy and a structured exercise programme are effective for chronic widespread pain (fibromyalgia)
Evidence-Based Medicine
1/17/2013
Commentary on: McBeth J, Prescott G, Scotland G, et al.. Cognitive behavior therapy, exercise, or both for treating chronic widespread pain. Arch Intern Med 2012;172:48–57. Context Chronic widespread pain (CWP) is the cardinal feature of fibromyalgia which is one of the three most common musculoskeletal disorders in clinical practice, the others being osteoarthritis and chronic low back pain. CWP is disabling as well as costly and difficult to treat. Methods In a 2x2 factorial randomised controlled trial, 442 patients with CWP were randomised to receive 6 months of telephone-delivered cognitive-behavioural therapy (TCBT), a structured exercise programme, combined TBCT-exercise or treatment as usual (TAU). The primary outcome, using a 7-point patient global assessment scale of change ...
http://www.medworm.com/rss/comments.php?id=6960129
Phytothermotherapy in fibromyalgia and osteoarthritis: Between tradition and modern medicine
European Journal of Integrative Medicine
1/17/2013
The objective of this review was to summarize the actually available knowledges on possible effects of PTT in RD.Methodology: We conducted a search of the literature in May 2012. Medline was searched using the term “phytothermotherapy” and “hay baths” in combination with “rheumatic diseases”, “fibromyalgia syndrome”, “osteoarthritis”.Results: We identified one article reporting the clinical effects of PTT in 56 patients with fibromyalgia syndrome (FMS) and 3 trials describing the results of PTT in osteoarthritis (OA). The available data demonstrate that PTT is efficacy in decreasing pain and disability and improving function in patients with FMS and OA. Furthermore, the tolerability of PTT is excellent. The actual mechanism of action of PTT is yet not completely known, ...
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A Medicolegal Analysis of Worker Appeals for Fibromyalgia as a Compensable Condition Following Workplace Soft-tissue Injury.
J Rheumatol
1/15/2013
CONCLUSION: Over half of appeals for aggravation or causation of FM following a work-related softtissue injury were accepted by the tribunal, with importance ascribed to a rheumatologist diagnosis. Concerns are raised regarding lengthy duration from injury to diagnosis, claimants' high healthcare use, and neglect of mention of previous health status. The attribution of causation of FM to a softtissue workplace traumatic event is contentious and requires further examination. PMID: 23322465 [PubMed - as supplied by publisher] (Source: J Rheumatol)
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Association of Guanosine Triphosphate Cyclohydrolase 1 Gene Polymorphisms with Fibromyalgia Syndrome in a Korean Population.
J Rheumatol
1/15/2013
CONCLUSION: Our study provides evidence that certain GCH1 haplotypes may be protective against susceptibility and pain sensitivity in FM. Our data suggest that NO is responsible for pain sensitivity in the pathogenesis of FM. PMID: 23322459 [PubMed - as supplied by publisher] (Source: J Rheumatol)
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When life is just a pain
The Irish Times - Health
1/14/2013 7:19:23 PM
MARTINA LEAHY:After being diagnosed with fibromyalgia two years ago, a mother-of-two has learned to live with the pain (Source: The Irish Times - Health)
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Psychometric properties of the Spanish version of the mindful attention awareness scale (MAAS) in patients with fibromyalgia
Health and Quality of Life Outcomes
1/14/2013
Conclusion: Psychometric properties of the Spanish version of the MAAS in patients with FM are adequate. The dimensionality of the MAAS found in this sample and directions for future research are discussed. (Source: Health and Quality of Life Outcomes)

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Suicidality associated with antiepileptic drugs: Implications for the treatment of neuropathic pain and fibromyalgia
Pain
1/14/2013
Antiepileptic drugs (AEDs) have a prominent role in the treatment of several types of chronic pain. Gabapentin and pregabalin are recommended as first-line treatments for various neuropathic pain conditions, carbamazepine and oxcarbazepine are commonly used in trigeminal neuralgia, and certain AEDs are considered second- or third-line treatments for neuropathic pain . In addition, pregabalin is recommended for fibromyalgia , and topiramate and valproic acid are considered first-line treatments for migraine prophylaxis . (Source: Pain)
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Arthritis Research UK report: Complementary and alternative medicines for the treatment of rheumatoid arthritis, osteoarthritis and fibromyalgia
NeLM - News
1/10/2013
Source: Arthritis Research UK Area: News Arthritis Research UK has launched its evidence-based report on complementary and alternative medicines for the treatment of rheumatoid arthritis, osteoarthritis and fibromyalgia.   Twenty-five therapies were considered in the report. Each therapy was scored according to their effectiveness on a scale of 1 (little or no evidence that it was effective) to 5 (good evidence that it was effective), based on published data from clinical trials. Effectiveness was measured in terms of improvements in pain, disability or quality of life. In addition the safety of each therapy was graded green, amber or red.   The report found that many of the therapies have not been subjected to a clinical trial or may have only been tested in a single st...
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A pilot study of myofascial release therapy compared to Swedish massage in Fibromyalgia
Journal of Bodywork and Movement Therapies
1/7/2013
Summary: Fibromyalgia (FM) is characterized by widespread muscle pain and soft tissue tenderness. However, a lack of definitive muscle pathology has made FM both a diagnostic and a treatment puzzle. Much of the evidence for pathology in FM lies in the central nervous system – in particular abnormal amplification of pain signals in the spinal cord – a manifestation of central sensitization. An emerging body of evidence posits that peripheral pain generated from the muscles and fascia may trigger and maintain central sensitization in FM.Since FM patients so frequently seek manual therapy to relieve muscle symptoms, the present study compared two different manual therapy techniques in a parallel study of women with FM. Eight subjects received myofascial release (MFR) while four subjects r...
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Social support and invalidation by others contribute uniquely to the understanding of physical and mental health of patients with rheumatic diseases
Journal of Health Psychology
1/4/2013
This study examined whether social support and invalidation (lack of understanding and discounting by others) are differently associated with physical and mental health. Participants were 1455 patients with fibromyalgia, rheumatoid arthritis, ankylosing spondylitis, osteorarthritis, or another rheumatic disease. Participants completed online questionnaires. Social support correlated negatively with discounting responses of others (moderately) and lack of understanding (strongly). Both invalidation and social support were additively associated with patients’ mental health, but only discounting was significantly associated with patients’ physical health. This suggests that improving health of patients with rheumatic diseases requires the consideration of both social support and i...

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Amitriptyline for neuropathic pain and fibromyalgia in adults
NeLM - Drug Specific Reviews
1/3/2013
Source: Cochrane Area: Evidence > Drug Specific Reviews Background   Amitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and is recommended in many guidelines. These types of pain can be treated with antidepressant drugs in doses below those at which the drugs act as antidepressants.         Objectives   To assess the analgesic efficacy of amitriptyline for chronic neuropathic pain and fibromyalgia.To assess the adverse events associated with the clinical use of amitriptyline for chronic neuropathic pain and fibromyalgia.         Search methods     We searched CENTRAL, MEDLINE, and EMBASE ...
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Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up
Trials
1/3/2013
DiscussionThere is a need for the development of innovative and more effective treatments for fibromyalgia. This clinical trial will determine whether memantine can be an effective pharmacological treatment for fibromyalgia patients.Trial registration: Current Controlled Trials ISRCTN45127327EUDRACT 2011-006244-73 (Source: Trials)
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Migraines and fibromyalgia: the TMJ connection
NaturalNews.com
1/2/2013 1:00:00 AM
What follows is heavy reading. If you suffer from headaches, migraines or fibromyalgia, it will be well worth it to discover the relationship of these issues to the position of your lower jaw. The content of this article could change your life. We have my colleague Leonard... (Source: NaturalNews.com)

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A Randomized, Controlled, Double-Blind Pilot Study of the Effects of Cranial Electrical Stimulation on Activity in Brain Pain Processing Regions in Individuals with Fibromyalgia
Explore
1/1/2013
Conclusions: The observed decrease in activation in the pain processing regions may indicate a decrease in neural activity in these regions that may be related to decreased pain. This is the first randomized, controlled trial of CES in patients diagnosed with fibromyalgia to report functional magnetic resonance imaging data. (Source: Explore)
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Implicit memory function in fibromyalgia syndrome.
Behavioral Medicine
1/1/2013
Authors: Duschek S, Werner NS, Winkelmann A, W.ner S Abstract The study investigated implicit memory function in fibromyalgia syndrome (FMS) and its association with clinical parameters. Implicit memory refers to the influence of past experience on current behavior without conscious awareness of these experiences. Eighteen FMS patients and 25 healthy individuals accomplished a word-stem completion task. As possible factors mediating the expected impairment, pain severity, emotional disorders, and medication were taken into account. The patients displayed markedly reduced task performance and higher levels of depression and anxiety. Among the clinical features, pain severity was most closely associated with performance, whereas depression, anxiety, and medication showed only a minor...
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Patients' and professionals' views on managing fibromyalgia.
Pain Research and Management
1/1/2013
CONCLUSION: The present study contributes to a better understanding regarding why current management of fibromyalgia is neither effective nor satisfactory. It also provides insight into how health professionals can support fibromyalgia patients to achieve beneficial results. Health care services should offer greater support for these patients in the form of specific resources such as fibromyalgia clinics and health professionals with increased awareness of the disease. PMID: 23457682 [PubMed - indexed for MEDLINE] (Source: Pain Research and Management)

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Men With Fibromyalgia Often Go Undiagnosed, Mayo Clinic Study Suggests
Health News from Medical News Today
12/31/2012 3:00:00 AM
Fibromyalgia is a complex illness to diagnose and to treat. There is not yet a diagnostic test to establish that someone has it, there is no cure and many fibromyalgia symptoms - pain, fatigue, problems sleeping and memory and mood issues - can overlap with or get mistaken for other conditions. A new Mayo Clinic study suggests that many people who have fibromyalgia, especially men, are going undiagnosed. The findings appear in the online edition of the journal Arthritis Care & Research... (Source: Health News from Medical News Today)
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Helen Foundation Announces Breakthrough Treatment for Fibromyalgia...
PRWeb: Medical Pharmaceuticals
12/31/2012 1:00:05 AM
The non-profit organization Helen Foundation released the results of a 12-year study, saying the results confirm Microdose TherapyTM is a breakthrough in fibromyalgia treatment. Since commencement of...(PRWeb December 30, 2012)Read the full story at http://www.prweb.com/releases/2012/12/prweb10278185.htm (Source: PRWeb: Medical Pharmaceuticals)
http://www.medworm.com/rss/comments.php?id=6893456
Qigong Exercise in Patients With Fibromyalgia: Two Cases
Complementary Health Practice Review
12/28/2012
We report 2 case studies of patients with fibromyalgia who completed a 6-week Qigong exercise program. In both cases, patients’ fibromyalgia symptoms improved after the Qigong exercise program. The patient in case 1 also experienced a drastic decline in the serial measurement of CA-125 (a biomarker for ovarian cancer) after the 6-week Qigong exercise. In case 2, the patient’s uncontrolled crying also significantly improved. These observations indicate that Qigong exercise can bring about wide-ranging benefits to patients with fibromyalgia. (Source: Complementary Health Practice Review)
http://www.medworm.com/rss/comments.php?id=6887399
The fibromyalgia family study: A genome‐scan linkage study
Arthritis and Rheumatism
12/28/2012
Conclusion:The estimated sibling recurrence risk ratio suggests a strong genetic component of fibromyalgia. This is the first study to report genome‐wide suggestive linkage of fibromyalgia to the chromosome 17p11.2‐q11.2 region. Further investigation of these multi‐case families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia. © 2012 American College of Rheumatology. (Source: Arthritis and Rheumatism)
http://www.medworm.com/rss/comments.php?id=6887877
Fibromyalgia Diagnosis Often Missed in Men
MedlinePlus Health News
12/27/2012 12:00:00 PM
Condition causing pain, fatigue, sleep woes is much more common in women Source: HealthDay Related MedlinePlus Pages: Fibromyalgia, Men's Health (Source: MedlinePlus Health News)
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Fibromyalgia Underdiagnosed, Report Mayo Clinic ExpertsFibromyalgia Underdiagnosed, Report Mayo Clinic Experts
Medscape Today Headlines
12/26/2012 6:18:31 PM
Many fibromyalgia cases may be undiagnosed, according to a comparison of population-based data for prevalence of diagnosed fibromyalgia with a random population survey. Medscape Medical News (Source: Medscape Today Headlines)
http://www.medworm.com/rss/comments.php?id=6882131
Men with Fibromyalgia Often Go Undiagnosed, Mayo Clinic Study Suggests
News from Mayo Clinic
12/21/2012 11:44:49 AM
A new Mayo Clinic study suggests that many people who have fibromyalgia, especially men, are going undiagnosed. (Source: News from Mayo Clinic)

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Is chronic fatigue syndrome the same illness as fibromyalgia: evaluating the 'single syndrome' hypothesis
QJM
12/20/2012
Chronic fatigue syndrome (CFS) and fibromyalgia (FM) are medically unexplained syndromes that can and often do co-occur. For this reason, some have posited that the two are part of the same somatic syndrome—examples of symptom amplification. This hypothesis would suggest that few differences exist between the two syndromes. To evaluate this interpretation, we have searched the literature for articles comparing CFS to FM, reviewing only those articles which report differences between the two. This review presents data showing differences across a number of parameters—implying that the underlying pathophysiology in CFS may differ from that of FM. We hope that our review encourages other groups to look for additional differences between CFS and FM. By continuing to preserve the un...
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The influence of family environment on long‐term psychosocial functioning of adolescents with juvenile fibromyalgia
Arthritis Care and Research
12/19/2012
Conclusions:Adolescents with JFM from controlling family environments are at increased risk for poorer emotional functioning in early adulthood. Behavioral and family interventions should foster independent coping among adolescents with JFM and greater parenting flexibility to enhance successful long‐term coping. © 2012 by the American College of Rheumatology (Source: Arthritis Care and Research)

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Men with fibromyalgia often go undiagnosed, Mayo Clinic study suggests
EurekAlert! - Medicine and Health
12/19/2012
(Mayo Clinic) Fibromyalgia is a complex illness to diagnose and to treat. There is not yet a diagnostic test to establish that someone has it, there is no cure and many fibromyalgia symptoms -- pain, fatigue, problems sleeping and memory and mood issues -- can overlap with or get mistaken for other conditions. (Source: EurekAlert! - Medicine and Health)
http://www.medworm.com/rss/comments.php?id=6858213
Neurological disorder MMF found to be caused by vaccines: scientific proof
NaturalNews.com
12/18/2012 1:00:00 AM
It is a little-known condition that can trigger persistent and debilitating symptoms similar to those associated with multiple sclerosis (MS) and fibromyalgia, but is also one that the medical profession at large is still unwilling to acknowledge. And yet emerging research... (Source: NaturalNews.com)
http://www.medworm.com/rss/comments.php?id=6856206
Unique immunologic patterns in fibromyalgia
BMC Clinical Pathology - Latest articles
12/17/2012
Conclusion: The cytokine responses to mitogenic activators of PBMC isolated from patients with FM were significantly lower than those of healthy individuals, implying that cell-mediated immunity is impaired in FM patients. This novel cytokine assay reveals unique and valuable immunologic traits, which, when combined with clinical patterns, can offer a diagnostic methodology in FM. (Source: BMC Clinical Pathology - Latest articles)
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Is there a relationship between fibromyalgia and rhinitis?
Allergy and Asthma Proceedings
12/16/2012
(Source: Allergy and Asthma Proceedings)
http://www.medworm.com/rss/comments.php?id=6847111
Which aspects of health differ between working and nonworking women with fibromyalgia?A cross-sectional study of work status and health
BMC Public Health - Latest articles
12/14/2012
Conclusion: Working women with FM reported better health than nonworking women with FM in terms of pain, fatigue, stiffness, depression, disease specific health status and physical aspects of quality of life, which represent body functions and overall health status. However, they were equally impaired in tests of physical capacity. Moderate pain levels were compatible with work, while severe pain appeared to compromise work. Fatigue was better tolerated, as women scoring severe levels of fatigue worked. (Source: BMC Public Health - Latest articles)
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South Florida Pain Clinics, National Pain Institute, Now Offering Over...
PRWeb: Medical Pharmaceuticals
12/13/2012 10:00:06 PM
The leading pain clinics in South Florida, National Pain Institute, are now offering over a dozen fibromyalgia treatments. The options range from medication management to injection treatments to...(PRWeb December 13, 2012)Read the full story at http://www.prweb.com/releases/painclinicsouthflorida/painmanagementwestpalmbea/prweb10205765.htm (Source: PRWeb: Medical Pharmaceuticals)
http://www.medworm.com/rss/comments.php?id=6838579
Effect of hydrotherapy on quality of life, functional capacity and sleep quality in patients with fibromyalgia
Revista Brasileira de Reumatologia
12/10/2012 2:31:03 PM
CONCLUSION: Hydrotherapy improves sleep quality, physical function, professional status, psychological disorders and physical symptoms in patients with fibromyalgia. (Source: Revista Brasileira de Reumatologia)
http://www.medworm.com/rss/comments.php?id=6817955
Is brief psychodynamic psychotherapy in primary fibromyalgia syndrome with concurrent depression an effective treatment? A randomized controlled trial
General Hospital Psychiatry
12/6/2012
Conclusions: A high-standard routine treatment focusing on the improvement of health behavior and including antidepressant and analgesic medication is equally effective as a short-term individual psychodynamic psychotherapy in improving fibromyalgia-related symptoms. (Source: General Hospital Psychiatry)

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Theravance begins Phase II fibromyalgia study of TD-9855
Drug Development Technology
12/4/2012 7:00:00 PM
Theravance has begun a Phase II study with TD-9855, an investigational norepinephrine and serotonin reuptake inhibitor (NSRI), for the treatment of fibromyalgia. (Source: Drug Development Technology)
http://www.medworm.com/rss/comments.php?id=6815433
Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia
ClinicalTrials.gov
12/4/2012 12:00:00 PM
Condition:   FibromyalgiaIntervention:   Procedure: Transcranial Direct Current Stimulation (tDCS)Sponsors:   University of Michigan;   University of MichiganRecruiting - verified December 2012 (Source: ClinicalTrials.gov)
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Editorial Comment
Urology
12/1/2012
This comprehensive evaluation of the Rand Interstitial Cystitis Epidemiology database, analyzing temporal trends in interstitial cystitis/bladder pain syndrome (IC/BPS) and associated conditions, adds further credibility to the hypothesis that some patients with IC/BPS may have, over time, experienced phenotypic progression. If we examine the data for 2 of the most common comorbid associations, irritable bowel syndrome (IBS) and fibromyalgia (FM), it becomes very probable, that at least for many patients, there is temporal (and/or age related) progression from one of these conditions to one or two of the others. For the group with a clinical diagnosis of IC/BPS (the usual patient evaluated in IC/BPS studies by urology researchers), there seems to be a phenotype progression from the bladder...
http://www.medworm.com/rss/comments.php?id=6819670
Prevalence of fibromyalgia: A population‐based study in Olmsted County, Minnesota, utilizing the Rochester Epidemiology project
Arthritis Care and Research
11/30/2012
Conclusion:To the best of our knowledge, this is the first report of the rate at which fibromyalgia is being diagnosed in a community. This is also the first report of prevalence as assessed by the fibromyalgia research survey criteria. Our results suggest that patients, particularly men, who meet the fibromyalgia research survey criteria are unlikely to have been given a diagnosis of fibromyalgia. © 2012 by the American College of Rheumatology (Source: Arthritis Care and Research)

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Anderson Chiropractor: Chronic Pain Management Possible With Whole Body Care
Medical News (via PRIMEZONE)
11/26/2012 1:10:11 AM
ANDERSON, S.C., Nov. 25, 2012 (GLOBE NEWSWIRE) -- Garcia Chiropractic is educating patients about the benefits of natural pain management. Dr. Harvey Garcia uses non-invasive therapies to help with chronic conditions, including fibromyalgia and peripheral neuropathy. According to Dr. Garcia, chiropractic care is an effective alternative to traditional prescription painkillers. Care options include hands-on and brain-based therapies, such as decompression therapy, mechanical traction, Rebuilder Neurology Therapy and Advanced Therapeutic Movement therapy. This whole body approach to chronic pain is designed to address both the symptoms and underlying causes that trigger health problems. (Source: Medical News (via PRIMEZONE))
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Assessment of the relationship between postural stability and sleep quality in patients with fibromyalgia
Clinical Rheumatology
11/25/2012 4:37:07 PM
Abstract  The aim of this study is to investigate the relationship of postural stability and sleep disorders in patients with fibromyalgia syndrome. Frequency of falls in the last 6 months in 48 fibromyalgia and 32 control subjects were recorded. Postural stability was assessed by static posturography device (Tetrax, Sunlight Medical Ltd., Israel). Functional assessment consisted of lower-body strength; one-leg stance test were applied to all subjects. Fibromyalgia impact questionnaire (FIQ), sleep quality numeric rating scale (NRS), and Pittsburgh Sleep Quality Index were inquired. The number of falls in the last 6 months was significantly higher in the fibromyalgia group. Mean total value of stability indexes was 201.7 ± 70.9 vs. 162.6 ± 29.6 in fibromy...
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Effects of Class IV Laser Therapy on Fibromyalgia Impact and Function in Women with Fibromyalgia
The Journal of Alternative and Complementary Medicine
11/23/2012 8:12:10 PM
The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0. (Source: The Journal of Alternative and Complementary Medicine)
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Cross-cultural adaptation and validation of the South African Pain Catastrophizing Scale (SA-PCS) among patients with fibromyalgia
Health and Quality of Life Outcomes
11/22/2012
Conclusion: The SA-PCS can therefore be recommended as simple, efficient, valid and reliable tool which shows satisfactory sensitivity to change, for use among English, Afrikaans and Xhosa-speaking patients with fibromyalgia attending the public health sector in the Western Cape area of South Africa. (Source: Health and Quality of Life Outcomes)
http://www.medworm.com/rss/comments.php?id=6761662
Fibromyalgia Family and Relationship Impact Exploratory Survey
Musculoskeletal Care
11/21/2012
ConclusionsIn addition to physical impairments that are well documented among individuals with fibromyalgia, fibromyalgia can result in a substantial negative impact on important relationships with family and close friends. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Musculoskeletal Care)

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Gender Differences in Pain Severity, Disability, Depression, and Widespread Pressure Pain Sensitivity in Patients with Fibromyalgia Syndrome Without Comorbid Conditions
Pain Medicine
11/21/2012
ConclusionsWomen with FMS showed higher pain severity and lower PPT than men, whereas men exhibited longer duration of symptoms and disability. In men with FMS, the intensity of ongoing pain was positively correlated to pressure hyperalgesia over the neck. This study suggests that FMS could show a different phenotype in women and men and confirm that women exhibit lower PPT than men. (Source: Pain Medicine)
http://www.medworm.com/rss/comments.php?id=6770041
Impact of Animal‐Assisted Therapy for Outpatients with Fibromyalgia
Pain Medicine
11/21/2012
Conclusions.Brief therapy dog visits may provide a valuable complementary therapy for fibromyalgia outpatients. (Source: Pain Medicine)
http://www.medworm.com/rss/comments.php?id=6770042
Effect of low-level laser therapy on pain, quality of life and sleep in patients with fibromyalgia: study protocol for a double-blinded randomized controlled trial
Trials
11/21/2012
Background: Low-level laser therapy (LLLT) has been widely used as adjuvant strategy for treatment of musculoskeletal disorders. The light-tissue interaction (photobiostimulation) promotes analgesic and anti-inflammatory effects and improves tissue healing, which could justify the recommendation of this therapy for patients with fibromyalgia, leading to an improvement in pain and possibly minimizing social impact related to this disease. The present study proposes to evaluate the effect of LLLT on tender points in patients with fibromyalgia, correlating this outcome with quality of life and sleep. Methods: One hundred and twenty patients with fibromyalgia will be treated at the Integrated Health Center and the Sleep Laboratory of the Post Graduate Program in Rehabilitation Sciences of the ...
http://www.medworm.com/rss/comments.php?id=6759929
Pregabalin CR Meets Goal in Fibromyalgia, Not Seizure TrialPregabalin CR Meets Goal in Fibromyalgia, Not Seizure Trial
Medscape Today Headlines
11/20/2012 5:04:00 PM
Pfizer reports top-line results from 2 phase 3 trials of a once-daily controlled-release formulation of pregabalin. Medscape Medical News (Source: Medscape Today Headlines)

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Contextual and time dependent pain in fibromyalgia: An explorative study
BMC Research Notes
11/20/2012
Conclusion: Pain and pain predictors seem to vary by contexts and time, with less pain at home than to a doctor the same day, but with unchanged pain in the same context after 14 years. Thus, contextual pain cues should be accounted for when pain is measured and treated, e.g. by focusing more on home-measured pain and by optimizing the doctor office context. This explorative study should be followed up by a larger full-scale study. (Source: BMC Research Notes)
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Pfizer reports positive data from Phase 3 fibromyalgia study of pregabalin CR
Drug Development Technology
11/19/2012 7:00:00 PM
Pfizer has reported positive results from a double-blind, Phase 3 study of pregabalin controlled-release (CR) formulation as treatment for fibromyalgia patients. (Source: Drug Development Technology)
http://www.medworm.com/rss/comments.php?id=6753354
Pfizer's once-daily Lyrica met goal of trial in fibromyalgia
Reuters: Health
11/19/2012 8:58:16 AM
(Reuters) - Pfizer Inc said on Monday a late-stage trial of a once-daily version of its drug Lyrica in patients with fibromyalgia, a pain condition affecting more than 5 million Americans, met its main goal. (Source: Reuters: Health)
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Once-daily pregabalin met goal of trial in fibromyalgia
Modern Medicine
11/19/2012
(Source: Modern Medicine)
http://www.medworm.com/rss/comments.php?id=6749224
Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
Antioxidants and Redox Signaling
11/16/2012 1:46:47 PM
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
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Orofacial Pain and Fibromyalgia: What's the Connection?Orofacial Pain and Fibromyalgia: What's the Connection?
Medscape Today Headlines
11/16/2012 12:30:40 PM
Dr. Stoopler reviews the clinical implications for dentists when a patient with fibromyalgia is in the chair. Medscape Dentistry & Oral Health (Source: Medscape Today Headlines)
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TONIX Pharmaceuticals Holding Corp.: Tonix Pharmaceuticals Completes Convertible Note Offering
Market Wire - Pharmaceuticals and Biotech
11/14/2012 4:15:00 PM
NEW YORK, NY (MARKET WIRE) Tonix Pharmaceuticals Holding Corp. (OTCQB: TNXP) ("TONIX" or the "Company"), a specialty pharmaceutical company developing novel treatments for challenging disorders of the central nervous system, including fibromyalgia ("FM") and post-traumatic stress disorder ("PTSD"), today reported that it has raised $710,000 in a convertible note offering. The notes bear interest at 8% and may convert into a future private placement at a 25% discount unless redeemed. The notes have a one year term and may be converted into shares of the Company's common stock at a conversion price of $1.00 per share, (Source: Market Wire - Pharmaceuticals and Biotech)

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The impact of Fibromyalgia on health-related quality of life in patients according to age
Rheumatology International
11/14/2012 1:54:38 PM
In conclusion, it is important to control age effect on HRQOL to determine the specific impact of FM. Controlling the age effect on the HRQOL with standardized scores, elderly women with FM (≥60 years) have less impact of the disease on the physical and social dimensions of the HRQOL than younger patients. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00296-012-2568-0Authors Ricardo Pereira Campos, ISJD-S. José’s Health House, Largo S. João de Deus, No. 1, 4755-044 Areias de Vilar, Barcelos, PortugalMaria Isabel Vázquez, Department of Clinical Psychology and Psychobiology, Faculty Psychology, University of Santiago de Compostela, c/ Xosé María Suárez Núñez s/n, 15782 Santiago de Compostela, Spain Journal Rheumatology Internation...

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Pain Regulation Goes Awry in Fibromyalgia
MedPage Today Primary Care
11/14/2012 1:00:00 PM
WASHINGTON (MedPage Today) -- The main pain inhibitory mechanisms in the brain may not function properly in fibromyalgia patients, researchers said here. (Source: MedPage Today Primary Care)
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Functional somatic syndromes may be either “polysyndromic” or “monosyndromic”
Journal of Psychosomatic Research
11/12/2012
Functional somatic syndromes are probably the most useful description of a group of conditions presenting with physical symptoms and disability for which medicine cannot find presently a convincing explanation . They include common conditions such as irritable bowel syndrome, tension headaches, and fibromyalgia (chronic widespread pain), and less common conditions, such as chronic fatigue syndrome and certain “atypical” regional pain syndromes. Almost all are more common in women than men, and they affect young and middle aged adults most frequently. Premorbid risk markers include childhood adversity and mood disorders, such as depressive illness . Concurrent associations include abnormalities of the hypothalamic–pituitary adrenal axis and autonomic nervous system, as well as central...
http://www.medworm.com/rss/comments.php?id=6887732
Nocturnal sleep, daytime sleepiness and fatigue in fibromyalgia patients compared to rheumatoid arthritis patients and healthy controls: A preliminary study
Sleep Medicine
11/12/2012
Conclusions: Women with FM have similar nocturnal sleep disturbance as those with RA, but FM patients report greater self-rated daytime sleepiness and fatigue than RA and HC, which did not correspond to the relatively low level of objectively determined daytime sleepiness of FM patients. These findings suggest a generalized hyperarousal state in FM. (Source: Sleep Medicine)
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Fibromyalgia and the brain: New clues reveal how pain and therapies are processed
ScienceDaily Headlines
11/11/2012 3:34:34 PM
According to new research, pain experienced by people with fibromyalgia may be caused by a problem with the way pain stimuli are processed in the brain. Abnormal pain signal processing may also be related to a lack of responsiveness to opioids, a common class of pain relievers. (Source: ScienceDaily Headlines)
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Cocoa butter is not just for chocolate anymore - Discover the healthy secrets behind this sensuous food
NaturalNews.com
11/10/2012 1:00:00 AM
Need another reason to love the cacao bean? As it turns out, cocoa butter has its own set of health enhancing properties apart from cocoa. External use of the butter clears everything from psoriasis to dermatitis to eczema, while conditions such as fibromyalgia, chronic... (Source: NaturalNews.com)
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Table of Contents
The Brown University Psychopharmacology Update
11/9/2012 1:54:17 PM
Abstract Genetic Background Affects Response to Disulfiram Treatment for Cocaine Abuse Creatine in Addition to Antidepressant Speeds Up Response in Depressed Women First‐ and Second‐Generation Antidepressants and Antipsychotics and Hip Fracture Olanzapine Monotherapy Shows Efficacy for Bipolar Depression MAS‐ER and Topiramate for Cocaine Dependence Study Finds Rapid Response to Fluoxetine for PMDD Symptoms Varenicline for Smoking Cessation in Schizophrenia Patients Naltrexone for Smoking Cessation and Weight Gain Mixed Results with Add‐on Quetiapine for Fibromyalgia Omega‐3 Fatty Acid Ineffective for Bipolar Disorder Mechanisms of Stimulant/Nonstimulant Treatments for ADHD Approvals (Source: The Brown University Psychopharmacology Update)
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Chaoyi Fanhuan Qigong and Fibromyalgia: Methodological Issues and Two Case Reports
The Journal of Alternative and Complementary Medicine
11/9/2012 9:06:44 AM
The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0. (Source: The Journal of Alternative and Complementary Medicine)

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Duloxetine versus other anti-depressive agents for depression
NeLM - Mental Health
11/7/2012
Source: Cochrane Area: Evidence > Drug Specific Reviews Background Although pharmacological and psychological interventions are both effective for major depression, in primary and secondary care settings antidepressant drugs remain the mainstay of treatment. Amongst antidepressants many different agents are available. Duloxetine hydrochloride is a dual reuptake inhibitor of serotonin and norepinephrine and has been licensed by the Food and Drug Administration in the US for major depressive disorder (MDD), generalised anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia and chronic musculoskeletal pain.       Objectives To assess the evidence for the efficacy, acceptability and tolerability of duloxetine in comparison with all other antidep...
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Relationship Between Performance Validity Testing, Disability Status, and Somatic Complaints in Patients With Fibromyalgia.
The Clinical Neuropsychologist
11/5/2012
This study reinforces the importance of effort testing when working with medical populations. PMID: 23121595 [PubMed - as supplied by publisher] (Source: The Clinical Neuropsychologist)
http://www.medworm.com/rss/comments.php?id=6735327
FIBROMYALGIA HP (Aluminum Oxide 30c, Silver Nitrate 30c, Berberis Vulgaris Fruit 30c, Conium Maculatum Flowering Top 30c, Iron 30c, Gelsemium Sempervirens Root 30c, Guaiacum Officinale Resin 30c, Hydrogen 30c, Lachesis Muta Venom 30c, Phosphoric Acid 30c, Toxicodendron Pubescens Leaf 30c) Liquid [Natural Creations, Inc.]
DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
11/5/2012
Updated Date: Nov 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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FIBROMYALGIA RELIEF (Aconitum Napellus, Arsenicum Album, Belladonna, Coniinum, Gelsemium Sempervirens, Hypericum Perforatum, Kali Bichromicum) Tablet [The Magni Company]
DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
11/5/2012
Updated Date: Nov 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
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Autonomic nervous system profile in fibromyalgia patients and its modulation by exercise: a mini review
Clinical Physiology and Functional Imaging
11/3/2012 11:00:00 PM
Summary This review imparts an impressionistic tone to our current understanding of autonomic nervous system abnormalities in fibromyalgia. In the wake of symptoms present in patients with fibromyalgia (FM), autonomic dysfunction seems plausible in fibromyalgia. A popular notion is that of a relentless sympathetic hyperactivity and hyporeactivity based on heart rate variability (HRV) analyses and responses to various physiological stimuli. However, some exactly opposite findings suggesting normal/hypersympathetic reactivity in patients with fibromyalgia do exist. This heterogeneous picture along with multiple comorbidities accounts for the quantitative and qualitative differences in the degree of dysautonomia present in patients with FM. We contend that HRV changes in fibromyalgia may not ...

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Sexuality of men with fibromyalgia: what are the factors that cause sexual dysfunction?
Rheumatology International
11/3/2012 12:59:15 PM
Abstract  The purpose of the present study is to compare male patients with the fibromyalgia syndrome (FMS) with healthy individuals in terms of the sexual function. For the purposes of this study, 37 sexually active male FMS patients and 30 healthy controls were enrolled. The demographic data of the patients were recorded, and the widespread pain observed in FMS was graded with the help of the visual analogue scale (VAS 0–100 mm). Sexual function was assessed according to the international index of erectile function (IIEF) scoring system. The disease-related quality of life was measured with the help of the Short Form-36 quality of life questionnaire (SF-36 QoL). Levels of anxiety and depression observed in the patients were graded through the Hospital Anxiety and D...
http://www.medworm.com/rss/comments.php?id=6693989
Elevated serum high-sensitivity C-reactive protein levels in fibromyalgia syndrome patients correlate with body mass index, interleukin-6, interleukin-8, erythrocyte sedimentation rate
Rheumatology International
11/3/2012 12:59:12 PM
Abstract  The levels of several inflammatory cytokines are abnormal in many patients with the fibromyalgia syndrome (FMS) and may play a role in its pathogenesis. The inflammatory marker C-reactive protein (CRP) is associated with the disease activity in patients with inflammatory rheumatic diseases, but its role in FMS is unknown. We undertook this study to determine whether high-sensitivity CRP (hsCRP) is elevated in FMS and whether its levels relate to key biologic or clinical measures. One hundred and five patients with FMS (1990 ACR criteria) and 61 healthy normal controls (HNC) at a ratio of 2:1 were recruited. The serum concentrations of hsCRP, interleukin-8 (IL-8), and interleukin-6 (IL-6) were assessed using enzyme-linked immunosorbent assays. The hsCRP levels were...
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Effects of guided imagery on biobehavioral factors in women with fibromyalgia
Journal of Behavioral Medicine
11/2/2012 11:47:23 AM
Abstract  Women diagnosed with fibromyalgia (N = 72) participated in a 10-week randomized trial to examine the effectiveness of guided imagery on self-efficacy, perceived stress, and selected biobehavioral factors (FMS symptoms; immune biomarkers). Participants in both guided imagery and usual care control conditions completed measures and donated 3 cc of blood at baseline, 6- and 10-weeks. A mixed effects linear model to test for differences between groups for all behavioral and biologic variables demonstrated that after 10 weeks of daily intervention use, guided imagery participants reported statistically significant increases in self-efficacy and statistically significant decreases in stress, fatigue, pain, and depression. There were no statistically signi...
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Duloxetine and Pregabalin for Pain Management in Multiple Rheumatic Diseases Associated with Fibromyalgia
Pain Practice
10/31/2012 11:00:00 PM
Abstract The fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno‐rheumatic diseases. Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by “central sensitization,” which is common to many other painful conditions. The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new‐generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome. The association of two drug...
http://www.medworm.com/rss/comments.php?id=6694209
Autonomic nervous system profile in fibromyalgia patients and its modulation by exercise: a minireview
Clinical Physiology and Functional Imaging
10/31/2012 11:00:00 PM
Summary This review imparts an impressionistic tone to our current understanding of autonomic nervous system abnormalities in fibromyalgia. In the wake of symptoms present in patients with fibromyalgia (FM), autonomic dysfunction seems plausible in fibromyalgia. A popular notion is that of a relentless sympathetic hyperactivity and hyporeactivity based on heart rate variability (HRV) analyses and responses to various physiological stimuli. However, some exactly opposite findings suggesting normal/hypersympathetic reactivity in patients with fibromyalgia do exist. This heterogeneous picture along with multiple comorbidities accounts for the quantitative and qualitative differences in the degree of dysautonomia present in patients with FM. We contend that HRV changes in fibromyalgia may not ...
http://www.medworm.com/rss/comments.php?id=6689781
Differentiation of the clinical features of psoriatic arthritis and fibromyalgia.
J Rheumatol
10/31/2012 11:00:00 PM
Authors: Konno T PMID: 23118294 [PubMed - in process] (Source: J Rheumatol)
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Fibromyalgia is associated with altered skeletal muscle characteristics which may contribute to post‐exertional fatigue in post‐menopausal women
Arthritis and Rheumatism
10/31/2012 11:00:00 PM
Conclusion.Peripheral mechanisms i.e. altered muscle fiber size distribution and decreased capillary density may contribute to post‐exertional fatigue in subjects with FM. Understanding these defects in fibromyalgic muscle may provide valuable insight for treatment © 2012 American College of Rheumatology. (Source: Arthritis and Rheumatism)
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[Optimising the use of exercise for the treatment of fibromyalgia].
Atencion Primaria
10/31/2012 11:00:00 PM
Authors: López-Lázaro L PMID: 23101565 [PubMed - in process] (Source: Atencion Primaria)

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Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia
Arthritis Research and Therapy
10/31/2012 11:00:00 PM
Conclusions: Our results suggest an alteration of muscle oxygen utilization in the FM population. This study demonstrates the potential of using combined diffuse optical spectroscopies (i.e., NIRS/DCS) to comprehensively evaluate tissue oxygen and flow kinetics in skeletal muscle. (Source: Arthritis Research and Therapy)
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Exercise in Muscle Pain Disorders
PM and R
10/31/2012 11:00:00 PM
Abstract: Muscle pain disorders range from local or regional (myofascial pain) to widespread (fibromyalgia). Many people with muscle pain have decreased fitness. Exercise intolerance is a common feature as well, and yet exercise plays an important role in the treatment of muscle pain disorders. Results of studies have shown repeatedly, via multiple modes and methods of delivery, that exercise is at least as effective as the best pharmacologic treatments. An understanding by clinicians and their patients of the unique benefits of a carefully crafted exercise program is one step in the successful management of these often frustrating muscle pain disorders. (Source: PM and R)

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TEMPORARY FIBROMYALGIA PAIN AND DISCOMFORT RELIEF (Atropa Belladonna - Bryonia Alba Root - Causticum - Phosphorus - Strychnos Nux-Vomica Seed - Pulsatilla Vulgaris - Toxicodendron Pubescens Leaf -) Tablet, Orally Disintegrating [TRP Company]
DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
10/31/2012
Updated Date: Oct 31, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
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Increased brain responses during subjectively-matched mechanical pain stimulation in fibromyalgia patients as evidenced by MEG.
Clinical Neurophysiology
10/29/2012 11:00:00 PM
CONCLUSION: Fibromyalgia patients show enhanced brain responses after reducing the amount of pressure to produce similar subjective levels of pain than to the control subjects. SIGNIFICANCE: The present results suggest that central pain augmentation is present in fibromyalgia, not only when the objective level of stimulation is kept the same as for control subjects, but also when stimulation is adjusted to produce similar levels of pain in patients and controls. PMID: 23121899 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
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Complementary and Alternative Medicine for Rheumatic DiseasesComplementary and Alternative Medicine for Rheumatic Diseases
Medscape Today Headlines
10/29/2012 5:36:20 AM
A majority of sufferers of rheumatic diseases such as arthritis and fibromyalgia have turned to complementary and alternative therapies in search of relief. Which, if any, offer benefit? Aging Health (Source: Medscape Today Headlines)
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Autoimmune Disease and Hair Loss
Dermatologic Clinics
10/28/2012 11:00:00 PM
Once systemic disease is in remission, it is prudent to recognize the importance of alopecia in the patient's overall sense of well-being and quality-of-life clinical outcome. Scarring alopecia (scalp discoid lupus erythematosus) can be the presenting manifestation of lupus in more than half of affected individuals. Diffuse nonscarring alopecia in lupus is usually responsive to treatment of the systemic disease. Severe, often intractable burning pruritus of the scalp is a frequent complaint in dermatomyositis. Lichen planopilaris may mimic other autoimmune forms of scarring alopecia. Alopecia can also be caused by medications used to treat systemic autoimmune disease and fibromyalgia. (Source: Dermatologic Clinics)
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TONIX Pharmaceuticals Completes Pre-IND Meeting With FDA For Potential New Treatment For Post-Traumatic Stress Disorder
Pharmaceutical Online News
10/25/2012 1:04:11 AM
Tonix Pharmaceuticals Holding Corp. (OTCQB:TNXP) ("TONIX" or the "Company"), a specialty pharmaceutical company developing novel treatments for challenging disorders of the central nervous system, including fibromyalgia ("FM") and post-traumatic stress disorder ("PTSD"), today reported that it recently held a pre-Investigational New Drug ("IND") meeting with the US Food and Drug Administration ("FDA") to discuss its proposed development of the Company's novel sublingual tablet formulation of cyclobenzaprine ("CBP") for bedtime use, TNX-102 SL, for the treatment of PTSD. (Source: Pharmaceutical Online News)
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Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing
Arthritis Research and Therapy
10/24/2012 11:00:00 PM
Conclusions: These findings provide empirical evidence that catastrophizing processes might precede and contribute to subsequent alterations in the pain experience for FM patients. (Source: Arthritis Research and Therapy)
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Improvement in pain, fatigue, and subjective sleep quality through sleep hygiene tips in patients with fibromyalgia
Revista Brasileira de Reumatologia
10/23/2012 5:31:03 PM
CONCLUSION: The sleep hygiene instructions allowed changing the patients' behavior, which resulted in pain and fatigue improvement, increased subjective quality of sleep, in addition to facilitating falling asleep after waking up in the middle of the night. (Source: Revista Brasileira de Reumatologia)

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Many Fibromyalgia Patients Have Small-Fiber PolyneuropathyMany Fibromyalgia Patients Have Small-Fiber Polyneuropathy
Medscape Today Headlines
10/18/2012 11:03:44 AM
Of the many patients labeled as having fibromyalgia, half may have small-fiber polyneuropathy, a potentially treatable specific diagnosis, and should therefore be tested. Medscape Medical News (Source: Medscape Today Headlines)

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Representations of Symptom History in Women with Fibromyalgia vs Chronic Low Back Pain: A Qualitative Study
Pain Medicine
10/17/2012 11:00:00 PM
Conclusions.The narratives of patients with FM expressed high psychological loads and dramatic connotations and emphasized legitimacy issues. In contrast, patients with LBP stressed overload, wear and tear, and treatment inefficacy. The combination of chronicity and lack of specificity may render FM and LBP prone to raise skepticism in the therapists. Investigating and discussing patients’ perceptions allows overcoming the apparent uniformity of patients’ complaints. It contributes defining realistic and shared treatment goals and help therapists cope with pain chronicity. (Source: Pain Medicine)
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Relationship status and quality moderate daily pain-related changes in physical disability, affect, and cognitions in women with chronic pain
Pain
10/16/2012 11:00:00 PM
The objectives of this study were to examine whether (1) daily pain-related changes in physical functioning differed between happily partnered, unhappily partnered, and unpartnered female chronic pain patients, and (2) affect and pain cognitions mediated the partner status effect on pain-related changes in physical functioning. Two hundred fifty-one women with chronic pain due to osteoarthritis and/or fibromyalgia completed 30 daily electronic diaries assessing pain, affect, pain-related cognitions, and physical functioning. Patients living with a romantic partner also completed a modified version of the Locke-Wallace Marital Adjustment Scale to assess relationship satisfaction. Multilevel modeling revealed that patients in satisfying unions showed more adaptive daily pain-related changes ...
http://www.medworm.com/rss/comments.php?id=6887284
The association of sleep difficulties with health-related quality of life among patients with fibromyalgia
BMC Musculoskeletal Disorders
10/16/2012 11:00:00 PM
Background: Difficulty sleeping is common among patients with fibromyalgia (FM); however, its impact on health-related quality of life (HRQoL) is not well understood. The aim of the current study was to assess the burden of sleep difficulty symptoms on HRQoL among patients with FM. Methods: The current study included data from the 2009 National Health and Wellness Survey (N=75,000), which is a cross-sectional, Internet-based survey representative of the adult US population. The prevalence of sleep difficulty symptoms among patients with FM (n=2,196) were compared with matched controls (n=2,194), identified using propensity-score matching. Additionally, the relationship between the number of sleep difficulty symptoms (none, one, or two or more) and HRQoL (using the SF-12v2) was assessed usi...
http://www.medworm.com/rss/comments.php?id=6615252
Plasma nitrite levels, total antioxidant status, total oxidant status, and oxidative stress index in patients with tension-type headache and fibromyalgia
Clinical Neurology and Neurosurgery
10/15/2012 11:00:00 PM
Conclusion: These results indicated that; FM and TTH patients revealed higher oxidative stress index and lower total nitrite levels than healthy controls. We conclude that oxidative stress may have a role in the pathophysiological mechanisms of TTH and FM, although, whether it is the cause or the consequence, is not clear. (Source: Clinical Neurology and Neurosurgery)
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Antipsychotics are among the psychoactive medications that may prove to be of benefit in treating fibromyalgia
Drugs
10/14/2012 9:52:38 AM
(Source: Drugs)
http://www.medworm.com/rss/comments.php?id=6601373
Mindfulness therapy for somatization disorder and functional somatic syndromes: Analysis of economic consequences alongside a randomized trial
Journal of Psychosomatic Research
10/11/2012 11:00:00 PM
The objective of the present study is to estimate the economic consequences of somatization disorder and functional somatic syndromes such as fibromyalgia and chronic fatigue syndrome, defined as bodily distress syndrome (BDS), when mindfulness therapy is compared with enhanced treatment as usual.Methods: A total of 119 BDS patients were randomized to mindfulness therapy or enhanced treatment as usual and compared with 5950 matched controls. Register data were analyzed from 10years before their inclusion to 15-month follow-up. The main outcome measures were disability pension at the 15-month follow-up and a reduction in total health care costs. Unemployment and sickness benefit prior to inclusion were tested as possible risk factors.Results: At 15-month follow-up, 25% from the mindfulness ...
http://www.medworm.com/rss/comments.php?id=6887739
A randomized, double-blind, multicenter, placebo-controlled phase III trial to evaluate the efficacy and safety of pregabalin in Japanese patients with fibromyalgia
Arthritis Research and Therapy
10/11/2012 11:00:00 PM
Conclusions: This trial demonstrated that pregabalin, at doses of up to 450 mg/day, was effective for the symptomatic relief of pain in Japanese patients with fibromyalgia. Pregabalin also improved measures of sleep and functioning and was well tolerated. These data indicate that pregabalin is an effective treatment option for the relief of pain and sleep problems in Japanese patients with fibromyalgia.Trial registration: clinicaltrials.gov NCT00830167 (Source: Arthritis Research and Therapy)
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Challenges in demonstrating the effectiveness of multidisciplinary treatment on quality of life, participation and health care utilisation in patients with fibromyalgia: a randomised controlled trial
Clinical Rheumatology
10/10/2012 1:03:26 AM
This study aimed to examine the effectiveness of a multidisciplinary intervention with aftercare (MD) compared to aerobic exercise (AE) and usual care (UC) in recently diagnosed patients with fibromyalgia (FM). In a Zelen-like design, eligible patients from the outpatient rheumatology clinics of three medical centres in the South of the Netherlands were consecutively recruited and pre-randomised to MD (n = 108), AE (n = 47) or UC (n = 48). MD consisted of a 12-week course of sociotherapy, physiotherapy, psychotherapy and creative arts therapy (three half days per week), followed by five aftercare meetings in 9 months. AE was given twice a week in a 12-week course. UC varied but incorporated at least education and lifestyle advice. Primary outcomes were health-related ...

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Survey of physician experiences and perceptions about the diagnosis and treatment of fibromyalgia
BMC Health Services Research
10/9/2012 11:00:00 PM
Conclusions: Diagnosis and managing FM is challenging for physicians, especially PCPs and psychiatrists,but other specialties, including rheumatologists, also express difficulties. Improved trainingin FM and initiatives to improve patient-doctor communication are needed and may help themanagement of this condition. (Source: BMC Health Services Research)
http://www.medworm.com/rss/comments.php?id=6586996
Survey of physician experiences and perceptions about the diagnosis and treatment of fibromyalgia.
Pain Physician
10/9/2012 11:00:00 PM
CONCLUSIONS: Diagnosis and managing FM is challenging for physicians, especially PCPs and psychiatrists, but other specialties, including rheumatologists, also express difficulties. Improved training in FM and initiatives to improve patient-doctor communication are needed and may help the management of this condition. PMID: 23051101 [PubMed - as supplied by publisher] (Source: Pain Physician)
http://www.medworm.com/rss/comments.php?id=6601568
Ozone Therapy as Add-On Treatment in Fibromyalgia Management by Rectal Insufflation: An Open-Label Pilot Study
The Journal of Alternative and Complementary Medicine
10/9/2012 10:25:52 AM
The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0. (Source: The Journal of Alternative and Complementary Medicine)
http://www.medworm.com/rss/comments.php?id=6586804
Is Fibromyalgia Progressive?
About.com Eating Disorders
10/6/2012 11:00:00 PM
: Is Fibromyalgia Progressive? Is fibromyalgia a progressive disorder, meaning does it get worse over (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6575054
Diagnosis and diagnostic tests for fibromyalgia (syndrome).
Reumatismo
10/6/2012 5:00:01 PM
Conclusions: The diagnosis of FMS is easy in most patients with CWP and does not ordinarily require a rheumatologist. A rheumatologist's expertise might be needed to exclude difficult to diagnose or concomitant inflammatory rheumatic diseases. In the presence of mental illness referral to a mental health specialist for evaluation is recommended. PMID: 23024964 [PubMed - in process] (Source: Reumatismo)
http://www.medworm.com/rss/comments.php?id=6572911
Fibromyalgia dyscognition: concepts and issues.
Reumatismo
10/6/2012 5:00:01 PM
Authors: Ambrose KR, Gracely RH, Glass JM Abstract Fibromyalgia is characterized by widespread pain and tenderness; however, comorbid cognitive difficulties are a common complaint among patients. Known as fibro fog or dyscognition, this symptom comprises difficulties with complex cognitive processes including memory, executive function, concentration and attention. While the mechanisms that initiate and maintain these cognitive deficits are still largely unknown, recent research has increased the understanding of subjective symptoms and objectively-determined deficits in cognitive performance. Treatments have also improved to include complementary cognitive and physical strategies. This review focuses on issues of dyscognition in fibromyalgia. Details of objective testing methods a...
http://www.medworm.com/rss/comments.php?id=6572910
Pediatric fibromyalgia.
Reumatismo
10/6/2012 5:00:01 PM
Authors: Buskila D, Ablin J Abstract Fibromyalgia (FM) is currently defined as chronic widespread pain (CWP) with allodynia or hyperalgesia to pressure pain. It is classified as one of the large group of soft-tissue pain syndromes. Pain is the cardinal symptom of FM; however, most patients also experience additional symptoms such as debilitating fatigue, disrupted or non-restorative sleep, functional bowel disturbances, and a variety of neuropsychiatric problems, including cognitive dysfunction, anxiety and depressive symptoms. Its pathogenesis is not entirely understood, although it is currently believed to be the result of a central nervous system (CNS) malfunction that increases pain transmission and perception. FMS usually involves females, and in these patients it often makes ...
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Neurophysiological background for physical therapies in fibromyalgia.
Reumatismo
10/6/2012 5:00:01 PM
Authors: Casale R, Atzeni F, Sarzi-Puttini P Abstract This paper describes the techniques for controlling pain by the physical means that are most widely used clinically, particularly in the case of fibromyalgia. They are grouped on the basis of the physical energy used: mechanical, thermal (including magnetic and electromagnetic), and light (LASER). The main underlying neurophysiological mechanisms are gate activation, the stimulation of descending systems of pain control, and the endogenous opiate system. PMID: 23024968 [PubMed - in process] (Source: Reumatismo)

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Identification of subgroups among fibromyalgia patients.
Reumatismo
10/6/2012 5:00:01 PM
Authors: Auvinet B, Chaleil D Abstract This paper presents some hypotheses concerning the identification of homogeneous subgroups among fibromyalgia (FM) patients in order to improve the management of the disease. It also reviews the available literature about this subject. Three methods for subgrouping are discussed according to clinical features, biomarkers, and gait analysis. Clinical subgrouping based on cluster analysis has been used for the identification of homogeneous subgroups of patients and, more recently, homogeneous clinical features. So far, longitudinal studies using clinical subgroups to direct treatment and predict outcome are still required. Biomarkers in FM, which is a neurobiological disease, are of promising interest, nevertheless currently, none of them can be...
http://www.medworm.com/rss/comments.php?id=6572906
Fibromyalgia and sexual problems.
Reumatismo
10/6/2012 5:00:01 PM
Authors: Bazzichi L, Giacomelli C, Rossi A, Sernissi F, Scarpellini P, Consensi A, Bombardieri S Abstract The aim of this review was to describe the recent literature concerning sexual dysfunction in fibromyalgic patients. To this end, we used the common online databases PubMed, MEDLINE and EMBASE (up to June 2012) and searched for the key words fibromyalgia (FM) and sexual dysfunction. All the studies examined underlined that FM is strictly associated with sexual dysfunction in women. The major findings observed were related to a decreased sexual desire and arousal, decreased experience of orgasm, and in some studies an increase in genital pain. The psychological aspects, together with the stress related to the constant presence of chronic widespread pain, fatigue and sleep distur...
http://www.medworm.com/rss/comments.php?id=6572905
Psychiatric problems in fibromyalgia: clinical and neurobiological links between mood disorders and fibromyalgia.
Reumatismo
10/6/2012 5:00:01 PM
Conclusions. The finding of comparable pathophysiological characteristics of pain and depression provides a framework for understanding the relationship between the two conditions and sheds some light on neurobiological and therapeutic aspects. PMID: 23024971 [PubMed - in process] (Source: Reumatismo)
http://www.medworm.com/rss/comments.php?id=6572904
Cognitive-behavioral and operant-behavioral therapy for people with fibromyalgia.
Reumatismo
10/6/2012 5:00:01 PM
Authors: Thieme K, Turk DC Abstract The current article reviews the cognitive-behavioral (CB) and operant-behavioral perspectives on chronic pain and suggests an answer to the question why changes in behaviors, attitudes, and emotions are associated with decreases in pain severity and impact discussing potential psychobiological mechanisms that may underlie cognitive and behavioral techniques. The impact of learning such as classical and operant conditioning in behaviors and physical responses including baroreflex sensitivity (BRS), as well as the influence of cognitions on pain perception and impact will be presented to explain general efficacy of cognitive-behavior therapy (CBT) and operant-behavioral therapy (OBT) in the treatment of people with fibromyalgia (FM) describing some...
http://www.medworm.com/rss/comments.php?id=6572902
Fibromyalgia and arthritides.
Reumatismo
10/6/2012 5:00:01 PM
Authors: Atzeni F, Sallì S, Benucci M, Di Franco M, Alciati A, Sarzi-Puttini P Abstract Fibromyalgia (FM) is a chronic pain syndrome that affects at least 2% of the adult population. It is characterised by widespread pain, fatigue, sleep alterations and distress, and emerging evidence suggests a central nervous system (CNS) malfunction that increases pain transmission and perception. FM is often associated with other diseases that act as confounding and aggravating factors, such as rheumatoid arthritis (RA), spondyloarthritides (SpA), osteoarthritis (OA) and thyroid disease. Mechanism-based FM management should consider both peripheral and central pain, including effects due to cerebral input and that come from the descending inhibitory pathways. Rheumatologists should be able to ...

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Fibromyalgia syndrome: still a medical dilemma.
Reumatismo
10/6/2012 5:00:01 PM
Authors: Sarzi-Puttini P, Atzeni F, Perrot S Abstract This issue of "Reumatismo" deals with a variety of aspects of chronic widespread pain (CWP) and its rheumatological quasi-synonym of fibromyalgia (FM). The definitions of CWP and FM both have a long history. Chronic musculoskeletal pain conditions are universally prevalent in both genders and all age groups and, although their pathophysiology varies, they are inter-related anatomically and by their association with pain and impaired physical function. However, there is still no consensus as to whether FM should be considered a discrete entity or just the tip of the iceberg of CWP... PMID: 23024962 [PubMed - in process] (Source: Reumatismo)

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If fibromyalgia did not exist, we should have invented it. A short history of a controversial syndrome.
Reumatismo
10/6/2012 5:00:01 PM
Authors: Perrot S Abstract Fibromyalgia is a recent disease, and some physicians remain doubtful about its reality. The history of fibromyalgia is a story of controversies: the fight between subjectivity and cartesianism, and between old mind and body concepts. Fibromyalgia represents the emblematic condition of unexplained medical symptoms, far from well-defined diseases with objective biomarkers. In this review we will follow the fibromyalgia story along the ages and sciences to better understand this complex pain disorder, between soma and psyche, and between medicine and psycho-sociology and to demonstrate that fibromyalgia exist, we have not invented it. PMID: 23024963 [PubMed - in process] (Source: Reumatismo)
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Fibromyalgia: A Syndrome of Dysfunctional Pain, a Clinical Context Report (CME/CE)
MedPage Today Rheumatology
10/6/2012 1:13:26 PM
(MedPage Today) -- Fibromyalgia needs more recognition and understanding from clinicians, Serge Perrot, MD, of Paris Descartes University in Paris, France, tells MedPage Today staff writer Nancy Walsh in this exclusive video report. (Source: MedPage Today Rheumatology)
http://www.medworm.com/rss/comments.php?id=6572755
Turmeric
About.com Eating Disorders
10/5/2012 11:00:00 PM
Learn the benefits of turmeric (curcumin) for fibromyalgia and chronic fatigue syndrome, along with the side effects, typical dosage, and how to add turmeric to your diet. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6572846
Lysine
About.com Eating Disorders
10/5/2012 11:00:00 PM
Find out why lysine supplements are sometimes used to treat fibromyalgia and chronic fatigue syndrome and what research shows. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6572847
[Special Series on Neuroscience in Health and Disease] Cerebral Blood Flow Dynamics During Pain Processing in Patients With Fibromyalgia Syndrome
Psychosomatic Medicine
10/3/2012 11:00:00 PM
Conclusions The increased blood flow response in the anterior cerebral arteries reflects hyperactivity of medial structures of the neuromatrix of nociception, structures involved in the processing of affective and cognitive aspects of pain. Aberrances in cerebral blood flow related to fibromyalgia and its clinical characteristics become particularly apparent in the enhancement of the initial component of the hemodynamic response. (Source: Psychosomatic Medicine)
http://www.medworm.com/rss/comments.php?id=6563217
Electrostimulation Device Shown to Improve FibromyalgiaElectrostimulation Device Shown to Improve Fibromyalgia
Medscape Today Headlines
10/3/2012 6:10:04 AM
Cortical stimulation treatment resulted in long-term improvement, a new trial shows. Medscape Medical News (Source: Medscape Today Headlines)

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Returning to the Revision
Psychology Today Depression Center
10/1/2012 10:02:59 AM
Diagnosing fibromyalgia has always involved grasping at a gestalt. Treating fibromyalgia has always involved fingers crossed. read more (Source: Psychology Today Depression Center)
http://www.medworm.com/rss/comments.php?id=6549270
Catechol-O-Methyltransferase Val158Met Polymorphism Influences Anxiety, Depression, and Disability, but not Pressure Pain Sensitivity, in Women With Fibromyalgia Syndrome
The Journal of Pain
9/30/2012 11:00:00 PM
This study is important because it strives to understand potential genetic factors that predispose some women with FMS to exhibit a more severe phenotypic expression of the disease. Future studies are needed to elucidate potential relevance of the differences.Perspective: This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes. This study provides further evidence of potential genetic factors that predispose women with FMS to exhibit the disease more severely. (Source: The Journal of Pain)
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Pain Is Associated With Short Leukocyte Telomere Length in Women With Fibromyalgia
The Journal of Pain
9/30/2012 11:00:00 PM
Abstract: Telomere length, considered a measure of biological aging, is linked to morbidity and mortality. Psychosocial factors associated with shortened telomeres are also common in chronic pain; yet, little is known about telomere length in pain populations. Leukocyte telomere length was evaluated in 66 women with fibromyalgia and 22 healthy female controls. Participants completed questionnaires and a subgroup of fibromyalgia patients underwent quantitative sensory testing (QST; n = 12) and neuroimaging (n = 12). Telomere length was measured using the quantitative polymerase chain reaction method. Although patients had shorter telomere length than controls, the difference was not statistically significant. However, higher levels of pain within fibromyalgia were associated with shorter te...
http://www.medworm.com/rss/comments.php?id=6552946
Helen Foundation Confirms Fibromyalgia Breakthrough
PRWeb: Medical Pharmaceuticals
9/29/2012 8:00:07 AM
Since commencement of the study in the year 2000, the 586 fibromyalgia patients enrolled for Microdose TherapyTM have reported dramatically greater symptom relief than reported for other treatments,...(PRWeb September 28, 2012)Read the full story at http://www.prweb.com/releases/2012/9/prweb9954305.htm (Source: PRWeb: Medical Pharmaceuticals)
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Role of Tai Chi in the Treatment of Rheumatologic Diseases
Current Rheumatology Reports
9/28/2012 10:56:36 AM
Abstract  Rheumatologic diseases (e.g., fibromyalgia, osteoarthritis, and rheumatoid arthritis) consist of a complex interplay between biologic and psychological aspects, resulting in therapeutically challenging chronic conditions to control. Encouraging evidence suggests that Tai Chi, a multi-component Chinese mind–body exercise, has multiple benefits for patients with a variety of chronic disorders, particularly those with musculoskeletal conditions. Thus, Tai Chi may modulate complex factors and improve health outcomes in patients with chronic rheumatologic conditions. As a form of physical exercise, Tai Chi enhances cardiovascular fitness, muscular strength, balance, and physical function. It also appears to be associated with reduced stress, anxiety, and depression, ...
http://www.medworm.com/rss/comments.php?id=6547239
Premier Biomedical, Inc. Issues Laboratory Testing Update
Medical News (via PRIMEZONE)
9/28/2012 7:00:00 AM
PORT RICHEY, Fla., Sept. 28, 2012 (GLOBE NEWSWIRE) -- Premier Biomedical, Inc. (OTCBB:BIEI), a research-based company that intends to discover and develop medical treatments for humans, specifically targeting the treatment of Alzheimer's Disease, Fibromyalgia, Multiple Sclerosis, Traumatic Brain Injury, Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig's Disease), Blood Sepsis and Viremia, and Cancer/Leukemia, today reported on recent successes in laboratory testing of its patent-pending technology at the University of Texas El Paso (UTEP). (Source: Medical News (via PRIMEZONE))
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The prevalence of fibromyalgia in patients with Behçet’s disease and its relation with disease activity
Rheumatology International
9/28/2012 12:56:01 AM
Abstract  Behçet’s disease (BD) is a chronic disorder characterized by mucocutaneous and multisystem manifestations. Fibromyalgia (FM) is characterized by widespread musculoskeletal pain and may be present concomitantly with several rheumatic diseases. Our aims were to investigate the prevalence of FM in patients with BD and to evaluate the possible relation of FM presence with BD disease activity. A total of 104 Behcet patients were included in this study. Age, sex, disease durations and the BD Current Activity Form (BDCAF) scores as disease activity evaluation were recorded. Presence of FM and the Fibromyalgia Impact Questionnaire (FIQ) scores was investigated. Also, ESR and CRP concentrations were determined in all patients. Mann–Whitney U test and Pearson’s correl...
http://www.medworm.com/rss/comments.php?id=6547233
Effects of a one week multidisciplinary inpatient self-management programme for patients with fibromyalgia: a randomised controlled trial
BMC Musculoskeletal Disorders
9/25/2012 11:00:00 PM
Conclusion: This study shows that in patients with FM the SMP had no effect on psychological distress, functional and symptomatic consequences and self-efficacy, except for a small short-term effect on skills and behaviour that are important for managing and participating in health care (EC-17). ClinicalTrials.gov Id: NCT01035125.Trial registrationClinicalTrials.gov Id: NCT01035125 (Source: BMC Musculoskeletal Disorders)
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SNRIs Show Inferiority to TCAs for Chronic PainSNRIs Show Inferiority to TCAs for Chronic Pain
Medscape Today Headlines
9/24/2012 12:27:54 PM
The antidepressants are commonly used for fibromyalgia and neuropathic pain; however reduction in average pain score is lower with SNRIs. Medscape Medical News (Source: Medscape Today Headlines)
http://www.medworm.com/rss/comments.php?id=6520299
Upper limb position control in fibromyalgia
BMC Musculoskeletal Disorders
9/23/2012 11:00:00 PM
Conclusion: FM patients exhibit an altered neuromuscular strategy for upper limb position control compared to HCs. The predominance of low-frequency limb oscillations among FM patients may indicate a sensory deficit. (Source: BMC Musculoskeletal Disorders)
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The Japanese version of the modified ACR Preliminary Diagnostic Criteria for Fibromyalgia and the Fibromyalgia Symptom Scale: reliability and validity
Modern Rheumatology
9/23/2012 10:36:43 AM
Conclusion  Our findings indicate that mACR 2010-J as a positive test and mFS-J as a quantification scale might be suitable for assessing fibromyalgia among Japanese chronic pain populations. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s10165-012-0759-xAuthors Chie Usui, Department of Psychiatry, Juntendo University Nerima Hospital, 3-1-10 Takanodai, Nerima-ku, Tokyo, 177-8521 JapanKotaro Hatta, Department of Psychiatry, Juntendo University Nerima Hospital, 3-1-10 Takanodai, Nerima-ku, Tokyo, 177-8521 JapanSatoko Aratani, Institute of Innovative Medical Science and Education, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402 JapanNaoko Yagishita, Institute of Medical Science, St. Marianna University School of Medicine...
http://www.medworm.com/rss/comments.php?id=6532538
Device to Ease Fibromyalgia Pain?
Dr. Weil Q and A
9/21/2012 6:10:18 AM
I've heard that there's some new method of treating the pain of fibromyalgia by stimulating the brain. Can you tell me anything about it? I would like to know how it works and where it is available. (Source: Dr. Weil Q and A)

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FIBROMYALGIA RELIEF (Arnica Montana,Lactic Acid,Strychnos Nux-Vomica Seed,Potassium Phosphate, Dibasic,Cupric Arsenite.) Pellet [Homeocare Laboratories]
DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
9/20/2012
Updated Date: Sep 20, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
http://www.medworm.com/rss/comments.php?id=6506396
Is It FM or CFS?
About.com Eating Disorders
9/19/2012 11:00:00 PM
It's often difficult to distinguish between fibromyalgia and chronic fatigue syndrome. Are they unrelated, siblings or twins? Researchers and specialists are still trying to determine the answer to this question. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6505997
The 2010 American college of rheumatology fibromyalgia survey diagnostic criteria and symptom severity scale is a valid and reliable tool in a French speaking fibromyalgia cohort
BMC Musculoskeletal Disorders
9/19/2012 11:00:00 PM
Background: Fibromyalgia (FM) is a pain condition with associated symptoms contributing to distress. The Fibromyalgia Survey Diagnostic Criteria and Severity Scale (FSDC) is a patient-administered questionnaire assessing diagnosis and symptom severity. Locations of body pain measured by the Widespread Pain Index (WPI), and the Symptom Severity scale (SS) measuring fatigue, unrefreshing sleep, cognitive and somatic complaints provide a score (0--31), measuring a composite of polysymptomatic distress. The reliability and validity of the translated French version of the FSDC was evaluated. Methods: The French FSDC was administered twice to 73 FM patients, and was correlated with measures of symptom status including: Fibromyalgia Impact Questionnaire (FIQ), Health Assessment Questionnaire (HAQ...

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Things Not to Say
About.com Eating Disorders
9/18/2012 11:00:00 PM
It can be hard talking to someone with fibromyalgia, chronic fatigue syndrome, or another invisible illness. See what things you should avoid and what to say instead. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6502241
Purine metabolites in fibromyalgia syndrome.
Clinical Biochemistry
9/17/2012 11:00:00 PM
CONCLUSIONS: Study results suggest that purines, in particular adenosine and inosine, may be involved in pain transmission in fibromyalgia. PMID: 23000315 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
http://www.medworm.com/rss/comments.php?id=6536815
Supplements: Getting Started
About.com Eating Disorders
9/17/2012 11:00:00 PM
Learn seven important things about supplements for fibromyalgia and chronic fatigue syndrome, including what to expect and what to look out for. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6494781
Treating fibromyalgia reduces overall costs
PharmacoEconomics and Outcomes News
9/17/2012 6:41:44 AM
(Source: PharmacoEconomics and Outcomes News)
http://www.medworm.com/rss/comments.php?id=6489946
Fibromyalgia: Neurological condition causing numbness, insomnia, pain and fatigue for 1.8m Britons
the Mail online | Health
9/17/2012 2:00:54 AM
Fibromyalgia is a neurological condition thought to affect 1.8 million Britons - and it blighted Sinead O'Conner's (pictured) career. There is no cure, but there ARE ways to cope. (Source: the Mail online | Health)

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Quantitative sensory testing somatosensory profiles in patients with cervical radiculopathy are distinct from those in patients with nonspecific neck–arm pain
Pain
9/12/2012 11:00:00 PM
Summary: Patients with cervical radiculopathy and patients with nonspecific neck–arm pain demonstrated distinctive somatosensory profiles, potentially reflecting differences in underlying pathophysiology and pain mechanisms.Abstract: The aim of this study was to establish the somatosensory profiles of patients with cervical radiculopathy and patients with nonspecific neck–arm pain associated with heightened nerve mechanosensitivity (NSNAP). Sensory profiles were compared to healthy control (HC) subjects and a positive control group comprising patients with fibromyalgia (FM). Quantitative sensory testing (QST) of thermal and mechanical detection and pain thresholds, pain sensitivity and responsiveness to repetitive noxious mechanical stimulation was performed in the maximal pain area, t...
http://www.medworm.com/rss/comments.php?id=6701429
Physical activity monitoring in adolescents with juvenile fibromyalgia: Findings from a clinical trial of cognitive behavioral therapy
Arthritis Care and Research
9/11/2012 11:00:00 PM
Conclusions: Actigraphy monitoring provides a unique source of information about patient outcomes. CBT intervention was not associated with increased physical activity in adolescents with JFM indicating that combining CBT with interventions to increase physical activity may enhance treatment effects. © 2012 by the American College of Rheumatology (Source: Arthritis Care and Research)
http://www.medworm.com/rss/comments.php?id=6475926
Inflammatory/Stress Feedback Dysregulation in Women with Fibromyalgia
Neuroimmunomodulation
9/11/2012 4:10:43 PM
Neuroimmunomodulation 2012;19:343–351 (DOI:10.1159/000341664) (Source: Neuroimmunomodulation)

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Health Tip: Help Ease Fibromyalgia Symptoms
Primary Care News - Doctors Lounge
9/11/2012 7:00:00 AM
Be sure to get enough sleep (Source: Primary Care News - Doctors Lounge)
http://www.medworm.com/rss/comments.php?id=6467716
Neuromuscular fatigue and exercise capacity in fibromyalgia syndrome
Arthritis Care and Research
9/9/2012 11:00:00 PM
Conclusion:Larger impairment in muscle contractility is associated with enhanced perception of exertion and reduced maximal exercise capacity in FMS patients. Neuromuscular impairments should be considered as an important factor underlying functional limitations in FMS patients. (Source: Arthritis Care and Research)
http://www.medworm.com/rss/comments.php?id=6460633
Panic Disorder
About.com Eating Disorders
9/7/2012 11:00:00 PM
Panic disorder is common in people with fibromyalgia and chronic fatigue syndrome. Learn how to recognize, treat and live with panic disorder. (Source: About.com Eating Disorders)

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http://www.medworm.com/rss/comments.php?id=6456093
Burden of Illness and Treatment Patterns for Patients with Fibromyalgia.
Pain Physician
9/6/2012 11:00:00 PM
Conclusions.  Burden of illness was high for patients with FM, and treatment patterns were highly variable. Importantly, the treatments with the most evidence to support their use were not always the most frequently chosen. PMID: 22958298 [PubMed - as supplied by publisher] (Source: Pain Physician)
http://www.medworm.com/rss/comments.php?id=6487226
Burden of Illness and Treatment Patterns for Patients with Fibromyalgia
Pain Medicine
9/6/2012 11:00:00 PM
Conclusions.  Burden of illness was high for patients with FM, and treatment patterns were highly variable. Importantly, the treatments with the most evidence to support their use were not always the most frequently chosen. (Source: Pain Medicine)
http://www.medworm.com/rss/comments.php?id=6452760
Effect of weight reduction on the quality of life in obese patients with fibromyalgia syndrome: a randomized controlled trial
Clinical Rheumatology
9/4/2012 11:56:28 AM
This study was a randomized controlled trial. Obese patients with fibromyalgia were randomly assigned to 6-month dietary weight loss (n = 41) and no weight loss (n = 42) groups. Patients were assessed at baseline and at 6 months. The primary outcome measure was FIQ. Secondary measures included the tender point (TP) examination, Beck Depression Inventory-II, and Pittsburg Sleep Quality Index. Compared to the control group, patients who underwent weight reduction obtained significantly better FIQ (p = 0.007), lower mean TP count (p = 0.015), and lower mean TP pain rating in the lower body (p < 0.001). Patients who lost weight had less depression and better sleep quality than the controls. Patients who lost weight had significantly lower interleukin 6 and C-rea...
http://www.medworm.com/rss/comments.php?id=6454835
2.17 Fibromyalgia
APLAR Journal of Rheumatology
9/2/2012 11:00:00 PM
(Source: APLAR Journal of Rheumatology)
http://www.medworm.com/rss/comments.php?id=6431687
Co-morbidities of interstitial cystitis.
Pain Physician
9/2/2012 4:15:03 PM
This study aimed to estimate the proportion of patients with interstitial cystitis/painful bladder syndrome (IC/BPS) with systemic dysfunction associated co-morbidities such as irritable bowel syndrome (IBS) and fibromyalgia (FM). Materials and Methods: Two groups of subjects with IC/BPS were included: (1) physician diagnosed patients with IC/BPS and (2) subjects meeting NIDDK IC/PBS criteria based on a questionnaire (ODYSA). These groups were compared to healthy controls matched for age and socio-economic status. NIDDK criteria required: pain with bladder filling that improves with emptying, urinary urgency due to discomfort or pain, polyuria >11 times/24 h, and nocturia >2 times/night. The ODYSA instrument evaluates symptoms pertaining to a range of disorders including chronic fa...
http://www.medworm.com/rss/comments.php?id=6429234
Norepinephrine
About.com Eating Disorders
9/1/2012 11:00:00 PM
Find out about the neurotransmitter norepinephrine and how abnormalities contribute to fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6428914
Nociceptor
About.com Eating Disorders
9/1/2012 11:00:00 PM
Definition of nociceptors. See how they're involved in the pain associated with fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6428916
Dopamine
About.com Eating Disorders
8/31/2012 11:00:00 PM
Definition of dopamine. See how dopamine is involved in fibromyalgia and chronic fatigue syndrome. Also get links to definitions of other terms related to fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6426059
Substance P
About.com Eating Disorders
8/31/2012 11:00:00 PM
Get a definition of substance p and find out how it is involved in fibromyalgia pain. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6426061
Hyperalgesia
About.com Eating Disorders
8/31/2012 11:00:00 PM
Get a definition of hyperalgesia and see how it's involved in fibromyalgia pain. (Source: About.com Eating Disorders)

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Central Sensitization
About.com Eating Disorders
8/31/2012 11:00:00 PM
Learn what sensitization and central sensitization mean and why the terms are associated with fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6426070
Glutamate
About.com Eating Disorders
8/31/2012 11:00:00 PM
Get a definition of glutamate and learn how it applies to fibromyalgia. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6426071
Serotonin
About.com Eating Disorders
8/31/2012 11:00:00 PM
Get a definition of serotonin and learn how it is linked to fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6426074
Allodynia
About.com Eating Disorders
8/31/2012 11:00:00 PM
Is your skin painful to touch? Allodynia is a type of fibromyalgia pain that can be caused by a simple touch, pressure from clothing, or gentle massage. Learn more about allodynia. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6426078
Pain Threshold
About.com Eating Disorders
8/31/2012 11:00:00 PM
Get a definition of pain threshold and see how it relates to fibromyalgia. (Source: About.com Eating Disorders)

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http://www.medworm.com/rss/comments.php?id=6426079
Tender Points
About.com Eating Disorders
8/31/2012 11:00:00 PM
Get a definition of fibromyalgia tender points and learn how they are used to diagnose the condition. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6426082
Cross‐Cultural Adaptation and Validation of the Brazilian Portuguese Version of the Pain Catastrophizing Scale
Pain Medicine
8/31/2012 11:00:00 PM
Conclusion.  Our findings support the validity and reliability of the BP‐PCS. The scale showed satisfactory psychometric properties. CFA provides support for the three‐factor structure reported in previous studies. This factor structure presented good discriminative properties to identify catastrophizers who present with mild chronic pain, fibromyalgia, and CTH. The BP‐PCS is a valuable tool for use in scientific studies and in the clinical setting in patients with chronic pain in Brazilian Portuguese‐speaking countries. (Source: Pain Medicine)
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Incorporate Nondrug Therapy for Fibromyalgia
Rheumatology News International
8/31/2012 11:00:00 PM
ESTES PARK, COLO. – Nonpharmacologic therapy is as important as medication in successful management of fibromyalgia, yet the nondrug interventions are greatly underused, according Dr. Sterling G. West. (Source: Rheumatology News International)

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Perfectionism and health functioning in women with fibromyalgia
Journal of Psychosomatic Research
8/30/2012 11:00:00 PM
Conclusion: Collectively, these findings clarify that overall levels of perfectionism are not elevated among women with fibromyalgia, but those women who are exceptionally high in levels of self-oriented perfectionism or high in socially prescribed perfectionism are particularly likely to suffer lower health functioning. These results suggest that perfectionism should be specifically assessed and targeted for intervention among women with fibromyalgia and there should be a particular emphasis on the pressure to meet perceived or actual expectations imposed on the self. (Source: Journal of Psychosomatic Research)
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Characteristics of referred muscle pain to the head from active trigger points in women with myofascial temporomandibular pain and fibromyalgia syndrome
The Journal of Headache and Pain
8/30/2012 4:09:24 PM
Abstract  Our aim was to compare the differences in the prevalence and the anatomical localization of referred pain areas of active trigger points (TrPs) between women with myofascial temporomandibular disorder (TMD) or fibromyalgia (FMS). Twenty women (age 46 ± 8 years) with TMD and 20 (age 48 ± 6 years) with FMS were recruited from specialized clinic. Bilateral temporalis, masseter, sternocleidomastoid, upper trapezius, and suboccipital muscles were examined for TrPs. TrPs were identified by palpation and considered active when the pain reproduced familiar pain symptom experienced by the patient. The referred pain areas were drawn on anatomical maps, digitalized and also measured. A new analysis technique based on a center of gravity (COG) m...
http://www.medworm.com/rss/comments.php?id=6429301
Role of Functional Brain Imaging in Understanding Rheumatic Pain
Current Rheumatology Reports
8/30/2012 4:05:13 PM
Abstract  Rheumatic pain and, in particular, rheumatoid arthritis, osteoarthritis and fibromyalgia, are common and debilitating chronic pain syndromes. Recently, human functional neuroimaging, for example EEG, fMRI, and PET has begun to reveal some of the crucial central nervous system mechanisms underlying these diseases. The purpose of this review is to summarise current knowledge on the brain mechanisms of rheumatic pain revealed by functional neuroimaging techniques. The evidence suggests that two mechanisms may be largely responsible for the clinical pain associated with these rheumatic diseases: abnormalities in the medial pain system and/or central nervous system sensitisation and inhibition. If we can understand how functioning of the central nociceptive system beco...
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Health Tip: Living With Fibromyalgia
The Doctors Lounge - Health News
8/30/2012 7:00:00 AM
Make sure you get enough sleep (Source: The Doctors Lounge - Health News)
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Health Tip: Living with Fibromyalgia
MedlinePlus Health News
8/30/2012 6:00:00 AM
Make sure you get enough sleep Source: HealthDay Related MedlinePlus Page: Fibromyalgia (Source: MedlinePlus Health News)
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Health Tip: Living With Fibromyalgia
MedicineNet Chronic Pain General
8/30/2012 2:00:00 AM
Title: Health Tip: Living With FibromyalgiaCategory: Health NewsCreated: 8/30/2012 8:05:00 AMLast Editorial Review: 8/30/2012 12:00:00 AM (Source: MedicineNet Chronic Pain General)
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Eliminate gout, arthritis and fibromyalgia pain FAST with 3 natural home remedies
NaturalNews.com
8/27/2012 1:00:00 AM
Anyone experiencing the pain of an acute gout or rheumatoid arthritis attack would sell their soul to get fast relief from the agony. Most drugs take time to build up in the system before relief occurs; and, many of those same drugs cause unacceptable side effects. What... (Source: NaturalNews.com)

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Cross-cultural adaptation and validation of a Bengali version of the modified fibromyalgia impact questionnaire
BMC Musculoskeletal Disorders
8/26/2012 11:00:00 PM
Conclusion: This study supports the reliability and validity of the B-FIQ as a measure of functional disability and health status in Bangladeshi women with FM. (Source: BMC Musculoskeletal Disorders)
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Health Tip: Defining Fibromyalgia
The Doctors Lounge - Health News
8/22/2012 7:00:00 AM
Symptoms typically include widespread pain and tender points (Source: The Doctors Lounge - Health News)
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High prevalence of orofacial complaints in patients with fibromyalgia: a case–control study
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
8/19/2012 11:00:00 PM
Conclusions: Orofacial complaints including TMD may be present either as symptoms of FS or as a comorbidity associated with this condition. A comprehensive evaluation of patients with FS is necessary to identify the need for specific treatments for orofacial complaints. Future studies, especially those with longitudinal design, should clarify whether a cause-effect relationship exists between orofacial complaints and fibromyalgia. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
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RealTimeRemedies Releases New Review to Educate Those with...
PRWeb: Medical Pharmaceuticals
8/18/2012 4:10:05 PM
RealTimeRemedies has launched a new informational review on the natural supplement Anatrin. This new report on the Fibromyalgia product will help the many people suffering with this ailment understand...(PRWeb August 18, 2012)Read the full story at http://www.prweb.com/releases/AnatrinReview/FibromyalgiaTreatment/prweb9814496.htm (Source: PRWeb: Medical Pharmaceuticals)
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Screening for the presence of FMR1 premutation alleles in a Spanish population with fibromyalgia
Clinical Rheumatology
8/17/2012 11:46:52 AM
Abstract  Fragile X mental retardation 1 (FMR1) premutation carriers, who are at risk of having children with fragile X Syndrome, were initially considered as clinically unaffected. However, recent clinical and molecular studies have shifted this point of view. The incidence of premutation in the general population is substantial. Apart from the well-documented fragile X-associated tremor–ataxia and fragile X premature ovarian insufficiency, there is a broad constellation of symptoms including depression, anxiety, muscle pain, autoimmune and thyroid disease, chronic fatigue, and fibromyalgia that has been described, particularly in females with the premutation (55–200 repeats). Fibromyalgia (FM) is the most common cause of widespread pain and comprises a heterogeneous g...

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Immune‐mediated disorders among women carriers of fragile X premutation alleles
American Journal of Medical Genetics Part A
8/16/2012 11:00:00 PM
Abstract The relative risk of immune‐mediated disorders (IMDs) among women carriers of premutation alleles is estimated by a survey for IMDs among 344 carrier women (age 19–81 years; mean 46.35 and SD 12.60) and 72 controls (age 18–87 years; mean 52.40 and SD 15.40). One hundred fifty four (44.77%) women carrier had at least one IMD, as did 20 controls (27.78%). Among women carriers, autoimmune thyroid disorder was the most common (24.4%), then fibromyalgia (10.2%), irritable bowel syndrome (IBS; 9.9%), Raynaud's phenomenon (7.6%), rheumatoid arthritis (RA; 3.8%), Sjögren syndrome (2.6%), systemic lupus erythematosus (SLE; 2.03%), multiple sclerosis (1.74%). Of 55 carriers age 40 or older with FXTAS, 72.73% had at least one IMD, compared to 46.54% of those without FXTAS (n = 159...
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Tonix Pharmaceuticals CEO Dr. Seth Lederman Describes Potential Treatment for Fibromyalgia, Post-Traumatic Stress Disorder and Traumatic Brain Injury
Drugs.com - Clinical Trials
8/16/2012 8:28:41 AM
Restful Sleep from a New Drug May Alleviate Chronic Pain, Lederman Says in Interview With CEOLive NEW YORK--(BUSINESS WIRE)--Aug 16, 2012 - Seth Lederman, M.D., President and CEO of New York City-based Tonix Pharmaceuticals Holding Corp.... (Source: Drugs.com - Clinical Trials)
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[Psychopharmacological treatment in patients with somatoform disorders and functional body syndromes.]
Der Nervenarzt
8/15/2012 11:00:00 PM
Authors: Kapfhammer HP Abstract Somatoform disorders and functional body syndromes define a major, diagnostically heterogeneous group of patients with medically unexplained physical symptoms. Psychopharmacological approaches can be derived from the conceptualization of somatoform symptoms and syndromes within a biopsychosocial model. The survey presented focuses on randomized, double-blind and placebo-controlled studies. Antidepressants show a statistically and clinically relevant impact on many somatoform symptoms. In special reference to pain symptoms serotonergic and noradrenergic antidepressants seem to mediate a more favorable effect than selective serotonin reuptake inhibitors. For some functional body syndromes, e.g. irritable bowel syndrome and fibromyalgia, a major analges...
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The efficacy of a multidisciplinary fibromyalgia treatment adapted for women with low educational levels: A randomised, controlled trial
Arthritis Care and Research
8/15/2012 11:00:00 PM
Conclusions.Multidisciplinary treatment adapted for individuals with low educational levels is effective in reducing key symptoms of FM. Some improvements were maintained one year after completing the multidisciplinary treatment. (Source: Arthritis Care and Research)
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Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient
Nutrition
8/15/2012 11:00:00 PM
In this report, we show the effect of CoQ10 treatment on clinical symptoms, blood mononuclear cells, and mitochondrial and oxidative stress markers from a woman with FM. After CoQ10 treatment, the patient reported a significant improvement of clinical symptoms. At the cellular level, CoQ10 treatment restored mitochondrial dysfunction and the mtDNA copy number, decreased oxidative stress, and increased mitochondrial biogenesis. Our results suggest that CoQ10 could be an alternative therapeutic approach for FM. (Source: Nutrition)

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Fibromyalgia: Unknown pathogenesis and a “chicken or the egg” causality dilemma
Nutrition
8/15/2012 11:00:00 PM
In this issue of Nutrition, Cordero et al. describe the alleviated symptoms in a woman with fibromyalgia during treatment with coenzyme Q10. The endogenous production of Q10 decreases with age , thus increasing the importance of nutritional intake. Q10 has been approved by the U.S. Food and Drug Administration for the treatment of mitochondrial disease in research. The restored mitochondrial function as described by Cordero et al. during Q10 treatment suggests that, in this case, mitochondrial dysfunction is likely to be the effector, and possibly even the primary, pathophysiologic mechanism. The hypothesis that mitochondrial dysfunction is involved in fibromyalgia has existed for some time, as exemplified by the mention of the word mitochondria 18 times in a 10-page review article publi...
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LiquidCMO Formulation Gives Dramatic Results For Fibromyalgia Patients
PRWeb: Medical Pharmaceuticals
8/15/2012 3:40:06 PM
First fully emulsified, natural and proprietary blend can help millions eliminate symptoms(PRWeb August 15, 2012)Read the full story at http://www.prweb.com/releases/2012/8/prweb9798145.htm (Source: PRWeb: Medical Pharmaceuticals)

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Tonix Pharmaceuticals Reports That Sublingual Formulation of Fibromyalgia Drug Reduces Production of a Psychoactive Metabolite, Improving Suitability for Long-Term, Chronic Treatment
Drugs.com - Clinical Trials
8/14/2012 8:08:45 AM
Results Further Support the Development of Sublingual TNX-102 to Treat Fibromyalgia by Improving Sleep NEW YORK--(BUSINESS WIRE)--Aug 14, 2012 - Tonix Pharmaceuticals Holding Corp. (OTCBB: TNXP) (“TONIX” or... (Source: Drugs.com - Clinical Trials)
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Medical Evidence Does Not Support Disability, Judge Rules
LexisNexis® Mealey's™ Disability Insurance Legal News
8/14/2012 2:00:15 AM
LAS VEGAS - An ERISA-governed disability insurer that denied benefits to a claimant with fibromyalgia acted reasonably, a Nevada federal judge ruled July 30 (Miae Decovich v. Venetian Casino Resort, LLC, et al., No. 2:11-cv-872, D. Nev. 2012 U.S. Dist. LEXIS 105465). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
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Predictors of multidisciplinary treatment outcome in fibromyalgia:a systematic review.
Disability and Rehabilitation
8/13/2012 11:00:00 PM
Discussion: It was found that a higher level of depression was a predictor of poor outcome in FM (moderate evidence). In addition, it was found that the baseline status, specific patient profiles, belief in fate, disability, and pain were predictors of the outcome of multidisciplinary treatment. Our results highlight the lack of high quality studies for evaluating predictors of the outcome of multidisciplinary treatment in FM. Further research on predictors of multidisciplinary treatment outcome is needed. [Box: see text]. PMID: 22889312 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
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Ditch healthy berries to beat muscle pain: The eating plan that helped me cure my aches and pains
the Mail online | Health
8/13/2012 9:00:14 PM
Dr Clare Morrison overcame fibromyalgia by cutting out certain foods - such as fruit, vegetables, salad, nuts and beans - from her diet. (Source: the Mail online | Health)
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[In Process Citation].
Reumatismo
8/12/2012 12:30:03 AM
Authors: Minelli A, Vaona A Abstract Fibromyalgia (FM) is a chronic disorder caused by a dysfunction of central nervous system sensitization. This syndrome is characterized by widespread pain and diffuse tenderness, but often also presents fatigue, sleep disturbances, and a whole range of symptoms such as morning stiffness, decreased physical function and dyscognition. FM is usually treated with pharmacological and non-pharmacological treatments. The non-pharmacological interventions include cognitive behavioral therapy (CBT), physiotherapy, acupuncture and patient education programs. In order to evaluate the efficacy of CBT and compare it with other non-pharmacological treatments, we performed a review of the meta-analytic literature. We evaluated the methodological quality of pub...

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Assessment of different instruments used as outcome measures in patients with fibromyalgia
Revista Brasileira de Reumatologia
8/11/2012 3:31:26 AM
CONCLUSION: Considering VSAC as gold standard, none of the instruments assessed could optimally identify a change in the health status of patients with fibromyalgia. (Source: Revista Brasileira de Reumatologia)
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Fibromyalgia and hysterectomy: the impact on health status and health care costs
Clinical Rheumatology
8/9/2012 2:16:28 PM
In this study, having a hysterectomy and a diagnosis of FMS was related to poorer health status and higher health care costs. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s10067-012-2051-zAuthors Maya S. Santoro, Joint Doctoral Program in Clinical Psychology, San Diego State University/ University of California, San Diego, San Diego, CA 92120-4913, USATerry A. Cronan, Joint Doctoral Program in Clinical Psychology, San Diego State University/ University of California, San Diego, San Diego, CA 92120-4913, USARebecca N. Adams, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USADhwani J. Kothari, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA Journal Clinical RheumatologyOnline ISSN 1434-9949Print IS...
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Qigong Eases Fibromyalgia Pain (CME/CE)
MedPage Today Primary Care
8/9/2012 10:00:54 AM
(MedPage Today) -- Routine practice of qigong, a form of meditative movement, significantly improved pain in patients with fibromyalgia and lessened the impact of the disorder, a randomized trial showed. (Source: MedPage Today Primary Care)
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Cyclobenzaprine
About.com Eating Disorders
8/8/2012 11:00:00 PM
See what studies show about cyclobenzaprine for treating fibromyalgia and get information on dosages and side effects. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6329878
Vulvodynia confers risk for other chronic pain syndromes
MedWire News - Ob/Gyn
8/8/2012 12:19:27 PM
Women who experience vulvodynia are more likely than those without the pain syndrome to have fibromyalgia, interstitial cystitis, and irritable bowel syndrome, research suggests. (Source: MedWire News - Ob/Gyn)

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Vulvodynia Ups Chances of Other Chronic Pain ConditionsVulvodynia Ups Chances of Other Chronic Pain Conditions
Medscape Today Headlines
8/7/2012 11:05:41 AM
Women with vulvodynia are 2 to 3 times more likely than their peers to be affected by other chronic pain conditions, such as interstitial cystitis, irritable bowel syndrome, or fibromyalgia. Medscape Medical News (Source: Medscape Today Headlines)
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Women With Vulvodynia At Much Higher Risk For Other Chronic Pain Conditions
Health News from Medical News Today
8/6/2012 2:00:00 AM
Millions of women suffer from unexplained vulvar pain so severe it can make intercourse, exercise and even sitting unbearable. New research now shows that women with this painful vaginal condition known as vulvodynia are two to three times more likely to also have one or more other chronic pain conditions, including irritable bowel syndrome, fibromyalgia (musculoskeletal pain) and interstitial cystitis (bladder pain)... (Source: Health News from Medical News Today)
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Myofascial Pain Syndrome
About.com Eating Disorders
8/5/2012 11:00:00 PM
Fibromyalgia and myofascial pain syndrome frequently go together and are sometimes confused for being the same condition. Learn the differences between fibromyalgia and myofascial pain syndrome symptoms, diagnosis, and treatment. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6310013
Reader Grocery Tips
About.com Eating Disorders
8/4/2012 11:00:00 PM
Get tips for successful grocery shopping from people with fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)
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FMS & Rheumatoid Arthritis
About.com Eating Disorders
8/4/2012 11:00:00 PM
Fibromyalgia and rheumatoid arthritis frequently go together. Find out their similarities and differences, how to treat the conditions when you have both fibromyalgia and rheumatoid arthritis, and get resources to help you maintain functionality. (Source: About.com Eating Disorders)
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Cigarette Smoking & FMS
About.com Eating Disorders
8/4/2012 11:00:00 PM
Did you know cigarette smoking and other tobacco use can make your fibromyalgia symptoms worse? Find out what the research shows, and get resources to help you quit. (Source: About.com Eating Disorders)
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Reader Laundry Tips
About.com Eating Disorders
8/4/2012 11:00:00 PM
Is it hard for you to do laundry because of fibromyalgia or chronic fatigue syndrome? Get some great laundry tips from other people like you. (Source: About.com Eating Disorders)

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New Fibromyalgia Disability Ruling from Social Security Administration
Disabled World
8/4/2012 2:12:08 PM
Social Security Administration Issues New Fibromyalgia Disability Ruling - Learn about the latest developments that may affect your right to Social Security Disability benefits. (Source: Disabled World)
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A randomized controlled trial of qigong for fibromyalgia
Arthritis Research and Therapy
8/2/2012 11:00:00 PM
Conclusions: This study demonstrates that CFQ, a particular form of qigong, provides long-term benefits in several core domains in fibromyalgia. CFQ may be a useful adjuvant self-care treatment for fibromyalgia.Trial Registration: clinicalrials.gov NCT00938834 (Source: Arthritis Research and Therapy)

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Language Impairment
About.com Eating Disorders
8/2/2012 11:00:00 PM
Brain fog and language impairment can be big problems in people with fibromyalgia and chronic fatigue syndrome. Learn about possible causes, treatments and how to live with brain fog and language problems. (Source: About.com Eating Disorders)

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Vaginal Pain May Mean Irritable Bowl Syndrome Or Fibromyalgia
Health News from Medical News Today
8/2/2012 4:00:00 PM
Unexplained vulvar pain, also known as vulvodynia, affects millions of women worldwide. It can be so severe that it makes exercise, intercourse and even sitting unbearable. A new study published in the journal American College of Obstetricians and Gynecologists has now revealed that women who suffer from this painful vaginal condition have a 2 to 3 times higher risk of also developing other chronic pain conditions, such as irritable bowel syndrome, interstitial cystitis known as and fibromyalgia or musculoskeletal pain... (Source: Health News from Medical News Today)
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Chronic vulvar pain related to irritable bowel syndrome, fibromyalgia and interstitial cystitis
EurekAlert! - Medicine and Health
8/1/2012 11:00:00 PM
(University of Michigan Health System) Increasingly prevalent chronic pain conditions are known to be under-diagnosed - and new data sheds more light on how they may also be related. (Source: EurekAlert! - Medicine and Health)
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Fibromyalgia and surgery.
Journal of Perianesthesia Nursing
7/31/2012 11:00:00 PM
Authors: Noble KA PMID: 22828026 [PubMed - in process] (Source: Journal of Perianesthesia Nursing)
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Tonix Pharmaceuticals Announces Completion of Clinical Trial of Sublingual TNX-102
Drugs.com - Clinical Trials
7/30/2012 8:30:09 AM
Results Support Development as a Bedtime Therapy for Fibromyalgia NEW YORK--(BUSINESS WIRE)--Jul 30, 2012 - Tonix Pharmaceuticals Holding Corp. (OTCBB: TNXP) (“TONIX” or the “Company”), a specialty pharmaceutical... (Source: Drugs.com - Clinical Trials)
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Understanding Fibromyalgia
About.com Eating Disorders
7/29/2012 11:00:00 PM
Have you tried to understand fibromyalgia but can't get past the medical jargon? Are you struggling to comprehend how a bizarre conglomeration of symptoms that come and go can all stem from one condition? Get a simple explanation of what's going on in the body of someone with fibromyalgia. (Source: About.com Eating Disorders)

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FMS Clothing Pain Tips
About.com Eating Disorders
7/28/2012 11:00:00 PM
Do you have fibromyalgia-related clothing pain? Get tips from other people like you on how to cut that pain out of your life. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6254672
Fibromyalgia Pain & Clothes
About.com Eating Disorders
7/28/2012 11:00:00 PM
Get tips for taking the fibromyalgia pain out of wearing clothing when your skin is painful to touch, including what to look for in a waistband, what fabrics tend to cause the least fibromyalgia pain, and other tips that work for people with fibromyalgia. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6254679
Short-term efficacy of topical capsaicin therapy in severely affected fibromyalgia patients
Rheumatology International
7/27/2012 10:45:18 AM
In conclusion, patients severely affected by fibromyalgia can obtain short-term improvements following topical capsaicin 0.075 % treatment three times daily for 6 weeks. Content Type Journal ArticleCategory Short CommunicationPages 1-6DOI 10.1007/s00296-012-2490-5Authors Benigno Casanueva, Rheumatology Service at the Specialist Clinic of Cantabria, Santander, SpainBaltasar Rodero, Rodero Center, Santander, SpainCovadonga Quintial, Neurophysiology Service, Santa Clotilde Hospital, Santander, SpainJavier Llorca, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IFIMAV, Santander, SpainMiguel A. González-Gay, Rheumatology Service, Hospital Universitario Marqués de Valdecilla. IFIMAV, Avenida Valdecilla 25, 39008 Santander, C...
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Differences between questionnaire- and interview-based measures of activities of daily living (ADL) ability and their association with observed ADL ability in women with rheumatoid arthritis, knee osteoarthritis, and fibromyalgia.
Scandinavian Journal of Rheumatology
7/27/2012 10:00:02 AM
CONCLUSION: Measures of self-reported ADL ability based on either questionnaire or interview have limited relationship to each other or to observed performance of ADL tasks. PMID: 22283877 [PubMed - indexed for MEDLINE] (Source: Scandinavian Journal of Rheumatology)

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Corrigendum to “Systematic review: Placebo response in drug trials of fibromyalgia syndrome and painful peripheral diabetic neuropathy—Magnitude and patient-related predictors” [PAIN® 152 (8) (2011) 1709–1717]
Pain
7/26/2012 11:00:00 PM
The authors would like to inform you that unfortunately some data were confounded in the following sentence of their ABSTRACT: The pooled WMD in the FMS-placebo group was 7.69 (95% confidence interval [CI] 6.10 to 9.29) and 17.11 (95% CI 16.41 to 17.90) in painful DPN. The pooled WMD in the FMS-active drug group was 13.96 (95% CI 11.93 to 15.99) and in painful DPN was 22.54 (95% CI 20.49 to 24.58). (Source: Pain)
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Association of herbal cannabis use with negative psychosocial parameters in patients with fibromyalgia
Arthritis Care and Research
7/26/2012 11:00:00 PM
ConclusionCannabinoids were used by 13% of patients referred with a diagnosis of FM. The association of herbal cannabis use with negative psychosocial parameters raises questions regarding the motive for this self‐medication practice. Although cannabinoids may offer some therapeutic effect, caution regarding any recommendation should be exercised pending clarification of general health and psychosocial problems, especially for those self‐medicating. (Source: Arthritis Care and Research)
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Norepinephrine Levels
About.com Eating Disorders
7/26/2012 11:00:00 PM
Learn about the the role of norepinephrine in fibromyalgia and chronic fatigue syndrome, the symptoms of low norepinephrine, medications and natural treatments for relief of symptoms caused by dysregulation of norepinephrine in fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6241193
Last observation carried forward approach threatens the validity of intent‐to‐treat analysis in fibromyalgia trials: Comment on the article by Arnold et al
Arthritis and Rheumatism
7/26/2012 11:00:00 PM
(Source: Arthritis and Rheumatism)
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FIBROMYALGIA REAL RELIEF (Calcarea Phosphorica, Ignatia Amara, Causticum, Rhus Toxicodendron, Magnesia Phosphorica, Bryonia, Arnica Montana) Tablet, Chewable [HOMEOLAB USA INC]
DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
7/26/2012
Updated Date: Jul 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
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Evaluation of Upper Extremity Nerve Conduction Velocities and the Relationship Between Fibromyalgia and Carpal Tunnel Syndrome
Archives of Medical Research
7/25/2012 11:00:00 PM
Background and Aims: We undertook this study to evaluate upper extremity nerve conduction velocities (NCVs) in fibromyalgia syndrome (FS) and the relationship of the electrophysiological findings between carpal tunnel syndrome (CTS) and FS.Methods: Sixty three right-handed female patients diagnosed with FS and 52 right-handed age- and gender-matched healthy controls were enrolled in the study. Conduction studies of the median and ulnar nerves and median nerve F-wave latencies were assessed in both upper extremities using standard methods. CTS was diagnosed electrophysiologically if the median nerve sensory NCV was decreased and/or motor distal latency (DL) was prolonged.Results: CTS was detected electrophysiologically in 26 (20.63%) of 126 extremities of 63 patients and in three (2.82%) of...
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Qigong Exercise for the Treatment of Fibromyalgia: A Systematic Review of Randomized Controlled Trials
The Journal of Alternative and Complementary Medicine
7/25/2012 2:25:05 PM
The Journal of Alternative and Complementary Medicine Jul 2012, Vol. 18, No. 7: 641-646. (Source: The Journal of Alternative and Complementary Medicine)

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Fibromyalgia and Surgery
Journal of PeriAnesthesia Nursing
7/24/2012 11:53:32 AM
FIBROMYALGIA IS A common chronic pain syndrome affecting the physical and mental well-being of millions of people worldwide. Fibromyalgia is more common in women than men, affecting approximately 4 to 8 million individuals in the United States. Originally described as fibrositis or psychogenic rheumatism, this disorder is highly individualized in scope and impact on activities of daily living (ADLs). Understanding fibromyalgia has evolved owing to the explosion of research interest and empirical data collection related to this multifaceted disorder. A perioperative experience may present special challenges for the patient with fibromyalgia, as this disorder can be exacerbated by many factors commonly associated with a surgical experience. Following a description of the physiology of norm...
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What Is Cymbalta (Duloxetine)?
Health News from Medical News Today
7/24/2012 2:00:00 AM
Cymbalta (Duloxetine), which is also sold under the brand names Duzela, Yentreve, Xeristar, and Ariclaim, is an SNRI (serotonin-norepinephrine reuptake inhibitor). It is prescribed for the treatment of major depressive disorder, generalized anxiety disorder, painful peripheral neuropathy (especially diabetic neuropathy), and osteoarthritis pain. Duloxetine is also prescribed for patients with fibromyalgia... (Source: Health News from Medical News Today)

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Awareness of diagnostic and clinical features of fibromyalgia among orthopedic surgeons
Rheumatology International
7/23/2012 3:56:37 PM
Abstract  Fibromyalgia Syndrome (FMS) is a chronic pain syndrome characterized by widespread musculoskeletal pain and fatigue. The current study was designed to evaluate the awareness and skills of orthopedic surgeons (OS) regarding FMS diagnosis and treatment. For the examination of awareness and familiarity of OS in Israel to Fibromyalgia, a questionnaire-based survey was conducted. Two hundred and nineteen OS, residents and specialists, were asked anonymously about awareness, knowledge, and treatment of FM. Multivariable statistical analysis was performed. 91 % (199) of responders reported that they recognized the disease. Notwithstanding, the mean knowledge score was 7.6 out of 17. In addition, OS who were trained in the south of Israel were found to have a better ...
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Quantitative assessment of the “inexplicability” of fibromyalgia patients: a pilot study of the fibromyalgia narrative of “medically unexplained” pain
Clinical Rheumatology
7/23/2012 3:53:53 PM
Abstract  The purpose of this study was to quantify the degree to which fibromyalgia patients perceive the cause of their pain to be inexplicable or difficult to understand. The author developed two simple Likert scales, Understand Pain Scale and Explain Pain Scale, which ask the subject to indicate the degree to which they are able to, respectively, understand the cause of their pain and to explain the cause of their pain to others. A total of 104 subjects who met the 1990 American College of Rheumatology Diagnostic Criteria for fibromyalgia (FM group), and 272 subjects with widespread pain who did not meet these criteria (non-FM group) completed these two instruments. On the Understand Pain Scale, 67.3 % of FM subjects endorsed either the item “understand very litt...
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Ipsilateral cortical activation in fibromyalgia patients during brushing correlates with symptom severity
Clinical Neurophysiology
7/22/2012 11:00:00 PM
Conclusions: Results indicate ipsilateral cortical activations in FMS patients, but not in healthy controls, during brushing. Ipsilateral ERD during brushing is associated with MTPS score suggesting abnormal processing of somatosensory input which may contribute to clinical pain.Significance: Altered functioning in FMS may reflect physiological changes in response to afferent somatosensory information manifesting in chronic pain. (Source: Clinical Neurophysiology)

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Erratum to “Cognitive Behavioral Therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgia” [PAIN® 153 (7) (2012) 1495–1503]
Pain
7/22/2012 11:00:00 PM
Please note that in the title of the published version of this article fibromyalgia was incorrectly spelled as fibromyalgeia. The Publisher apologises for this error. (Source: Pain)
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Ipsilateral cortical activation in fibromyalgia patients during brushing correlates with symptom severity.
Clinical Neurophysiology
7/19/2012 11:00:00 PM
CONCLUSIONS: Results indicate ipsilateral cortical activations in FMS patients, but not in healthy controls, during brushing. Ipsilateral ERD during brushing is associated with MTPS score suggesting abnormal processing of somatosensory input which may contribute to clinical pain. SIGNIFICANCE: Altered functioning in FMS may reflect physiological changes in response to afferent somatosensory information manifesting in chronic pain. PMID: 22819596 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
http://www.medworm.com/rss/comments.php?id=6328251
Monotherapy or Combination Therapy for Fibromyalgia Treatment?
Current Rheumatology Reports
7/18/2012 10:46:57 AM
Abstract  Fibromyalgia is a chronic pain disease whose clinical symptomatology also includes different symptom domains: fatigue, sleep disturbances, morning stiffness, dyscognition, and psychological distress. These associated symptoms usually vary in frequency and intensity from patient to patient. Because the efficacy of monotherapy is limited, more severely affected patients frequently require drug combinations. There is, however, scarce scientific information concerning the benefits and risks of such combinations. To date, only ten studies investigating the efficacy and tolerability of two-drug combinations have been published; some of these studies are old and/or studied drugs that are now known to be of little or no interest in fibromyalgia management. Thus, when poly...
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Predictors of pain and functioning over time in fibromyalgia syndrome: An autoregressive path analysis
Arthritis Care and Research
7/16/2012 11:00:00 PM
Conclusion:Our model suggests that self‐efficacy is a salient factor in fibromyalgia symptomatology. Our findings support designing interventions that use a multimodal approach, with an explicit focus on combining exercise (or other means) to improve physical functioning and psychotherapy (e.g., cognitive‐behavioral therapy) with the intention of reprocessing the functional improvements gained and the implications of these improvements for one's ability to manage their fibromyalgia symptoms. By doing so, self‐efficacy should be enhanced, which will produce the greatest and broadest benefits for fibromyalgia patients. (Source: Arthritis Care and Research)

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One in Eight With Fibromyalgia Uses Cannabis as MedicineOne in Eight With Fibromyalgia Uses Cannabis as Medicine
Medscape Rheumatology Headlines
7/15/2012 10:49:58 PM
One in eight people with fibromyalgia self-medicates with cannabis products, according to a new Canadian study. Reuters Health Information (Source: Medscape Rheumatology Headlines)
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High cell surface CD26-associated activities and low plasma adenosine concentration in fibromyalgia
Annals of the Rheumatic Diseases
7/13/2012 11:00:00 PM
The fibromyalgia syndrome (FMS) affects 2%–10% of the population. Its diagnosis is only based on a history of widespread pain involving limbs and trunk and mild or greater tenderness to digital palpation of tender points.1 While the role of several neurotransmitters including serotonin, dopamine and SP has been suggested, the influence of endogenous adenosine has never been investigated. Adenosine exerts strong antinociceptive effects mostly via the activation of A1 adenosine receptors2 following its release by endothelial cells and myocytes3 into the extracellular space where it is degraded by the enzyme adenosine deaminase (ADA). Large amounts of ADA are found at the surface of mononuclear cells (mononuclear cell adenosine deaminase activity; MCADA) in association with the multifun...
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One in eight with fibromyalgia uses cannabis as medicine
Reuters: Health
7/12/2012 9:32:55 PM
NEW YORK (Reuters Health) - One in eight people with the painful condition fibromyalgia self-medicate with pot and other cannabis products, according to a new Canadian study. (Source: Reuters: Health)
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Fibromyalgia Patients Self-Medicating With Cannabis May Have Poor Mental Health Outcomes
Health News from Medical News Today
7/11/2012 4:00:00 PM
According to new research, 10% of fibromyalgia (FM) patients use marijuana for medicinal relief to combat FM symptoms, such as unexplained fatigue, and insomnia, widespread pain and other somatic symptoms. Fibromyalgia is a chronic pain syndrome that affects around 3% of the population and is more common in women. Herbal cannabis has been used for centuries as a painkiller, but nowadays it is mainly used outside of conventional medicine... (Source: Health News from Medical News Today)
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Medicinal Marijuana Use Found in 10% of Fibromyalgia Patients
MedlinePlus Health News
7/11/2012 12:06:34 AM
Source: American College of Rheumatology Related MedlinePlus Pages: Fibromyalgia, Marijuana (Source: MedlinePlus Health News)

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Changes in pain and insulin-like growth factor 1 in fibromyalgia during exercise: the involvement of cerebrospinal inflammatory factors and neuropeptides
Arthritis Research and Therapy
7/8/2012 11:00:00 PM
Conclusions: The baseline level of serum free IGF-1 did not change during high or low-intensity of aerobic exercise. Changes in IGF-1 correlated positively with a variation in CSF SP, NPY and pain threshold. These data indicate a beneficial role of IGF-1 during exercise in FM.Trial registration. ClinicalTrials.gov NCT00643006. (Source: Arthritis Research and Therapy)
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An evaluation of anxiety and depression symptoms in fibromyalgia
Revista da Escola de Enfermagem da USP
7/8/2012 12:23:18 PM
The objective of this study was to identify the frequency of anxiety and depression symptoms by verifying the association between anxiety traits, current depression and anxiety symptoms in fibromyalgia patients. Interviews were performed with 60 subjects diagnosed with fibromyalgia at the Rheumatology Outpatient Clinic at Universidade Federal de Sergipe between August 2007 and March 2008, in which two questionnaires were administered: the Hospital Anxiety and Depression Scale (HADS) and the State-Trait Anxiety Inventory (STAI). The frequency of anxiety and depression symptoms was, respectively, 50% and 86% for individuals with fibromyalgia, and the mean trait-anxiety score was 59.38. An association was observed between trait and state anxiety. Anxiety and depression were frequent symptoms ...
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[Original Articles] The Effect of Duloxetine Treatment on Cognition in Patients With Fibromyalgia
Psychosomatic Medicine
7/5/2012 11:00:00 PM
Conclusions Although scores differed somewhat from norms for age, substantial cognitive impairment was not evident in patients with fibromyalgia as assessed by the Symbol Digit Substitution Test, Trail-Making Test, and Verbal Learning and Recall Test. Overall, duloxetine treatment had neither positive nor negative effects on cognition. Trial Registration Clintrials.gov NCT00673452. (Source: Psychosomatic Medicine)
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Targeting Cortical Representations in the Treatment of Chronic Pain: A Review
Neurorehabilitation and Neural Repair
7/4/2012 11:00:00 PM
Recent neuroscientific evidence has confirmed the important role of cognitive and behavioral factors in the development and treatment of chronic pain. Neuropathic and musculoskeletal pain are associated with substantial reorganization of the primary somatosensory and motor cortices as well as regions such as the anterior cingulate cortex and insula. What is more, in patients with chronic low back pain and fibromyalgia, the amount of reorganizational change increases with chronicity; in phantom limb pain and other neuropathic pain syndromes, cortical reorganization correlates with the magnitude of pain. These findings have implications for both our understanding of chronic pain and its prevention and treatment. For example, central alterations may be viewed as pain memories that modulate th...
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The comparative economic burden of mild, moderate, and severe fibromyalgia: results from a retrospective chart review and cross-sectional survey of working-age u.s. Adults.
Pain Physician
6/30/2012 11:00:00 PM
CONCLUSIONS: Direct and indirect costs related to fibromyalgia are higher among subjects with worse fibromyalgia severity. Indirect costs account for a majority of fibromyalgia-related costs at all fibromyalgia severity levels. PMID: 22839682 [PubMed - in process] (Source: Pain Physician)
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Multidisciplinary and biodanza intervention for the management of fibromyalgia.
Acta Reumatologica Portuguesa
6/30/2012 11:00:00 PM
Conclusions: 16 weeks of multidisciplinary intervention induced greater benefits than a Biodanza intervention for social functioning and the use of passive coping strategies in women with fibromyalgia. PMID: 23348113 [PubMed - as supplied by publisher] (Source: Acta Reumatologica Portuguesa)
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The Relationship Between Performances on Neuropsychological Symptom Validity Testing and the MCMI-III in Patients With Fibromyalgia.
The Clinical Neuropsychologist
6/30/2012 11:00:00 PM
This study investigated the association between Symptom Validity Test (SVT) performance and psychiatric symptoms as measured by the Millon Clinical Multiaxial Inventory-III (MCMI-III), a common measure of psychopathology. A total of 72 fibromyalgia patients at a tertiary care clinic completed the MCMI-III, an embedded cognitive symptom validity test (Reliable Digit Span), and a stand-alone cognitive symptom validity test (the Word Memory Test or Test of Memory Malingering). Of these patients, 21% failed a stand-alone SVT, whereas an additional 15% failed both a stand-alone and embedded SVT. Individuals who failed both stand-alone and embedded cognitive SVTs had higher scores on a number of MCMI-III personality subscales and had elevated scores on MCMI-III modifying indices compared to indi...
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Novel Drug Helped in Fibromyalgia (CME/CE)
MedPage Today Rheumatology
6/29/2012 12:43:08 PM
(MedPage Today) -- Treatment with a novel selective norepinephrine reuptake inhibitor led to decreases in pain among patients with fibromyalgia and lessened the impact of the disease on their daily lives, a large multicenter clinical trial found. (Source: MedPage Today Rheumatology)
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Brain Activity Reflects Pain in Fibromyalgia (CME/CE)
MedPage Today Primary Care
6/29/2012 8:00:00 AM
(MedPage Today) -- A novel functional MRI approach that measures resting brain activity and connectivity may provide a much-needed objective measure of pain in patients with fibromyalgia, researchers suggested. (Source: MedPage Today Primary Care)
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Mechanical and Heat Hyperalgesia Highly Predict Clinical Pain Intensity in Patients With Chronic Musculoskeletal Pain Syndromes
The Journal of Pain
6/27/2012 11:00:00 PM
Abstract: Multiple abnormalities in pain processing have been reported in patients with chronic musculoskeletal pain syndromes. These changes include mechanical and thermal hyperalgesia, decreased thresholds to mechanical and thermal stimuli (allodynia), and central sensitization, all of which are fundamental to the generation of clinical pain. Therefore, we hypothesized that quantitative sensory tests may provide useful predictors of clinical pain intensity of such patients. Our previous studies of fibromyalgia (FM) patients have shown statistically significant correlations of quantitative sensory test results with clinical pain intensity, including mechanical spatial summation, number of pain areas, wind-up, and wind-up aftersensations. Although these tests predicted up to 59% of the var...
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Information Seeking over the Course of Illness: The Experience of People with Fibromyalgia
Musculoskeletal Care
6/26/2012 11:00:00 PM
ConclusionThe areas of information need identified in the present study can be used to tailor patient education materials and information services to address contextual and temporal factors in the illness experiences of those with fibromyalgia. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Musculoskeletal Care)
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Illegal Marijuana Usage Among Fibromyalgia Patients
Health News from Medical News Today
6/26/2012 12:00:00 PM
Ten percent of individuals suffering from fibromyalgia (FM) buy marijuana illegally in order to relieve pain, according to a study published in the journal Arthritis Care & Research. According to Medilexicon's medical dictionary, Fibromyalgia is: "A common syndrome of chronic widespread soft-tissue pain accompanied by weakness, fatigue, and sleep disturbances; the cause is unknown." Dr... (Source: Health News from Medical News Today)
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Safety and efficacy of esreboxetine in patients with fibromyalgia: A fourteen‐week, randomized, double‐blind, placebo‐controlled, multicenter clinical trial
Arthritis and Rheumatism
6/25/2012 11:00:00 PM
ConclusionEsreboxetine was generally well tolerated and was associated with significant improvements in pain, FIQ, PGIC, and fatigue scores compared with placebo. The lack of a dose‐response relationship in both the efficacy and safety analyses suggests that esreboxetine at a dosage of 4 mg/day would offer clinical benefit with the least risk of drug exposure. (Source: Arthritis and Rheumatism)
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Brief Report: Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia
Arthritis and Rheumatism
6/25/2012 11:00:00 PM
ConclusionOur findings suggest that intrinsic brain connectivity can be used as a candidate objective marker that reflects changes in spontaneous chronic pain within individual FM patients. We propose that intrinsic connectivity measures could potentially be used in either research or clinical settings as a complementary, more objective outcome measure for use in FM. (Source: Arthritis and Rheumatism)

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Online Acceptance-based Behavioural Treatment for Fibromyalgia
ClinicalTrials.gov
6/25/2012 11:00:00 AM
Condition:   Fibromyalgia SyndromeInterventions:   Behavioral: Acceptance-based behavioural therapy;   Other: Will vary per participantSponsors:   University of Manitoba;   University of ManitobaNot yet recruiting - verified July 2012 (Source: ClinicalTrials.gov)

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Characteristics of elderly patients with fibromyalgia: a pilot retrospective study.
Aging Clinical and Experimental Research
6/24/2012 11:00:00 PM
The objective of the study was to know better what are some of their specificities in order to tailor the management of elderly patients with FM as well as possible. Methods: Retrospective chart review of all patients with a diagnosis of FM addressed to the pain consultation of a geriatric hospital, have been analysed. Results: Forty patients (38 women and 2 men) were included. Mean age at the moment of diagnosis of FM was (±SD) 75±9.1 years. Patients were hospitalized mean (±SD) 6 ±5.2 years after onset of FM. Median pain intensity measured by a visual or numerical pain scale was 6 at rest and 9 during mobilisation. Seventeen patients were isolated at home because of pain. Symptoms associated with FM were depression (n: 25), fatigue and poor sleep quality (n: 24), anxiety (n: 15), irr...
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Is fibromyalgia part of the climacteric syndrome?
Maturitas
6/24/2012 11:00:00 PM
Abstract: Fibromyalgia syndrome (FMS) is a disorder usually affecting middle aged women, who complain of diffuse musculoskeletal aches, pains or stiffness associated with tiredness, anxiety and poor sleep. Neurotransmission disorders linked both to pain perception as well as mood, sleep and cognition modulation are involved in FMS etiopathogenesys. Treatments that may be effective to decrease pain and fatigue include tricyclic antidepressants, dual reuptake inhibitors of serotonin/noradrenalin and pregabalin. The climacteric syndrome is a set of symptoms caused by the decline of ovarian hormone levels, which alters brain neurotransmission and provokes musculoskeletal pains, mood disorders, poor sleep quality and hot flushes. The hormone therapy reverses those symptoms and its risks are mar...
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1 in 10 Fibromyalgia Patients Uses Marijuana to Ease Pain
MedlinePlus Health News
6/22/2012 8:00:00 AM
They also tend to have poorer mental health, researchers say Source: HealthDay Related MedlinePlus Pages: Fibromyalgia, Marijuana (Source: MedlinePlus Health News)
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Perceived injustice in fibromyalgia: Psychometric characteristics of the Injustice Experience Questionnaire and relationship with pain catastrophising and pain acceptance
Journal of Psychosomatic Research
6/21/2012 11:00:00 PM
Conclusion: The IEQ is a reliable assessment tool for measuring PI among patients with fibromyalgia. PI seems to be distinct from catastrophising, although the two constructs are very similar. The factor analysis showed that PI and acceptance represent related constructs, and this entails relevant implications for therapy, as acceptance-based interventions would be appropriate. (Source: Journal of Psychosomatic Research)
http://www.medworm.com/rss/comments.php?id=6200330
The Effects of Meditation-Based Interventions on the Treatment of Fibromyalgia
Current Pain and Headache Reports
6/21/2012 2:02:37 AM
Abstract  Meditation is the third most commonly requested complementary and alternative medicine (CAM) therapy reported in a US survey. Those who suffer from chronic pain are those who most frequently use CAM therapies. This review aims to evaluate whether meditation-based interventions can help the treatment of fibromyalgia. A PubMed search was conducted using the terms “fibromyalgia” and “meditation”, or “mindfulness”, or “mantra” or “relaxation response”. We selected articles which clearly described a meditation intervention being used in the treatment of fibromyalgia. Only four articles were classified with score 3 in the Jadad scale. Another seven articles were included in this review. Most of the results indicate improvement in fibromyalgia-related ...

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Brain Imaging in Fibromyalgia
Current Pain and Headache Reports
6/21/2012 2:02:35 AM
Abstract  Fibromyalgia is a primary brain disorder or a result of peripheral dysfunctions inducing brain alterations, with underlying mechanisms that partially overlap with other painful conditions. Although there are methodologic variations, neuroimaging studies propose neural correlations to clinical findings of abnormal pain modulation in fibromyalgia. Growing evidences of specific differences of brain activations in resting states and pain-evoked conditions confirm clinical hyperalgesia and impaired inhibitory descending systems, and also demonstrate cognitive-affective influences on painful experiences, leading to augmented pain-processing. Functional data of neural activation abnormalities parallel structural findings of gray matter atrophy, alterations of intrinsic c...
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Medicinal Marijuana Use Found In 10% Of Fibromyalgia Patients
Health News from Medical News Today
6/21/2012 2:00:00 AM
Doctors Caution Self-medicating with Herbal Cannabis Sparks Poor Mental Health New research reveals that 10% of fibromyalgia (FM) patients use marijuana for medicinal relief from symptoms such as widespread pain, fatigue, and insomnia caused by this chronic illness. Findings published in Arthritis Care & Research, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR), suggest that patients who self-medicate with herbal cannabis have poorer mental health... (Source: Health News from Medical News Today)
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Pot Popular for Pain in Fibromyalgia (CME/CE)
MedPage Today Psychiatry
6/20/2012 11:01:00 PM
(MedPage Today) -- Use of cannabinoids for medicinal purposes -- particularly for pain relief -- is popular among patients with fibromyalgia, who either smoke marijuana or take synthethic prescription formulations, a Canadian study found. (Source: MedPage Today Psychiatry)
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A Survey of Conventional and Complementary Therapies Used by Youth with Juvenile-Onset Fibromyalgia
Pain Management Nursing
6/20/2012 11:00:00 PM
Abstract: Little is known regarding treatment choices of youth diagnosed with juvenile-onset fibromyalgia (JFM) as they move into young adulthood. Additionally, there is little empirical evidence to guide youth with FM into appropriate treatment options, leading to a variety of therapies used to manage FM symptoms. The purpose of this descriptive study was to examine all therapies used by individuals with JFM as they entered young adulthood and the perceived effectiveness of these treatments. As part of a larger follow-up study, participants completed a web-based survey of all current and past treatments received for FM symptoms 2 years after their initial presentation and diagnosis at a pediatric rheumatology clinic. One hundred ten out of 118 eligible patients participated in the follow-...
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Judge: Fibromyalgia Diagnosis Cannot Be Measured Objectively
LexisNexis® Mealey's™ Disability Insurance Legal News
6/20/2012 10:00:16 PM
NASHVILLE, Tenn. - A Tennessee federal judge on May 25 ruled that a claimant's fibromyalgia cannot be measured by objective tests, finding that an ERISA-governed disability insurer's benefit denial was arbitrary and capricious (Sandra Edwards v. The Lincoln National Life Insurance Co., No. 3:11-00021, M.D. Tenn.; 2012 U.S. Dist. LEXIS 73421). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
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Use of Gabapentin and Pregabalin for Hand Surgery Patients
The Journal of Hand Surgery
6/20/2012 12:18:12 PM
The widespread interest of 2 anticonvulsants, gabapentin (Neurontin; Pfizer, Inc., New York, NY) and pregabalin (Lyrica; Pfizer, Inc.), is reflected by their clinical versatility and over 1500 related publications in just the past 5 years. Gabapentin is a synthetic analog of gamma-aminobutyric acid, initially approved by the US Food and Drug Administration (FDA) in 1994 for the adjunctive treatment of seizure disorders. One decade later, pharmacologically similar pregabalin received FDA approval for the treatment of partial onset seizures, diabetic neuropathy, and postherpetic neuralgia. In 2007, pregabalin became the first FDA-approved medication indicated specifically for the treatment of fibromyalgia. Prescriptions intended for off-label uses, however, constitute a vast majority of tota...
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Validation of the Fibromyalgia Survey Questionnaire within a Cross-Sectional Survey.
Pain Physician
6/20/2012 12:06:02 PM
Authors: Häuser W, Jung E, Erbslöh-Möller B, Gesmann M, Kühn-Becker H, Petermann F, Langhorst J, Weiss T, Winkelmann A, Wolfe F Abstract The Fibromyalgia Survey Questionnaire (FSQ) assesses the key symptoms of fibromyalgia syndrome. The FSQ can be administrated in survey research and settings where the use of interviews to evaluate the number of pain sites and extent of somatic symptom intensity and tender point examination would be difficult. We validated the FSQ in a cross-sectional survey with FMS patients. In a cross-sectional survey, participants with physician diagnosis of FMS were recruited by FMS-self help organisations and nine clinical institutions of different levels of care. Participants answered the FSQ (composed by the Widespread Pain Index...
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The role of benign joint hypermobility in the pain experience in Juvenile Fibromyalgia: an observational study
Pediatric Rheumatology
6/14/2012 11:00:00 PM
Conclusion: The presence of HM among adolescent patients with JFM appears to be associated with enhanced physiologic pain sensitivity, but not self-report of clinical pain. Further examination of the mechanisms for increased pain sensitivity associated with HM, especially in adolescents with widespread pain conditions such as JFM is warranted. (Source: Pediatric Rheumatology)

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Narcolepsy Drug Aids Sleep, Pain in Fibromyalgia (CME/CE)
MedPage Today State Required CME
6/14/2012 10:59:30 AM
(MedPage Today) -- Patients with fibromyalgia treated with the narcolepsy drug sodium oxybate (Xyrem) had significant improvements in the important clinical domains of pain and sleep, an international study showed. (Source: MedPage Today State Required CME)

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The Impact of a Nurse‐Led Chronic Musculoskeletal Pain Clinic on Healthcare Utilization
Musculoskeletal Care
6/12/2012 11:00:00 PM
ConclusionA nurse‐led chronic pain clinic for fibromyalgia patients can have a positive impact on primary and secondary healthcare utilization.Relevance to clinical practiceHaving a designated nurse‐led pain clinic can enable patients to access the appropriate service at an earlier stage in their condition and receive the support needed to manage the impact of their pain. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Musculoskeletal Care)
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Hinders for continued work among persons with fibromyalgia
BMC Musculoskeletal Disorders
6/10/2012 11:00:00 PM
Conclusions: Limited physical capacity and an increased need of rest made it difficult for these women to manage the physical, psychosocial and organizational work demands. Adjustment of the work tasks and work environment were the main factors influencing whether the women with FM could work or not. (Source: BMC Musculoskeletal Disorders)
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A case of fibromyalgia syndrome with anaphylaxis induced by intradermal injection of purified protein derivative
Modern Rheumatology
6/10/2012 8:34:52 AM
Abstract  When a 36-year-old woman with fibromyalgia syndrome (FMS) underwent the tuberculin test, urticaria developed on her trunk at 30 min after intradermal injection of purified protein derivative. Although the urticaria resolved, fever, facial edema, and generalized urticaria occurred after 8 h. A patient with FMS who developed a systemic allergic reaction after an intradermal skin test has not been reported. We should pay attention to anaphylactic reactions after intradermal injection in patients with FMS. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10165-012-0679-9Authors Etsuko Maeshima, Department of Health and Sport Management, Osaka University of Health and Sport Sciences, 1-1 Asashirodai, Kumatori-cho, Sennan-gun, Osaka 5...
http://www.medworm.com/rss/comments.php?id=6152744
Linking disease symptoms and subtypes with personalized systems-based phenotypes: A proof of concept study.
Brain, Behavior, and Immunity
6/8/2012 11:00:00 PM
Authors: Aschbacher K, Adam EK, Crofford LJ, Kemeny ME, Demitrack MA, Ben-Zvi A Abstract A dynamic systems model was used to generate parameters describing a phenotype of Hypothalamic-Pituitary-Adrenal (HPA) behavior in a sample of 36 patients with chronic fatigue syndrome (CFS) and/or fibromyalgia (FM) and 36 case-matched healthy controls. Altered neuroendocrine function, particularly in relation to somatic symptoms and poor sleep quality, may contribute to the pathophysiology of these disorders. Blood plasma was assayed for cortisol and ACTH every 10min for 24h. The dynamic model was specified with an ordinary differential equation using three parameters: (1) ACTH-adrenal signaling, (2) inhibitory feedback, and (3) non-ACTH influences. The model was "personalized" by estimating a...
http://www.medworm.com/rss/comments.php?id=6180540
In Fibromyalgia, It's Not the Weather (CME/CE)
MedPage Today Meeting Coverage
6/7/2012 4:56:33 PM
BERLIN (MedPage Today) -- Many patients with fibromyalgia blame worsening of their symptoms on the weather, but when the effects of different weather conditions were analyzed, very few and only small effects were seen, a Dutch researcher said here. (Source: MedPage Today Meeting Coverage)
http://www.medworm.com/rss/comments.php?id=6142653
Amisulpride in the treatment of fibromyalgia: an uncontrolled study
Clinical Rheumatology
6/5/2012 1:03:45 AM
Abstract  Some antipsychotics, including amisulpride, have shown to be effective in the treatment of various painful conditions, lessening pain as well as symptoms of anxiety and/or depression. In this open-label, 12-week study, we explored the efficacy and tolerability of amisulpride in patients with fibromyalgia. We recruited 40 patients, 1 male and 39 females, aged 46.2 ± 6.8 years, who met the ACR criteria for fibromyalgia and had a score equal to or greater than 4 in the pain severity item of the Fibromyalgia Impact Questionnaire (FIQ). Amisulpride was added to their current treatment regimen at an initial dose of 25 mg/day and titrated according to the clinical response and tolerability (mean final dose, 87.5 ± 41.3 mg/day). In the intent-to-tr...

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TEMPORARY FIBROMYALGIA PAIN AND DISCOMFORT RELIEF (Aconitum Napellus, Atropa Belladonna, Causticum, Magnesium Phosphate, Dibasic, Strychnos Nux-Vomica Seed, Toxicodendron Pubescens Leaf) Tablet, Multilayer [TRP Company]
DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST)
6/5/2012
Updated Date: Jun 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
http://www.medworm.com/rss/comments.php?id=6134424
Phenytoin for neuropathic pain and fibromyalgia in adults
NeLM - Drug Specific Reviews
6/4/2012 11:00:00 PM
Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Phenytoin is an established antiepileptic drug that has been used occasionally to treat intractable trigeminal neuralgia.   Objectives To assess the analgesic efficacy and adverse effects of the antiepileptic drug phenytoin in neuropathic pain and fibromyalgia.   Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 2), MEDLINE, and EMBASE to 28 February 2012, together with reference lists of retrieved papers and reviews, and ClinicalTrials.gov.   Selection criteria We p...
http://www.medworm.com/rss/comments.php?id=6135555
The association between overactive bladder and fibromyalgia syndrome: A community survey
Neurourology and Urodynamics
6/4/2012 11:00:00 PM
ConclusionsOAB is associated with FMS. Moreover FMS increases with severity of OAB. Neurourol. Urodynam. © 2012 Wiley Periodicals, Inc. (Source: Neurourology and Urodynamics)
http://www.medworm.com/rss/comments.php?id=6134923
Does abnormal non-rapid eye movement sleep impair declarative memory consolidation? Disturbed thalamic functions in sleep and memory processing
Sleep Medicine Reviews
6/4/2012 11:29:12 AM
Summary: Non-rapid eye movement (NREM) sleep has recently garnered support for its role in consolidating hippocampus-based declarative memories in humans. We provide a brief review of the latest research on NREM sleep activity and its association with declarative memory consolidation. Utilizing empirical findings from sleep studies on schizophrenia, Alzheimer’s disease, and fibromyalgia, we argue that a significant reduction of slow-wave sleep and sleep spindle activity contribute to the development of deficits in declarative memory consolidation along with concomitant sleep disturbances commonly experienced in the aforementioned disorders. A tentative model is introduced to describe the mediating role of the thalamocortical network in disruptions of both declarative memory consolidation...
http://www.medworm.com/rss/comments.php?id=6129410
Temporal Summation of Pain Is Not Amplified in a Large Proportion of Fibromyalgia Patients
International Journal of Photoenergy
6/3/2012 9:16:01 AM
Discussion. Our results suggest that temporal summation of pain is normal, rather than increased, in a large proportion of FM patients. Future studies on temporal summation in FM will need to be careful since some FM patients require abnormally low experimental temperatures that may confound results and make necessary to separate patients into subgroups. (Source: International Journal of Photoenergy)
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Researcher Calls For Expansion Of Programs To Identify Potential Drug Abusers And Protect Pain Patients
Health News from Medical News Today
6/1/2012 2:00:00 AM
Individual use of prescription opioids has increased four-fold since the mid-1990s, in part due to increased awareness of pain control for chronic conditions such as low back pain and fibromyalgia and a Joint Commission mandate that hospitals assess patients' pain as a "vital sign" along with their blood pressure and temperature. During the same timeframe, however, the number of people using these drugs recreationally, becoming addicted to them, and dying of overdoses has also shot up... (Source: Health News from Medical News Today)
http://www.medworm.com/rss/comments.php?id=6119138
A Review of Duloxetine 60 mg Once‐Daily Dosing for the Management of Diabetic Peripheral Neuropathic Pain, Fibromyalgia, and Chronic Musculoskeletal Pain Due to Chronic Osteoarthritis Pain and Low Back Pain
Pain Practice
5/31/2012 11:00:00 PM
Conclusions:  The studies reviewed report that duloxetine 60 mg once‐daily dosing is an effective option for the management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain due to chronic OA pain and chronic LBP. As these pains are often comorbid with MDD or GAD, duloxetine might possess the pharmacologic properties to be a versatile agent able to address several symptoms in these patients. With adequate attention to FDA prescribing guidance regarding safety and drug–drug interactions, duloxetine 60 mg once‐daily dosing appears to be an effective option in the appropriate pain patient population. (Source: Pain Practice)
http://www.medworm.com/rss/comments.php?id=6173126
Aquatic exercise & balneotherapy in musculoskeletal conditions
Best Practice and Research. Clinical Rheumatology
5/31/2012 11:00:00 PM
This is a best-evidence synthesis providing an evidence-based summary on the effectiveness of aquatic exercises and balneotherapy in the treatment of musculoskeletal conditions. The most prevalent musculoskeletal conditions addressed in this review include: low back pain, osteoarthritis, fibromyalgia and rheumatoid arthritis. Over 30 years of research demonstrates that exercises in general, and specifically aquatic exercises, are beneficial for reducing pain and disability in many musculoskeletal conditions demonstrating small to moderate effect sizes ranging between 0.19 and 0.32. Balneotherapy might be beneficial, but the evidence is yet insufficient to make a definitive statement about its use. High-quality trials are needed on balneotherapy and aquatic exercises research especially in ...
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Clinical characteristics of 150 consecutive fibromyalgia patients attending an Australian public hospital clinic
APLAR Journal of Rheumatology
5/31/2012 11:00:00 PM
ConclusionBaseline clinical characteristics in this group were comparable to other study populations. The use of management modalities with proven benefit in fibromyalgia was limited; however, those patients who were engaged in regular exercise or using medication had better self‐reported outcome measures than those who were not. (Source: APLAR Journal of Rheumatology)
http://www.medworm.com/rss/comments.php?id=6197368
[The role of orthopedic surgeons in the treatment of fibromyalgia].
Der Orthopade
5/31/2012 11:00:00 PM
Authors: Hettfleisch J, Späth M PMID: 22644059 [PubMed - in process] (Source: Der Orthopade)
http://www.medworm.com/rss/comments.php?id=6183733
Herbal cannabis use in patients labeled as fibromyalgia is associated with negative psychosocial parameters
Arthritis Care and Research
5/31/2012 11:00:00 PM
Conclusion:Cannabinoids were used by 13% of patients referred with a diagnosis of FM. The association of herbal cannabis use with negative psychosocial parameters raises questions regarding the motive for this self‐medication practice. Although cannabinoids may offer some therapeutic effect, caution regarding any recommendation should be exercised pending clarification of general health and psychosocial problems, especially for those self‐medicating. (Source: Arthritis Care and Research)

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Comorbidities of Central Nervous System Hypersomnia
Sleep Medicine Clinics
5/31/2012 11:54:20 AM
Patients with central nervous system hypersomnia may have a spectrum of comorbid medical, neurologic, and psychiatric conditions. These include eating disorders and obesity, diabetes, schizophrenia, depression, fibromyalgia, migraine headaches, cognitive dysfunction, and psychosocial impairment. The associations between narcolepsy and many of these comorbid medical problems have not been clearly defined, and there are often conflicting data in the medical literature. Nevertheless, it is important to be aware of possible associated medical comorbidities when caring for patients with narcolepsy to facilitate early diagnosis and treatment of these disorders. (Source: Sleep Medicine Clinics)

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Stress perception and depressive symptoms: functionality and impact on the quality of life of women with fibromyalgia
Revista Brasileira de Reumatologia
5/29/2012 2:06:46 PM
CONCLUSION: The relationship between stress, depression and functionality seems to be part of a complex mechanism, which might affect the quality of life of patients with FM. (Source: Revista Brasileira de Reumatologia)
http://www.medworm.com/rss/comments.php?id=6107879
Omega-3 Fatty Acids
About.com Eating Disorders
5/27/2012 11:00:00 PM
See what benefits omega-3 fatty acids may have for fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)

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http://www.medworm.com/rss/comments.php?id=6103808
Cognitive Behavioral Therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgeia
Pain
5/21/2012 11:00:00 PM
Summary: Treatment with Cognitive Behavioral Therapy leads to clinical improvements in fibromyalgia patients, paired with increased activity and connectivity in the brain’s pain modulatory regions.Abstract: Interventions based on Cognitive Behavioral Therapy (CBT) are widely used to treat chronic pain, but the brain mechanisms responsible for these treatment effects are poorly understood. The aim of this study was to validate the relevance of the cortical control theory in response to an exposure-based form of CBT, Acceptance and Commitment Therapy, in patients with chronic pain. Forty-three female patients diagnosed with fibromyalgia syndrome were enrolled in a randomized, 12-week, waiting-list controlled clinical trial (CBT n=25; controls n=18). CBT was administered in groups of six pa...
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Pfizer Exploratory Study Measures Effects Of Lyrica (pregabalin) On Brain Activity In Fibromyalgia Patients
Drugs.com - Clinical Trials
5/18/2012 8:22:50 AM
First fMRI Data in Fibromyalgia Among Lyrica Presentations at APS Meeting   NEW YORK--(BUSINESS WIRE)--May 18, 2012 - Pfizer Inc. (NYSE: PFE) announced today the results of studies on Lyrica® (pregabalin) capsules CV presented at... (Source: Drugs.com - Clinical Trials)

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German fibromyalgia consumer reports - a crosssectional survey
BMC Musculoskeletal Disorders
5/17/2012 11:00:00 PM
Conclusion: The German fibromyalgia consumer reports highlight the importance of non-pharmcological therapies in the long-term management of FMS, and challenges the strong recommendationsfor drug therapies given by FMS-guidelines. (Source: BMC Musculoskeletal Disorders)

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[Comparison between aquatic-biodanza and stretching for improving quality of life and pain in pations with fibromyalgia.]
Atencion Primaria
5/13/2012 11:00:00 PM
CONCLUSIONS: The biodanza aquatic exercises improve pain and quality of life in fibromyalgia patients. PMID: 22591551 [PubMed - as supplied by publisher] (Source: Atencion Primaria)
http://www.medworm.com/rss/comments.php?id=6184054
A randomized controlled trial of 8-form Tai chi improves symptoms and functional mobility in fibromyalgia patients
Clinical Rheumatology
5/13/2012 1:00:42 AM
Abstract  Previous researchers have found that 10-form Tai chi yields symptomatic benefit in patients with fibromyalgia (FM). The purpose of this study was to further investigate earlier findings and add a focus on functional mobility. We conducted a parallel-group randomized controlled trial FM-modified 8-form Yang-style Tai chi program compared to an education control. Participants met in small groups twice weekly for 90 min over 12 weeks. The primary endpoint was symptom reduction and improvement in self-report physical function, as measured by the Fibromyalgia Impact Questionnaire (FIQ), from baseline to 12 weeks. Secondary endpoints included pain severity and interference (Brief Pain Inventory (BPI), sleep (Pittsburg sleep Inventory), self-efficacy, and ...
http://www.medworm.com/rss/comments.php?id=6061013
Effect of supervised exercise program including balance exercises on the balance status and clinical signs in patients with fibromyalgia
Rheumatology International
5/12/2012 1:12:34 AM
The objective of this study is to investigate whether the supervised exercise program including balance exercises was superior to home exercise programs in improving clinical parameters and balance status in patients with FM. Fifty women who were diagnosed with primary FM were assigned into supervised exercise group (Group 1) and home exercise group (Group 2). Evaluation parameters were clinical parameters [pain, number of tender points (NTP), Beck Depression Scale (BDS), Fibromyalgia Impact Questionnaire (FIQ)], and parameters associated with balance [timed up and go test (TUGT), four square step test (FSST), Berg Balance Scale (BBS), Activities-Specific Balance Confidence Scale (ABC), and static balance measurements]. Significant differences were determined between all pre- and post-...
http://www.medworm.com/rss/comments.php?id=6052272
The raw foods diet greatly increased the quality of life of individuals struggling with fibromyalgia
NaturalNews.com
5/12/2012 1:00:00 AM
In 2001, a study was conducted in North Carolina to investigate the potential effects of a meat-free raw foods diet on the physical and psychological well-being of individuals with fibromyalgia. Less pain, more gain Fibromyalgia patients are afflicted with chronic... (Source: NaturalNews.com)
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Beat Fibromyalgia naturally
NaturalNews.com
5/12/2012 1:00:00 AM
Fibromyalgia is a chronic inflammatory condition consisting of muscular and joint pain and fatigue. Three to five percent of the population suffers with this condition with over 80% being women. This is one of the fastest growing disabling conditions in the US. Beat... (Source: NaturalNews.com)
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Overlapping Conditions
About.com Eating Disorders
5/10/2012 11:00:00 PM
Learn about the host of comorbidity in fibromyalgia and chronic fatigue syndrome, including myofascial pain syndrome, migraine, multiple chemical sensitivity, Gulf War syndrome, post-traumatic stress disorder, sleep disorders and more. See how these conditions can interact with fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)
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WAISMANN METHOD® Medical Director Voices Support for Fibromyalgia...
PRWeb: Medical Pharmaceuticals
5/10/2012 4:20:14 AM
Head of Leading Opiate Detoxification Treatment Expresses Concern for Rise in Painkiller Use Among Fibromyalgia Patients(PRWeb May 09, 2012)Read the full story at http://www.prweb.com/releases/2012/5/prweb9493685.htm (Source: PRWeb: Medical Pharmaceuticals)
http://www.medworm.com/rss/comments.php?id=6038967
Effectiveness of a Tai-Chi Training and Detraining on Functional Capacity, Symptomatology and Psychological Outcomes in Women with Fibromyalgia
Journal of Biomedicine and Biotechnology
5/9/2012 6:21:12 AM
Conclusions. A 28-week Tai-Chi intervention showed improvements on pain, functional capacity, symptomatology and psychological outcomes in female FM patients. (Source: Journal of Biomedicine and Biotechnology)

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Home‐Based Aerobic Conditioning for Management of Symptoms of Fibromyalgia: A Pilot Study
Pain Medicine
5/7/2012 11:00:00 PM
Conclusions.  Patients suffering from fibromyalgia who can participate in an aerobic conditioning program may experience physiological and psychological benefits, perhaps with improvement in symptoms of fibromyalgia, specifically pain ratings. More definitive trials are needed, and this pilot demonstrates the feasibility of the quantitative VO2 max method. Subjects who experience significant perceived disability and negative affective symptoms are not likely to maintain a home‐based conditioning program, and may need a more comprehensive interdisciplinary program offering greater psychological and social support. (Source: Pain Medicine)
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Pentoxifylline's Theoretical Efficacy in the Treatment of Fibromyalgia Syndrome
Pain Medicine
5/7/2012 11:00:00 PM
(Source: Pain Medicine)
http://www.medworm.com/rss/comments.php?id=6034067
Sodium oxybate therapy provides multidimensional improvement in fibromyalgia: results of an international phase 3 trial
Annals of the Rheumatic Diseases
5/6/2012 11:00:00 PM
Conclusion These results, combined with findings from previous phase 2 and 3 studies, provide supportive evidence that SXB therapy affordsimportant benefits across multiple symptoms in subjects with fibromyalgia. (Source: Annals of the Rheumatic Diseases)
http://www.medworm.com/rss/comments.php?id=6028198
10 Things to Stop Doing to Yourself
About.com Eating Disorders
5/5/2012 11:00:00 PM
It's easy to get into bad habits when you're struggling to live with a chronic illness like fibromyalgia or chronic fatigue syndrome. See 10 things you should stop doing to yourself. (Source: About.com Eating Disorders)

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Neurotransmitters
About.com Eating Disorders
5/5/2012 11:00:00 PM
Learn the role of neurotransmitters in fibromyalgia and chronic fatigue syndrome. What is a neurotransmitter and what does it do? What neurotransmitter levels are out of balance in fibromyalgia and chronic fatigue syndrome? Also find links to symptoms of and treatments for specific neurotransmitter imbalances. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6024877
Tender Point vs. Trigger Point
About.com Eating Disorders
5/5/2012 11:00:00 PM
Are tender points and trigger points the same thing? If not, what roles does each play in fibromyalgia? (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6024886
Benefits of Laughter
About.com Eating Disorders
5/4/2012 11:00:00 PM
Learn the real health benefits of laughter and how laughing may help ease symptoms of fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=6022293
Vitamin D May Be of Help in Fibromyalgia (CME/CE)
MedPage Today Meeting Coverage
5/3/2012 4:34:46 PM
GLASGOW (MedPage Today) -- Only 15% of fibromyalgia patients in a small study had adequate levels of vitamin D, suggesting implications for treatment. (Source: MedPage Today Meeting Coverage)
http://www.medworm.com/rss/comments.php?id=6013709
Should rheumatologists retain ownership of fibromyalgia? A survey of Ontario rheumatologists.
Pain Physician
5/1/2012 11:00:00 PM
This study surveyed the opinion of Ontario rheumatologists with respect to their beliefs about the nature and management of fibromyalgia. A key objective was to ascertain if rheumatologists should continue to be the main care providers for these patients. A survey comprising 13 questions was sent electronically to all 150 Ontario rheumatologists. The questionnaire was designed to obtain demographic data as well as opinions regarding different aspects of fibromyalgia. Data were analysed descriptively, and comparisons were made using chi-square tests. A total of 80 respondents completed our survey for a completion rate of 53 %. The majority had completed their training in Canada (85 %) and had been practising for more than 15 years (50 %). Key findings were: (1) 71 % believe that rheuma...

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http://www.medworm.com/rss/comments.php?id=6013181
Fall experiences of persons with fibromyalgia over 6 months
Journal of Advanced Nursing
5/1/2012 11:00:00 PM
Conclusions.  Nurses caring for persons with fibromyalgia should assess for potential fall‐risk factors and offer plans for individualized fall‐prevention strategies. (Source: Journal of Advanced Nursing)
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Mayo Clinic Experts Available for Arthritis Action Month
Mayo Clinic Rochester News
5/1/2012 7:42:25 AM
May is Arthritis Action Month. Mayo Clinic invites the public to ask questions during hour-long online chats with Mayo physicians about four of the most common conditions — rheumatoid arthritis, gout, osteoarthritis and fibromyalgia. (Source: Mayo Clinic Rochester News)

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http://www.medworm.com/rss/comments.php?id=6002031
Should rheumatologists retain ownership of fibromyalgia? A survey of Ontario rheumatologists
Clinical Rheumatology
5/1/2012 12:56:38 AM
This study surveyed the opinion of Ontario rheumatologists with respect to their beliefs about the nature and management of fibromyalgia. A key objective was to ascertain if rheumatologists should continue to be the main care providers for these patients. A survey comprising 13 questions was sent electronically to all 150 Ontario rheumatologists. The questionnaire was designed to obtain demographic data as well as opinions regarding different aspects of fibromyalgia. Data were analysed descriptively, and comparisons were made using chi-square tests. A total of 80 respondents completed our survey for a completion rate of 53 %. The majority had completed their training in Canada (85 %) and had been practising for more than 15 years (50 %). Key findings were: (1) 71&...
http://www.medworm.com/rss/comments.php?id=6019216
Fibromyalgia: treatment options in primary care.
The American Journal of Nursing
4/30/2012 11:00:00 PM
Authors: Kayyali A, Rosenberg K PMID: 22543664 [PubMed - in process] (Source: The American Journal of Nursing)
http://www.medworm.com/rss/comments.php?id=6022504
Intact Cognitive Inhibition in Patients With Fibromyalgia but Evidence of Declined Processing Speed
The Journal of Pain
4/30/2012 11:00:00 PM
In this study we examined performance on 2 cognitive inhibition tests, the Stroop Color-Word Test (SCWT) and the Multi-Source Interference Test (MSIT), in 35 female patients with fibromyalgia and 35 age-matched healthy female controls. Experimental pressure pain thresholds (PPT) were determined, and fibromyalgia patients rated their current pain on a visual analog scale and completed the pain and fatigue subscales of the Fibromyalgia Impact Questionnaire. Further, all subjects completed questionnaires assessing symptoms of pain catastrophizing, depression, and anxiety. Significant group differences were found for SCWT and MSIT performance in both the neutral (N) and interference (I) conditions with slower reaction times in patients versus controls. However, no significant group differences...
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Sex With FMS & ME/CFS
About.com Eating Disorders
4/29/2012 11:00:00 PM
Sex can be difficult when you have fibromyalgia or chronic fatigue syndrome. Find out how to overcome the obstacles to a healthy sex life. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=5995248
Yoga for FMS & ME/CFS
About.com Eating Disorders
4/28/2012 11:00:00 PM
See why yoga is recommended for people with fibromyalgia and chronic fatigue syndrome, what benefits yoga offers, how to get started, and what special things you need to consider. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=5992712
Genetic Causes
About.com Eating Disorders
4/28/2012 11:00:00 PM
Is there evidence for genetic causes of fibromyalgia and chronic fatigue syndrome? Find out what research says about fibromyalgia and chronic fatigue syndrome running in families. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=5992678
Fibromyalgia Pain Relief
About.com Eating Disorders
4/28/2012 11:00:00 PM
Fibromyalgia pain relief can be difficult to find. Learn your range of fibromyalgia pain relief options so you can find a treatment regimen that works for you. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=5992684
Gardening
About.com Eating Disorders
4/28/2012 11:00:00 PM
Afraid you'll have to give up gardening because of fibromyalgia or chronic fatigue syndrome? See what tools and tricks can keep you in the garden. (Source: About.com Eating Disorders)

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Fatigue Not a Factor in Fibromyalgia Pain, Study Says
MedicineNet Chronic Pain General
4/27/2012 2:00:00 AM
Title: Fatigue Not a Factor in Fibromyalgia Pain, Study SaysCategory: Health NewsCreated: 4/26/2012 4:06:00 PMLast Editorial Review: 4/27/2012 12:00:00 AM (Source: MedicineNet Chronic Pain General)
http://www.medworm.com/rss/comments.php?id=5987829
Association between Thyroid Autoimmunity and Fibromyalgia
Experimental and Clinical Endocrinology and Diabetes
4/26/2012 11:00:00 PM
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0032-1309008Evidence exists that autoimmune thyroiditis is present in a high percentage of fibromyalgia (FM) and associated with the presence of typical symptoms of FM. However, the role of thyroperoxidase antibody (TPO Ab) in the manifestation of FM is still unclear. The goal of this study was to investigate the prevalence of positive TPO Ab in euthyroid FM patients, and whether TPO Ab positivity is associated with the clinical manifestations in euthyroid FM patients.Thyroid assessment was done by free T4, TSH and TPO Ab. The clinical parameters including Fibromyalgia Impact questionnaire (FIQ), pain visual analogical scale (VAS) and tender point counts were evaluated in euthyroid primary FM patients, not associated with autoimmune rheumatic dise...

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Monoamine oxidase inhibitors (MAOIs) for fibromyalgia syndrome
NeLM - Drug Class Focused Reviews
4/26/2012 11:00:00 PM
The objective of this review was to assess the effectiveness and safety of monoamine oxidase inhibitors (MAOIs) in the treatment of FM syndrome.   Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010, Issue 10), MEDLINE (1966 to November 2010), EMBASE (1980 to November 2010) and the reference lists of reviewed articles.   Selection criteria We selected all randomised, double-blind trials of MAOIs used for the ... (Source: NeLM - Drug Class Focused Reviews)
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Bartonella spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease-endemic Region.
Pain Physician
4/26/2012 5:48:59 PM
Authors: Maggi RG, Mozayeni BR, Pultorak EL, Hegarty BC, Bradley JM, Correa M, Breitschwerdt EB Abstract Bartonella spp. infection has been reported in association with an expanding spectrum of symptoms and lesions. Among 296 patients examined by a rheumatologist, prevalence of antibodies against Bartonella henselae, B. koehlerae, or B. vinsonii subsp. berkhoffii (185 [62%]) and Bartonella spp. bacteremia (122 [41.1%]) was high. Conditions diagnosed before referral included Lyme disease (46.6%), arthralgia/arthritis (20.6%), chronic fatigue (19.6%), and fibromyalgia (6.1%). B. henselae bacteremia was significantly associated with prior referral to a neurologist, most often for blurred vision, subcortical neurologic deficits, or numbness in the extremities, whereas B. koehlerae bact...
http://www.medworm.com/rss/comments.php?id=5980202
Fatigue Not a Factor in Fibromyalgia Pain, Study Says
The Doctors Lounge - Health News
4/26/2012 2:00:00 PM
Lack of sleep did not predict intensity, duration of discomfort with the disorder (Source: The Doctors Lounge - Health News)
http://www.medworm.com/rss/comments.php?id=5980235
Patients With Fibromyalgia Display Less Functional Connectivity In The Brain's Pain Inhibitory Network
Molecular Pain
4/25/2012 11:00:00 PM
Background: There is evidence for augmented processing of pain and impaired endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the mechanisms involved in FM pathology, there is a need for closer investigation of endogenous pain modulation. In the present study, we compared the functional connectivity of the descending pain inhibitory network in age-matched FM patients and healthy controls (HC).We performed functional magnetic resonance imaging (fMRI) in 42 subjects; 14 healthy and 28 age-matched FM patients (2 patients per HC), during randomly presented, subjectively calibrated pressure pain stimuli. A seed-based functional connectivity analysis of brain activity was performed. The seed coordinates were based on the findings from our previous study, comp...
http://www.medworm.com/rss/comments.php?id=5978788
The impact of mood, anxiety, and sleep disorders on fibromyalgia
Comprehensive Psychiatry
4/24/2012 11:00:00 PM
Conclusion: Psychiatric comorbidity, in particular with mood disorders, provokes a significant impairment of the HRQoL and, when current, a higher severity of pain in FM patients. (Source: Comprehensive Psychiatry)
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Role of impaired sleep in fibromyalgia pain explored
ScienceDaily Headlines
4/23/2012 9:37:37 AM
Patients coping with the complex pain disorder fibromyalgia often have difficulty sleeping, and a new study reports that despite the negative quality of life implications, poor sleep is not a significant predictor of fibromyalgia pain intensity and duration. (Source: ScienceDaily Headlines)
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Long-Term Outcomes in Fibromyalgia Patients Treated With Noninvasive Cortical Electrostimulation
Archives of Physical Medicine and Rehabilitation
4/22/2012 11:00:00 PM
Abstract: Hargrove JB, Bennett RM, Clauw DJ. Long-term outcomes in fibromyalgia patients treated with noninvasive cortical electrostimulation. Objective: To evaluate long-term outcomes of a noninvasive cortical stimulation technology in the treatment of fibromyalgia (FM). Design: After trial follow-up survey of subjects who had completed a randomized, controlled, double-blind study of noninvasive cortical stimulation therapy some 45 months previously. Setting: General community. Participants: Patients with FM (N=69) who participated in the previous study, 39 of whom were mailed surveys. Interventions: Not applicable. Main Outcome Measure: Changes in the Fibromyalgia Impact Questionnaire. Results: There was a 64% survey return rate. The total Fibromyalgia Impact Questionnaire...
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Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: Results of supervised learning techniques applied on clinical and inflammatory data
Psychiatry Research
4/22/2012 11:00:00 PM
This study examines whether CF and CFS, with and without PEM, are distinct diagnostic categories.Fukuda's criteria were used to diagnose 144 patients with chronic fatigue and identify patients with CFS and CF, i.e. those not fulfilling the Fukuda's criteria. PEM was rated by means of a scale with defined scale steps between 0 and 6. CFS patients were divided into those with PEM lasting more than 24h (labeled: ME) and without PEM (labeled: CFS). The 12-item Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale was used to measure severity of illness. Plasma interleukin-1 (IL-1), tumor necrosis factor (TNF)α, and lysozyme, and serum neopterin were employed as external validating criteria.Using fatigue, a subjective feeling of infection and PEM we found that ME, CFS, and CF were distin...

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Monoamine oxidase inhibitors (MAOIs) for fibromyalgia syndrome.
Cochrane Database of Systematic Reviews
4/21/2012 1:17:34 PM
CONCLUSIONS: Data suggest that the effectiveness of MAOIs for the treatment of FM symptoms is limited. Although we observed a moderate effect size on pain and a small one on tender points, these results should be taken with caution as they are only based on two studies with a small number of patients and inconsistent risk of bias among them. PMID: 22513976 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
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Study: Fibromyalgia patients taking pregabalin see improvement in sleep, daily pain
Modern Medicine
4/19/2012 11:00:00 PM
Fibromyalgia patients taking pregabalin had significant improvements in sleep and decreased daily pain, according to a new study published in the April 2012 issue of Arthritis Care & Research. (Source: Modern Medicine)
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Assessment of Nutritional Status and Eating Disorders in Female Adolescents With Fibromyalgia
Journal of Adolescent Health
4/17/2012 11:00:00 PM
Conclusions: This study verified an absence of nutritional and eating disorders in adolescents recently diagnosed with fibromyalgia that, in addition to the correlation between adiposity indexes and KEDS total score, emphasizes the importance of nutritional and body composition assessment, allowing an early and adequate nutritional intervention. (Source: Journal of Adolescent Health)
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Efficacy of supervised exercise combined with transcutaneous electrical nerve stimulation in women with fibromyalgia: a prospective controlled study
Rheumatology International
4/17/2012 1:05:18 AM
Abstract  The aim of this study was to investigate the results of a supervised exercise with transcutaneous electrical nerve stimulation (TENS) in an exercise controlled study in women with fibromyalgia. Sixty-six women with fibromyalgia who admitted to the outpatient clinic of our hospital were randomized into two treatment groups. The patients in both groups participated in a supervised combined exercise program for 12 weeks. The women in first group had additional TENS in the first 3 weeks of the study. All subjects were analyzed at the baseline, at the end of the 3rd and 12th weeks. Outcome measures were tender point count (TPC), myalgic pain score (MPS), Fibromyalgia Impact Questionnaire (FIQ) and Short Form-36 (SF-36) Health Survey. Sixty women with fibromya...
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The basis for medical therapy of fibromyalgia with growth hormone
Pain
4/15/2012 11:00:00 PM
A criterion-based analysis of “fibrositis” was defined in 1990 for making the clinical diagnosis of the fibromyalgia syndrome (FMS) . FMS was classified as a chronic musculoskeletal condition with effusive pain in at least 11 tender points from a group of 18 anatomically-defined structures . A new criteria for the diagnosis of FMS that was published in 2010 proposed that the weight given to the tender point count criteria be significantly lessened in favor of placing increased emphasis on the patient’s overall symptoms. Thus, this change in diagnosis criteria for FMS is likely to increase the number of patient’s with this condition, but the revised diagnosis criteria for FMS is also consistent with the idea proposed by Henricksson that FMS should be reclassified as a multisystemic ...
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Safety Profile and Tolerability of Up to 1 Year of Pregabalin Treatment in 3 Open-Label Extension Studies in Patients With Fibromyalgia.
Clinical Therapeutics
4/13/2012 11:00:00 PM
CONCLUSIONS: The data from these extension studies suggest that the adverse event safety profile and tolerability of patients with FM treated with open-label pregabalin (75-300 mg BID) for up to 1 year were stable and were consistent with those of previous studies. ClinicalTrials.gov identifiers: NCT00151528 (A0081057 [study 1]), NCT00282997 (A0081078 [study 2]), and NCT00346034 (A0081101 [study 3]). PMID: 22503162 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)

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Fibromyalgia syndrome and depression: common pathways.
British Journal of Hospital Medicine
4/10/2012 11:00:00 PM
Authors: Dunne FJ, Dunne CA Abstract Fibromyalgia is a common, poorly understood, debilitating chronic pain syndrome, which by definition lasts longer than 3 months. The cause is unknown although the usual possibilities of genes, viruses, physical trauma, hormones, autoimmune disease and stress have all been implicated. PMID: 22585197 [PubMed - in process] (Source: British Journal of Hospital Medicine)
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“Last observation carried forward” threatens the validity of intention‐to‐treat analysis in fibromyalgia trials: Comment on the paper by Arnold et al.
Arthritis and Rheumatism
4/9/2012 11:00:00 PM
(Source: Arthritis and Rheumatism)
http://www.medworm.com/rss/comments.php?id=5879267
[In Process Citation].
Reumatismo
4/8/2012 8:36:01 PM
Authors: Salaffi F, Ciapetti A, Sarzi Puttini P, Atzeni F, Iannuccelli C, Di Franco M, Cazzola M, Bazzichi L Abstract Fibromyalgia (FM) is a complex syndrome that, in Italy, affects at least 2% of the adult population. It is characterized by chronic widespread musculoskeletal pain often accompanied by multiple other symptoms. The aim of this study was to identify a set of clinical domains for FM considered relevant by both clinicians and patients using a consensus process. Consensus was achieved using the Delphi method based on questionnaires and systematic, controlled opinion feedback. The Delphi exercise involved a panel of 252 rheumatologists and 86 patients with FM as defined by the American College of Rheumatology criteria. All of the patients and clinicians were asked to rank...
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Managing Chronic Pain with Nonopioid Analgesics: A Multidisciplinary Consult
The American Journal of Medicine
4/6/2012 9:41:20 PM
As detailed in this online CME activity (www.cmeaccess.com/AJM/ChronicPain04), determining pain mechanism is an important aspect guiding treatment selection for chronic musculoskeletal pain states. Although broad classifications provide a framework, any combination of mechanisms may be present in a chronic pain patient, and there is growing evidence that pain states generally considered nociceptive may also involve elements of augmented central nervous system pain processing. Nonopioid analgesics, including serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, and alpha-2-delta ligand anticonvulsants, are the treatments of choice for fibromyalgia and other central neuropathic pain states. Additionally, studies have now shown that certain SNRIs can be effective in...

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TONIX Pharmaceuticals Completes Pharmacokinetic Study on New Formulation of TNX-102 for Fibromyalgia
Drugs.com - Clinical Trials
4/5/2012 6:00:57 PM
Results Justify Further Development of TNX-102 as Potential Bedtime Treatment for Fibromyalgia NEW YORK--(BUSINESS WIRE)--Apr 5, 2012 - Tonix Pharmaceuticals Holding Corp. (OTCBB:TNXP) (“TONIX” or the “Company”), a specialty... (Source: Drugs.com - Clinical Trials)
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Author reply to “last‐observation‐carried‐forward threatens the validity of intention‐to‐treat analysis in fibromyalgia trials”
Arthritis and Rheumatism
4/4/2012 11:00:00 PM
(Source: Arthritis and Rheumatism)
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Fibromyalgia Syndrome and Chronotype: Late Chronotypes Are More Affected
Journal of Biological Rhythms
4/2/2012 11:00:00 PM
In this study, 1548 individuals with FMS completed an online survey containing questions on demographics, stimulant consumption, sleep quality, well-being and subjective pain, chronotype (assessed by the Munich ChronoType Questionnaire, MCTQ), and FMS impact. Chronotype (expressed as the mid-sleep-point on free days, corrected for sleep deficit on workdays, MSFsc) significantly correlated with stress-ratings, so-called "memory failures in everyday life," fatigue, FMS impact, and depression but not with anxiety. When chronotypes were categorized into 3 groups (early, intermediate, late), significant group differences were found for sum scores of perceived stress, memory failures in everyday life, fatigue, FMS impact, and depression but not anxiety, with late chronotypes being more affected ...

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Growth hormone treatment for sustained pain reduction and improvement in quality of life in severe fibromyalgia
Pain
4/1/2012 11:00:00 PM
This study investigated the efficacy and safety of low-dose GH as an add-on therapy in patients with both severe FM and low insulin-like growth factor 1 levels. A total of 120 patients were enrolled in a multicenter, placebo-controlled study for 18months. They were randomly assigned to receive either 0.006mg/kg/day of GH subcutaneously (group A, n=60) or placebo (group B, n=60) for 6months (blind phase). The placebo arm was switched to GH treatment from month 6 to month 12 (open phase), and a follow-up period after GH discontinuation was performed until month 18. Standard treatment for fibromyalgia (selective serotonin re-uptake inhibitors, opioids, and amitriptyline) was maintained throughout the study. Number and intensity of tender points, Fibromyalgia Impact Questionnaire (FIQ) with it...
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Effective Connectivity Among Brain Regions Associated With Slow Temporal Summation of C-Fiber-Evoked Pain in Fibromyalgia Patients and Healthy Controls
The Journal of Pain
3/31/2012 11:00:00 PM
Abstract: Temporal summation of “second pain” (TSSP) or “windup” results from the summation of C-fiber-evoked responses of dorsal-horn neurons. This phenomenon is dependent on stimulus frequency (≥.33 Hz) and relevant to central sensitization and chronic pain. Our previous neuroimaging studies characterized brain regions associated with TSSP in normal control (NC) and fibromyalgia (FM) groups. During an fMRI scan, subjects received sensitivity-adjusted repetitive heat pulses at .33 on the right foot. FM subjects required significantly lower stimulus intensities than NC to achieve similar TSSP and no significant group differences in the pain-related brain activity were detected. In our current study, we asked whether the effective connectivity among a set of TSSP-related brain r...
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Improving musculoskeletal health: Global issues
Best Practice and Research. Clinical Rheumatology
3/31/2012 11:00:00 PM
Musculoskeletal (MSK) disorders are among the leading reasons why patients consult a family or primary health practitioner, take time off work and become disabled. Many of the MSK disorders are more common in the elderly. Thus, as the proportion of the elderly increases all over the world, MSK disorders will make a greater contribution to the global burden of disease. Epidemiological studies have shown that the spectrum of MSK disorders in developing countries is similar to that seen in industrialised countries, but the burden of disease tends to be higher due to a delay in diagnosis or lack of access to adequate health-care facilities for effective treatment. Musculoskeletal pain is very common in the community while fibromyalgia is being recognised as part of a continuum of chronic wides...
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Cognitive hypnotherapy for pain management.
The American Journal of Clinical Hypnosis
3/31/2012 11:00:00 PM
This article reviews clinical techniques and methods of cognitive hypnotherapy for pain management. Current research with emphasis given to randomized, controlled trials is presented and the efficacy of hypnotherapy for pain management is discussed. Evidence for cognitive hypnotherapy in the treatment in chronic pain, cancer, osteoarthritis, sickle cell disease, temporomandibular disorder, fibromyalgia, non-cardiac chest pain, and disability related chronic pains are identified. Implications for clinical practice and research are discussed in light of the accumulating evidence in support of the efficacy and effectiveness of cognitive hypnotherapy for pain management. PMID: 22655332 [PubMed - in process] (Source: The American Journal of Clinical Hypnosis)
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Efficacy of Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation for Treating Fibromyalgia Syndrome: A Systematic Review
Pain Practice
3/31/2012 11:00:00 PM
Conclusion:  Studies involving excitatory rTMS/tDCS at M1 showed analogous pain reductions as well as considerably fewer side effects compared to FDA approved FMS pharmaceuticals. The most commonly reported side effects were mild, including transient headaches and scalp discomforts at the stimulation site. Yearly use of rTMS/tDCS regimens appears costly ($11,740 to 14,507/year); however, analyses to appropriately weigh these costs against clinical and quality of life benefits for patients with FMS are lacking. Consequently, rTMS/tDCS should be considered when treating patients with FMS, particularly those who are unable to find adequate symptom relief with other therapies. Further work into optimal stimulation parameters and standardized outcome measures is needed to clarify associated e...

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Predictors of Clinical Outcome in Fibromyalgia After a Brief Interdisciplinary Fibromyalgia Treatment Program: Single Center Experience
PM and R
3/31/2012 11:00:00 PM
Conclusions: Patients with younger age, more years of education (with college or graduate degree), higher baseline FIQ depression score, lower tender point count, and absent abuse history experience greater benefit from a brief FTP. (Source: PM and R)
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Ask the Authors
PM and R
3/31/2012 11:00:00 PM
These follow-up questions were directed to the author by a PM&R senior editor and are meant to stimulate further clinical insight. Sr. Editor: Your descriptive study identified that fewer than half of the patients newly diagnosed with fibromyalgia were advised to exercise as part of treatment recommendations by the physician (a rheumatologist). Did you find that number surprising? (Source: PM and R)
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Milnacipran for neuropathic pain and fibromyalgia in adults
NeLM - Drug Specific Reviews
3/31/2012 11:00:00 PM
Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) that is sometimes used to treat chronic neuropathic pain and fibromyalgia.     Objectives To evaluate the analgesic efficacy and adverse effects of milnacipran in the management of chronic neuropathic pain or fibromyalgia.     Search methods We searched CENTRAL, MEDLINE, and EMBASE to 4th of January 2012, together with reference lists of retrieved papers and reviews.     Selection criteria We included randomised, double-blind studies of eight weeks duration or longer, comparing milnacipran with placebo or another active treatment in chronic neuropathic pain or fibromyalgia.   &...
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[Benefits and disadvantages of therapy for fibromyalgia syndrome : New insights and decision aids from consumer reports?].
Schmerz
3/31/2012 11:00:00 PM
Authors: Petzke F PMID: 22527641 [PubMed - in process] (Source: Schmerz)
http://www.medworm.com/rss/comments.php?id=5980372
[Development of an Internet-based clinical pathway exemplified by the fibromyalgia syndrome].
Schmerz
3/31/2012 11:00:00 PM
Authors: Noll-Hussong M Abstract Clinical pathways (CP) are considered to be a tool of clinical process management describing the optimal route for diagnostic and therapeutic medical treatment of a specified patient. Apart from economic aspects CPs can make a contribution to optimization of health quality management as well as to improvement of medical staff and both patient satisfaction and patient safety whereas the feasibility and acceptance of evidence-based medicine guidelines are often found to be low. In order to stimulate critical discussion by offering the opportunity to easily gain first practical experience, a free web-based clinical pathway system for diagnosis and treatment for patients with fibromyalgia syndrome (FMS) will be presented. PMID: 22527642 [PubMed - in...
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[German fibromyalgia consumer reports : Benefits and harms of fibromyalgia syndrome therapies].
Schmerz
3/31/2012 11:00:00 PM
CONCLUSION: The German fibromyalgia consumer reports highlight the importance of non-pharmcological therapies in the long-term management of FMS. PMID: 22527644 [PubMed - in process] (Source: Schmerz)

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[Placebo for fibromyalgia - but how?].
Schmerz
3/31/2012 11:00:00 PM
Authors: Mindach M, Häuser W, Tölle TR PMID: 22527652 [PubMed - in process] (Source: Schmerz)
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Evaluation of patient-rated stiffness associated with fibromyalgia: a post-hoc analysis of 4 pooled, randomized clinical trials of duloxetine.
Clinical Therapeutics
3/31/2012 11:00:00 PM
CONCLUSIONS: Stiffness scores were high in this population with FM and best correlated at baseline with BPI pain score and FIQ function. Not unexpectedly, improvement in stiffness with duloxetine correlated with many of the other markers of FM severity, presumably a result of amelioration in FM comorbidities. PMID: 22421576 [PubMed - in process] (Source: Clinical Therapeutics)
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Neuropsychological assessment of cognitive disorders in patients with fibromyalgia, rheumatoid arthritis, and systemic lupus erythematosus
Revista Brasileira de Reumatologia
3/30/2012 4:35:38 PM
CONCLUSION: The variables studied (low educational level and advanced age) were associated with various degrees of impairment in the different cognitive functions in the three pathological groups. However, FM and SLE groups showed significantly higher means of the neuropsychiatric symptoms of anxiety, irritability and hallucinations than the RA group in the neuropsychiatric inventory. (Source: Revista Brasileira de Reumatologia)
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Acupuncture in adolescents with juvenile fibromyalgia
Revista Paulista de Pediatria
3/30/2012 3:03:13 PM
CONCLUSIONS: Acupuncture is a traditional chinese medicine modality that can be used in pediatric patients with fibromyalgia. Future controlled studies are necessary.OBJETIVO: Describir el uso de acupuntura en adolescentes con fibromialgia juvenil. MÉTODOS: Estudio retrospectivo realizado en pacientes con fibromialgia juvenil (criterios del Colegio Americano de Reumatología) sometidos a al menos 11 sesiones semanales de acupuntura. Las evaluaciones antes y después de la acupuntura incluyeron datos demográficos, características del dolor musculoesquelético, número de puntos dolorosos (NPD), escala visual analógica (EVA) de dolor, algiometría e índice de mialgia (IM). Durante el estudio, los pacientes pudieron usar analgésicos, amitriptilina, y fueron orientados a practicar activi...

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The Role of Antidepressants in the Management of Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis
CNS Drugs
3/30/2012 2:50:08 AM
(Source: CNS Drugs)
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Pregabalin Lets Fibromyalgia Patients Sleep (CME/CE)
MedPage Today Neurology
3/29/2012 2:35:29 PM
(MedPage Today) -- Sleep difficulties commonly experienced by patients with fibromyalgia were greatly improved during 4 weeks of treatment with pregabalin (Lyrica), a randomized trial found. (Source: MedPage Today Neurology)
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Nocturnal Heart Rate as Potential Fibromyalgia BiomarkerNocturnal Heart Rate as Potential Fibromyalgia Biomarker
Medscape Today Headlines
3/21/2012 7:31:13 AM
Could nocturnal heart rate variability be the answer to the search for a fibromyalgia biomarker? Arthritis Research & Therapy (Source: Medscape Today Headlines)
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Evidence for an association between an enhanced reactivity of interleukin-6 levels and reduced glucocorticoid sensitivity in patients with fibromyalgia
Psychoneuroendocrinology
3/19/2012 9:49:47 PM
Summary: Pain and fatigue have been identified as core symptoms of fibromyalgia syndrome (FMS). Since both symptoms are also characteristic of hypocortisolemic disorders, reduced cortisol levels have been thought to promote an exacerbation of these FMS core symptoms by an enhanced reactivity of interleukin-6 (IL-6) levels. The aim of the current study was to investigate the pathophysiologic relevance of reduced cortisol levels for manifestation of FMS core symptoms. Twelve female FMS patients with 15 female controls were compared regarding the function of hypothalamus–pituitary–adrenal (HPA) axis and behavioral, endocrine and IL-6 responses after measuring the pressure pain thresholds (PPTs) at tender points. Function of HPA axis was assessed by determining the cortisol awakening respo...
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A cohort-controlled trial of the addition of customized foot orthotics to standard care in fibromyalgia
Clinical Rheumatology
3/19/2012 12:44:17 AM
Abstract  Customized foot orthotics are widely prescribed for patients with chronic, non-specific low back pain and lower limb pain, but there are few trials demonstrating effectiveness, and none for fibromyalgia. A total of 67consecutive patients presenting with chronic, widespread pain, who met the 1990 American College of Rheumatology criteria for fibromyalgia, were included in the study. A total of 32 subjects were prescribed a spinal exercise therapy program along with analgesics. These subjects formed the Control group. A second group, comprised of 35 subjects, received the same therapy, along with customized foot orthotics (Orthotics group). All subjects completed the Revised Fibromyalgia Impact Questionnaire (FIQR) at the initiation of the study and at 8 weeks ...
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Milnacipran for neuropathic pain and fibromyalgia in adults.
Cochrane Database of Systematic Reviews
3/17/2012 4:54:03 PM
CONCLUSIONS: The evidence available indicates that milnacipran 100 mg or 200 mg is effective for a minority in the treatment of pain due to fibromyalgia, providing moderate levels of pain relief (at least 30%) to about 40% of participants, compared with about 30% with placebo. There were insufficient data to assess substantial levels of pain relief (at least 50%), and the use of last observation carried forward imputation may overestimate drug efficacy. Milnacipran is associated with increased adverse events and adverse event withdrawals, which were significantly greater for the higher dose. There were no data for the use of milnacipran for other chronic neuropathic pain conditions. PMID: 22419330 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
http://www.medworm.com/rss/comments.php?id=5807439
Treatment-related changes in brain activation in patients with fibromyalgia syndrome.
Experimental Brain Research
3/16/2012 11:00:00 PM
This study examined changes in pain-evoked brain activation following behavioral extinction training in fibromyalgia patients. Using functional magnetic resonance imaging, brain activation to painful mechanical stimuli applied to the 2nd phalanx of the left 2nd digit (m. flexor digitorum) was assessed in 10 patients with fibromyalgia syndrome (FM) before and after behavioral extinction training. The behavioral treatment significantly reduced interference from pain in the FM patients. Mechanical pain threshold and pain tolerance increased significantly after treatment. Activation in the insula shifted bilaterally from a more anterior site before treatment to a more posterior location after treatment. The pre- to post-treatment reduction in both interference related to pain and pain severity...
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The Relationship Between Performances on Neuropsychological Symptom Validity Testing and the MCMI-III in Patients With Fibromyalgia.
The Clinical Neuropsychologist
3/14/2012 11:00:00 PM
This study investigated the association between Symptom Validity Test (SVT) performance and psychiatric symptoms as measured by the Millon Clinical Multiaxial Inventory-III (MCMI-III), a common measure of psychopathology. A total of 72 fibromyalgia patients at a tertiary care clinic completed the MCMI-III, an embedded cognitive symptom validity test (Reliable Digit Span), and a stand-alone cognitive symptom validity test (the Word Memory Test or Test of Memory Malingering). Of these patients, 21% failed a stand-alone SVT, whereas an additional 15% failed both a stand-alone and embedded SVT. Individuals who failed both stand-alone and embedded cognitive SVTs had higher scores on a number of MCMI-III personality subscales and had elevated scores on MCMI-III modifying indices compared to indi...
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Beyond Cognitive-behavioral Therapy for FibromyalgiaBeyond Cognitive-behavioral Therapy for Fibromyalgia
Medscape Today Headlines
3/14/2012 11:00:00 AM
Does addressing unresolved stressors help fibromyalgia patients? Arthritis Research & Therapy (Source: Medscape Today Headlines)

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Muscle fiber velocity and electromyographic signs of fatigue in fibromyalgia
Muscle and Nerve
3/11/2012 11:00:00 PM
Conclusions:In the patients with FM, we clearly showed functional abnormalities of the muscle membrane which lead to high conduction velocity and resistance to fatigue in electromyography. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve)
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Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent.
Neurotoxicology
3/10/2012
Authors: Schmechel DE, Edwards CL Abstract Persons with single copies of common alpha-1-antitrypsin polymorphisms such as S and Z are often considered "silent carriers". Published evidence however supports a complex behavioral phenotype or trait - intense creative energy ("ICE")-associated with A1AT polymorphisms. We now confirm that phenotype and present an association of fibromyalgia syndrome (FMS) and A1AT in a consecutive series of neurological patients. This is a retrospective case control series of 3176 consecutive patients presenting to Duke University Memory Clinic (747 patients) and to regional community-based Caldwell Hospital Neurology and Memory center (2429 patients). Work-up included medical history and examination, psychological evaluation, and genetic analysis. Chro...
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Exercise Recommendations in Patients With Newly Diagnosed Fibromyalgia
PM and R
3/9/2012
Conclusions: Although there is well-documented evidence that exercise is beneficial for patients with fibromyalgia, we found that less than half of patients with newly diagnosed fibromyalgia in our study were provided recommendations to initiate an exercise program as part of their treatment plan. Further investigation of these findings are warranted, including evaluation of other university and community rheumatology practices as well as that of other physicians caring for patients with fibromyalgia. However, our findings indicate that there appears to be an opportunity to provide more specific and practical education regarding the implementation of an exercise regimen for patients with newly diagnosed fibromyalgia. Physiatrists may be particularly well suited to manage the exercise comp...
http://www.medworm.com/rss/comments.php?id=5980628
Relationship between the body image and level of pain, functional status, severity of depression, and quality of life in patients with fibromyalgia syndrome
Clinical Rheumatology
3/6/2012 12:20:04 PM
Abstract  The aims were to investigate how the body image is affected in fibromyalgia syndrome (FMS) in comparison to healthy people, as well as to explore the relationship of the body image with the level of pain, functional status, severity of depression, and quality of life (QoL). Demographic variables, symptoms of fibromyalgia, and number of fibromyalgia tender points for 51 patients with FMS and 41 control subjects were recorded. All patients were asked to mark the level of pain on visual analogue scale (VAS). Six-minute walking test was recorded for functional assessment. The impact of the disease was evaluated by fibromyalgia impact questionnaire (FIQ). All patients were asked to complete body image scale (BIS), Beck depression inventory (BDI), and short form-36 (SF-...
http://www.medworm.com/rss/comments.php?id=5776732
Predictors of Clinical Pain in Fibromyalgia: Examining the Role of Sleep
The Journal of Pain
3/2/2012
This study suggests that measures of sleep duration and nightly wake time do not predict fibromyalgia pain at the group level. Fibromyalgia patients may benefit from a 3-pronged approach to pain management: reducing pain’s spatial extent, normalization of central nervous system hypersensitivity, and psychobehavioral therapies for negative mood. (Source: The Journal of Pain)

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A Mind-Body Technique for Symptoms Related to Fibromyalgia and Chronic Fatigue
Explore
3/1/2012
Context: A novel mind–body approach (amygdala retraining) is hypothesized to improve symptoms related to fibromyalgia and chronic fatigue. Objective: To examine the use of a mind–body approach for improving symptoms related to fibromyalgia and chronic fatigue. Design: This was a single-blind, randomized controlled trial. Setting: The study was conducted in a tertiary-care fibromyalgia and chronic fatigue clinic. Patients: Patients with fibromyalgia, chronic fatigue, or both were included. Interventions: Patients were randomly assigned to receive amygdala retraining along with standard care or standard care alone. Standard care involved attending a 1.5-day multidisciplinary program. The amygdala retraining group received an additional 2.5-hour training course in which the key...
http://www.medworm.com/rss/comments.php?id=5760982
Validity Testing of the Quality of Life Scale, Swedish Version: Focus Group Interviews of Women with Fibromyalgia
Occupational Therapy International
3/1/2012
AbstractFocus group interviews were used to examine validity of the Quality of Life Scale, Swedish version (QOLS‐S) for use with women with fibromyalgia. Five interviews with 18 women with fibromyalgia were completed. The opening question was “What does quality of life mean to you?” Later, participants were asked to respond to questions about the specific domains and items in the QOLS‐S. The transcribed interviews were analysed, and categories were identified. Opinions concerning domains and items in the QOLS‐S were linked to domains of the QOLS‐S. Four categories emerged from the opening question: finances, to be an active person and participate in society, relations with others, and health. Overall, the women's perceptions of quality of life were congruent with the domains of...
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Evaluation of leptin levels among fibromyalgia patients before and after three months of treatment, in comparison with healthy controls.
Pain Research and Management
3/1/2012
CONCLUSIONS: The results of the present study do not support the existence of a significant relationship between leptin and fibromyalgia pathogenesis. Increasing the sample size or examining the interaction between leptin and additional hormones⁄mediators of metabolism and body weight control may yet uncover significant information in this field. PMID: 22518370 [PubMed - in process] (Source: Pain Research and Management)
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Confirmation: Low-Dose Naltrexone Eases Fibromyalgia PainConfirmation: Low-Dose Naltrexone Eases Fibromyalgia Pain
Medscape Today Headlines
2/27/2012 2:55:34 PM
The opioid antagonist likely works by suppressing microglial function. Medscape Medical News (Source: Medscape Today Headlines)
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Reliability and Validity of a Low Load Endurance Strength Test for Upper and Lower Extremities in Patients With Fibromyalgia
Archives of Physical Medicine and Rehabilitation
2/27/2012
Abstract: Munguía-Izquierdo D, Legaz-Arrese A. Reliability and validity of a low load endurance strength test for upper and lower extremities in patients with fibromyalgia. Objective: To evaluate the reliability, standard error of the mean (SEM), clinical significant change, and known group validity of 2 assessments of endurance strength to low loads in patients with fibromyalgia syndrome (FS). Design: Cross-sectional reliability and comparative study. Setting: University Pablo de Olavide, Seville, Spain. Participants: Middle-aged women with FS (n=95) and healthy women (n=64) matched for age, weight, and body mass index (BMI) were recruited for the study. Interventions: Not applicable. Main Outcome Measures: The endurance strength to low loads tests of the upper and lower ext...
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Lacosamide for neuropathic pain and fibromyalgia in adults
NeLM - Drug Specific Reviews
2/27/2012
Source: Cochrane Area: Evidence > Drug Specific Reviews Background Antiepileptic drugs have been used in pain management since the 1960s; some seem to be especially useful for neuropathic pain. Lacosamide is an antiepileptic drug that has recently been investigated for neuropathic pain relief, although it failed to get approval for painful diabetic peripheral neuropathy from either the Food and Drug Administration or the European Medicines Agency.     Objectives To evaluate the analgesic efficacy and adverse effects of lacosamide in the management of chronic neuropathic pain or fibromyalgia.   Search methods We searched the Cochrane Neuromuscular Disease Group Specialized Register (2011, Issue 4), CENTRAL (2011, Issue 3), MEDLINE (January 2000 to August 201...
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Naltrexone May Lessen Chronic Pain
MedPage Today Pain Management
2/26/2012 3:13:09 PM
(MedPage Today) -- PALM SPRINGS, Calif. -- Low doses of the opioid antagonist naltrexone may relieve pain associated with fibromyalgia compared with placebo, researchers said here. (Source: MedPage Today Pain Management)
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Clinical dimensions of fibromyalgia symptoms and development of a combined index of severity: The CODI index
Quality of Life Research
2/25/2012 11:50:53 AM
Conclusion  The clinical implications and utility of the CODI are discussed in relation to previous research on FM. Content Type Journal ArticlePages 1-8DOI 10.1007/s11136-012-0134-6Authors Antonio Cuesta-Vargas, Departamento de Psiquiatría y Fisioterapia, Universidad de Málaga, Málaga, SpainJuan V. Luciano, Parc Sanitari Sant Joan de Déu & Fundació Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, SpainMaria Teresa Peñarrubia-María, Red de Investigación en Actividades Preventivas y Promoción de la Salud (RedIAPP), Barcelona, SpainJavier García-Campayo, Red de Investigación en Actividades Preventivas y Promoción de la Salud (RedIAPP), Barcelona, SpainRita Fernández-Vergel, Red de Investigación en Actividades Preventivas y Promoción de la Salud (RedIAPP)...
http://www.medworm.com/rss/comments.php?id=5743336
Esreboxetine effective in treating fibromyalgia
Modern Medicine
2/23/2012
NEW YORK (Reuters Health) - Esreboxetine, a highly selective norepinephrine reuptake inhibitor, safely relieved pain and improved quality of life in patients with fibromyalgia in a phase II trial, according to a report published recently. (Source: Modern Medicine)
http://www.medworm.com/rss/comments.php?id=5730876
Fibromyalgia in Men
About.com Eating Disorders
2/22/2012
Fibromyalgia is more common in women, but men get it, too. Find out what's different about fibromyalgia in men. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=5728635
Working Memory
About.com Eating Disorders
2/22/2012
Find out what working memory is, what activities it affects, and the role it's believed to play in fibromyalgia and chronic fatigue syndrome. (Source: About.com Eating Disorders)

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Transient receptor potential A1 receptor‐mediated neural cross‐talk and afferent sensitization induced by oxidative stress: Implication for the pathogenesis of interstitial cystitis/bladder pain syndrome
International Journal of Urology
2/21/2012 9:34:32 PM
AbstractAlthough the pathogenesis of interstitial cystitis/bladder pain syndrome remains unknown, there is a significant correlation of interstitial cystitis/bladder pain syndrome with other chronic pain disorders, such as irritable bowel syndrome, endometriosis and fibromyalgia syndrome. In this review, we highlight evidence supporting neural cross‐talk in the dorsal root ganglia, spinal cord and brain levels, which might play a role in the development of chronic pain disorders through central sensitization. In addition, we focus on transient receptor potential V1 and transient receptor potential A1 as the receptor targets for chronic pain conditions, because transient receptor potential V1 and transient receptor potential A1 act as a nocisensor to mediate not only an afferent signal to...
http://www.medworm.com/rss/comments.php?id=5719112
Sleep problems and risk of fibromyalgia: Untenable conclusions
Arthritis and Rheumatism
2/21/2012
(Source: Arthritis and Rheumatism)

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Reply to Letter to Editor: “Sleep problems and risk of fibromyalgia: Untenable conclusions”
Arthritis and Rheumatism
2/21/2012
(Source: Arthritis and Rheumatism)
http://www.medworm.com/rss/comments.php?id=5718810
Transient receptor potential A1 receptor‐mediated neural cross‐talk and afferent sensitization induced by oxidative stress: Implication for the pathogenesis of interstitial cystitis/bladder pain syndrome
International Journal of Urology
2/21/2012
AbstractAlthough the pathogenesis of interstitial cystitis/bladder pain syndrome remains unknown, there is a significant correlation of interstitial cystitis/bladder pain syndrome with other chronic pain disorders, such as irritable bowel syndrome, endometriosis and fibromyalgia syndrome. In this review, we highlight evidence supporting neural cross‐talk in the dorsal root ganglia, spinal cord and brain levels, which might play a role in the development of chronic pain disorders through central sensitization. In addition, we focus on transient receptor potential V1 and transient receptor potential A1 as the receptor targets for chronic pain conditions, because transient receptor potential V1 and transient receptor potential A1 act as a nocisensor to mediate not only an afferent signal to...
http://www.medworm.com/rss/comments.php?id=5907295
Sleep problems and risk of fibromyalgia: Untenable conclusions
Arthritis and Rheumatism
2/21/2012
(Source: Arthritis and Rheumatism)
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Reply to Letter to Editor: “Sleep problems and risk of fibromyalgia: Untenable conclusions”
Arthritis and Rheumatism
2/21/2012
(Source: Arthritis and Rheumatism)
http://www.medworm.com/rss/comments.php?id=5905824
Primary total knee arthroplasty in patients with fibromyalgia.
Orthopedics
2/20/2012 6:54:03 AM
Authors: D'Apuzzo MR, Cabanela ME, Trousdale RT, Sierra RJ Abstract No data on the results of total knee arthroplasty (TKA) in patients with fibromyalgia have been published. The purposes of this study were to review a cohort of patients with fibromyalgia undergoing TKA to determine the level of postoperative pain and satisfaction with the surgery, the incidence of postoperative surgical complications, and revision rates and their relationship to TKA design. One hundred ten patients with fibromyalgia (141 knees) who underwent primary TKA between 1990 and 2001 were studied. The average age was 64 years (range, 39-86 years), and the average follow-up was 7 years (range, 2-16 years). Forty-five knees were cruciate retaining, and 96 had a posterior stabilized design. Clinical outcome w...
http://www.medworm.com/rss/comments.php?id=5712054
Autonomic dysfunction in women with fibromyalgia
BioMed Central
2/20/2012
Fibromyalgia (FM) is an idiopathic disease characterized by widespread pain and a myriad of symptoms. Symptoms are diverse and include not only pain but also anxiety, depression, orthostatic intolerance, and cold intolerance. While the etiology of FM is not fully understood, data have suggested that FM may stem from dysfunction of the autonomic nervous system. This dysfunction has been reported at rest, and after a physiological stressor such as exercise. However, few studies have examined the responses during exercise. This novel approach may shed some new light on the effect of exercise in women with FM. (Source: BioMed Central)

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Response to “A new definition of neuropathic pain”
Pain
2/20/2012
A recent commentary in PAIN® entitled “A new definition of neuropathic pain” contains inaccuracies concerning the complex regional pain syndrome (CRPS). The Scientific Advisory Committee of the Reflex Sympathetic Dystrophy Syndrome Association (RSDSA; http://www.rsds.org) would like to correct these in the interest of CRPS patients and to make the ongoing debate on the IASP definition of neuropathic pain factual. The commentary states that the new definition would exclude CRPS from among neuropathic pain syndromes because of “the lack of structural abnormalities in so-called dysfunctional states (fibromyalgia, CRPS, vulvodynia, interstitial cystitis, etc.)”. (Source: Pain)
http://www.medworm.com/rss/comments.php?id=5810134
A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia
BMC Musculoskeletal Disorders
2/20/2012
Conclusion: In this ethnic group; a disabling form of FM is associated to a particular SCN9A sodium channel gene variant. These preliminary results raise the possibility that some patients with severe FM may have a dorsal root ganglia sodium channelopathy. (Source: BMC Musculoskeletal Disorders)
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Lacosamide for neuropathic pain and fibromyalgia in adults.
Cochrane Database of Systematic Reviews
2/19/2012 1:00:03 PM
CONCLUSIONS: Lacosamide has limited efficacy in the treatment of peripheral diabetic neuropathy. Higher doses did not give consistently better efficacy, but were associated with significantly more adverse event withdrawals. Where adverse event withdrawals are high with active treatment compared with placebo and when last observation carried forward imputation is used, as in some of these studies, significant overestimation of treatment efficacy can result. It is likely, therefore, that lacosamide is without any useful benefit in treating neuropathic pain; any positive interpretation of the evidence should be made with caution if at all. PMID: 22336864 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
http://www.medworm.com/rss/comments.php?id=5710946
Neuroticism in Young Women with Fibromyalgia Links to Key Clinical Features
Computational Intelligence and Neuroscience
2/19/2012 11:48:00 AM
Conclusion. The personality trait of neuroticism significantly associates with the key FM characteristics of pain, sleep, fatigue and confusion as well as the common co-morbidities of depression, anxiety and stress. Personality appears to be an important modulator of FM clinical symptoms. (Source: Computational Intelligence and Neuroscience)

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Experiences of a Web-Based Nursing Intervention—Interviews with Women with Chronic Musculoskeletal Pain
Pain Management Nursing
2/17/2012 4:46:14 PM
Abstract: Patients with fibromyalgia must simultaneously cope with chronic pain, emotional distress, activity avoidance and disability. The majority of fibromyalgia patients are women. New interventions using information and communications technologies such as Internet applications and smart phones can be used for text-based communications between providers and patients with chronic pain. The aim of this qualitative study was to explore female patients' experiences of participating in a 4-week web-based home intervention after in-house multidimensional rehabilitation. The framework of the intervention was inspired by mindfulness-based cognitive behavioral therapy using daily diaries and situational feedback as tools. Interviews were made with seven women about their general experiences of ...
http://www.medworm.com/rss/comments.php?id=5704090
Societal and individual burden of illness among fibromyalgia patients in France: Association between disease severity and OMERACT core domains
BMC Musculoskeletal Disorders
2/17/2012
This study aimed to provide an assessment of the burden of illness associated with FM in France and its association with disease severity and core domains as defined by Outcome Measures in Rheumatology Clinical Trials (OMERACT) for FM. Methods: This cross-sectional, observational study recruited patients with a prior diagnosis of FM from 18 community-based physician offices in France. Patients completed questions about FM impact (Fibromyalgia-Impact Questionnaire [FIQ]), core symptoms (defined by OMERACT), health-related quality of life (EQ-5D), current overall health status (rated on a scale from 0 to 100), productivity, treatment satisfaction, and out-of-pocket expenses related to FM. Site staff recorded patients' treatment and health resource use based on medical record review. Costs we...
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Effects of strength vs aerobic exercise on pain severity in adults with fibromyalgia: A randomized equivalence trial
Pain
2/17/2012
Summary: Strengthening and aerobic exercise had equivalent effects on reducing pain severity in patients with fibromyalgia.Abstract: Strength training and aerobic exercise have beneficial effects on pain in adults with fibromyalgia. However, the equivalence of strengthening and aerobic exercise has not been reported. The primary aim of this randomized equivalence trial involving patients with fibromyalgia admitted to an interdisciplinary pain treatment program was to test the hypothesis that strengthening (n=36) and aerobic (n=36) exercise have equivalent effects (95% confidence interval within an equivalence margin ±8) on pain, as measured by the pain severity subscale of the Multidimensional Pain Inventory. Secondary aims included determining the effects of strengthening and aerobic exe...
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Study Suggests Erasing Neuronal Memories May Help Control Persistent Pain
Health News from Medical News Today
2/16/2012 3:00:00 AM
For some, the pain is so great that they can't even bear to have clothes touch their skin. For others, it means that every step is a deliberate and agonizing choice. Whether the pain is caused by arthritic joints, an injury to a nerve or a disease like fibromyalgia, research now suggests there are new solutions for those who suffer from chronic pain. A team of researchers led by McGill neuroscientist Terence Coderre, who is also affiliated with the Research Institute of the McGill University Health Centre, has found the key to understanding how memories of pain are stored in the brain... (Source: Health News from Medical News Today)
http://www.medworm.com/rss/comments.php?id=5696133
[Fibromyalgia and sleep: a review].
Revista de Neurologia
2/16/2012
CONCLUSIONS. The importance of sleep in this syndrome is increasingly being understood thanks to the progress made in research on fibromyalgia and the use of biopsychosocial explanatory models. Many studies have shown complex inter-actions between sleep disturbances, neuroendocrine and immune abnormalities and the clinical symptoms present in fibromyalgia. Such interactions suggest that sleep disturbances may be both a cause and a consequence of fibromyalgia. Although sleep improvement contributes to alleviating various symptoms of fibromyalgia, there are few effective drugs available and their use has some disadvantages. Regarding other non-drug therapies, it is important to highlight the promising findings of cognitive-behavioral therapy and aerobic exercise. Future research should deter...
http://www.medworm.com/rss/comments.php?id=5710799
Tai chi benefits people with chronic health problems like Parkinsons, arthritis and fibromyalgia
NaturalNews.com
2/15/2012 1:00:00 AM
Recent studies conducted by Fushong Li of the Oregon Research Institute in Eugene, Oregon have determined that the ancient Chinese practice of tai chi can a positive impact on those afflicted with Parkinson's disease (PD). Parkinson's disease is a degenerative neurological... (Source: NaturalNews.com)
http://www.medworm.com/rss/comments.php?id=5695451
Land- and water-based exercise intervention in women with fibromyalgia: the al-Andalus physical activity randomised control trial
BMC Musculoskeletal Disorders
2/15/2012
DiscussionOur study attempts to reduce the impact of fibromyalgia and improve patients' health status by implementing two types of exercise interventions. Results from this study will help to assess the efficacy of exercise interventions for the treatment of fibromyalgia. If the interventions would be effective, this study will provide low-cost and feasible alternatives for health professionals in the management of fibromyalgia. Results from the al-Andalus physical activity intervention will help to better understand the potential of regular physical activity for improving the well-being of women with fibromyalgia. (Source: BMC Musculoskeletal Disorders)

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Efficacy and safety of meditative movement therapies in fibromyalgia syndrome: a systematic review and meta-analysis of randomized controlled trials
Rheumatology International
2/14/2012 11:59:47 AM
Abstract  A systematic review with meta-analysis of the efficacy and safety of meditative movement therapies (Qigong, Tai Chi and Yoga) in fibromyalgia syndrome (FMS) was carried out. We screened Clinicaltrials.Gov, Cochrane Library, PsycINFO, PubMed and Scopus (through December 2010) and the reference sections of original studies for meditative movement therapies (MMT) in FMS. Randomized controlled trials (RCT) comparing MMT to controls were analysed. Outcomes of efficacy were pain, sleep, fatigue, depression and health-related quality of life (HRQOL). Effects were summarized using standardized mean differences (SMD [95% confidence interval]). Outcomes of safety were drop out because of adverse events and serious adverse events. A total of 7 out of 117 studies with 362 sub...
http://www.medworm.com/rss/comments.php?id=5705834
Matrix Assessment Profile (MAP) helps reveal solutions for fibromyalgia, chronic symptoms and vicious cycle disorder - Dr. DiCenso
NaturalNews.com
2/14/2012 1:00:00 AM
Whether you are suffering from depression, anxiety, stress, fibromyalgia, arthritis, osteoporosis, artificial sweetener disease, IBS, nicotine addiction, mood swings, migraine headaches, lack of energy, or you just have a long list of chronic symptoms and no definitive... (Source: NaturalNews.com)
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Association of employment and working conditions with physical and mental health symptoms for people with fibromyalgia.
Disability and Rehabilitation
2/12/2012
Conclusions: Work modifications could allow more people with FM to remain employed and alleviate symptoms. Persons with FM should be counseled to consider what elements of their work may lead to symptom exacerbation. [Box: see text]. PMID: 22324423 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
http://www.medworm.com/rss/comments.php?id=5714108
Coenzyme Q(10) in salivary cells correlate with blood cells in Fibromyalgia: Improvement in clinical and biochemical parameter after oral treatment.
Clinical Biochemistry
2/10/2012
CONCLUSIONS: Patients with FM showed an important dysfunction in CoQ(10) levels and might benefit from oral supplementation. PMID: 22342824 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
http://www.medworm.com/rss/comments.php?id=5729473
Frequency of fibromyalgia syndrome in breast cancer patients
International Journal of Clinical Oncology
2/9/2012 12:12:06 PM
Conclusion  We note that the frequency of FM in the operated breast cancer patients in this study was higher than that reported in normal populations in the literature. Also, we found that the presence of FM had negative effects on the quality of life of the breast cancer patients. Accordingly, in the evaluation of widespread pain and complaints of fatigue in long-surviving breast cancer patients, after metastatic disease is excluded, the probability of FM should be kept in mind, so that appropriate treatment can be initiated to improve their functional status and quality of life. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s10147-012-0377-9Authors Nuray Akkaya, Department of Physical Medicine and Rehabilitation, Medicine Faculty, Univ...
http://www.medworm.com/rss/comments.php?id=5685843
Effect of Whole-Body Vibration Exercise on Balance in Women with Fibromyalgia Syndrome: A Randomized Controlled Trial
The Journal of Alternative and Complementary Medicine
2/9/2012 9:38:58 AM
The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0. (Source: The Journal of Alternative and Complementary Medicine)

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Obesity Linked to Worse Fibromyalgia Symptoms
MedicineNet Sleep General
2/9/2012 2:00:00 AM
Title: Obesity Linked to Worse Fibromyalgia SymptomsCategory: Health NewsCreated: 2/8/2012 6:06:00 PMLast Editorial Review: 2/9/2012 (Source: MedicineNet Sleep General)

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Exercising With Fibromyalgia
About.com Eating Disorders
2/9/2012
Learn the benefits of exercise in easing the chronic pain of Fibromyalgia from your About Exercise Guide (Source: About.com Eating Disorders)

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Obesity Linked to Worse Fibromyalgia Symptoms
The Doctors Lounge - Neurology
2/8/2012 5:00:00 PM
As weight increases, so do patient reports of greater pain, poor quality of life, researchers say (Source: The Doctors Lounge - Neurology)
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Mayo Clinic Study Finds Obesity Affects Severity of Symptoms in Fibromyalgia Patients
News from Mayo Clinic
2/8/2012 7:49:50 AM
One factor associated with fibromyalgia symptoms is a patient's weight, according to a Mayo Clinic study published this month in "Arthritis Care & Research." A higher rate of obesity in those who have fibromyalgia may be caused by a cycle of pain and physical inactivity. (Source: News from Mayo Clinic)
http://www.medworm.com/rss/comments.php?id=5667127
RETRACTED ARTICLE: Impact of Different Treatment of Whole-Body Cryotherapy on Circulatory Parameters
Archivum Immunologiae et Therapiae Experimentalis
2/7/2012 2:01:46 AM
Abstract  Cryotherapy is commonly used as a procedure to relieve pain symptoms, particularly in inflammatory diseases, injuries and overuse symptoms. A peculiar form of cold therapy or stimulation was proposed 30 years ago for the treatment of rheumatic diseases. The therapy consists in the exposure to very cold air in special cryochambers. The air is maintained at temperatures between −110 and −160°C. The treatment was named whole-body cryotherapy (WBC). It consists in a brief exposure to extreme cold in a temperature-controlled chamber. It is applied to relieve pain and inflammatory symptoms caused by numerous disorders, particularly those associated with rheumatic conditions, and it is recommended for the treatment of arthritis, fibromyalgia and ankylosing spon...
http://www.medworm.com/rss/comments.php?id=6243255
Impact of Different Treatment of Whole-Body Cryotherapy on Circulatory Parameters
Archivum Immunologiae et Therapiae Experimentalis
2/7/2012 2:01:46 AM
Abstract  Cryotherapy is commonly used as a procedure to relieve pain symptoms, particularly in inflammatory diseases, injuries and overuse symptoms. A peculiar form of cold therapy or stimulation was proposed 30 years ago for the treatment of rheumatic diseases. The therapy consists in the exposure to very cold air in special cryochambers. The air is maintained at temperatures between −110 and −160°C. The treatment was named whole-body cryotherapy (WBC). It consists in a brief exposure to extreme cold in a temperature-controlled chamber. It is applied to relieve pain and inflammatory symptoms caused by numerous disorders, particularly those associated with rheumatic conditions, and it is recommended for the treatment of arthritis, fibromyalgia and ankylosing spon...
http://www.medworm.com/rss/comments.php?id=5683264
Serum vitamin D level and bone mineral density in premenopausal Egyptian women with fibromyalgia
Rheumatology International
2/6/2012 2:37:15 PM
This study confirmed high prevalence of hypovitaminosis D among in patients with PFMS. This study confirmed the concept that FMS is a risk factor for OP. Based on this, an early nutrition program rich in calcium and vitamin D, appropriate exercise protocols, and medical treatment should be considered in these patients in terms of preventing OP development. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00296-012-2361-0Authors Shereem Mohamed Olama, Departments of Rheumatology and Rehabilitation, Faculty of Medicine, Mansoura University, Mansoura, EgyptMohammed K. Senna, Departments of Rheumatology and Rehabilitation, Faculty of Medicine, Mansoura University, Mansoura, EgyptMohammed Mohamed Elarman, Department of Clinical Pathology, Faculty of Medicine, ...
http://www.medworm.com/rss/comments.php?id=5671421
Pain Negatively Affects Cognition in FibromyalgiaPain Negatively Affects Cognition in Fibromyalgia
Medscape Today Headlines
2/6/2012 1:15:26 PM
Pain decreased mathematical abilities and attention control more than depression, anxiety, fatigue, sleep complaints, or medication use. Medscape Medical News (Source: Medscape Today Headlines)
http://www.medworm.com/rss/comments.php?id=5664170
Lyrica for Fibromyalgia
About.com Eating Disorders
2/6/2012
Study results promising for Lyrica as a treatment for fibromyalgia. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=5665051
The Role of Antipsychotics in the Management of Fibromyalgia
CNS Drugs
2/5/2012 8:22:15 PM
(Source: CNS Drugs)
http://www.medworm.com/rss/comments.php?id=5660910
Using questionnaires to assess the quality of life and multidimensionality of fibromyalgia patients
Revista Brasileira de Reumatologia
2/3/2012 5:19:07 AM
CONCLUSIONS: All instruments had good discriminating power (P < 0.05), especially FIQ, VAS and PSI, whose areas under the ROC curve were greater (Source: Revista Brasileira de Reumatologia)

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Pall Protocol
About.com Eating Disorders
2/3/2012
Is a build up of nitric oxide one of the causes of fibromyalgia and chronic fatigue syndrome? Read Washington State University researcher Martin Pall's NO/ONOO theory and experimental treatment protocol for fibromyalgia, chronic fatigue syndrome, multiple chemical sensitivity and post-traumatic stress disorder. (Source: About.com Eating Disorders)
http://www.medworm.com/rss/comments.php?id=5657725
[Restrictions in participation in women with fibromyalgia syndrome : An explorative pilot study].
Schmerz
2/1/2012
CONCLUSION: Fibromyalgia syndrome patients admit to be extremely impaired in a variety of social roles. Their statements have enabled us to develop a questionnaire that reflects the range of factors restricting participation from the patient's perspective. PMID: 22366934 [PubMed - in process] (Source: Schmerz)
http://www.medworm.com/rss/comments.php?id=5770987
Fibromyalgia, is it a true rheumatological or a psychogenic condition?
Ir Med J
2/1/2012
Authors: O'Connor MB, Phelan MJ PMID: 22455246 [PubMed - indexed for MEDLINE] (Source: Ir Med J)
http://www.medworm.com/rss/comments.php?id=5989746
The validity and reliability of the Moroccan version of the Revised Fibromyalgia Impact Questionnaire
Rheumatology International
1/31/2012 2:06:02 AM
Abstract  The Revised Fibromyalgia Impact Questionnaire (FIQ-R) is an updated version of the FIQ attempts to address the limitations of the Fibromyalgia Impact Questionnaire (FIQ). As there is no Moroccan version of the FIQ-R available, we aimed to investigate the validity and reliability of a Moroccan translation of the FIQR in Moroccan fibromyalgia (FM) patients. After translating the FIQR into Moroccan, it was administered to 80 patients with FM. All of the patients filled out the questionnaire together with Arabic version of short form-36 (SF-36). The tender-point count was calculated from tender points identified by thumb palpation. Three days later, FM patients filled out the Moroccan FIQR at their second visit. The test–retest reliability of the Moroccan FIQR quest...
http://www.medworm.com/rss/comments.php?id=5662678
Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia
Arthritis and Rheumatism
1/31/2012
CONCLUSIONS:Our findings suggest that intrinsic brain connectivity can be used as a candidate objective marker that tracks intra‐subject with changes in spontaneous chronic pain in FM. We propose that intrinsic connectivity measures could potentially be used either in research or clinical settings as a complementary, more objective outcome. © 2012 American College of Rheumatology. (Source: Arthritis and Rheumatism)
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Reduced insular γ‐aminobutyric acid in fibromyalgia
Arthritis and Rheumatism
1/30/2012 8:25:29 AM
ConclusionDiminished inhibitory neurotransmission resulting from lower concentrations of GABA within the right anterior insula may play a role in the pathophysiology of FM and other central pain syndromes. (Source: Arthritis and Rheumatism)
http://www.medworm.com/rss/comments.php?id=5641541
Cyberchondria: the one diagnosis patients miss
American Medical News - HEALTH
1/30/2012 7:00:00 AM
Physicians say patient anxiety is increasing because of medical information read online, with self-diagnoses of diseases like fibromyalgia and lupus. (Source: American Medical News - HEALTH)
http://www.medworm.com/rss/comments.php?id=5646714
Multicomponent Cognitive-Behavioral Group Therapy With Hypnosis for the Treatment of Fibromyalgia: Long-Term Outcome
The Journal of Pain
1/30/2012
This study compared the efficacy of 2 psychological treatments for fibromyalgia with each other and with standard care. Ninety-three patients with fibromyalgia (FM) were randomly assigned to 1 of the 3 experimental conditions: 1) multicomponent cognitive-behavioral therapy (CBT); 2) multicomponent CBT with hypnosis; and 3) pharmacological treatment (standard care control group). The outcome measures of pain intensity, catastrophizing, psychological distress, functionality, and sleep disturbances were assessed before treatment, immediately after treatment, and at 3- and 6-month follow-up visits. CBT and CBT with hypnosis participants received the standard pharmacological management plus 14 weekly, 120-minute-long sessions of psychological treatment. All but 1 session followed a group format...
http://www.medworm.com/rss/comments.php?id=5755858
Differences between questionnaire- and interview-based measures of activities of daily living (ADL) ability and their association with observed ADL ability in women with rheumatoid arthritis, knee osteoarthritis, and fibromyalgia.
Scandinavian Journal of Rheumatology
1/30/2012
Conclusion: Measures of self-reported ADL ability based on either questionnaire or interview have limited relationship to each other or to observed performance of ADL tasks. PMID: 22283877 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
http://www.medworm.com/rss/comments.php?id=5666373
2. The blink reflex: Long known, but still fascinating
Clinical Neurophysiology
1/28/2012 11:42:16 AM
The blink reflex is routinely used in clinical neurophysiology to characterize the functional integrity of the trigemino-facial reflex pathway covering supraorbital nerve, pons, medulla oblongata, and facial nerve. Recent findings of unconditioned blink reflex alterations, as well as changes in blink reflex modulation by subthreshold prepulse stimuli or suprathreshold double pulse stimulation, in patients with spinal cord injury or chronic pain syndromes, e.g. fibromyalgia, suggest plastic changes at the brainstem level in these conditions. The blink reflex and its modulation also serve to document acute pharmacological effects, e.g. following intrathecal bolus application of the GABA-ergic drug baclofen, thus concurring with an antispastic action of baclofen at the brainstem level. Finall...
http://www.medworm.com/rss/comments.php?id=5636734
Treatment of fibromyalgia at the Maharishi Ayurveda Health Centre in Norway II—a 24-month follow-up pilot study
Clinical Rheumatology
1/26/2012 1:44:10 AM
Abstract  Treatments offered at the Maharishi Ayurveda Health Centre in Norway are based on Maharishi Vedic Medicine (MVM). MVM is a consciousness-based revival by Maharishi Mahesh Yogi, the founder of the Transcendental Meditation (TM) program of the ancient Ayurvedic medicine tradition in India. To extend from 6 to 24 months, a pilot study of the effects of the treatment program at the Health Centre on fibromyalgia. Retesting 2 years after a clinical trial. In this intention to treat study, 31 women with a diagnosis of fibromyalgia received an individually tailored program of (1) physiological purification therapy (Maharishi Panchakarma) and (2) Ayurvedic recommendations regarding daily routine and diet including a novel approach to food intolerance. Five subjec...

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Sleep problems linked to risk of fibromyalgia
Modern Medicine
1/26/2012
Women with sleep problems have a higher risk of developing fibromyalgia than women who don’t have trouble sleeping, according to a large prospective Norwegian study. (Source: Modern Medicine)

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Problems and Accommodation Strategies Reported by Computer Users with Rheumatoid Arthritis or Fibromyalgia
Journal of Occupational Rehabilitation
1/24/2012 2:30:35 AM
Conclusions: The number of problems during computer use was substantial in our sample, and our respondents with RA and FM may not implement the most effective strategies to deal with their chair, keyboard, or mouse problems. This study suggests that workers with RA and FM might potentially benefit from education and interventions to assist with the development of accommodation strategies to reduce problems related to computer use. Content Type Journal ArticlePages 1-10DOI 10.1007/s10926-012-9353-5Authors Nancy A. Baker, Department of Occupational Therapy, University of Pittsburgh, 5012 Forbes Tower, Pittsburgh, PA 15260, USAElaine N. Rubinstein, Department of Measurement and Evaluation of Teaching, University of Pittsburgh, Pittsburgh, PA, USAJoan C. Rogers, Department of Occupat...
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Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?
Rheumatology International
1/24/2012 1:53:32 AM
Abstract  The aims of this study were to investigate the relationship between magnesium levels and fibromyalgia symptoms and to determine the effect of magnesium citrate treatment on these symptoms. Sixty premenopausal women diagnosed with fibromyalgia according to the ACR criteria and 20 healthy women whose age and weight matched the premenopausal women were evaluated. Pain intensity, pain threshold, the number of tender points, the tender point index, the fibromyalgia impact questionnaire (FIQ), the Beck depression and Beck anxiety scores and patient symptoms were evaluated in all the women. Serum and erythrocyte magnesium levels were also measured. The patients were divided into three groups. The magnesium citrate (300 mg/day) was given to the first group (n =&...
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Reversible ptosis probably related to duloxetine use
General Hospital Psychiatry
1/24/2012
Duloxetine (Cymbalta) is a dual serotonin–noradrenaline reuptake inhibitor and is used to treat depressive disorders, stress urinary incontinence and fibromyalgia . Here we report a case of reversible ptosis of eye lid that we judged to be related to duloxetine use. (Source: General Hospital Psychiatry)
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Safety and efficacy of esreboxetine in patients with fibromyalgia: A 14‐week, randomized, double‐blind, placebo‐controlled, multicenter clinical trial
Arthritis and Rheumatism
1/24/2012
Conclusion.Esreboxetine was generally well tolerated and associated with significant improvements in pain, FIQ, PGIC, and fatigue scores compared with placebo. The lack of a dose‐response relationship in both the efficacy and safety analyses suggests that 4‐mg/d esreboxetine would offer clinical benefit with the least risk of drug exposure. (Source: Arthritis and Rheumatism)
http://www.medworm.com/rss/comments.php?id=5632963
"Governed by the pain": narratives of fibromyalgia.
Disability and Rehabilitation
1/23/2012
Conclusions: The narrative is characterized by a lack of movement and resolution, with participants engaged in an enduring struggle against the challenges of FM. Psychological approaches that facilitate this ongoing adjustment process may prove beneficial in FM treatment and rehabilitation. [Box: see text]. PMID: 22263672 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
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Discover which foods and chemical additives cause arthritis inflammation, gout and fibromyalgia pain
NaturalNews.com
1/21/2012 11:01:45 PM
Certain foods and chemical additives disguised as food can aggravate or cause muscle and joint pain associated with arthritis, gout and fibromyalgia. Avoiding these foods can pave the way for reduced inflammation, stiffness and pain - setting the stage for ongoing relief... (Source: NaturalNews.com)
http://www.medworm.com/rss/comments.php?id=5617757
Judge: Insurer's Reliance On Record Reviews, Video Surveillance Reasonable
LexisNexis® Mealey's™ Disability Insurance Legal News
1/20/2012 7:05:53 PM
BOSTON - An ERISA-governed disability insurer that relied on record reviews and surveillance video in its decision to deny benefits to a claimant with reflex sympathetic dystrophy (RSD) and fibromyalgia acted reasonably, a Massachusetts federal judge ruled Jan. 6 (Diahann L. Gross v. Sun Life Assurance Company of Canada, No. 09-11678, D. Mass.; 2012 U.S. Dist. LEXIS 1595). Full story on lexis.com (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
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Characteristics of suitable work from the perspective of patients with fibromyalgia
Rheumatology
1/20/2012
Conclusions. According to patients with FM, suitable work is paced in such a way that one can perform the job well and with satisfaction while keeping energy for home and free time and having acknowledgement and help from management and colleagues. The brief suitable work checklist that is provided can help patients with FM to negotiate with employers and job professionals to improve the match between job demands and capabilities. (Source: Rheumatology)
http://www.medworm.com/rss/comments.php?id=5614192
Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats.
Autonomic Neuroscience
1/20/2012
Authors: Oliveira LR, de Melo VU, Macedo FN, Barreto AS, Badaue-Passos D, Viana Dos Santos MR, Dias DP, Sluka KA, Desantana JM, Santana-Filho VJ Abstract Fibromyalgia (FM) is characterized by chronic non-inflammatory widespread pain (CWP) and changes in sympathetic function. In attempt to elucidate the pathophysiological mechanisms of FM we used a well-established CWP animal model. We aimed to evaluate changes in cardiac autonomic balance and baroreflex function in response to CWP induction in rats. CWP was induced by two injections of acidic saline (pH 4.0, n=8) five days apart into the left gastrocnemius muscle. Control animals were injected twice with normal saline (pH 7.2, n=6). One day after the second injection of acidic saline or normal saline, the animals had pulse interval...

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Some foods and chemical additives cause arthritis inflammation, gout and fibromyalgia pain
NaturalNews.com
1/18/2012 1:00:00 AM
Certain foods and chemical additives disguised as food can aggravate or cause muscle and joint pain associated with arthritis, gout and fibromyalgia. Avoiding these foods can pave the way for reduced inflammation, stiffness and pain - setting the stage for ongoing relief... (Source: NaturalNews.com)
http://www.medworm.com/rss/comments.php?id=5604993
Lowe & Fibromyalgia
About.com Eating Disorders
1/18/2012
When muscle and joint aches and pains accompany hypothyroidism, are they a separate problem -- fibromyalgia -- or is fibromyalgia a symptom of the thyroid problem itself, from Mary Shomon, Thyroid Guide, patient advocate and author of a number of books and guides on thyroid disease and autoimmune disease (Source: About.com Eating Disorders)

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Physical Activity, Sustained Sedentary Behavior, and Pain Modulation in Women With Fibromyalgia
The Journal of Pain
1/16/2012
Abstract: Fibromyalgia (FM) has been conceptualized as a disorder of the central nervous system, characterized by augmented sensory processing and an inability to effectively modulate pain. We previously reported that physical activity is related to brain processing of pain, providing evidence for a potential mechanism of pain management. The purpose of this study was to extend our work by manipulating pain modulation and determining relationships to both physical activity and sustained sedentary behavior. Eleven women with FM completed accelerometer measures of physical activity and underwent functional magnetic resonance imaging of painful heat, administered alone and during distracting cognitive tasks. Results showed that physical activity was significantly (P < .005) and positively rel...
http://www.medworm.com/rss/comments.php?id=5658116
Identification of the Clinical Features Distinguishing Psoriatic Arthritis and Fibromyalgia.
J Rheumatol
1/15/2012
CONCLUSION: The shared clinical features of PsA and FM that had the greatest discriminating power for FM were the number of FM-associated symptoms and tender point count. PMID: 22247363 [PubMed - as supplied by publisher] (Source: J Rheumatol)
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Functional capacity, muscle strength and falls in women with fibromyalgia. - Góes SM, Leite N, Shay BL, Homann D, Stefanello JM, Rodacki AL.
SafetyLit: All (Unduplicated)
1/14/2012 6:37:58 PM
The objective of this study was to evaluate the functional performance and lower limb muscle ... (Source: SafetyLit: All (Unduplicated))
http://www.medworm.com/rss/comments.php?id=5590149
Exercise, Talk Therapy by Phone May Help Relieve Fibromyalgia Pain
eMedicineHealth.com
1/13/2012 2:00:00 AM
(Source: eMedicineHealth.com)
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The Effects of Fibromyalgia Syndrome on Female Sexuality: A Controlled Study
The Journal of Sexual Medicine
1/12/2012
Conclusions.  Fibromyalgia has negative effects on female sexual function that are aggravated by depression. Yilmaz H, Yilmaz SD, Polat HAD, Salli A, Erkin G, and Ugurlu H. The effects of fibromyalgia syndrome on female sexuality: a controlled study. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)
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Fibromyalgia and chronic fatigue syndrome in children
Pediatrics International
1/12/2012
Conclusion:  CFS and FM are different from each other at least in childhood, from an immunological aspect, although some patients could have both conditions. (Source: Pediatrics International)
http://www.medworm.com/rss/comments.php?id=5899810
Fibromyalgia and Diet: What's the Link?
WebMD Health
1/10/2012 2:24:21 PM
WebMD talks to experts for details on the best diet for fibromyalgia, including foods to avoid and foods to help your body stay strong. Also includes what you should know about supplements and nutrition for fibromyalgia. (Source: WebMD Health)
http://www.medworm.com/rss/comments.php?id=5577889
Real‐World Role of Tricyclic Antidepressants in the Treatment of Fibromyalgia
Pain Practice
1/9/2012
Discussion:  Research covering 1999 to 2005 using the same methods found that 15.9% of patients with FM used TCAs during the year before FM diagnosis and 20.7% used TCAs during the year after. These findings suggest that TCA use among the patients with FM is uncommon and may be declining in real‐world practice. (Source: Pain Practice)
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Functional capacity, muscle strength and falls in women with fibromyalgia
Clinical Biomechanics
1/9/2012
The objective of this study was to evaluate the functional performance and lower limb muscle strength in women with fibromyalgia and determine the relationship between muscle strength and falls.Methods: Sixteen females with fibromyalgia and 16 healthy women participated in the study. Pain intensity, fibromyalgia impact on quality of life, physical activity level and fall prevalence were assessed. The peak torque and the rate of torque development were determined in maximal voluntary isometric contraction (hip, knee and ankle joints) using a load cell. The 30s chair stand, 8ft up and go, sit and reach, and functional reach tests were used to characterize functional performance.Findings: Women with fibromyalgia showed deficits in lower limb muscle strength, balance and agility and exhibited ...
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Real‐World Role of Tricyclic Antidepressants in the Treatment of Fibromyalgia
Pain Practice
1/9/2012
Discussion:  Research covering 1999 to 2005 using the same methods found that 15.9% of patients with FM used TCAs during the year before FM diagnosis and 20.7% used TCAs during the year after. These findings suggest that TCA use among the patients with FM is uncommon and may be declining in real‐world practice. (Source: Pain Practice)
http://www.medworm.com/rss/comments.php?id=5915283
Effect of pregabalin on sleep in patients with fibromyalgia and sleep maintenance disturbance: A randomized, placebo‐controlled, 2‐way crossover polysomnography study
Arthritis Care and Research
1/9/2012
Conclusion:Patients with fibromyalgia treated with pregabalin had statistically‐significant and meaningful improvements in sleep, as assessed by PSG. Patients with fibromyalgia also reported reduced daily pain. Pregabalin was well tolerated. © 2012 by the American College of Rheumatology (Source: Arthritis Care and Research)

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[Original Articles] Disrupted Functional Connectivity of the Pain Network in Fibromyalgia
Psychosomatic Medicine
1/9/2012
Conclusions These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggesting that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. (Source: Psychosomatic Medicine)
http://www.medworm.com/rss/comments.php?id=5586412
Impaired functional capacity and exacerbation of pain and exertion during the 6-minute walk test in women with fibromyalgia
Revista Brasileira de Fisioterapia
1/6/2012 10:16:29 PM
CONTEXTUALIZAÇÃO: A fibromialgia (FM) parece limitar o desempenho físico, e a realização de atividades da vida diária (AVDs) pode exacerbar a dor e o esforço percebido nesses pacientes. OBJETIVOS: Comparar o desempenho do teste de caminhada de 6 minutos (TC6) entre pacientes com FM e controles e verificar relações entre esse desempenho com o impacto na qualidade de vida, na realização de tarefas da vida diária e no nível de atividade física. MÉTODOS: Participaram do estudo 19 mulheres com FM e 20 mulheres saudáveis. Realizou-se o TC6 e, durante o teste, foram mensuradas a intensidade de dor e a percepção subjetiva de esforço (PSE). Foram aplicados o Fibromyalgia Impact Questionnaire (FIQ), Health Assessment Questionnaire (HAQ) e o International Physical Activity Question...
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Trauma and work-related pain syndromes: Risk factors, clinical picture, insurance and law interventions. - Buskila D, Mader R.
SafetyLit: All (Unduplicated)
1/6/2012 10:21:09 AM
In the past decade, major progress has been made in our understanding of fibromyalgia syndrome (FMS). Various triggers have been implicated as contributing to symptom development in FMS when genetically susceptible individuals are challenged. A substantial... (Source: SafetyLit: All (Unduplicated))
http://www.medworm.com/rss/comments.php?id=5566418
The Effects of Coexisting Fibromyalgia Syndrome on Pain Intensity, Disability, and Treatment Outcome in Patients with Chronic Lateral Epicondylitis
Pain Medicine
1/5/2012
Conclusion.  Coexisting FS may increase the pain intensity and disability, and negatively affect the treatment outcome in patients with chronic LE. (Source: Pain Medicine)
http://www.medworm.com/rss/comments.php?id=5571833
Executive function in chronic pain patients and healthy controls: different cortical activation during response inhibition in fibromyalgia. Glass JM, Williams DA, Fernandez-Sanchez ML, et al. J Pain 2011;12(12):1219–29. Epub 2011 Sep 25
The Spine Journal
1/1/2012
The primary symptom of fibromyalgia (FM) is chronic, widespread pain; however, patients report additional symptoms including decreased concentration and memory. Performance-based deficits are seen mainly in tests of working memory and executive function. Neural correlates of executive function were investigated in 18 FM patients and 14 age-matched healthy controls during a simple Go/No-Go task (response inhibition) while they underwent functional magnetic resonance imaging (fMRI). Performance was not different between FM and healthy control, in either reaction time or accuracy. However, fMRI revealed that FM patients had lower activation in the right premotor cortex, supplementary motor area, midcingulate cortex, putamen and, after controlling for anxiety, in the right insular cortex and r...
http://www.medworm.com/rss/comments.php?id=5650977
A Randomized Placebo‐Controlled Study of Noninvasive Cortical Electrostimulation in the Treatment of Fibromyalgia Patients
Pain Medicine
1/1/2012
Conclusions.  Noninvasive cortical electrostimulation in FM patients provided modest improvements in pain, TeP measures, fatigue, and sleep; and the treatment was well tolerated. This form of therapy could potentially provide worthwhile adjunctive symptom relief for FM patients. (Source: Pain Medicine)
http://www.medworm.com/rss/comments.php?id=5580809
Cognitive behavioral therapy for the treatment of juvenile fibromyalgia: A multisite, single‐blind, randomized, controlled clinical trial
Arthritis and Rheumatism
1/1/2012
ConclusionIn this controlled trial, CBT was found to be a safe and effective treatment for reducing functional disability and symptoms of depression in adolescents with juvenile FMS. (Source: Arthritis and Rheumatism)
http://www.medworm.com/rss/comments.php?id=5555381
Sleep problems and risk of fibromyalgia: Longitudinal data on an adult female population in Norway
Arthritis and Rheumatism
1/1/2012
ConclusionThese prospective data indicate a strong dose‐dependent association between sleep problems and risk of FM. The association is somewhat, although not significantly, stronger in middle‐aged and older women than in younger women. (Source: Arthritis and Rheumatism)

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[Chaos, complexity and cardiology].
Archivos de Cardiologia de Mexico
1/1/2012
Authors: Martínez-Lavín M Abstract Science is an ever-changing discipline. Modern medical knowledge is based on science. Current medical paradigm is both linear and reductionist. There is a new general theory validated by computer's calculations named chaos and complexity theory. This new paradigm will probably have an impact on medical practice. Cardiovascular physiology may display fractal and/ or chaotic behavior. Computerized heart rhythm analyses enhanced our understanding of complex diseases otherwise not explainable by current linear-reductionist paradigms. Cases in point are diverse dysautonomia including orthostatic intolerance, cardiac X syndrome and fibromyalgia. Derived from this, new knowledge is a different diagnostic and therapeutic stance: scientific holism. P...
http://www.medworm.com/rss/comments.php?id=5855137
Hypertension, tachycardia, and reversible cardiomyopathy temporally associated with milnacipran use.
Texas Heart Institute Journal
12/31/2011 3:54:03 AM
Authors: Forman MB, Sutej PG, Jackson EK Abstract Elevated catecholamine levels are a well-recognized cause of various types of cardiomyopathy. Causes of catecholamine elevation include tumors, toxins, drugs, emotional stress, and sepsis. Milnacipran is a dual and equipotent inhibitor of norepinephrine and serotonin uptake. It is frequently prescribed as therapy for fibromyalgia, and the drug has a good safety profile. Herein, we report the case of a 42-year-old woman with undefined connective-tissue disease and fibromyalgia who developed a severe and reversible cardiomyopathy while taking recommended doses of milnacipran. The cardiomyopathy was associated with a hyperadrenergic state manifested by tachycardia, hypertension, and elevated plasma catecholamine levels. The discontinua...
http://www.medworm.com/rss/comments.php?id=5552751
Phenytoin for neuropathic pain and fibromyalgia in adults
NeLM - Drug Specific Reviews
12/31/2011
The objectives are as follows: 1. To assess the analgesic efficacy of phenytoin for chronic neuropathic pain and fibromyalgia. 2. To assess the adverse events associated with the clinical use of phenytoin for chronic neuropathic pain and fibromyalgia. (Source: NeLM - Drug Specific Reviews)
http://www.medworm.com/rss/comments.php?id=5560665
Brain-derived neurotrophic factor and exercise in fibromyalgia syndrome patients: a mini review
Rheumatology International
12/30/2011 11:41:53 AM
Abstract  Fibromyalgia syndrome (FMS) is a common chronic pain condition characterized by chronic widespread pain and decreased pain threshold, with hyperalgesia and allodynia. Associated signs include fatigue, morning stiffness, non-restorative sleep, mood disturbance, depression, irritable bowel syndrome, and headache. In addition to the administration of drugs, psychological therapies treatment of FMS mainly consists of physical therapies. Although the precise pathogenesis of FMS remains elucidated, modern understanding conceptualizes FMS as central sensitization as a consequence of altered endogenous pain- and stress-response system and continuous nociceptive input. Altered brain-derived neurotrophic factor (BDNF) levels in FMS suggest that BDNF—well known for its eff...
http://www.medworm.com/rss/comments.php?id=5564807
Erratum to: Health-related quality of life in women with fibromyalgia: clinical and psychological factors associated
Clinical Rheumatology
12/30/2011 2:10:35 AM
Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s10067-011-1904-1Authors Ricardo Pereira Campos, ISJD-S. José’s Health House, Largo S. João de Deus, No. 1, 4755-044 Areias de Vilar, Barcelos, PortugalMaria Isabel Vázquez Rodríguez, Clinical Psychology and Psychobiology Department, Psychology School, Santiago de Compostela’s University, Rúa Xosé María Suárez Núñez, s/n. Campus sur, 15782 Santiago de Compostela, Spain Journal Clinical RheumatologyOnline ISSN 1434-9949Print ISSN 0770-3198 (Source: Clinical Rheumatology)
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Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study
Acta Psychiatrica Scandinavica
12/30/2011
Conclusion:  Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (1H‐MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD. (Source: Acta Psychiatrica Scandinavica)
http://www.medworm.com/rss/comments.php?id=5550840
Evaluation of a Wearable Body Monitoring Device During Treadmill Walking and Jogging in Patients With Fibromyalgia Syndrome
Archives of Physical Medicine and Rehabilitation
12/28/2011 8:24:28 PM
Abstract: Munguía-Izquierdo D, Santalla A, Legaz-Arrese A. Evaluation of a wearable body monitoring device during treadmill walking and jogging in patients with fibromyalgia syndrome. Objective: To evaluate the reliability and validity of a body monitoring device against measures obtained from indirect calorimetry (IC) in patients with fibromyalgia syndrome (FMS) during various incremental exercise intensities. Design: Cross-sectional reliability and validity study. Setting: Testing was completed in a university exercise physiology laboratory. Participants: Women (N=25) with FMS, with a mean age ± SD of 48.6±8.4 years and a median symptom duration of 15 years (25th–75th percentiles, 10–23y), were recruited to the study. Interventions: Not applicable. Main Outcome Measure...
http://www.medworm.com/rss/comments.php?id=5546627
Delineating psychological and biomedical profiles in a heterogeneous fibromyalgia population using cluster analysis
Clinical Rheumatology
12/27/2011 1:33:50 AM
Abstract  The heterogeneity of patients meeting American College of Rheumatology (ACR) criteria for a diagnosis of fibromyalgia (FM) challenges our ability to understand the underlying pathogenesis and to optimize treatment of this enigmatic disorder. Our goal was to discern clinically relevant subgroups across multiple psychological and biomedical domains to better characterize the phenomenology of FM. Women meeting 1990 ACR criteria for FM (N = 107) underwent psychological (childhood trauma, mood, anxiety, and stress) and biomedical (neuroendocrine, immune, and metabolic) testing. Cluster analysis identified four distinct subgroups. Subgroups I, II, and III exhibited profiles that included high psychological distress. Subgroup I was further distinguished by a history o...
http://www.medworm.com/rss/comments.php?id=5555351
Temperament and character profile of patients with fibromyalgia
Rheumatology International
12/26/2011 11:44:15 AM
Abstract  Personality may play an important role in the development and initiation of fibromyalgia (FM). It may also be used for individualized treatment planning. We aimed to assess personality profiles of FM patients and to evaluate the association of personality profiles with education, symptom severity, depression, anxiety, and functioning. Forty-two female patients with FM and 48 healthy female controls were enrolled in the study. We assessed personality profiles of FM patients using the Temperament and Character Inventory (TCI). Spearman’s rank correlation coefficient was used to detect the correlation between the TCI and education, symptom severity, depression, anxiety, and functioning. FM patients had significantly higher harm avoidance (HA) and self-transcendence...
http://www.medworm.com/rss/comments.php?id=5555339
Tai Chi for Health
Sound Medicine
12/25/2011
I'm Jeremy Shere. For thousands of years, practitioners of the ancient Chinese martial art tai chi have touted its healthful benefits. But did you know that there's growing clinical evidence of the benefits of tai chi, too? For example, a study by researchers at Tufts Medical Center found that tai chi benefited patients with fibromyalgia -- a condition where people experience long-lasting, b.... (Source: Sound Medicine)

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Diffuse pain? More sleep may help
Health Facts and Fears
12/23/2011
Fibromyalgia is a syndrome that has long been shrouded in misunderstanding, and sufferers of this syndrome experience symptoms — particularly chronic pain — that can make daily life difficult. To shed some light on the nature of this disorder, a new, large study suggests that sleep problems are associated with developing fibromyalgia. (Source: Health Facts and Fears)
http://www.medworm.com/rss/comments.php?id=5542525
Chelsea Therapeutics Reports Topline Results From Phase II Trial of Droxidopa in Fibromyalgia
Drugs.com - Clinical Trials
12/22/2011 3:12:45 PM
CHARLOTTE, N.C., Dec. 22, 2011 (GLOBE NEWSWIRE) -- Chelsea Therapeutics International, Ltd. (Nasdaq:CHTP) announced results of a Phase II dose-finding study designed to evaluate the safety and determine the potential therapeutic dose range of... (Source: Drugs.com - Clinical Trials)
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Melatonin levels in premenopausal women with fibromyalgia syndrome
Rheumatology International
12/22/2011 7:47:33 AM
We examined the characteristics and levels of melatonin in 25 consecutive premenopausal women with FMS. Serum blood samples were collected from 25 patients and 20 the age and gender matched healthy controls. Melatonin levels were measured by enzyme-linked immunosorbent assay. Then, the results were compared with those from healthy subjects. Serum melatonin levels of FMS patients were not statistically different from those of controls (P > 0.05). No association was observed between melatonin levels of patients with FMS and disease duration, sleep disturbances, fatigue, and pain scores. Our results demonstrate that melatonin levels were similar in patients with FMS and healthy controls. Further studies are needed to determine the possible role of melatonin. Content Typ...

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Chelsea Therapeutics Reports Topline Results From Phase II Trial of Droxidopa in Fibromyalgia
Medical News (via PRIMEZONE)
12/22/2011 7:30:00 AM
CHARLOTTE, N.C., Dec. 22, 2011 (GLOBE NEWSWIRE) -- Chelsea Therapeutics International, Ltd. (Nasdaq:CHTP) announced results of a Phase II dose-finding study designed to evaluate the safety and determine the potential therapeutic dose range of droxidopa, alone or in combination with carbidopa, that might be effective for the treatment of fibromyalgia. (Source: Medical News (via PRIMEZONE))
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α1‐Antitrypsin in Fibromyalgia: Results of a Randomized, Placebo‐Controlled, Double‐Blind and Crossover Pilot Trial
Musculoskeletal Care
12/22/2011
ConclusionTreatment with a human plasma‐derived AAT concentrate did not demonstrate significant improvement over placebo on reducing pain severity and other symptoms of FM. Further research should examine other FM subpopulations and drug doses. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Musculoskeletal Care)
http://www.medworm.com/rss/comments.php?id=5910741
Fibromyalgia Syndrome: Is It Related to Vitamin D Deficiency in Premenopausal Female Patients?
Pain Management Nursing
12/22/2011
In conclusion, the results of this study indicate that deficiency of vitamin D is not more common in premenopausal female patients with FM than in control subjects without FM. However, the association between pain and vitamin D levels in FM patients emphasizes that hypovitaminosis of vitamin D in the FM syndrome may have an augmenting impact on pain intensity and functional status. Future studies are needed to show the effect of vitamin D supplementation in the reduction of pain intensity and disability in patients suffering from this chronic condition. (Source: Pain Management Nursing)
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[Thalamic infarction with disappearance of the clinical signs and symptoms of rheumatic fibromyalgia].
Revista de Neurologia
12/16/2011
Authors: Lopez-Pousa S, Vilanova JC, Lopez-Ojeda P, En Representacion Del Fibromialgia Research Group ER PMID: 22127664 [PubMed - in process] (Source: Revista de Neurologia)
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Comparison of the cortisol awakening response in women with shoulder and neck pain and women with fibromyalgia
Psychoneuroendocrinology
12/14/2011 11:32:25 PM
Summary: Shoulder and neck pain (SNP) and fibromyalgia syndrome (FMS), two musculoskeletal conditions of unknown pathogenesis, share some common features in terms of altered neuroendocrine responses, pain and stress perception. However, the pain distribution in SNP is localized, whereas in FMS is more widespread. Because regional musculoskeletal pain may represent an intermediate stage along a continuum towards widespread musculoskeletal pain we compared the cortisol awakening response (CAR) in women with SNP with the CAR in FMS patients and healthy controls (HC) in a controlled hospital–hotel setting. The aim of the study was to investigate whether SNP is related to a deviant regulation of the hypothalamic–pituitary–adrenal (HPA) axis. Eighteen women with SNP, 29 female FMS patients...

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Development and Testing of the Fibromyalgia Diagnostic Screen for Primary Care
Journal of Women
12/14/2011 9:30:48 AM
Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women)
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Fibromyalgia: Do you suffer from this chronic condition?
USATODAY.com Health
12/14/2011 8:10:49 AM
There's no known cause, no blood test to diagnose it, no pill to cure it so it's no surprise that fibromyalgia is often misunderstood. (Source: USATODAY.com Health)
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Development and Testing of the Fibromyalgia Diagnostic Screen for Primary Care.
Pain Physician
12/14/2011
Conclusion: A patient-reported questionnaire with or without a brief physical examination may improve identification of fibromyalgia patients in primary care settings. PMID: 22165952 [PubMed - as supplied by publisher] (Source: Pain Physician)
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Does Your Patient Really Have Fibromyalgia?Does Your Patient Really Have Fibromyalgia?
Medscape Today Headlines
12/12/2011 12:00:00 PM
Dr. Charles Argoff reviews conditions that can mimic fibromyalgia. Differential diagnosis is key. Medscape Neurology (Source: Medscape Today Headlines)
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Artificial Sweetener Disease; a new breed of sickness
NaturalNews.com
12/11/2011 2:00:00 AM
(NaturalNews) Artificial Sweetener Disease (ASD) is sweeping across America, affecting tens of thousands of consumers, and Western medicine calls it anything but what it really is, so that doctors can prescribe expensive pharmaceuticals and set up "check up" appointments for the following weeks.Call it recurring headaches, unbearable migraines, depression, anxiety, muscle pain, arthritis flare ups, buzzing or ringing in the ears, chronic fatigue, fibromyalgia, irritable bowel syndrome (IBS), Crohn's disease, inflammation, even acid reflux, but don't call it ASD, or the patient may stop consuming synthetic sweeteners, and then not schedule more doctor visits.The symptoms of ASD can change overnight, depending on how much chemical sweetener you consume, and which ones. Some combinations are ...

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Exercise Relieves Fibromyalgia Pain, Ups Cognitive FunctionExercise Relieves Fibromyalgia Pain, Ups Cognitive Function
Medscape Today Headlines
12/9/2011 11:15:29 PM
Patients with FM report less pain and perform better on working memory tasks after a 6-week aerobics program, apparently because task-related brain areas are activated. Medscape Medical News (Source: Medscape Today Headlines)
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Effect of Low‐Dose Amitriptyline on Autonomic Functions and Peripheral Blood Flow in Fibromyalgia: A Pilot Study
Pain Medicine
12/5/2011
Conclusion.  Amitriptyline therapy (10 mg for 3 months) increases blood flow to the affected sites. It does not affect autonomic tone and reactivity in the patients with fibromyalgia. (Source: Pain Medicine)
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Behavioral therapy may ease kids' fibromyalgia
Reuters: Health
12/2/2011 5:19:24 PM
NEW YORK (Reuters Health) - Teaching teens coping skills to deal with the chronic pain of fibromyalgia may provide them some relief, a small study suggests. (Source: Reuters: Health)
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Behavioral Therapy May Ease Kids' Fibromyalgia
MedlinePlus Health News
12/2/2011 5:19:21 PM
Teaching teens coping skills to deal with the chronic pain of fibromyalgia may provide them some relief, a small study suggests.Source: Reuters Health Related MedlinePlus Pages: Fibromyalgia, Teen Health (Source: MedlinePlus Health News)
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Behavioral therapy may ease kids' fibromyalgia
Modern Medicine
12/2/2011
NEW YORK (Reuters Health) - Teaching teens coping skills to deal with the chronic pain of fibromyalgia may provide them some relief, a small study suggests. (Source: Modern Medicine)

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α1‐Antitrypsin in Fibromyalgia: Results of a Randomized, Placebo‐Controlled, Double‐Blind and Crossover Pilot Trial
Musculoskeletal Care
12/1/2011
ConclusionTreatment with a human plasma‐derived AAT concentrate did not demonstrate significant improvement over placebo on reducing pain severity and other symptoms of FM. Further research should examine other FM subpopulations and drug doses. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Musculoskeletal Care)
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Sleep as a window into the world of fibromyalgia syndrome.
J Rheumatol
12/1/2011
Authors: Thomas RJ PMID: 22134792 [PubMed - in process] (Source: J Rheumatol)
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Complementary and alternative medicine for the treatment of pain in fibromyalgia: A systematic review of the literature
Clinical Chiropractic
12/1/2011
Introduction: Fibromyalgia is a chronic condition characterized by diffuse widespread pain with associated symptoms of persistent fatigue and sleep disturbance. Since the original American College of Rheumatology (ACR) diagnostic criteria for fibromyalgia were first published in 1990, American and European guidelines have been developed for the standard medical management of this elusive condition. However, these guidelines only contain modest information about complementary and alternative medical (CAM) treatments, despite the common use of CAM therapies by fibromyalgia patients. The purpose of this study was to systematically review the literature for randomized trials of CAM interventions for fibromyalgia. (Source: Clinical Chiropractic)
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Beyond cognitive-behavioral therapy for fibromyalgia: addressing stress by emotional exposure
Arthritis Research and Therapy
12/1/2011
I comment on the well-designed trial by Alda and colleagues reported in a recent issue of Arthritis Research and Therapy which demonstrated some benefits of cognitive-behavioral therapy (CBT) for fibromyalgia (FM). CBT in this and other studies provides statistically significant but rather modest benefits for FM. This may be because CBT does not directly address the high rates of victimization, post-traumatic stress disorder, and emotional avoidance experienced by a substantial number of patients with FM. Interventions that encourage emotional exposure, processing, and resolution of stressful or traumatic experiences and relationships hold potential for larger effects for many patients and need to be tested. (Source: Arthritis Research and Therapy)
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Vitamin D Deficiency in Women with Fibromyalgia in Saudi Arabia
Pain Medicine
12/1/2011
Conclusion.  Vitamin D deficiency is often seen in patients diagnosed with fibromyalgia in our population. This was equally true in veiled and nonveiled, but conservatively dressed populations. Effective treatment with high‐dose vitamin D could lead to resolution of almost all symptoms. Further study of these populations and fortification of foods with vitamin D may be essential. (Source: Pain Medicine)
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[Placebo responders in randomized controlled drug trials of fibromyalgia syndrome : Systematic review and meta-analysis].
Schmerz
11/30/2011 10:37:17 PM
CONCLUSION: The magnitude of responders to placebo in drug trials of FMS is substantial. The efficacy, safety, and costs of drugs recommended for FMS therapy and open-label placebo should be compared in large multinational trials sponsored by public institutions. The English full-text version of this article is available at SpringerLink (under "Supplemental"). PMID: 22120916 [PubMed - in process] (Source: Schmerz)
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Combined Therapy (Ultrasound and Interferential Current) in Patients with Fibromyalgia: Once or Twice in a Week?
Physiotherapy Research International
11/26/2011 5:20:37 AM
ConclusionThere is no advantage in increasing the number of sessions of combined therapy in terms of reducing generalized pain, quality of life and sleep quality for patients with FM. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Physiotherapy Research International)
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Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility
Revista Brasileira de Reumatologia
11/25/2011 5:38:28 PM
CONCLUSION: These data suggest that these factors may predispose to FMS, especially in carriers of the 102C allele. However, studies with larger samples are required to confirm this hypothesis. (Source: Revista Brasileira de Reumatologia)

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FDA grants clearance for Tonix to begin TNX-102 study
Pharmaceutical Technology
11/25/2011 1:44:05 PM
Tonix Pharmaceuticals has received US Food Drug and Administration (FDA) approval to initiate a comparative pharmacokinetic and bioavailability study of TNX-102, an oral formulation of cyclobenzaprine for the treatment of fibromyalgia.Post to:Delicious  Digg  reddit  Facebook  StumbleUpon   (Source: Pharmaceutical Technology)
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Combined Therapy (Ultrasound and Interferential Current) in Patients with Fibromyalgia: Once or Twice in a Week?
Physiotherapy Research International
11/24/2011
ConclusionThere is no advantage in increasing the number of sessions of combined therapy in terms of reducing generalized pain, quality of life and sleep quality for patients with FM. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Physiotherapy Research International)
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Fibromyalgia And Chronic Fatigue Syndrome In Children
Pediatrics International
11/24/2011
Conclusions:  CFS and FM are diff erent from each other at least in childhood from the immunological aspects, although a few patients were suffering from both conditions. (Source: Pediatrics International)
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How Psychotherapy Led to a Cure for Vulvodynia and Possible Options for Fibromyalgia
Psychology Today Food and Diet Center
11/23/2011 5:54:31 PM
Some years ago I treated a woman named Sherry for suicidal depression. Sherry's problem was extreme pain in the vulvar area. The pain waxed and waned, but when it was on, any physical movement or contact with clothes or seating led to intolerable stabbing, shooting, fiery pain. Primary Topic:  Health read more (Source: Psychology Today Food and Diet Center)
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How Psychotherapy Led to Help for Vulvodynia and Possible New Options for Fibromyalgia
Psychology Today Food and Diet Center
11/23/2011 5:54:31 PM
Some years ago I treated a woman named Sherry for suicidal depression. Sherry's problem was extreme pain in the vulvar area. The pain waxed and waned, but when it was on, any physical movement or contact with clothes or seating led to intolerable stabbing, shooting, fiery pain. Primary Topic:  Health read more (Source: Psychology Today Food and Diet Center)
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Reducing Disability and Depression in Adolescents with Fibromyalgia by Psychological Intervention
Disabled World
11/22/2011 5:19:52 PM
Psychological intervention reduces disability and depression in adolescents with fibromyalgia - Cognitive-behavioral therapy is safe and effective treatment for juvenile fibromyalgia. (Source: Disabled World)

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Phone Therapy, Exercise Helpful in Chronic Widespread Pain Phone Therapy, Exercise Helpful in Chronic Widespread Pain
Medscape Today Headlines
11/22/2011 11:48:44 AM
Telephone-based cognitive behavioral therapy and exercise, alone or combined, improve global health in patients with fibromyalgia, new research suggests. Medscape Medical News (Source: Medscape Today Headlines)
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Psychological intervention reduces disability and depression in adolescents with fibromyalgia
ScienceDaily Headlines
11/22/2011 11:30:30 AM
A recent trial shows cognitive-behavioral therapy reduces functional disability and depressive symptoms in adolescents with juvenile fibromyalgia. The psychological intervention was found to be safe and effective, and proved to be superior to disease management education. (Source: ScienceDaily Headlines)
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Adolescents With Fibromyalgia - Psychological Intervention Helps Reduce Depression And Disability
Health News from Medical News Today
11/22/2011 8:00:00 AM
According to a recent multi-site trial published in Arthritis & Rheumatism, a peer-reviewed journal of the American College of Rheumatology (ACR), cognitive-behavioral therapy (CBT) reduces functional disability and depressive symptoms in adolescent with juvenile fibromyalgia. The trial demonstrated that the psychological therapy was safe and effective as well as superior to disease management education... (Source: Health News from Medical News Today)
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Vulvodynia: The Vaginal Equivalent of Fibromyalgia?
Psychology Today Depression Center
11/22/2011 12:27:25 AM
Lately, I have read blogs by fellow Psychology Today bloggers delineating the amazing qualities of vaginas. Primary Topic:  Health read more (Source: Psychology Today Depression Center)
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Psychological intervention reduces disability and depression in adolescents with fibromyalgia
EurekAlert! - Social and Behavioral Science
11/22/2011
(Wiley-Blackwell) A recent trial shows cognitive-behavioral therapy reduces functional disability and depressive symptoms in adolescents with juvenile fibromyalgia. The psychological intervention was found to be safe and effective, and proved to be superior to disease management education. Full findings from this multi-site clinical trial are published in Arthritis & Rheumatism, a peer-reviewed journal of the American College of Rheumatology. (Source: EurekAlert! - Social and Behavioral Science)

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Fibromyalgia in fragile X mental retardation 1 gene premutation carriers
Rheumatology
11/22/2011
Conclusion. Since FM affects 2–4% of the world's population and about 1 in 250 females are FMR1 carriers, a study screening females with FM for the presence of the FMR1 premutation is worthwhile. A finding of increased prevalence of FMR1 carriers among females with FM would impact the standard evaluation of FM. Presently, guidelines for FMR1 genetic testing includes early menopause, congenital intellectual disability, autism spectrum disorder, tremor or ataxia, and a family history of FXTAS or fragile X syndrome. The latter is a common cause of autism and developmental delay. Such testing is important because female carriers are at risk of having a child with fragile X syndrome. (Source: Rheumatology)
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A randomized clinical trial of cognitive behavioral therapy for the treatment of juvenile fibromyalgia
Arthritis and Rheumatism
11/22/2011
Conclusion.In this controlled trial, CBT was found to be a safe and effective treatment for reducing functional disability and depressive symptoms in adolescents with JFM. (Source: Arthritis and Rheumatism)
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College of Medicine launches new self care library
NeLM - News
11/21/2011
Source: NHS Networks Area: News The College of Medicine has launched its Self Care Library - an evidence-based resource for both healthcare professionals and the public.  It currently looks at the self-care approaches to 12 chronic conditions that are common 'effectiveness gaps' - including for example irritable bowel syndrome (IBS), tension type headache, low back pain, fibromyalgia, and mild to moderate depression.  Each condition has a page organised into four sections - an introduction, simple changes that can be made, buying something to try (including OTC medicines, nutritional supplements and herbal medicines), and attending classes/ visiting a practitioner (including complementary therapies, where appropriate).  Please see the link below for details.  ...
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Responses to a comment on "Autonomic cardiovascular control and responses to experimental pain stimulation in fibromyalgia syndrome"
Journal of Psychosomatic Research
11/21/2011
We agree with Dr. Helder Cavalcante that the expression "deficits in ascending pain inhibition arising from the cardiovascular system, which possibly contribute to the hyperalgesia" may be somewhat misleading in the present context. We did not mean to challenge established knowledge about pain modulation pathways. Using the expression "ascending pain inhibition" we aimed to emphasize that the source of the assumed anti-nociceptive effect is located in the periphery (i.e. baroreceptors) and that this input is transmitted through afferences to the nucleus of the tractus solitarius (NTS). Electrical stimulation of the NTS, as well as experimental activation of the carotid baroreceptors trigger marked anti-nociception . From this, one may conclude that the baroreceptors constitute the starting...

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Serum iron and iron stores in non-anemic patients with fibromyalgia
Clinical Rheumatology
11/18/2011 2:01:38 AM
Abstract  The aim of the study was to assess iron serum levels and markers of iron stores in non-anemic fibromyalgia (FM) patients and to evaluate their impact on the prevalence and clinical manifestations of FM patients. Eighty-four patients with primary FM and 87 controls were investigated. Demographic and clinical data were collected from all participants. All patients completed the fibromyalgia impact questionnaire (FIQ). Patients evaluated the effect of the disease on their daily activity (DA) and judged the severity (DS) of the disease on a 0–10 scale. Venous blood was tested for serum iron, transferrin, ferritin, and soluble transferrin receptors (sTfR). Iron deficiency was defined if any of the following were present: serum iron <40 μg/dL, serum ferritin ...
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Relationship between body mass index, fat mass and lean mass with SF-36 quality of life scores in a group of fibromyalgia patients
Rheumatology International
11/18/2011 1:53:45 AM
The objective of this study was to evaluate the relationship between body mass index (BMI), fat mass (fM) and lean mass (lM) with quality of life in a group of FM patients. 103 women, with a mean age of 53.74 ± 7.81, and members of different FM patient associations from Spain participated in our study. Some anthropometric measures were taken like weight, height, BMI, body fat mass and lean mass. FM patients QoL was assessed by the Short-Form Health Survey, SF-36 questionnaire. Statistical reports were based on mean, standard deviation and correlation, but significance was tested by nonparametric methods. BMI, fM and lM correlated differently with the specific SF-36 scores. BMI had a high negative correlation with emotional role, fM with bodily pain and lM almost with all ...
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Cardiac autonomic impairment and chronotropic incompetence in fibromyalgia
Arthritis Research and Therapy
11/18/2011
Fibromyalgia patients may suffer from chronotropic incompetence and delayed heart rate recovery, both of which are indicative of cardiac autonomic impairment and higher risk of cardiovascular events and mortality. (Source: Arthritis Research and Therapy)
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Exercise May Improve Memory in Fibromyalgia Patients
WebMD Health
11/17/2011 6:58:22 PM
Exercise improved pain and memory in women with fibromyalgia, even without medication, suggests a new study. (Source: WebMD Health)
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Improving Brain Function in Fibromyalgia Patients
Medical Headlines From Ivanhoe.com
11/17/2011
(Ivanhoe Newswire) -- Everyone is told to exercise, exercise, exercise - it improves your health. (Source: Medical Headlines From Ivanhoe.com)
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Major Advances in FibromyalgiaMajor Advances in Fibromyalgia
Medscape FamilyMedicine Headlines
11/16/2011 12:46:00 PM
Pathophysiologic breakthroughs, the role of depression, and other fibromyalgia highlights from this year's American College of Rheumatology Annual Scientific Meeting. Medscape Rheumatology (Source: Medscape FamilyMedicine Headlines)
http://www.medworm.com/rss/comments.php?id=5424435
Fibromyalgia linked to poor sleep habits
Health News: CBSNews.com
11/16/2011 11:53:02 AM
Provocative study may give one more reason to take sleep problems seriously (Source: Health News: CBSNews.com)

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Sleep Disorder Linked to Fibromyalgia RiskSleep Disorder Linked to Fibromyalgia Risk
Medscape Today Headlines
11/16/2011 9:43:58 AM
Chronic sleep disturbance is associated with up to a 5-fold increase in risk for fibromyalgia onset. Medscape Medical News (Source: Medscape Today Headlines)
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Poor Sleep Linked to Chronic Pain in Women (CME/CE)
MedPage Today Pain Management
11/16/2011 9:43:20 AM
(MedPage Today) -- Women who experience difficulties sleeping are at elevated risk for developing fibromyalgia, with their risk rising according to the severity of the sleep disturbance, a prospective Norwegian study found. (Source: MedPage Today Pain Management)
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Fibromyalgia Risk Greater Among Females With Poor Sleeping Habits
Health News from Medical News Today
11/16/2011 8:00:00 AM
Norwegian investigators have identified a link between sleep problems and an increased risk in women developing fibromyalgia (long-term body-wide pain and tenderness in the muscles, joints, tendons, and other soft tissues). The risk of developing the syndrome increased with severity of sleep problems and the association was stronger among women who were middle-age and older compared to younger women... (Source: Health News from Medical News Today)
http://www.medworm.com/rss/comments.php?id=5406807
Link Between Poor Sleep Habits And Increased Risk Of Fibromyalgia In Women
Health News from Medical News Today
11/16/2011 3:00:00 AM
Researchers from Norway have uncovered an association between sleep problems and increased risk of fibromyalgia in women. The risk of fibromyalgia increased with severity of sleep problems, and the association was stronger among middle-aged and older women than among younger women. Results of the prospective study, based on ten years of data, appear in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR)... (Source: Health News from Medical News Today)
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Women's Sleep Problems Linked to Fibromyalgia Risk
MedicineNet Arthritis General
11/16/2011 2:00:00 AM
Title: Women's Sleep Problems Linked to Fibromyalgia RiskCategory: Health NewsCreated: 11/16/2011 11:01:00 AMLast Editorial Review: 11/16/2011 (Source: MedicineNet Arthritis General)

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Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity
BioMed Central
11/16/2011
Nocturnal heart rate variability parameters indicative of sympathetic predominance are significantly different in fibromyalgia patients compared to healthy individuals, and correlate with several symptoms including pain severity. (Source: BioMed Central)
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Talk therapy by phone may ease fibromyalgia: study
Modern Medicine
11/15/2011
NEW YORK (Reuters Health) - Talk therapy done over the phone helped some people suffering chronic fibromyalgia-related pain to feel better in a study that looked at phone therapy as a potential cost-effective alternative to standard treatments. (Source: Modern Medicine)

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CBT, Exercise May Ease Chronic Pain (CME/CE)
MedPage Today Psychiatry
11/14/2011 7:13:15 PM
(MedPage Today) -- Exercise and sessions of telephone-based cognitive behavioral therapy can improve symptoms of fibromyalgia, researchers found. (Source: MedPage Today Psychiatry)
http://www.medworm.com/rss/comments.php?id=5405226
Talk therapy by phone may ease fibromyalgia: study
Reuters: Health
11/14/2011 5:48:44 PM
NEW YORK (Reuters Health) - Talk therapy done over the phone helped some people suffering chronic fibromyalgia-related pain to feel better in a study that looked at phone therapy as a potential cost-effective alternative to standard treatments. (Source: Reuters: Health)
http://www.medworm.com/rss/comments.php?id=5406126
Talk Therapy by Phone May Ease Fibromyalgia
MedlinePlus Health News
11/14/2011 5:48:41 PM
Talk therapy done over the phone helped some people suffering chronic fibromyalgia-related pain to feel better in a study that looked at phone therapy as a potential cost-effective alternative to standard treatments.Source: Reuters Health Related MedlinePlus Page: Fibromyalgia (Source: MedlinePlus Health News)
http://www.medworm.com/rss/comments.php?id=5406158
Sleep problems triple women's risk of developing fibromyalgia
CNN.com - Health
11/14/2011 3:27:35 PM
Women plagued by sleep problems have more than triple the risk of developing the pain disorder fibromyalgia compared with their better-rested peers, a new study from Norway suggests. (Source: CNN.com - Health)
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Fibromyalgia Pain and the Weather
Disabled World
11/14/2011 2:42:12 PM
A large percentage of people with fibromyalgia claim that weather directly affects their symptoms and pain levels. (Source: Disabled World)

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Study: Exercise may help memory of Fibromyalgia patients
USATODAY.com Health
11/14/2011 12:22:36 PM
Fibromyalgia patients who stopped taking medication and exercised regularly for six weeks reported improved memory function and less pain. (Source: USATODAY.com Health)
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Poor Sleep May Lead to Fibromyalgia in Women
The Doctors Lounge - Neurology
11/14/2011 10:00:00 AM
Sleep problems linked to the painful condition, especially in middle age and beyond, study says (Source: The Doctors Lounge - Neurology)
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Aerobic Exercise In Fibromyalgia Patients Improves Improves Memory Efficiency
Health News from Medical News Today
11/14/2011 4:00:00 AM
Areas of the brain responsible for pain processing and cognitive performance changed in fibromyalgia patients who exercised following a medication holiday, say researchers from Georgetown University Medical Center. They say the changes indicate brain functioning is more streamlined after an exercise intervention because less of the brain's resources is devoted to processing bothersome fibromyalgia perceptions such as pain. The study, presented at the Society of Neuroscience's annual meeting, Neuroscience 2011, used functional MRI scans to assess changes in the brain... (Source: Health News from Medical News Today)
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Poor Sleep May Lead to Fibromyalgia in Women
MedicineNet Chronic Pain General
11/14/2011 2:00:00 AM
Title: Poor Sleep May Lead to Fibromyalgia in WomenCategory: Health NewsCreated: 11/14/2011 10:06:00 AMLast Editorial Review: 11/14/2011 (Source: MedicineNet Chronic Pain General)

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Study Suggests Exercise May Help Memory of Fibromyalgia Patients
MedicineNet Arthritis General
11/14/2011 2:00:00 AM
Title: Study Suggests Exercise May Help Memory of Fibromyalgia PatientsCategory: Health NewsCreated: 11/13/2011 6:06:00 PMLast Editorial Review: 11/14/2011 (Source: MedicineNet Arthritis General)
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Poor Sleep May Lead to Fibromyalgia in Women
MedicineNet Arthritis General
11/14/2011 2:00:00 AM
Title: Poor Sleep May Lead to Fibromyalgia in WomenCategory: Health NewsCreated: 11/14/2011 10:06:00 AMLast Editorial Review: 11/14/2011 (Source: MedicineNet Arthritis General)
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Study Suggests Exercise May Help Memory of Fibromyalgia Patients
MedicineNet Feet and Fitness General
11/14/2011 2:00:00 AM
Title: Study Suggests Exercise May Help Memory of Fibromyalgia PatientsCategory: Health NewsCreated: 11/13/2011 6:06:00 PMLast Editorial Review: 11/14/2011 (Source: MedicineNet Feet and Fitness General)
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Poor Sleep May Lead to Fibromyalgia in Women
MedicineNet Sleep General
11/14/2011 2:00:00 AM
Title: Poor Sleep May Lead to Fibromyalgia in WomenCategory: Health NewsCreated: 11/14/2011 10:06:00 AMLast Editorial Review: 11/14/2011 (Source: MedicineNet Sleep General)

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Cerebral Blood Flow Alterations in Pain-Processing Regions of Patients with Fibromyalgia Using Perfusion MR Imaging [BRAIN]
American Journal of Neuroradiology
11/14/2011
CONCLUSIONS: Significant correlations were found between thalamic rCBF values and pain belief values. These data suggest that there are baseline alterations of brain perfusion in patients with FM. rCBF values of the thalami exhibited lower correlations with respect to other brain regions thought to be involved in pain processing compared with those in healthy controls. (Source: American Journal of Neuroradiology)

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Poor sleep habits linked to increased risk of fibromyalgia in women
EurekAlert! - Social and Behavioral Science
11/14/2011
(Wiley-Blackwell) Researchers from Norway have uncovered an association between sleep problems and increased risk of fibromyalgia in women. The risk of fibromyalgia increased with severity of sleep problems, and the association was stronger among middle-aged and older women than among younger women. Results of the prospective study, based on ten years of data, appear in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology. (Source: EurekAlert! - Social and Behavioral Science)
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Study Suggests Exercise May Help Memory of Fibromyalgia Patients
The Doctors Lounge - Neurology
11/13/2011 5:00:00 PM
The trial was small, however, and the researchers were hoping for better results (Source: The Doctors Lounge - Neurology)
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Improved memory efficiency seen after aerobic exercise in fibromyalgia patients
EurekAlert! - Medicine and Health
11/13/2011
(Georgetown University Medical Center) Areas of the brain responsible for pain processing and cognitive performance changed in fibromyalgia patients who exercised following a medication holiday, say researchers from Georgetown University Medical Center. They say the changes indicate brain functioning is more streamlined after an exercise intervention because less of the brain’s resources is devoted to processing bothersome fibromyalgia perceptions such as pain. (Source: EurekAlert! - Medicine and Health)
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ACR: Drug Brings Relief Long-Term in Fibromyalgia (CME/CE)
MedPage Today Pain Management
11/11/2011 3:50:00 PM
CHICAGO (MedPage Today) -- Milnacipran (Savella), a selective serotonin and norepinephrine reuptake inhibitor, brought long-term relief to fibromyalgia patients who remained on therapy, researchers said here. (Source: MedPage Today Pain Management)

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Fibromyalgia: Diagnosing and managing a complex syndrome
Journal of the American Academy of Nurse Practitioners
11/11/2011
Conclusions: Fibromyalgia is a complex muscular rheumatism that is not fully understood and often misdiagnosed. Signs and symptoms may overlap with many other conditions that must be properly ruled out to prevent diagnosis based upon arbitrary clinical judgment. Treatment is most beneficial when tailored to individual patient presentation, and further research is warranted, particularly in the domains of pathophysiology and efficacy of treatment options.Implications for practice: An accurate knowledge of current research will aid the nurse practitioner in effectively prescribing evidence‐based clinical interventions. Optimal fibromyalgia management can be achieved through a multifaceted treatment approach and is enhanced with early identification of the disease process. (Source: Journal ...
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The potential benefits of applying a narrative analytic approach for understanding the experience of fibromyalgia: a review.
Disability and Rehabilitation
11/11/2011
Conclusions: The review concludes by emphasizing that narrative analysis is a valuable method which offers the potential for uncovering novel insights about the illness experience for these individuals. [Box: see text]. PMID: 22077426 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
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Sleep problems and risk of fibromyalgia: Longitudinal data from the Norwegian HUNT‐study
Arthritis and Rheumatism
11/11/2011
Conclusion.These prospective data indicates a strong dose‐response association between sleep problems and risk of FM. The association is somewhat, although not significantly, stronger in middle‐aged and old women than in younger women. (Source: Arthritis and Rheumatism)
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The interest of gait markers in the identification of subgroups among fibromyalgia patients
BMC Musculoskeletal Disorders
11/11/2011
Conclusion: Gait analysis may provide additional information in the identification of subgroups among fibromyalgia patients. Gait analysis provided relevant information about physical and cognitive status, and pain behavior. Further studies are needed to better understand gait analysis implications in FM. (Source: BMC Musculoskeletal Disorders)
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Does a 3-month multidisciplinary intervention improve pain, body composition and physical fitness in women with fibromyalgia?
British Journal of Sports Medicine
11/10/2011
Conclusions A 3-month multidisciplinary intervention three times/week had a positive effect on pain threshold in several tender points in women with FM. Though no overall improvements were observed in physical fitness or body composition, the intervention had positive effects on lower-body flexibility. (Source: British Journal of Sports Medicine)

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Attention modification in persons with fibromyalgia: a double blind, randomized clinical trial.
Cognitive Behaviour Therapy
11/9/2011 7:45:53 AM
Authors: Carleton RN, Richter AA, Asmundson GJ Abstract Contemporary models of chronic musculoskeletal pain emphasize the critical roles of fear, anxiety, and avoidance as well as biases in attention in the development and maintenance of chronic pain disability. Evidence supports the influence of individual difference variables such as anxiety sensitivity, pain-related anxiety, and catastrophizing on the pain experience and on pain-related attentional biases. Changes in attentional biases have been associated with treatment gains in patients with clinically significant anxiety. The Attentional Modification Paradigm (AMP) is a modification of the dot-probe paradigm used to facilitate such changes in attentional biases. Given the relationship between chronic musculoskeletal pain and ...
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Exercise for fibromyalgia: evidence for an integrated modulation of autonomic and nociception neural regulation
Rheumatology International
11/9/2011 2:03:16 AM
Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00296-011-2255-6Authors Juvenia Bezerra Fontenele, Department of Pharmacy, Faculdade de Farmacia, Odontologia e Enfermagem, Universidade Federal do Ceara, Fortaleza, BrazilFrancisco Helder Cavalcante Felix, Pediatric Hemato-oncology Service, Hospital Infantil Albert Sabin, R Alberto Montezuma, 350-Vila Uniao, Fortaleza, CE 60410-770, Brazil Journal Rheumatology InternationalOnline ISSN 1437-160XPrint ISSN 0172-8172 (Source: Rheumatology International)
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ACR: Body Map No Help in Telling Where It Hurts (CME/CE)
MedPage Today Geriatrics
11/8/2011 6:07:32 PM
CHICAGO (MedPage Today) -- When patients who complain of fibromyalgia pain attempt to communicate which joints are painful, the reliance on body maps falls short, and, in fact, text often works better than illustrations, Canadian researchers said here. (Source: MedPage Today Geriatrics)
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Quality of life in patients with fibromyalgia: validation and psychometric properties of the German Quality of Life Scale (QOLS-G)
Rheumatology International
11/8/2011 2:13:05 PM
Abstract  Our objectives were to translate the Quality of Life Scale (QOLS) into German and to evaluate its reliability and validity for the use in patients with fibromyalgia (FMS). Together with German versions of the Fibromyalgia Impact Questionnaire (FIQ), the SF-36, a tender point count (TPC) and other questionnaires, we administered the QOLS to 146 patients with FMS. Patients were asked about the severity of pain today (VAS) and the duration of symptoms. Test–retest reliability was assessed using Spearman’s correlations. Internal consistency was evaluated with Cronbach’s alpha. Construct validity of the QOLS was evaluated by correlating the QOLS with the FIQ, the SF-36, the Beck Depression Inventory (BDI), and the Symptom Checklist (SCL-90-R) as well as with the ...
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Is psychological distress intrinsic to fibromyalgia syndrome? Cross-sectional analysis in two clinical presentations
Rheumatology International
11/7/2011 12:11:38 PM
Abstract  Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients’ long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90-R), we have assessed emotional distress in two FMS patient subpopulations discriminated on the basis of their differences in scores on specific items of the Fibromyalgia Impact Questionnaire (FIQ). Subjects classed as type II exhibited high emotional distress on all ten dimensions studied, which included somatization, obsessive–compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism, a...
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[Original Article] Cerebral Activation and Catastrophizing During Pain Anticipation in Patients With Fibromyalgia
Psychosomatic Medicine
11/7/2011
Conclusions The lack of difference in catastrophizing during the experimental pain suggests independent coping mechanisms during experimental and clinical pain. Regarding the importance of the frontal cortex and the PAG in the descending pain modulation system, it seems reasonable to assume that these functional changes related to the context of stimulus presentation may contribute to central sensitization in FMS. (Source: Psychosomatic Medicine)

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Profile's mood in women with fibromyalgia
Jornal Brasileiro de Psiquiatria
11/5/2011 6:14:13 PM
CONCLUSION: Women with fibromyalgia had a trend toward depressed mood, and this feature is presented associated with sociodemographic and clinical factors. (Source: Jornal Brasileiro de Psiquiatria)
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Prevalence of chronic widespread pain and fibromyalgia syndrome: a Korean hospital-based study
Rheumatology International
11/5/2011 12:07:56 PM
This study was conducted to estimate the point prevalence of chronic widespread pain (CWP) and fibromyalgia syndrome (FMS) in a primary care center of a hospital in Korea. CWP was defined as pain lasting more than 3 months involving all the classified pain sites (axial, left and right, above and below waist). FMS was diagnosed by the American College of Rheumatology (ACR) criteria and also by clinical judgment of a physician. All 1,077 subjects were classified into three groups as no chronic pain (NCP), chronic regional pain (CRP), and CWP. CRP was defined as chronic pain with the exception of CWP. The point prevalence of CWP was 6.5% (95% confidence interval (CI) 0.2–12.8) and the point prevalence of FMS was 1.7% (95% CI 0.0–4.9) by ACR criteria and 2.3% (95% CI 0.0–6.1) ...
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Sleep-Stage Dynamics in Patients with Chronic Fatigue Syndrome with or without Fibromyalgia
Sleep
11/5/2011 9:13:19 AM
Conclusions:These results suggest that CFS and FM may be different illnesses associated with different problems of sleep regulation.Citation:Kishi A; Natelson BH; Togo F; Struzik ZR; Rapoport DM; Yamamoto Y. Sleep-stage dynamics in patients with chronic fatigue syndrome with or without fibromyalgia. SLEEP 2011;34(11):1551-1560. (Source: Sleep)
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IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: New pathways that underpin the inflammatory and neuroprogressive pathophysiology
Journal of Affective Disorders
11/3/2011 6:29:33 PM
We examined serum IgM antibodies to the conjugated fatty acids, palmitic and myristic acids; acetylcholine; S-farnesyl-l-cysteine; and NO-modified adducts in 26 depressed patients and 17 normal controls. Severity of depression was measured with the Hamilton Depression Rating Scale and severity of fatigue and somatic (F&S) symptoms with the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.Results: The prevalences and mean values for the serum IgM levels directed against conjugated palmitic and myristic acids, acetylcholine, S-farnesyl-l-cysteine; and the conjugated NO adducts, NO-tyrosine, NO-phenylalanine, NO-aspartate, NO-histidine, and NO-creatine were significantly higher in depressed patients than in normal controls. The autoimmune responses were significantly related to FF ...
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Tailored cognitive-behavioural therapy and exercise training improves the physical fitness of patients with fibromyalgia
Annals of the Rheumatic Diseases
11/1/2011 11:00:00 PM
Conclusions A tailored multidisciplinary treatment approach for fibromyalgia consisting of CBT and exercise training is well tolerated, yields clinically relevant changes, and appears a promising approach to improve patients' physical fitness. ClinicalTrials.gov ID NCT00268606 (Source: Annals of the Rheumatic Diseases)

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Efficient practices associated with diagnosis, treatment and management of fibromyalgia among primary care physicians.
Pain Research and Management
10/31/2011 11:00:00 PM
CONCLUSIONS: Physicians self-reported an inadequacy in diagnosing, treating and managing patients with FM in current practice. A subset of PCPs, however, perceived an ability to reach a definitive diagnosis and initiate treatment plans relatively sooner than the other respondents. If the perception of this subset can be confirmed with objective clinical outcomes, and these behaviours modelled, steps could be taken to improve FM care within the broader PCP setting. PMID: 22184554 [PubMed - in process] (Source: Pain Research and Management)
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Duloxetine contributing to a successful multimodal treatment program for peripheral femoral neuropathy and comorbid 'reactive depression' in an adolescent.
Pain Research and Management
10/31/2011 11:00:00 PM
Authors: Kachko L, Ben Ami S, Liberman A, Birk E, Kronenberg S Abstract In the United States, duloxetine has been approved for the treatment of major depressive disorder, diabetic peripheral neuropathic pain and fibromyalgia in the adult population. Data regarding the use of duloxetine in the pediatric population, however, are very limited. Femoral nerve injury is a rare complication of cardiac catheterization. In the case described, duloxetine contributed to a successful multimodal treatment program for peripheral neuropathic pain due to femoral neuropathy in an adolescent with 'reactive depression' and conversion symptoms. To the best of the authors' knowledge, the present article is only the third such report on this dual use of duloxetine in children and adolescents, and the fi...
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Fibromyalgia: Diagnosing and managing a complex syndrome
Journal of the American Academy of Nurse Practitioners
10/31/2011 11:00:00 PM
Conclusions: Fibromyalgia is a complex muscular rheumatism that is not fully understood and often misdiagnosed. Signs and symptoms may overlap with many other conditions that must be properly ruled out to prevent diagnosis based upon arbitrary clinical judgment. Treatment is most beneficial when tailored to individual patient presentation, and further research is warranted, particularly in the domains of pathophysiology and efficacy of treatment options.Implications for practice: An accurate knowledge of current research will aid the nurse practitioner in effectively prescribing evidence‐based clinical interventions. Optimal fibromyalgia management can be achieved through a multifaceted treatment approach and is enhanced with early identification of the disease process. (Source: Journal ...
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Fibromyalgia’s Key Symptoms in Normal-Weight, Overweight, and Obese Female Patients
Pain Management Nursing
10/30/2011 11:00:00 PM
In conclusion, FM symptomatology in obese patients did not differ from overweight patients, whereas normal-weight patients significantly differed from overweight and obese patients in the studied symptoms. These findings suggest that keeping a healthy (normal) weight is not only associated with decreased risk for developing FM but might also be a relevant and useful way of improving FM symptomatology in women. (Source: Pain Management Nursing)
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The rise of fibromyalgia in 20th-century america.
Perspectives in Biology and Medicine
10/30/2011 7:40:05 PM
Authors: Grob GN Abstract Abstract:At the beginning of the 21st century, fibromyalgia syndrome (FM) has become a diagnostic category that includes extremely large numbers of people, predominantly women. Yet only a few decades ago, FM (and its predecessor fibrositis) was of little interest or concern to either physicians or the general public. What, then, were the origins of the FM diagnosis, and why did its boundaries expand so rapidly during and after the 1980s? The answers to such questions are complex. Broad social and intellectual currents, internal developments within medicine, the appearance of a self-conscious women's movement, and the rise of an increasingly important pharmaceutical industry all converged to elevate the importance of FM. Yet the diagnosi...
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A comprehensive study of autonomic dysfunction in the fibromyalgia patients
Clinical Autonomic Research
10/29/2011 12:48:57 AM
Abstract Objectives  The hypothesis of autonomic nervous system involvement in pathophysiology in the patients with fibromyalgia has been addressed and tested time and again but the existing reports are both contradictory and inconclusive. A complete knowledge of the degree of autonomic dysfunction in fibromyalgia patients would be more substantial. We conducted a comprehensive non-invasive study to investigate the complete autonomic profile of female patients with fibromyalgia. Method  An autonomic function test using a standard battery and heart rate variability analysis in the 42 fibromyalgia patients as well as 42 age matched healthy controls was performed. Both autonomic activity (tone) and reactivity were measured. Autonomic tone (both time and freq...
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Systematic review with meta-analysis: Cytokines in fibromyalgia syndrome
BMC Musculoskeletal Disorders
10/27/2011 11:00:00 PM
Conclusions: The pathophysiological role of cytokines in FMS is still unclear. Studies of higher quality and with higher numbers of subjects are needed. (Source: BMC Musculoskeletal Disorders)

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Catecholamines and heart rate in female fibromyalgia patients
Journal of Psychosomatic Research
10/25/2011 11:00:00 PM
Conclusions: The results indicate an altered regulation of the autonomic nervous system in fibromyalgia patients, with attenuated activity of both the sympathetic (adrenal medulla component) and the parasympathetic branch. (Source: Journal of Psychosomatic Research)
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Traditional Chinese medicine diagnoses in a sample of women with fibromyalgia.
Acupuncture in Medicine : journal of the British Medical Acupuncture Society
10/24/2011 11:00:00 PM
CONCLUSION: It is likely that previous studies of FM were treating a heterogeneous study population where variable results might be expected. Future acupuncture studies should either control for TCM diagnosis or consider its usefulness as an inclusion/exclusion criterion. PMID: 22026964 [PubMed - as supplied by publisher] (Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society)
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Fitness testing as a discriminative tool for the diagnosis and monitoring of fibromyalgia
Scandinavian Journal of Medicine and Science in Sports
10/23/2011 11:00:00 PM
We aimed to determine the ability of a set of physical fitness tests to discriminate between presence/absence of fibromyalgia (FM) and moderate/severe FM. The sample comprised 94 female FM patients (52 ± 8 years) and 66 healthy women (54 ± 6 years). We assessed physical fitness by means of the 30‐s chair stand, handgrip strength, chair sit and reach, back scratch, blind flamingo, 8‐feet up and go, and 6‐min walking tests. Patients were classified as having moderate FM if the score in the Fibromyalgia Impact Questionnaire (FIQ) was <70 and as having severe FM if the FIQ was ≥70. FM patients and patients with severe FM performed worse in most of the fitness tests studied (P < 0.001). Except the back scratch test, all the tests were able to discriminate between pre...

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Comment on ‘Autonomic cardiovascular control and responses to experimental pain stimulation in fibromyalgia syndrome’
Journal of Psychosomatic Research
10/23/2011 11:00:00 PM
I thought the report by Reyes del Paso et al. was most interesting but intriguing. It confirms the findings of many others about dysautonomia in fibromyalgia . Their findings are not entirely new, and the hypothesis of a causal relation to fibromyalgia pain has also been proposed before . Their work adds valuable evidence for the possible relationship between fibromyalgia and dysautonomia. The intriguing part is their depiction of the neural circuitry that may be involved. They refer to ‘deficits in ascending pain inhibition arising from the cardiovascular system, which possibly contribute to the hyperalgesia’. I found it confusing. Afferent pain stimuli from peripheral nociceptive neurons run into spinal synapses in laminae 1 and 2 of dorsal horn, and then run up to the thalamus via s...
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Sexual Functioning in Women and Men with Fibromyalgia
The Journal of Sexual Medicine
10/23/2011 11:00:00 PM
Conclusion.  Our results show that sexual dysfunction is common in patients with fibromyalgia. The disease seems to deeply affect all dimensions of sexual functioning in both females and males. Rico‐Villademoros F, Calandre EP, Rodríguez‐López CM, García‐Carrillo J, Ballesteros J, Hidalgo‐Tallón J, and García‐Leiva JM. Sexual functioning in women and men with fibromyalgia. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)
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Effectiveness of cognitive behaviour therapy for the treatment of catastrophisation in patients with fibromyalgia: A randomised controlled trial
Arthritis Research and Therapy
10/22/2011 11:00:00 PM
Cognitive behaviour therapy (CBT) should be included in standard treatment of fibromyalgia, as a clinical trial shows it improves outcomes including pain catastrophising, pain acceptance, function and quality of life. (Source: Arthritis Research and Therapy)
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Is fibromyalgia a discrete entity?
Autoimmunity Reviews
10/21/2011 11:00:00 PM
Authors: Ablin JN, Buskila D, Van Houde B, Luyten P, Atzeni F, Sarzi-Puttini P Abstract Fibromyalgia (FM) is defined as chronic widespread pain (CWP) with allodynia or hyperalgesia to pressure pain, and is classified as one of the largest group of soft tissue pain syndromes. Its pathogenesis is not entirely understood, although it is currently believed to be the result of a central nervous system (CNS) malfunction that increases pain transmission and perception. There are no instrumental tests to confirm the diagnosis, but many of the differential diagnoses can be excluded by means of an extensive clinical examination and patient history. Although fibromyalgia is a recognisable clinical entity, it would seem appropriate to consider the entire range of tenderness and distress in cli...
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Chronic Pain Care For Women Cost Nearly $13 Billion In 2008
Health News from Medical News Today
10/21/2011 3:00:00 AM
An estimated 12.1 million women age 18 and older reported suffering from chronic pain in 2008 as a result of underlying medical conditions such as chronic fatigue syndrome, endometriosis, fibromyalgia and vulvodynia. Of these women, only 8.7 million reported receiving treatment that year at a total cost of $12.9 billion, according to the latest News and Numbers from the Agency for Healthcare Research and Quality. Among other findings: -- About 11.2 percent of non-Hispanic white women, 8.3 percent of non-Hispanic black women and 8... (Source: Health News from Medical News Today)
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Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults
NeLM - Drug Specific Reviews
10/20/2011 11:00:00 PM
Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Valproic acid and its sodium salt (sodium valproate) are antiepileptic drugs that are sometimes used to treat chronic neuropathic pain and fibromyalgia, although they are not licensed for this use.   Objectives To evaluate the analgesic efficacy and adverse effects of valproic acid and sodium valproate in the management of chronic neuropathic pain and fibromyalgia.   Search strategy We identified randomised controlled trials (RCTs) of valproic acid and sodium valproate in acute, and chronic pain by searching MEDLINE, EMBASE and Cochrane CENTRAL to June 2011, together with reference lists of retrieved papers and reviews.   Selection criteria RCTs that were double blind and of eig...
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Exercise Eases Fibromyalgia Pain
WebMD Health
10/19/2011
When you have fibromyalgia, it can hurt just to think about exercising. But exercise actually eases painful symptoms, if you take it slowly. (Source: WebMD Health)
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The match–mismatch model of emotion processing styles and emotion regulation strategies in fibromyalgia
Journal of Psychosomatic Research
10/16/2011 11:00:00 PM
Conclusion: Findings suggest that for women with fibromyalgia who experience their emotions intensely, an emotional disclosure or expression intervention may be beneficial. This hypothesis requires verification in experimental studies. (Source: Journal of Psychosomatic Research)
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When is pain related to emotional distress and daily functioning in fibromyalgia syndrome? The mediating roles of self-efficacy and sleep quality.
British Journal of Health Psychology
10/16/2011 12:56:00 PM
Conclusions.  Sleep dysfunction is importantly related to FM symptoms and deserves more attention in both research and clinical practice. Our results suggest that, in addition to the usual treatment of FM, improving sleep could optimize the current management of the syndrome. PMID: 21988065 [PubMed - in process] (Source: British Journal of Health Psychology)

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Calling for End to Step-Therapy, Fail-First, and Special Tiers
Disabled World
10/15/2011 12:55:01 PM
National Fibromyalgia and Chronic Pain Association issues Position Paper Calling for End to Step-Therapy, Fail-First, and Special Tiers. (Source: Disabled World)

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Look Beyond the Disease Activity Score of 28 Joints (DAS28): Tender Points Influence the DAS28 in Patients with Rheumatoid Arthritis.
J Rheumatol
10/14/2011 11:00:00 PM
CONCLUSION: DAS28 is influenced by tender points, even in the non-fibromyalgia range, falsely suggesting higher disease activity and decreasing the sensitivity of the DAS28 criterion of low disease activity or remission. When applying DAS28-guided "tight control" or "treat-to-target" treatment strategies in RA, evaluation of not only the DAS28, but also its individual components along with a full joint and physical evaluation including assessment of TP is required to reliably estimate the individual's disease activity, which guides therapeutic decisions. PMID: 22002014 [PubMed - as supplied by publisher] (Source: J Rheumatol)
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Positive Associations Between Physical and Cognitive Performance Measures in Fibromyalgia
Archives of Physical Medicine and Rehabilitation
10/13/2011 11:00:00 PM
Conclusions: Researchers should continue to investigate the relationship between physical and cognitive function in both clinical and nonclinical populations, as well as explore changes across time. Because physical activity has been associated with neural improvements, further research may identify whether particular mechanisms, such as neurogenesis, synaptogenesis, or changes in inflammatory marker levels, are involved. (Source: Archives of Physical Medicine and Rehabilitation)
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Recurrent pain, stress, tender points, and fibromyalgia in childhood: an exploratory descriptive clinical study
Acta Paediatrica
10/12/2011 1:03:27 PM
Conclusions:  Children with psychosomatic pain can have an increased risk of developing fibromyalgia. A longer duration of pain and more locations in which pain is felt might increase this risk. In patients with a favourable outcome, the scores for stress tender points and fibromyalgia tender points decreased significantly. (Source: Acta Paediatrica)
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7th Circuit: Insurer's Application Of Self-Reporting Clause Wasn't Reasonable
LexisNexis® Mealey's™ Disability Insurance Legal News
10/12/2011 6:41:58 AM
CHICAGO - Upon panel rehearing, the Seventh Circuit U.S. Court of Appeals on Sept. 20 ruled that an insurer's termination of benefits based on the disability plan's self-reporting symptoms limitation clause was arbitrary and capricious because the claimant's diagnosis of disabling fibromyalgia was based on medical evidence and not the claimant's self-reported symptoms (Susie Weitzenkamp v. Unum Life Insurance Company of America, Nos. 10-3898 and 11-1006, 7th Cir.; 2011 U.S. App. LEXIS 19283). Full story on lexis.com (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
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Recurrent pain, stress, tender points and fibromyalgia in childhood: an exploratory descriptive clinical study
Acta Paediatrica
10/10/2011 11:00:00 PM
Conclusions:  Children with psychosomatic pain can have an increased risk of developing fibromyalgia. A longer duration of pain and more locations in which pain is felt might increase this risk. In patients with a favourable outcome, the scores for stress tender points and fibromyalgia tender points decreased significantly. (Source: Acta Paediatrica)

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[Fibromyalgia and psychiatry: 35 years later… What's new?]
Presse Medicale
10/10/2011 11:00:00 PM
Authors: Geoffroy PA, Amad A, Gangloff C, Thomas P Abstract Fibromyalgia (FM) is a complex disorder that affects 2 to 5% of the general population worldwide at any age and any sex, but more frequently in adult women. The variability of symptoms and the frequency of comorbidities among patients with fibromyalgia make this a difficult disorder to diagnose and treat. New diagnostic criteria are available to improve the diagnosis and care of patients. We propose the first French translation of the new diagnostic criteria proposed by the American College of Rheumatology (ACR) 2010. Although the etiology of fibromyalgia remains unclear, evidences suggest that biologic, genetic and environmental factors are involved. This chronic psychophysical suffering state of fibromyalgia adversely af...
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Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults.
Cochrane Database of Systematic Reviews
10/10/2011 8:20:04 PM
CONCLUSIONS: These three studies no more than hint that sodium valproate may reduce pain in diabetic neuropathy, and divalproex sodium in post-herpetic neuralgia, but the use of 'completer' analysis may overestimate efficacy, and there were too few data for pooled analysis of efficacy or harm, or to have confidence in the results of the individual studies. There is insufficient evidence to support the use of valproic acid or sodium valproate as a first-line treatment for neuropathic pain. There is more robust evidence of greater efficacy for a small number of other drugs. PMID: 21975791 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
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Cranial Electrical Stimulation Improves Symptoms and Functional Status in Individuals with Fibromyalgia
Pain Management Nursing
10/9/2011 11:00:00 PM
Abstract: To investigate the effects of microcurrent cranial electrical stimulation (CES) therapy on reducing pain and its associated symptoms in fibromyalgia (FM), we conducted a randomized, controlled, three-group (active CES device, sham device, and usual care alone [UC]), double-blind study to determine the potential benefit of CES therapy for symptom management in FM. Those individuals using the active CES device had a greater decrease in average pain (p = .023), fatigue (p = .071), and sleep disturbance (p = .001) than individuals using the sham device or those receiving usual care alone over time. Additionally, individuals using the active CES device had improved functional status versus the sham device and UC groups over time (p = .028). (Source: Pain Management Nursing)
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Opioid use, misuse, and abuse in patients labeled as fibromyalgia. - Fitzcharles MA, Ste-Marie PA, Gamsa A, Ware MA, Shir Y.
SafetyLit: All (Unduplicated)
10/9/2011 7:10:04 PM
BACKGROUND: As pain is the cardinal symptom of fibromyalgia, it is logical that treatments directed toward pain relief will be commonly used. Analgesic drug therapy remains the traditional treatment intervention for most chronic pain conditions, with a pro... (Source: SafetyLit: All (Unduplicated))
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Efficacy and Effectiveness of Exercise on Tender Points in Adults with Fibromyalgia: A Meta-Analysis of Randomized Controlled Trials
Infectious Diseases in Obstetrics and Gynecology
10/9/2011 10:27:12 AM
Fibromyalgia is a major public health problem affecting an estimated 200 to 400 million people worldwide. The purpose of this study was to use the meta-analytic approach to determine the efficacy and effectiveness of randomized controlled exercise intervention trials (aerobic, strength training, or both) on tender points (TPs) in adults with fibromyalgia. Using random effects models and 95% confidence intervals (CI), a statistically significant reduction in TPs was observed based on per-protocol analyses (8 studies representing 322 participants) but not intention-to-treat analyses (5 studies representing 338 participants) (per-protocol, g, −0.68, 95% CI, −1.16, −0.20; intention-to-treat, g, −0.24, 95% CI, −0.62, 0.15). Changes were equivalent to relative ...
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Prevalence of Fibromyalgia in France: a multi-step study research combining national screening and clinical confirmation: The DEFI study (Determination of Epidemiology of FIbromyalgia).
BMC Musculoskeletal Disorders
10/6/2011 11:00:00 PM
Conclusion: Fibromyalgia is a common condition; the 1.6% prevalence calculated in the French population in our study corroborates the figures published in the European literature. Our results also suggest that criteria such as regional pain score, stress level or SF36 quality of life, could represent useful tools in fibromyalgia diagnosis. (Source: BMC Musculoskeletal Disorders)
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Metabolic Abnormalities in Pain-Processing Regions of Patients with Fibromyalgia: A 3T MR Spectroscopy Study [FUNCTIONAL]
American Journal of Neuroradiology
10/6/2011 11:00:00 PM
CONCLUSIONS: The presence of elevated Glu/Cr levels in VLPFC strengthens the opinion that a complex neurophysiologic imbalance of different brain areas involved in pain processing underlies FM. These data may be useful in the diagnosis and development of more effective pharmacologic treatments. (Source: American Journal of Neuroradiology)

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Health-related quality of life in women with fibromyalgia: clinical and psychological factors associated
Clinical Rheumatology
10/6/2011 10:42:27 AM
The objective of the study was to analyse the impact of fibromyalgia (FM) on health-related quality of life (HRQOL) and to identify clinical and psychological factors associated with the disease. A cross-sectional study was conducted with adult Portuguese women with FM. Analysed data were demographic, clinical and psychological variables and HRQOL: SF-36 and Fibromyalgia Impact Questionnaire (FIQ). The relationship between HRQOL and the other variables was made with a bivariate analysis. To assess the relative contribution of clinical and psychological variables, a series of multiple regression analyses were designed and made. The study sample consisted of 76 women with FM (49.61 ± 10.07 years). All dimensions of HRQOL were affected in FM, especially Physical Functioning, P...
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Nocebo in fibromyalgia: meta‐analysis of placebo‐controlled clinical trials and implications for practice
European Journal of Neurology
10/3/2011 11:00:00 PM
Conclusions:  Nocebo is remarkably prevalent in FM patients participating in RCTs. Because nocebo contributes to drug intolerance and treatment failure in clinical practice, identification of predisposing factors and efforts to prevent nocebo by educating these patients appropriately may be important for FM outcome. (Source: European Journal of Neurology)
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The association of body mass index with symptom severity and quality of life in patients with fibromyalgia
Arthritis Care and Research
10/2/2011 11:00:00 PM
Conclusion:In patients with fibromyalgia, severe obesity (BMI ≥35.0) is associated with higher levels of fibromyalgia symptoms, and lower levels of QOL. © 2011 by the American College of Rheumatology. (Source: Arthritis Care and Research)
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An International, Randomized, Double-blind, Placebo-controlled, Phase III Trial of Pregabalin Monotherapy in Treatment of Patients with Fibromyalgia.
J Rheumatol
9/30/2011 11:00:00 PM
CONCLUSION: Pregabalin demonstrated modest efficacy in pain, global assessment, and function in FM at 450 mg/day, and improved sleep across all dose levels, but it did not provide consistent evidence of benefit at 300 and 600 mg/day in this study. Pregabalin was generally well tolerated for the treatment of FM. (Clinical trial registry NCT00333866). PMID: 21965636 [PubMed - as supplied by publisher] (Source: J Rheumatol)
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Opioid Use, Misuse, and Abuse in Patients Labeled as Fibromyalgia
The American Journal of Medicine
9/30/2011 11:00:00 PM
Conclusion: We have observed negative health and psychosocial status in patients using opioids and labeled as fibromyalgia. Prolonged use of opioids in fibromyalgia requires evaluation. (Source: The American Journal of Medicine)

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Fitness testing as a discriminative tool for the diagnosis and monitoring of fibromyalgia
Scandinavian Journal of Medicine and Science in Sports
9/30/2011 11:00:00 PM
We aimed to determine the ability of a set of physical fitness tests to discriminate between presence/absence of fibromyalgia (FM) and moderate/severe FM. The sample comprised 94 female FM patients (52 ± 8 years) and 66 healthy women (54 ± 6 years). We assessed physical fitness by means of the 30‐s chair stand, handgrip strength, chair sit and reach, back scratch, blind flamingo, 8‐feet up and go, and 6‐min walking tests. Patients were classified as having moderate FM if the score in the Fibromyalgia Impact Questionnaire (FIQ) was <70 and as having severe FM if the FIQ was ≥70. FM patients and patients with severe FM performed worse in most of the fitness tests studied (P < 0.001). Except the back scratch test, all the tests were able to discriminate between pre...
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Women with fibromyalgia have lower levels of calcium, magnesium, iron and manganese in hair mineral analysis.
J Korean Med Sci
9/30/2011 11:00:00 PM
In conclusion, the concentrations of calcium, magnesium, iron, and manganese in the hair of female patients with fibromyalgia are lower than of controls, even after adjustment of potential confounders. PMID: 22022174 [PubMed - in process] (Source: J Korean Med Sci)
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The longitudinal outcome of fibromyalgia: a study of 1555 patients.
J Rheumatol
9/30/2011 11:00:00 PM
CONCLUSION: Although we found no average clinically meaningful improvement in symptom severity overall, 25% had at least moderate improvement of pain over time. The result that emerged from this longitudinal study was one of generally continuing high levels of self-reported symptoms and distress for most patients, but a slight trend toward improvement. PMID: 21765102 [PubMed - in process] (Source: J Rheumatol)
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Link Discovered Between Smoking And Chronic Pain In Women
Health News from Medical News Today
9/30/2011 2:00:00 AM
Kentucky women who smoke heavily may experience more chronic musculoskeletal pain, suggests a new study led by University of Kentucky researchers. More than 6,000 Kentucky women over the age of 18 were surveyed on their smoking habits and symptoms of chronic pain. Syndromes included in the analysis were fibromyalgia, sciatica, chronic neck pain, chronic back pain, joint pain, chronic head pain, nerve problems, and pain all over the body... (Source: Health News from Medical News Today)
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Development of responder definitions for fibromyalgia clinical trials
Arthritis and Rheumatism
9/26/2011 11:00:00 PM
Conclusion:Among the 24 responder definitions tested, 2 were identified as most sensitive in identifying response to treatment. The identification of responder definitions for fibromyalgia clinical trials that include assessments of key symptom and functional domains may improve the sensitivity of clinical trials to identify meaningful improvements, leading to improved management of fibromyalgia. © 2011 American College of Rheumatology. (Source: Arthritis and Rheumatism)
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Executive Function in Chronic Pain Patients and Healthy Controls: Different Cortical Activation During Response Inhibition in Fibromyalgia
The Journal of Pain
9/25/2011 11:00:00 PM
Abstract: The primary symptom of fibromyalgia (FM) is chronic, widespread pain; however, patients report additional symptoms including decreased concentration and memory. Performance-based deficits are seen mainly in tests of working memory and executive function. Neural correlates of executive function were investigated in 18 FM patients and 14 age-matched healthy controls during a simple Go/No-Go task (response inhibition) while they underwent functional magnetic resonance imaging (fMRI). Performance was not different between FM and healthy control, in either reaction time or accuracy. However, fMRI revealed that FM patients had lower activation in the right premotor cortex, supplementary motor area, midcingulate cortex, putamen and, after controlling for anxiety, in the right insular co...
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Therapeutic effects of whole‐body devices applying pulsed electromagnetic fields (PEMF): A systematic literature review
Bioelectromagnetics
9/22/2011 4:03:25 PM
AbstractPulsed electromagnetic fields (PEMF) delivered by whole‐body mats are promoted in many countries for a wide range of therapeutic applications and for enhanced well‐being. However, neither the therapeutic efficacy nor the potential health hazards caused by these mats have been systematically evaluated. We conducted a systematic review of trials investigating the therapeutic effects of low‐frequency PEMF devices. We were interested in all health outcomes addressed so far in randomized, sham‐controlled, double‐blind trials. In total, 11 trials were identified. They were focused on osteoarthritis of the knee (3 trials) or the cervical spine (1), fibromyalgia (1), pain perception (2), skin ulcer healing (1), multiple sclerosis‐related fatigue (2), or heart rate variability a...

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Pain and Functional Capacity in Female Fibromyalgia Patients
Pain Medicine
9/20/2011 11:00:00 PM
Conclusions.  There is an inverse association of tender points count with the chair stand and distance walked in the 6‐minute walk tests, and a positive association of algometer score with the chair stand, distance walked in the 6‐minute walk and back scratch tests, yet, weight status seems to play a role in these associations. (Source: Pain Medicine)
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Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants
Molecular Pain
9/20/2011 11:00:00 PM
Conclusions: These results suggest that the repetitive intrathecal administration of antidepressants permanently cures ICS-induced FM pain in mice. (Source: Molecular Pain)
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Suicide attempts and risk of suicide in patients with fibromyalgia: a survey in Spanish patients
Rheumatology
9/19/2011 11:00:00 PM
Conclusions. FM is associated with an increased risk of suicide and suicide attempts. Suicidal behaviour seems to be related with the global severity of the disease. (Source: Rheumatology)
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Interference With Work in FibromyalgiaInterference With Work in Fibromyalgia
Medscape Today Headlines
9/19/2011 7:02:24 AM
Fibromyalgia leads to substantial interference with work and productivity. Does treatment with pregabalin help? BMC Musculoskeletal Disorders (Source: Medscape Today Headlines)

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The lived experience of fibromyalgia in female patients, a phenomenological study.
Chiropractic and Osteopathy
9/18/2011 11:00:00 PM
Conclusions: The study revealed the negative impact of fibromyalgia on patients' lives as comprising of great complexity and individuality. Several implications for health care practitioners can be extrapolated, including the need of a more efficient diagnostic process and increased education about the fibromyalgia experience. Further studies are required to better clarify the multifaceted nature of living with the condition. (Source: Chiropractic and Osteopathy)
http://www.medworm.com/rss/comments.php?id=5237199
Exploring online support spaces: Using cluster analysis to examine breast cancer, diabetes and fibromyalgia support groups
Patient Education and Counseling
9/18/2011 11:00:00 PM
Conclusion: The cluster analyses facilitate an increased understanding of various aspects of patient experience, including significant emotional and temporal aspects of the illness experience.Practice implications: The clusters highlighted the changing nature of patients’ information needs. Information provided to patients should be tailored to address their needs at various points during their illness. In addition, cluster analysis may be integrated into online support groups or other types of online interventions to assist patients in finding information. (Source: Patient Education and Counseling)
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Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: Comparison of reserpine-induced myalgia and chronic constriction injury rats.
Behavioural Brain Research
9/16/2011 11:00:00 PM
Authors: Nagakura Y, Takahashi M, Noto T, Sekizawa T, Oe T, Yoshimi E, Tamaki K, Shimizu Y Abstract The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms. The present study explored the pathophysiology underlying the pain symptoms in the RIM rat and the chronic constriction injury (CCI) rat, an animal model of neuropathic pain as a reference. Nerve tissue samples were collected from the nociception-tested animals for pathological examinations. Additionally, the therapeutic efficacy of a sodium channel blocker mexiletine was assessed in both rats. A slight vacuolization in the substantia nigra (SN) occurred in some of the RIM rats without any other histopathological changes in the brain or peripheral neurons. All the RIM rats, with or without vacu...
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Muscle Relaxant May Ease Fibromyalgia PainMuscle Relaxant May Ease Fibromyalgia Pain
Medscape Today Headlines
9/15/2011 2:00:08 PM
Low doses of cyclobenzaprine improved sleep and pain in a small study. WebMD Health News (Source: Medscape Today Headlines)
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Muscle Relaxant May Ease Fibromyalgia Pain
eMedicineHealth.com
9/15/2011 2:00:00 AM
(Source: eMedicineHealth.com)
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Efficacy of Hypnosis/guided Imagery in FibromyalgiaEfficacy of Hypnosis/guided Imagery in Fibromyalgia
Medscape Today Headlines
9/13/2011 6:07:07 AM
How effective is hypnosis/guided imagery in the treatment of fibromyalgia? BMC Musculoskeletal Disorders (Source: Medscape Today Headlines)
http://www.medworm.com/rss/comments.php?id=5213429
Fibromyalgia or fibromyalgia syndrome? A reply to the comment of Dr. Kroenke “Comparing fibromyalgia across different clinical settings: is it apples and oranges, or oranges and tangerines?”
European Journal of Pain
9/11/2011 11:00:00 PM
We are grateful for the interest of Dr. Kroenke in our article () and for expanding the scope of the paper from fibromyalgia syndrome (FMS) to functional somatic syndromes (). We appreciate the opportunity to respond to some of his profound comments. (Source: European Journal of Pain)
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Helicobacter pylori seropositivity in fibromyalgia syndrome
Clinical Rheumatology
9/9/2011 12:48:37 AM
Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10067-011-1839-6Authors Nuray Akkaya, Department of Physical Therapy and Rehabilitation, Pamukkale University Medical School, Denizli, TurkeySemih Akkaya, Department of Orthopedics and Traumatology, Pamukkale University Medical School, Denizli, TurkeyYusuf Polat, Clinical Microbiology, Denizli Government Hospital, Denizli, TurkeyMeral Turk, Clinical Parasitology, Denizli Government Hospital, Denizli, TurkeyTufan Turk, Clinic of Rheumatology, Denizli Government Hospital, Denizli, TurkeyElif Turhan, Department of Public Health, Pamukkale University Medical School, Denizli, TurkeyFusun Sahin, Department of Physical Medicine and Rehabilitation, Pamukkale University Medical School, Denizli, Turkey Journal ...
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Difference of fibromyalgia symptom scale between the Japanese version of the 2010 ACR preliminary diagnostic criteria for fibromyalgia and the modification of the ACR preliminary diagnostic criteria for fibromyalgia
Modern Rheumatology
9/9/2011 12:47:02 AM
Content Type Journal ArticleCategory LetterPages 1-1DOI 10.1007/s10165-011-0526-4Authors Katsuhiro Toda, Department of Rehabilitation, Hatsukaichi Memorial Hospital, 5-12 Youkoudai, Hatsukaichi, Hiroshima 738-0060, Japan Journal Modern RheumatologyOnline ISSN 1439-7609Print ISSN 1439-7595 (Source: Modern Rheumatology)

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Association of fibromyalgia characteristics in patients with non-metastatic breast cancer and the protective role of resilience
Rheumatology International
9/8/2011 1:09:48 AM
Abstract  Cancer patients often complain about weakness, fatigue, and pain. The aim of this study was to assess the features of the fibromyalgia syndrome (FMS) characteristics in patients with non-metastatic breast cancer. The study group included 40 women whose age ranged from 40 to 70 years with Stages 0–3 breast cancer. The control group included 40 healthy women matched by age. A diagnosis of FMS was established based on medical history, physical examination, and the Fibromyalgia Impact Questionnaire (FIQ). Pain measures and functional factors were evaluated by the Brief Pain Inventory and the Sheehan Questionnaire. Resilience was assessed by Antanovsky’s Sense of Coherence Questionnaire. Psychiatric disturbances were tested by the MINI Questionnaire and Hamilt...
http://www.medworm.com/rss/comments.php?id=5214636
Predictors of Pain Medication Selection Among Patients Diagnosed with Fibromyalgia
Pain Practice
9/7/2011 11:00:00 PM
Conclusions:  The presence of select comorbidities and prior use of certain medications were associated with the duloxetine initiation among working‐age, commercially insured patients with fibromyalgia. (Source: Pain Practice)
http://www.medworm.com/rss/comments.php?id=5915299
Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia
Arthritis and Rheumatism
9/7/2011 11:00:00 PM
Conclusion:Variation in these genes may serve as a basis for development of new diagnostic approaches, and these genes' products may contribute to the pathophysiology of FM and represent potential targets for therapeutic action. (Source: Arthritis and Rheumatism)
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TONIX Advances In Nighttime Fibromyalgia Meds Released
Health News from Medical News Today
9/7/2011 12:00:00 PM
In new research released this week, TONIX Pharmaceuticals has shared news that the very first drug being developed for night time usage in the treatment of fibromyalgia syndrome (FM), named cyclobenzaprine (CBP), is working on improving the condition's core symptoms. The analysis focused on the effect of doses administered at bedtime on FM symptoms, including pain, tenderness, fatigue, mood and EEG sleep physiology over eight weeks. The researchers hope to identify parameters that might be useful markers of drug effects. Fibromyalgia is not well understood by the medical community... (Source: Health News from Medical News Today)
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TONIX Pharmaceuticals' Bedtime Very Low Dose Cyclobenzaprine Study Featured in Journal of Rheumatology
Drugs.com - Clinical Trials
9/7/2011 8:09:09 AM
-Phase 2a Study Results Demonstrate Improvement in Core Fibromyalgia Symptoms Including Pain, Tenderness, Fatigue and Depression- -Correlation Between Improved Restorative Sleep and Drug Efficacy Among Treatment Group Subjects-   NEW... (Source: Drugs.com - Clinical Trials)
http://www.medworm.com/rss/comments.php?id=5198686
Psychological distress in fibromyalgia patients: A role for catechol-O-methyl-transferase Val158met polymorphism.
Health Psychology
9/4/2011 11:00:00 PM
Conclusions: The association of COMT genotype with psychological distress may be of importance as identifying subgroups is a challenge in the diagnosis and treatment of fibromyalgia patients. This association may contribute to open new perspectives into the understanding of the pathophysiology of fibromyalgia and stress-related genes. (PsycINFO Database Record (c) 2012 APA, all rights reserved) (Source: Health Psychology)
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Fibromyalgia and Chronic Pain LIFE Magazine
Disabled World
9/3/2011 9:26:13 AM
The National Fibromyalgia and Chronic Pain Association (NFMCPA)has released the inaugural issue of Fibromyalgia and Chronic Pain LIFE, the bi-monthly digital magazine for, by and about fibromyalgia and related chronic pain communities. (Source: Disabled World)

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Coping Strategies and Acceptance with FibromyalgiaCoping Strategies and Acceptance with Fibromyalgia
Medscape Today Headlines
9/2/2011 6:04:25 AM
Do acceptance-based or coping-based interventions lead to better functioning for fibromyalgia patients? BMC Musculoskeletal Disorders (Source: Medscape Today Headlines)
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Pirlindole in the Treatment of Depression and Fibromyalgia Syndrome
Clinical Drug Investigation
9/1/2011 9:05:29 PM
(Source: Clinical Drug Investigation)

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Fibromyalgia and Exercise
WebMD Health
9/1/2011 6:58:52 PM
Exercise can be one of the most effective treatments for fibromyalgia pain and other symptoms. But how to start? A step-by-step guide to getting motivated and sticking with exercise. (Source: WebMD Health)
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Fibromyalgia: Living a Balanced Life
WebMD Health
9/1/2011
Here’s how to get past chronic pain and fatigue to live a full life with fibromyalgia. (Source: WebMD Health)
http://www.medworm.com/rss/comments.php?id=5180470
T235 correlation of nk cells with symptom intensity in fibromyalgia syndrome patients
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5358873
T234 evaluation of cr, in comparison with gabapentin and amitriptyline, in a rat model of fibromyalgia
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)

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T233 fatigue: predictor of cognitive dysfunction in different diseases with chronic musculoskeletal pain: fibromyalgia and rheumatoid arthritis
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
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T231 microcirculation in skin and muscle during venous stasis, arterial ischemia and orthostatic challenge in patients with fibromyalgia and healthy controls
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5358869
T229 reducing of pain in patients with fibromyalgia syndrome by applying a vibration massage device
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
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T228 fibromyalgia and affective modulation of pain by using virtual environments
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5358866
T226 transcranial sonography and clinical findings in fibromyalgia patients – a pilot study
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)

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T225 multimodal physiotherapy plus deep water running (dwr) for fibromyalgia: a community based study
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5358863
T170 pathophysiology of fibromyalgia-like chronic pain in the reserpine-induced myalgia rat: comparison with neuropathic- and osteoarthritis-associated pain models
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5358835
51 european guidelines on fibromyalgia syndrome – pathogenesis and management
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5358761
Subtypes of patients with fibromyalgia, psychopathological characteristics and quality of life.
Actas Espanolas de Psiquiatria
8/31/2011 11:00:00 PM
Conclusions. Type I FM-group also had lower healthrelated quality of life, especially through emotional reactions and social isolation as well as more psychopathological affections than presented by type II FM-group. Keywords: Fibromyalgia, Subgroups, Health related quality of life, Psychopathology. PMID: 21953356 [PubMed - in process] (Source: Actas Espanolas de Psiquiatria)
http://www.medworm.com/rss/comments.php?id=5281569
Reduced insular gamma‐aminobutyric acid in fibromyalgia
Arthritis and Rheumatism
8/31/2011 11:00:00 PM
Conclusion:Diminished inhibitory neurotransmission resulting from lower concentrations of GABA within the right anterior insula may play a role in the pathophysiology of FM and other central pain syndromes. © 2011 American College of Rheumatology. (Source: Arthritis and Rheumatism)

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[Fibromyalgia].
Zeitschrift fur Rheumatologie
8/31/2011 11:00:00 PM
Authors: Späth M Abstract Although chronic musculoskeletal pain represents the main symptom of fibromyalgia, those affected usually experience many and various accompanying symptoms of differing frequency and extent. While symptoms such as non-restful sleep, daytime fatigue, impaired memory and concentration, morning stiffness, as well as digestive and urination disorders help to establish the diagnosis, they represent a particular disease burden on patients, those around them and on the social system. Pathogenetic research is focussed increasingly on a central dysregulation in pain perception and pain processing, leading to the concept of "central sensitisation" as a final common pathway for fibromyalgia and similar syndromes. This supports the recommendations for prompt multimod...
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Effects of Bedtime Very Low Dose Cyclobenzaprine on Symptoms and Sleep Physiology in Patients with Fibromyalgia Syndrome: A Double-blind Randomized Placebo-controlled Study.
J Rheumatol
8/31/2011 11:00:00 PM
CONCLUSION: Bedtime VLD CBP treatment improved core FM symptoms. Nights with CAP(A2+A3(Norm)) ≤ 33% may provide a biomarker for assessing treatment effects on nonrestorative sleep and associated fatigue and mood symptoms in persons with FM. PMID: 21885490 [PubMed - as supplied by publisher] (Source: J Rheumatol)
http://www.medworm.com/rss/comments.php?id=5209095
The modification of the american college of rheumatology preliminary diagnostic criteria for fibromyalgia should be supplemented and revised.
J Rheumatol
8/31/2011 11:00:00 PM
Authors: Toda K PMID: 21885522 [PubMed - in process] (Source: J Rheumatol)
http://www.medworm.com/rss/comments.php?id=5209046
Fibromyalgia - should we be testing and treating for vitamin D deficiency?
Australian Family Physician
8/31/2011 11:00:00 PM
Discussion The evidence for an association between fibromyalgia and vitamin D deficiency is inconclusive, with no improvement in pain on supplementation. However, patients with concurrent risk factors for deficiency should be tested and treated for vitamin D deficiency to minimise osteoporosis risk and maximise muscular strength. PMID: 21894281 [PubMed - in process] (Source: Australian Family Physician)
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Fibromyalgia: an overview and comparison of treatment options.
British Journal of Nursing
8/31/2011 11:00:00 PM
Authors: Ryan S Abstract Fibromyalgia is a common condition characterized by a multitude of physical and psychological symptoms which tend to persist overtime. The dominant symptom is that of widespread musculoskeletal pain. This paper discusses the possible causations of fibromyalgia, as well as the need for a biopsychosocial assessment to fully understand the pain experience and to inform treatment and the evidence base regarding therapeutic interventions. PMID: 22067492 [PubMed - in process] (Source: British Journal of Nursing)
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S238 spanish dna bank of patients with fibromyalgia and/or chronic fatigue syndrome
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359524
S237 functional brain imaging and cns involvement in fibromyalgia syndrome (fms): reviewing the evidence
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359523
S236 a confirmatory study of the combined index of severity of fibromyalgia (icaf): factorial structure, reliability and sensitivity to change
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)

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S235 hippocampus dysfunction in fibromyalgia syndrome assessment by magnetic resonance spectroscopy: systemic literature review
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359521
S234 bilateral cortical activation in fibromyalgia patients after unilateral painful stimulation measured with near-infrared spectroscopy
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
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S233 quantitative sensory testing in fibromyalgia associated or not to hemisensory syndrome: comparison with controls
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359519
S232 is fibromyalgia a neuropathic pain disease?
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359518
S230 serum paraoxonase (pon-1) activities, nitric oxide (no) and malondialdehyde (mda) levels are altered in patients with primer fibromyalgia syndrome (pfs)
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)

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F665 differential effects on pain, fatigue and positive affect ratings elicited by physical and emotional therapeutic interventions in fibromyalgia
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359365
F402 efficacy of executive functioning in fibromyalgia patients
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359243
F236 clinical and epidemiological evaluation of fibromyalgia in patients with hepatitis c virus
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359181
F235 cognitive-behavioural group therapy with hypnosis for the treatment of fibromyalgia: six month follow-up
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359180
F234 family distress in patients with fibromyalgia
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)

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F233 can we consider interleukin-6 as a responsible biomarker in fibromyalgia syndrome?
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359178
F232 does perception of control improve disability and symptoms in women with fibromyalgia?
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359177
F231 alexithymia in fibromyalgia syndrome: associations with pain intensity, anxiety, depression and well-being
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(Source: European Journal of Pain Supplements)
http://www.medworm.com/rss/comments.php?id=5359176
F230 comparison between quetiapine-xr and amitriptyline in fibromyalgia patients: a 16-week, randomized, open-label, non-inferiority trial
European Journal of Pain Supplements
8/31/2011 11:00:00 PM
(So